Sulforaphane attenuation of experimental diabetic nephropathy involves GSK-3 beta/Fyn/Nrf2 signaling pathway

Journal of Nutritional Biochemistry

Volumn 26, Issue 6, 2015, Pages 596-606

  Shang, Guoguo ^a,b   Tang, Xinjun ^a   Gao, Pan ^a   Guo, Fanli ^a   Liu, Hongpeng ^a   Zhao, Zhonghua ^a   Chen, Qi ^a   Jiang, Tao ^a   Zhang, Nong ^a   Li, Hui ^a  

^a FUDAN UNIVERSITY   (China)

^b FUDAN UNIVERSITY SHANGHAI CANCER CENTER   (China)

Author keywords

Diabetic nephropathy; Fyn; Glycogen synthase kinase 3 beta; Mesangial cells; Nrf2; Sulforaphane

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; ALBUMIN; COLLAGEN TYPE 4; CREATININE; FIBRONECTIN; GLUCOSE; GLYCOGEN SYNTHASE KINASE 3BETA; LITHIUM CHLORIDE; MESSENGER RNA; PROTEIN KINASE FYN; SERINE; SULFORAPHANE; TRANSCRIPTION FACTOR NRF2; TRANSFORMING GROWTH FACTOR BETA1; 8-OXO-7-HYDRODEOXYGUANOSINE; ANTIOXIDANT; DEOXYGUANOSINE; FYN PROTEIN, RAT; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; ISOTHIOCYANIC ACID DERIVATIVE; NFE2L2 PROTEIN, RAT; SULFORAFAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; CREATININE URINE LEVEL; DIABETIC NEPHROPATHY; DRUG MECHANISM; EXPERIMENTAL KIDNEY DISEASE; EXPERIMENTAL MODEL; EXTRACELLULAR MATRIX; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; GLUCOSE URINE LEVEL; HISTOPATHOLOGY; IN VITRO STUDY; IN VIVO STUDY; KIDNEY INJURY; MALE; MESANGIUM CELL; NONHUMAN; NUCLEAR EXPORT SIGNAL; NUCLEAR IMPORT; OXIDATIVE STRESS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; RENAL PROTECTION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; UPREGULATION; ANALOGS AND DERIVATIVES; ANIMAL; CELL CULTURE; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEPHROPATHIES; DNA DAMAGE; DRUG EFFECTS; GENETICS; METABOLISM; PHOSPHORYLATION; SPRAGUE DAWLEY RAT;

RATTUS;

ANIMALS; ANTIOXIDANTS; CELLS, CULTURED; COLLAGEN TYPE IV; DEOXYGUANOSINE; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEPHROPATHIES; DNA DAMAGE; FIBRONECTINS; GLYCOGEN SYNTHASE KINASE 3; ISOTHIOCYANATES; MALE; MESANGIAL CELLS; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-FYN; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84928926391     PISSN: 09552863     EISSN: 18734847     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2014.12.008     Document Type: Article

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