메뉴 건너뛰기




Volumn 406, Issue 1-2, 2009, Pages 134-138

KLOTHO gene polymorphisms G-395A and C1818T are associated with lipid and glucose metabolism, bone mineral density and systolic blood pressure in Japanese healthy subjects

Author keywords

Bone mineral density; Glucose metabolism; KLOTHO; Lipid metabolism; SNPs; Systolic blood pressure

Indexed keywords

ADENINE; CYTOSINE; GLUCOSE; GUANINE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; KLOTHO PROTEIN; THYMINE;

EID: 67650272365     PISSN: 00098981     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cca.2009.06.011     Document Type: Article
Times cited : (56)

References (23)
  • 1
    • 0028961446 scopus 로고
    • Salt-sensitive hypertension in transgenic mice overexpressing Na(+)-proton exchanger
    • Kuro-o M., Hanaoka K., Hiroi Y., et al. Salt-sensitive hypertension in transgenic mice overexpressing Na(+)-proton exchanger. Circ Res 76 (1995) 148-153
    • (1995) Circ Res , vol.76 , pp. 148-153
    • Kuro-o, M.1    Hanaoka, K.2    Hiroi, Y.3
  • 2
    • 0030724491 scopus 로고    scopus 로고
    • Mutation of the mouse KLOTHO gene leads to a syndrome resembling aging
    • Kuro-o M., Matsumura Y., Aizawa H., et al. Mutation of the mouse KLOTHO gene leads to a syndrome resembling aging. Nature 390 (1997) 45-51
    • (1997) Nature , vol.390 , pp. 45-51
    • Kuro-o, M.1    Matsumura, Y.2    Aizawa, H.3
  • 3
    • 0036729991 scopus 로고    scopus 로고
    • KLOTHO: a fundamental regulator of aging
    • Nabeshima Y. KLOTHO: a fundamental regulator of aging. Aging Res Rev 1 (2002) 627-638
    • (2002) Aging Res Rev , vol.1 , pp. 627-638
    • Nabeshima, Y.1
  • 4
    • 0032575483 scopus 로고    scopus 로고
    • Downregulation of the KLOTHO gene in the kidney under sustaioned circulatory stress in rats
    • Aizawa H., Saito Y., Nakamura T., et al. Downregulation of the KLOTHO gene in the kidney under sustaioned circulatory stress in rats. Biochem Biophys Res Commun 249 (1998) 865-871
    • (1998) Biochem Biophys Res Commun , vol.249 , pp. 865-871
    • Aizawa, H.1    Saito, Y.2    Nakamura, T.3
  • 5
    • 0035207072 scopus 로고    scopus 로고
    • Troglitazone improves endothelial function and augments renal KLOTHO mRNA expression in Otsuka Long-Evans Tokushima Fatty (OLETF) rats with multiple atherogenic risk factors
    • Yamagishi T., Saito Y., Nakamura T., et al. Troglitazone improves endothelial function and augments renal KLOTHO mRNA expression in Otsuka Long-Evans Tokushima Fatty (OLETF) rats with multiple atherogenic risk factors. Hypertens Res 24 (2001) 705-709
    • (2001) Hypertens Res , vol.24 , pp. 705-709
    • Yamagishi, T.1    Saito, Y.2    Nakamura, T.3
  • 6
    • 0032551734 scopus 로고    scopus 로고
    • KLOTHO protein protects against endothelial dysfunction
    • Saito Y., Yamagishi T., Nakamura T., et al. KLOTHO protein protects against endothelial dysfunction. Biochem Biophys Res Commum 248 (1998) 324-329
    • (1998) Biochem Biophys Res Commum , vol.248 , pp. 324-329
    • Saito, Y.1    Yamagishi, T.2    Nakamura, T.3
  • 7
    • 0034710838 scopus 로고    scopus 로고
    • In vivo KLOTHO gene delivery products against endothelial dysfunction in multiple risk factor syndrome
    • Saito Y., Nakamura T., Ohyama Y., et al. In vivo KLOTHO gene delivery products against endothelial dysfunction in multiple risk factor syndrome. Biochem Res Commun 276 (2000) 767-772
    • (2000) Biochem Res Commun , vol.276 , pp. 767-772
    • Saito, Y.1    Nakamura, T.2    Ohyama, Y.3
  • 8
    • 0033812019 scopus 로고    scopus 로고
    • Decreased insulin production and increased insulin sensitivity in the KLOTHO mutant mouse, a novel animal model for human aging
    • Utsugi T., Ohno T., Ohyama Y., et al. Decreased insulin production and increased insulin sensitivity in the KLOTHO mutant mouse, a novel animal model for human aging. Metabolism 49 (2000) 1118-1123
    • (2000) Metabolism , vol.49 , pp. 1118-1123
    • Utsugi, T.1    Ohno, T.2    Ohyama, Y.3
  • 9
    • 24944481544 scopus 로고    scopus 로고
    • Suppression of aging in mice by the hormone KLOTHO
    • Kurosu H., Yamamoto M., Clark J.D., et al. Suppression of aging in mice by the hormone KLOTHO. Science 309 (2005) 1829-1833
    • (2005) Science , vol.309 , pp. 1829-1833
    • Kurosu, H.1    Yamamoto, M.2    Clark, J.D.3
  • 10
    • 30044451280 scopus 로고    scopus 로고
    • KLOTHO-induced insulin resistance: a blessing in disguise?
    • Unger R.H. KLOTHO-induced insulin resistance: a blessing in disguise?. Nat Med 12 (2006) 56-57
    • (2006) Nat Med , vol.12 , pp. 56-57
    • Unger, R.H.1
  • 11
    • 0036785320 scopus 로고    scopus 로고
    • KLOTHO gene polymorphisms associated with bone density of aged postmenopausal women
    • Kawano K., Ogata N., Chiano M., et al. KLOTHO gene polymorphisms associated with bone density of aged postmenopausal women. J Bone Miner Res 17 (2002) 1744-1751
    • (2002) J Bone Miner Res , vol.17 , pp. 1744-1751
    • Kawano, K.1    Ogata, N.2    Chiano, M.3
  • 12
    • 0036309298 scopus 로고    scopus 로고
    • Association of KLOTHO gene polymorphism with bone density and spondylosis of the lumbar spine in postmenopausal women
    • Ogata N., Matsumura Y., Shiraki M., et al. Association of KLOTHO gene polymorphism with bone density and spondylosis of the lumbar spine in postmenopausal women. Bone 31 (2002) 37-42
    • (2002) Bone , vol.31 , pp. 37-42
    • Ogata, N.1    Matsumura, Y.2    Shiraki, M.3
  • 13
    • 12844263399 scopus 로고    scopus 로고
    • Association of polymorphisms of the androgen receptor and KLOTHO genes with bone mineral density in Japanese women
    • Yamada Y., Ando F., Niino N., and Shimokata H. Association of polymorphisms of the androgen receptor and KLOTHO genes with bone mineral density in Japanese women. J Mol Med 83 (2005) 50-57
    • (2005) J Mol Med , vol.83 , pp. 50-57
    • Yamada, Y.1    Ando, F.2    Niino, N.3    Shimokata, H.4
  • 14
    • 33748997951 scopus 로고    scopus 로고
    • Relationship between polymorphisms G395A in promoter and C1818T in exon 4 of the KLOTHO gene with glucose metabolism and cardiovascular risk factors in Korean women
    • Rhee E.J., Oh K.W., Yun E.J., et al. Relationship between polymorphisms G395A in promoter and C1818T in exon 4 of the KLOTHO gene with glucose metabolism and cardiovascular risk factors in Korean women. J Endocrinol Investig 29 (2006) 613-618
    • (2006) J Endocrinol Investig , vol.29 , pp. 613-618
    • Rhee, E.J.1    Oh, K.W.2    Yun, E.J.3
  • 15
    • 33746704926 scopus 로고    scopus 로고
    • KLOTHO gene polymorphism may be a genetic risk factor for atherosclerotic coronary artery disease but not for vasospastic angina in Japanese
    • Imamura A., Okumura K., Ogawa Y., et al. KLOTHO gene polymorphism may be a genetic risk factor for atherosclerotic coronary artery disease but not for vasospastic angina in Japanese. Clin Chim Acta 371 (2006) 66-70
    • (2006) Clin Chim Acta , vol.371 , pp. 66-70
    • Imamura, A.1    Okumura, K.2    Ogawa, Y.3
  • 16
    • 33748454417 scopus 로고    scopus 로고
    • The differential effects of age on the association of KLOTHO gene polymorphisms with coronary artery disease
    • Rhee E.J., Oh K.W., Lee W.Y., et al. The differential effects of age on the association of KLOTHO gene polymorphisms with coronary artery disease. Metabolism 55 (2006) 1344-1351
    • (2006) Metabolism , vol.55 , pp. 1344-1351
    • Rhee, E.J.1    Oh, K.W.2    Lee, W.Y.3
  • 17
    • 33748741795 scopus 로고    scopus 로고
    • KLOTHO is a genetic risk factor for ischemic stroke caused by cardioembolism in Korean females
    • Kim Y., Kim J.H., Nam Y.J., et al. KLOTHO is a genetic risk factor for ischemic stroke caused by cardioembolism in Korean females. Neurosci Lett 407 (2006) 189-194
    • (2006) Neurosci Lett , vol.407 , pp. 189-194
    • Kim, Y.1    Kim, J.H.2    Nam, Y.J.3
  • 18
    • 18244372958 scopus 로고    scopus 로고
    • Association of human aging with a functional variant of KLOTHO
    • Arking D.E., Krebsova A., Macek Sr. M., et al. Association of human aging with a functional variant of KLOTHO. Proc Natl Acad Sci U S A 99 (2002) 856-861
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 856-861
    • Arking, D.E.1    Krebsova, A.2    Macek Sr., M.3
  • 19
    • 0033779062 scopus 로고    scopus 로고
    • Polymerase chain reaction with confronting two-pair primers for polymorphism genotyping
    • Hamajima N., Saito T., Matsuo K., Kozaki K., Takahashi T., and Tajima K. Polymerase chain reaction with confronting two-pair primers for polymorphism genotyping. Jpn J Cancer Res 91 (2000) 865-868
    • (2000) Jpn J Cancer Res , vol.91 , pp. 865-868
    • Hamajima, N.1    Saito, T.2    Matsuo, K.3    Kozaki, K.4    Takahashi, T.5    Tajima, K.6
  • 20
    • 0026785968 scopus 로고
    • A novel exon mutation in the human beta-hexosaminidase beta subunit gene affects 3′ splice site selection
    • Wakamatsu N., Kobayashi H., Miyatake T., and Tsuji S. A novel exon mutation in the human beta-hexosaminidase beta subunit gene affects 3′ splice site selection. J Biol Chem 267 (1992) 2406-2413
    • (1992) J Biol Chem , vol.267 , pp. 2406-2413
    • Wakamatsu, N.1    Kobayashi, H.2    Miyatake, T.3    Tsuji, S.4
  • 21
    • 0031202066 scopus 로고    scopus 로고
    • Silent mutation induces exon skipping of fibrillin-1 gene in Marfan syndrome
    • Liu W., Qian C., and Francke U. Silent mutation induces exon skipping of fibrillin-1 gene in Marfan syndrome. Nat Genet 16 (1997) 328-329
    • (1997) Nat Genet , vol.16 , pp. 328-329
    • Liu, W.1    Qian, C.2    Francke, U.3
  • 22
    • 33751251421 scopus 로고    scopus 로고
    • Gender differences in free radical homeostasis during aging: shorter-lived female C57BL6 mice have increased oxidative stress
    • Ali S.S., Xiong C., Lucero J., Behrens M.M., Dugan L.L., and Quick K.L. Gender differences in free radical homeostasis during aging: shorter-lived female C57BL6 mice have increased oxidative stress. Aging Cell 5 (2006) 565-574
    • (2006) Aging Cell , vol.5 , pp. 565-574
    • Ali, S.S.1    Xiong, C.2    Lucero, J.3    Behrens, M.M.4    Dugan, L.L.5    Quick, K.L.6
  • 23
    • 57749190558 scopus 로고    scopus 로고
    • Current understanding of KLOTHO
    • Wang Y., and Sun Z. Current understanding of KLOTHO. Ageing Res Rev 8 (2009) 43-51
    • (2009) Ageing Res Rev , vol.8 , pp. 43-51
    • Wang, Y.1    Sun, Z.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.