-
1
-
-
67649197558
-
Modulation of phase II enzymes by sulforaphane: implications for its cardioprotective potential
-
Angeloni C, Leoncini E, Malaguti M, Angelini S, Hrelia P, Hrelia S. 2009. Modulation of phase II enzymes by sulforaphane: implications for its cardioprotective potential. J Agric Food Chem 57:5615-22.
-
(2009)
J Agric Food Chem
, vol.57
, pp. 5615-5622
-
-
Angeloni, C.1
Leoncini, E.2
Malaguti, M.3
Angelini, S.4
Hrelia, P.5
Hrelia, S.6
-
2
-
-
37649023810
-
Upregulation of heme oxygenase-1 by brazilin via the phosphatidylinositol 3-kinase/Akt and ERK pathways and its protective effect against oxidative injury
-
Choi BM, Kim BR. 2008. Upregulation of heme oxygenase-1 by brazilin via the phosphatidylinositol 3-kinase/Akt and ERK pathways and its protective effect against oxidative injury. Eur J Pharmacol 580:12-18.
-
(2008)
Eur J Pharmacol
, vol.580
, pp. 12-18
-
-
Choi, B.M.1
Kim, B.R.2
-
3
-
-
0034083227
-
Role of oxidative stress in cardiovascular diseases
-
Dhalla NS, Temsah RM, Netticadan T. 2000. Role of oxidative stress in cardiovascular diseases. J Hypertens 18:655-73.
-
(2000)
J Hypertens
, vol.18
, pp. 655-673
-
-
Dhalla, N.S.1
Temsah, R.M.2
Netticadan, T.3
-
4
-
-
52449089630
-
Direct and indirect antioxidant properties of inducers of cytoprotective proteins
-
Dinkova-Kostova AT, Talalay P. 2008. Direct and indirect antioxidant properties of inducers of cytoprotective proteins. Mol Nutr Food Res 52 (Suppl 1):S128-38.
-
(2008)
Mol Nutr Food Res
, vol.52
, Issue.SUPPL. 1
-
-
Dinkova-Kostova, A.T.1
Talalay, P.2
-
5
-
-
53449101213
-
Molecular mechanisms of natural products in chemoprevention: induction of cytoprotective enzymes by Nrf2
-
Eggler AL, Gay KA, Mesecar AD. 2008. Molecular mechanisms of natural products in chemoprevention: induction of cytoprotective enzymes by Nrf2. Mol Nutr Food Res 52 (Suppl 1):S84-94.
-
(2008)
Mol Nutr Food Res
, vol.52
, Issue.SUPPL. 1
-
-
Eggler, A.L.1
Gay, K.A.2
Mesecar, A.D.3
-
6
-
-
10344252804
-
Fruit, vegetable, and antioxidant intake and all-cause, cancer, and cardiovascular disease mortality in a community-dwelling population in Washington County, Maryland
-
Genkinger JM, Platz EA, Hoffman SC, Comstock GW, Helzlsouer KJ. 2004. Fruit, vegetable, and antioxidant intake and all-cause, cancer, and cardiovascular disease mortality in a community-dwelling population in Washington County, Maryland. Am J Epidemiol 160:1223-33.
-
(2004)
Am J Epidemiol
, vol.160
, pp. 1223-1233
-
-
Genkinger, J.M.1
Platz, E.A.2
Hoffman, S.C.3
Comstock, G.W.4
Helzlsouer, K.J.5
-
7
-
-
34548008730
-
Reperfusion injury salvage kinase signalling: taking a RISK for cardioprotection
-
Hausenloy DJ, Yellon DM. 2007. Reperfusion injury salvage kinase signalling: taking a RISK for cardioprotection. Heart Fail Rev 12:217-34.
-
(2007)
Heart Fail Rev
, vol.12
, pp. 217-234
-
-
Hausenloy, D.J.1
Yellon, D.M.2
-
8
-
-
0037164695
-
Doxorubicin induces early lipid peroxidation associated with changes in glucose transport in cultured cardiomyocytes
-
Hrelia S, Fiorentini D, Maraldi T, Angeloni C, Bordoni A, Biagi PL, Hakim G. 2002. Doxorubicin induces early lipid peroxidation associated with changes in glucose transport in cultured cardiomyocytes. Biochim Biophys Acta 1567:150-6.
-
(2002)
Biochim Biophys Acta
, vol.1567
, pp. 150-156
-
-
Hrelia, S.1
Fiorentini, D.2
Maraldi, T.3
Angeloni, C.4
Bordoni, A.5
Biagi, P.L.6
Hakim, G.7
-
9
-
-
3042688047
-
In vivopharmacokinetics and regulation of gene expression profiles by isothiocyanate sulforaphane in the rat
-
Hu R, Hebbar V, Kim BR, Chen C, Winnik B, Buckley B, Soteropoulos P, Tolias P, Hart RP, Kong AN. 2004. In vivopharmacokinetics and regulation of gene expression profiles by isothiocyanate sulforaphane in the rat. J Pharmacol Exp Ther 310:263-71.
-
(2004)
J Pharmacol Exp Ther
, vol.310
, pp. 263-271
-
-
Hu, R.1
Hebbar, V.2
Kim, B.R.3
Chen, C.4
Winnik, B.5
Buckley, B.6
Soteropoulos, P.7
Tolias, P.8
Hart, R.P.9
Kong, A.N.10
-
10
-
-
33746889956
-
Gene expression profiles induced by cancer chemopreventive isothiocyanate sulforaphane in the liver of C57BL/6J mice and C57BL/6J/Nrf2 (-/-) mice
-
Hu R, Xu C, Shen G, Jain MR, Khor TO, Gopalkrishnan A, Lin W, Reddy B, Chan JY, Kong AN. 2006. Gene expression profiles induced by cancer chemopreventive isothiocyanate sulforaphane in the liver of C57BL/6J mice and C57BL/6J/Nrf2 (-/-) mice. Cancer Lett 243:170-92.
-
(2006)
Cancer Lett
, vol.243
, pp. 170-192
-
-
Hu, R.1
Xu, C.2
Shen, G.3
Jain, M.R.4
Khor, T.O.5
Gopalkrishnan, A.6
Lin, W.7
Reddy, B.8
Chan, J.Y.9
Kong, A.N.10
-
11
-
-
0031577292
-
An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements
-
Itoh K, Chiba T, Takahashi S, Ishii T, Igarashi K, Katoh Y, Oyake T, Hayashi N, Satoh K, Hatayama I, Yamamoto M, Nabeshima Y. 1997. An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. Biochem Biophys Res Commun 236:313-22.
-
(1997)
Biochem Biophys Res Commun
, vol.236
, pp. 313-322
-
-
Itoh, K.1
Chiba, T.2
Takahashi, S.3
Ishii, T.4
Igarashi, K.5
Katoh, Y.6
Oyake, T.7
Hayashi, N.8
Satoh, K.9
Hatayama, I.10
Yamamoto, M.11
Nabeshima, Y.12
-
12
-
-
19344367171
-
Role of PI3K/Akt and MEK/ERK signaling pathways in sulforaphane- and erucin-induced phase II enzymes and MRP2 transcription, G2/M arrest and cell death in Caco-2 cells
-
Jakubikova J, Sedlak J, Mithen R, Bao Y. 2005. Role of PI3K/Akt and MEK/ERK signaling pathways in sulforaphane- and erucin-induced phase II enzymes and MRP2 transcription, G2/M arrest and cell death in Caco-2 cells. Biochem Pharmacol 69:1543-52.
-
(2005)
Biochem Pharmacol
, vol.69
, pp. 1543-1552
-
-
Jakubikova, J.1
Sedlak, J.2
Mithen, R.3
Bao, Y.4
-
13
-
-
0033530268
-
Fruit and vegetable intake in relation to risk of ischemic stroke
-
Joshipura KJ, Ascherio A, Manson JE, Stampfer MJ, Rimm EB, Speizer FE, Hennekens CH, Spiegelman D, Willett WC. 1999. Fruit and vegetable intake in relation to risk of ischemic stroke. JAMA 282:1233-9.
-
(1999)
JAMA
, vol.282
, pp. 1233-1239
-
-
Joshipura, K.J.1
Ascherio, A.2
Manson, J.E.3
Stampfer, M.J.4
Rimm, E.B.5
Speizer, F.E.6
Hennekens, C.H.7
Spiegelman, D.8
Willett, W.C.9
-
14
-
-
0037203464
-
Bioactive compounds in foods: their role in the prevention of cardiovascular disease and cancer
-
Kris-Etherton PM, Hecker KD, Bonanome A, Coval SM, Binkoski AE, Hilpert KF, Griel AE, Etherton TD. 2002. Bioactive compounds in foods: their role in the prevention of cardiovascular disease and cancer. Am J Med 113 (Suppl 9B):71S-88S.
-
(2002)
Am J Med
, vol.113
, Issue.SUPPL. 9B
-
-
Kris-Etherton, P.M.1
Hecker, K.D.2
Bonanome, A.3
Coval, S.M.4
Binkoski, A.E.5
Hilpert, K.F.6
Griel, A.E.7
Etherton, T.D.8
-
15
-
-
0033833788
-
Oxidative stress and cardiac disease
-
Lefer DJ, Granger DN. 2000. Oxidative stress and cardiac disease. Am J Med 109:315-23.
-
(2000)
Am J Med
, vol.109
, pp. 315-323
-
-
Lefer, D.J.1
Granger, D.N.2
-
16
-
-
0036849879
-
EU-funded research on functional foods
-
Lucas J. 2002. EU-funded research on functional foods. Br J Nutr 88 (Suppl 2):S131-32.
-
(2002)
Br J Nutr
, vol.88
, Issue.SUPPL. 2
-
-
Lucas, J.1
-
17
-
-
62249089498
-
Targeting the redox sensitive Nrf2-Keap1 defense pathway in cardiovascular disease: protection afforded by dietary isoflavones
-
Mann GE, Bonacasa B, Ishii T, Siow RC. 2009. Targeting the redox sensitive Nrf2-Keap1 defense pathway in cardiovascular disease: protection afforded by dietary isoflavones. Curr Opin Pharmacol 9:139-45.
-
(2009)
Curr Opin Pharmacol
, vol.9
, pp. 139-145
-
-
Mann, G.E.1
Bonacasa, B.2
Ishii, T.3
Siow, R.C.4
-
18
-
-
1542335553
-
Regulation of heme oxygenase-1 expression through the phosphatidylinositol 3-kinase/Akt pathway and the Nrf2 transcription factor in response to the antioxidant phytochemical carnosol
-
Martin D, Rojo AI, Salinas M, Diaz R, Gallardo G, Alam J, De Galarreta CM, Cuadrado A. 2004. Regulation of heme oxygenase-1 expression through the phosphatidylinositol 3-kinase/Akt pathway and the Nrf2 transcription factor in response to the antioxidant phytochemical carnosol. J Biol Chem 279:8919-29.
-
(2004)
J Biol Chem
, vol.279
, pp. 8919-8929
-
-
Martin, D.1
Rojo, A.I.2
Salinas, M.3
Diaz, R.4
Gallardo, G.5
Alam, J.6
De Galarreta, C.M.7
Cuadrado, A.8
-
19
-
-
9744283511
-
Transcription factor Nrf2 is essential for induction of NAD(P)H:quinone oxidoreductase 1, glutathione S-transferases, and glutamate cysteine ligase by broccoli seeds and isothiocyanates
-
McWalter GK, Higgins LG, McLellan LI, Henderson CJ, Song L, Thornalley PJ, Itoh K, Yamamoto M, Hayes JD. 2004. Transcription factor Nrf2 is essential for induction of NAD(P)H:quinone oxidoreductase 1, glutathione S-transferases, and glutamate cysteine ligase by broccoli seeds and isothiocyanates. J Nutr 134 (12 Suppl):3499S-3506S.
-
(2004)
J Nutr
, vol.134
, Issue.12 SUPPL.
-
-
McWalter, G.K.1
Higgins, L.G.2
McLellan, L.I.3
Henderson, C.J.4
Song, L.5
Thornalley, P.J.6
Itoh, K.7
Yamamoto, M.8
Hayes, J.D.9
-
20
-
-
73749083369
-
Plant foods and the risk of cerebrovascular diseases: a potential protection of fruit consumption
-
Mizrahi A, Knekt P, Montonen J, Laaksonen MA, Heliovaara M, Jarvinen R. 2009. Plant foods and the risk of cerebrovascular diseases: a potential protection of fruit consumption. Br J Nutr 102:1075-83.
-
(2009)
Br J Nutr
, vol.102
, pp. 1075-1083
-
-
Mizrahi, A.1
Knekt, P.2
Montonen, J.3
Laaksonen, M.A.4
Heliovaara, M.5
Jarvinen, R.6
-
21
-
-
77950353159
-
Comparison of the protective effects of steamed and cooked broccolis on ischaemia-reperfusion-induced cardiac injury
-
Mukherjee S, Lekli I, Ray D, Gangopadhyay H, Raychaudhuri U, Das DK. 2010. Comparison of the protective effects of steamed and cooked broccolis on ischaemia-reperfusion-induced cardiac injury. Br J Nutr 103:815-23.
-
(2010)
Br J Nutr
, vol.103
, pp. 815-823
-
-
Mukherjee, S.1
Lekli, I.2
Ray, D.3
Gangopadhyay, H.4
Raychaudhuri, U.5
Das, D.K.6
-
22
-
-
48049089409
-
(-)-Epigallocatechin gallate induces Nrf2-mediated antioxidant enzyme expression via activation of PI3K and ERK in human mammary epithelial cells
-
Na HK, Kim EH, Jung JH, Lee HH, Hyun JW, Surh YJ. 2008. (-)-Epigallocatechin gallate induces Nrf2-mediated antioxidant enzyme expression via activation of PI3K and ERK in human mammary epithelial cells. Arch Biochem Biophys 476:171-7.
-
(2008)
Arch Biochem Biophys
, vol.476
, pp. 171-177
-
-
Na, H.K.1
Kim, E.H.2
Jung, J.H.3
Lee, H.H.4
Hyun, J.W.5
Surh, Y.J.6
-
23
-
-
3142570440
-
The pathways and molecular mechanisms regulating Nrf2 activation in response to chemical stress
-
Nguyen T, Yang CS, Pickett CB. 2004. The pathways and molecular mechanisms regulating Nrf2 activation in response to chemical stress. Free Radic Biol Med 37:433-41.
-
(2004)
Free Radic Biol Med
, vol.37
, pp. 433-441
-
-
Nguyen, T.1
Yang, C.S.2
Pickett, C.B.3
-
24
-
-
0035853157
-
Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice
-
Ramos-Gomez M, Kwak MK, Dolan PM, Itoh K, Yamamoto M, Talalay P, Kensler TW. 2001. Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice. Proc Natl Acad Sci USA 98:3410-5.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 3410-3415
-
-
Ramos-Gomez, M.1
Kwak, M.K.2
Dolan, P.M.3
Itoh, K.4
Yamamoto, M.5
Talalay, P.6
Kensler, T.W.7
-
25
-
-
48749085399
-
Resveratrol protects primary rat hepatocytes against oxidative stress damage: activation of the Nrf2 transcription factor and augmented activities of antioxidant enzymes
-
Rubiolo JA, Mithieux G, Vega FV. 2008. Resveratrol protects primary rat hepatocytes against oxidative stress damage: activation of the Nrf2 transcription factor and augmented activities of antioxidant enzymes. Eur J Pharmacol 591:66-72.
-
(2008)
Eur J Pharmacol
, vol.591
, pp. 66-72
-
-
Rubiolo, J.A.1
Mithieux, G.2
Vega, F.V.3
-
27
-
-
56249106571
-
Nrf2 as a master redox switch in turning on the cellular signaling involved in the induction of cytoprotective genes by some chemopreventive phytochemicals
-
Surh YJ, Kundu JK, Na HK. 2008. Nrf2 as a master redox switch in turning on the cellular signaling involved in the induction of cytoprotective genes by some chemopreventive phytochemicals. Planta Med 74:1526-39.
-
(2008)
Planta Med
, vol.74
, pp. 1526-1539
-
-
Surh, Y.J.1
Kundu, J.K.2
Na, H.K.3
-
28
-
-
0034490852
-
Chemoprotection against cancer by induction of phase 2 enzymes
-
Talalay P. 2000. Chemoprotection against cancer by induction of phase 2 enzymes. Biofactors 12:5-11.
-
(2000)
Biofactors
, vol.12
, pp. 5-11
-
-
Talalay, P.1
-
29
-
-
0037106099
-
Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray
-
Thimmulappa RK, Mai KH, Srisuma S, Kensler TW, Yamamoto M, Biswal S. 2002. Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray. Cancer Res 62:5196-203.
-
(2002)
Cancer Res
, vol.62
, pp. 5196-5203
-
-
Thimmulappa, R.K.1
Mai, K.H.2
Srisuma, S.3
Kensler, T.W.4
Yamamoto, M.5
Biswal, S.6
-
31
-
-
67649670106
-
Curcumin upregulates transcription factor Nrf2, HO-1 expression and protects rat brains against focal ischemia
-
Yang C, Zhang X, Fan H, Liu Y. 2009. Curcumin upregulates transcription factor Nrf2, HO-1 expression and protects rat brains against focal ischemia. Brain Res 1282:133-41.
-
(2009)
Brain Res
, pp. 1282-1241
-
-
Yang, C.1
Zhang, X.2
Fan, H.3
Liu, Y.4
-
32
-
-
0036135910
-
Quantitative determination of dithiocarbamates in human plasma, serum, erythrocytes and urine: pharmacokinetics of broccoli sprout isothiocyanates in humans
-
Ye L, Dinkova-Kostova AT, Wade KL, Zhang Y, Shapiro TA, Talalay P. 2002. Quantitative determination of dithiocarbamates in human plasma, serum, erythrocytes and urine: pharmacokinetics of broccoli sprout isothiocyanates in humans. Clin Chim Acta 316:43-53.
-
(2002)
Clin Chim Acta
, vol.316
, pp. 43-53
-
-
Ye, L.1
Dinkova-Kostova, A.T.2
Wade, K.L.3
Zhang, Y.4
Shapiro, T.A.5
Talalay, P.6
-
33
-
-
70349639202
-
Protective effect of sulforaphane on indomethacin-induced cytotoxicity via heme oxygenase-1 expression in human intestinal Int 407 cells
-
Yeh CT, Chiu HF, Yen GC. 2009. Protective effect of sulforaphane on indomethacin-induced cytotoxicity via heme oxygenase-1 expression in human intestinal Int 407 cells. Mol Nutr Food Res 53:1166-76.
-
(2009)
Mol Nutr Food Res
, vol.53
, pp. 1166-1176
-
-
Yeh, C.T.1
Chiu, H.F.2
Yen, G.C.3
-
34
-
-
43049117465
-
Sulforaphane protects kidneys against ischemia-reperfusion injury through induction of the Nrf2-dependent phase 2 enzyme
-
Yoon HY, Kang NI, Lee HK, Jang KY, Park JW, Park BH. 2008. Sulforaphane protects kidneys against ischemia-reperfusion injury through induction of the Nrf2-dependent phase 2 enzyme. Biochem Pharmacol 75:2214-23.
-
(2008)
Biochem Pharmacol
, vol.75
, pp. 2214-2223
-
-
Yoon, H.Y.1
Kang, N.I.2
Lee, H.K.3
Jang, K.Y.4
Park, J.W.5
Park, B.H.6
-
35
-
-
73949142348
-
Activation of Nrf2 in endothelial cells protects arteries from exhibiting a proinflammatory state
-
Zakkar M, Van der Heiden K, Luong le A, Chaudhury H, Cuhlmann S, Hamdulay SS, Krams R, Edirisinghe I, Rahman I, Carlsen H, Haskard DO, Mason JC, Evans PC. 2009. Activation of Nrf2 in endothelial cells protects arteries from exhibiting a proinflammatory state. Arterioscler Thromb Vasc Biol 29:1851-7.
-
(2009)
Arterioscler Thromb Vasc Biol
, vol.29
, pp. 1851-1857
-
-
Zakkar, M.1
Van der Heiden, K.2
Luong le, A.3
Chaudhury, H.4
Cuhlmann, S.5
Hamdulay, S.S.6
Krams, R.7
Edirisinghe, I.8
Rahman, I.9
Carlsen, H.10
Haskard, D.O.11
Mason, J.C.12
Evans, P.C.13
-
36
-
-
51449117002
-
Nuclear factor E2-related factor 2-dependent myocardiac cytoprotection against oxidative and electrophilic stress
-
Zhu H, Jia Z, Misra BR, Zhang L, Cao Z, Yamamoto M, Trush MA, Misra HP, Li Y. 2008. Nuclear factor E2-related factor 2-dependent myocardiac cytoprotection against oxidative and electrophilic stress. Cardiovasc Toxicol 8:71-85.
-
(2008)
Cardiovasc Toxicol
, vol.8
, pp. 71-85
-
-
Zhu, H.1
Jia, Z.2
Misra, B.R.3
Zhang, L.4
Cao, Z.5
Yamamoto, M.6
Trush, M.A.7
Misra, H.P.8
Li, Y.9
|