Resveratrol induced premature senescence is associated with DNA damage mediated SIRT1 and SIRT2 down-regulation

PLoS ONE

Volumn 10, Issue 4, 2015, Pages

  Eren, Mehtap Kilic ^a   Kilincli, Ayten ^a   Eren, Özkan ^a  

^a ADNAN MENDERES UNIVERSITY   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; CASPASE 3; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN DEPENDENT KINASE INHIBITOR 2A; DOXORUBICIN; HISTONE H2AX; PROTEIN P53; RESVERATROL; SIRTUIN 1; SIRTUIN 2; SIRT1 PROTEIN, HUMAN; SIRT2 PROTEIN, HUMAN; STILBENE DERIVATIVE;

ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CELL AGING; CELL GROWTH; CELL PROLIFERATION; CELLULAR STRESS RESPONSE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA DAMAGE; DOWN REGULATION; DRUG EFFICACY; DRUG MECHANISM; ENZYME ACTIVITY; GROWTH INHIBITION; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RNA INTERFERENCE; SKIN FIBROBLAST; BIOSYNTHESIS; DRUG EFFECTS; FIBROBLAST; GENE EXPRESSION REGULATION; GENETICS; PRIMARY CELL CULTURE;

MAMMALIA;

CELL AGING; CELL PROLIFERATION; DNA DAMAGE; FIBROBLASTS; GENE EXPRESSION REGULATION; HUMANS; PRIMARY CELL CULTURE; SIRTUIN 1; SIRTUIN 2; STILBENES;

EID: 84928791794     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0124837     Document Type: Article

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