Resveratrol, but not dihydroresveratrol, induces premature senescence in primary human fibroblasts

Age

Volumn 33, Issue 4, 2011, Pages 555-564

  Faragher, Richard G A ^a   Burton, Dominic G A ^b   Majecha, Patricia ^a   Fong, Noel S Y ^a   Davis, Terence ^c   Sheerin, Angela ^a   Ostler, Elizabeth L ^a  

^a UNIVERSITY OF BRIGHTON   (United Kingdom)

^b UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^c CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Ageing; Cellular senescence; Ek1.Br; HCA2; MRC5; p38 MAP kinase; Resveratrol

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ALPHA DIHYDRORESVERATROL; BETA DIHYDRORESVERATROL; BETA GALACTOSIDASE; DIHYDRORESVERATROL; MITOGEN ACTIVATED PROTEIN KINASE P38; RESVERATROL; UNCLASSIFIED DRUG;

ARTICLE; CELL AGING; CELL CULTURE; CELL CYCLE ARREST; CELL PROLIFERATION; CELL STRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DRUG SYNTHESIS; FETUS; FIBROBLAST; HUMAN; HUMAN CELL; LIFESPAN; NICK END LABELING; PREMATURE CELL AGING;

BETA-GALACTOSIDASE; CELL AGING; CELL LINE; CELL PROLIFERATION; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; FIBROBLASTS; HUMANS; IMIDAZOLES; KI-67 ANTIGEN; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PYRIDINES; STILBENES;

EID: 80755172103     PISSN: 01619152     EISSN: 15744647     Source Type: Journal    
DOI: 10.1007/s11357-010-9201-5     Document Type: Article

References (32)

1. TM Bass D Weinkove K Houthoofd D Gems L Partridge 2007 Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans Mech Age Dev 128 546 552 10.1016/j.mad.2007.07.007 1:CAS:528:DC%2BD2sXhtFeiurrL (Pubitemid 47498522)
2. JL Barger T Kayo JM Vann EB Arias J Wang TA Hacker Y Wang D Raederstorff JD Morrow C Leeuwenburgh DB Allison KW Saupe GD Cartee R Weindruch TA Prolla 2008 A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice PLoS ONE 3 e2264 18523577 10.1371/journal.pone. 0002264
3. N Bellance G Benard F Furt H Begueret K Smolková E Passerieux JP Delage JM Baste P Moreau R Rossignol 2009 Bioenergetics of lung tumors: alteration of mitochondrial biogenesis and respiratory capacity Int J Biochem Cell Biol 41 2566 2577 19712747 10.1016/j.biocel.2009.08.012 1:CAS:528:DC%2BD1MXhtlGhsrvN
4. J Bird EL Ostler RGA Faragher 2003 Can we say that senescent cells cause aging? Exp Gerontol 38 11-12 1319 1326 14698811 10.1016/j.exger.2003.09.011 1:CAS:528:DC%2BD3sXhtVWisrbL (Pubitemid 38041218)
5. DGA Burton A Sheerin EL Ostler K Smith PJ Giles J Lowe W Rhys-Williams DG Kipling RGA Faragher 2007 Cyclin D1 over-expression permits the reproducible detection of senescent human vascular smooth muscle cells Ann NY Acad Sci 1119 20 31 18056951 10.1196/annals.1404.026 1:CAS:528:DC%2BD1cXpvVGjuw%3D%3D (Pubitemid 350191243)
6. DGA Burton 2009 Cellular senescence, ageing and disease AGE 31 1 1 9 19234764 10.1007/s11357-008-9075-y 1:STN:280:DC%2BD1M7lvVKhsQ%3D%3D
7. C Cao S Lu R Kivlin B Wallin E Card A Bagdasarian T Tamakloe WJ Wang X Song WM Chu N Kouttab A Xu Y Wan 2009 SIRT1 confers protection against UVB- and H2O2-induced cell death via modulation of p53 and JNK in cultured skin keratinocytes J Cell Mol Med 13 9b 3632 3643 18681908 10.1111/j.1582-4934.2008. 00453.x
8. T Davis DM Baird MF Haughton CJ Jones D Kipling 2005 Prevention of accelerated cell aging in Werner syndrome using a p38 mitogen-activated protein kinase inhibitor J Gerontol Biol Sci Med Sci 60 1386 1393 10.1093/gerona/60.11. 1386 (Pubitemid 41798444)
9. A Delgado J Casas A Llebaria JL Abad G Fabrias 2006 Inhibitors of sphingolipid metabolism enzymes Biochim Biophys Acta 1758 1957 1977 17049336 10.1016/j.bbamem.2006.08.017 1:CAS:528:DC%2BD28Xht12kt7zO (Pubitemid 44879369)
10. Ferry-Dumazet H, Garnier O, Mamani-Matsuda M, Vercauteren J, Belloc F, Billiard C, Dupouy M, Thiolat D, Kolb JP, Marit G, Reiffers J, Mossalayi MD. (2002) Resveratrol inhibits the growth and induces the apoptosis of both normal and leukemic hematopoietic cells. Carcinogenesis 23:1327-33
11. WD Funk CK Wang DN Shelton CB Harley GD Pagon WK Hoeffler 2000 Telomerase expression restores dermal integrity to in vitro-aged fibroblasts in a reconstituted skin model Exp Cell Res 258 270 278 10896778 10.1006/excr.2000. 4945 1:CAS:528:DC%2BD3cXkvVWrtro%3D (Pubitemid 30483505)
12. Giovannelli L, Pitozzi V, Jacomelli M, Mulinacci N, Laurenzana A, Dolara P, Mocali A (2010) Protective effects of resveratrol against senescence-associated changes in cultured human fibroblasts. J Gerontol A Biol Sci Med Sci (in press)
13. GL Grove VJ Cristofalo 1977 Characterization of the cell cycle of cultured human diploid cells: effects of aging and hydrocortisone J Cell Physiol 90 415 422 856836 10.1002/jcp.1040900305 1:CAS:528:DyaE2sXhvVels70%3D (Pubitemid 8078180)
14. C Henry X Vitrac A Decendit R Ennamany S Krisa JM Merillon 2005 Cellular uptake and efflux of trans-piceid and its aglycone trans-resveratrol on the apical membrane of human intestinal Caco-2 cells J Agric Food Chem 53 798 803 15686436 10.1021/jf048909e 1:CAS:528:DC%2BD2MXislSitg%3D%3D (Pubitemid 40194406)
15. U Herbig M Ferreira L Condel D Carey JM Sedivy 2006 Cellular senescence in aging primates Science 311 1257 16456035 10.1126/science.1122446 1:CAS:528:DC%2BD28XitV2hsbk%3D (Pubitemid 43334708)
16. KT Howitz KJ Bitterman HY Cohen DW Lamming S Lavu JG Wood RE Zipkin P Chung A Kisielewski LL Zhang B Scherer DA Sinclair 2003 Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan Nature 425 191 196 12939617 10.1038/nature01960 1:CAS:528:DC%2BD3sXntFCitr4%3D (Pubitemid 37150899)
17. M Jang L Cai GO Udeani KV Slowing CF Thomas CW Beecher HH Fong NR Farnsworth AD Kinghorn RG Mehta RC Moon JM Pezzuto 1997 Cancer chemopreventive activity of resveratrol, a natural product derived from grapes Science 275 218 220 8985016 10.1126/science.275.5297.218 1:CAS:528:DyaK2sXks1Sjtw%3D%3D (Pubitemid 127696281)
18. D Kipling DL Jones SK Smith PJ Giles K Jennert-Burston B Ibrahim AN Sheerin AJ Evans W Rhys-Willams RG Faragher 2009 A transcriptomic analysis of the EK1. Br strain of human fibroblastoid keratocytes: the effects of growth, quiescence and senescence Exp Eye Res 88 2 277 285 19087878 10.1016/j.exer.2008. 11.030 1:CAS:528:DC%2BD1MXjt1Sqsro%3D
19. A Lançon N Hanet B Jannin D Delmas J-M Heydel G Lizard M-C Chagnon Y Artur N Latruffe 2007 Resveratrol in human hepatoma HepG2 Cells: metabolism and inducibility of detoxifying enzymes Drug Metab Dispos 35 699 703 17287390 10.1124/dmd.106.013664 (Pubitemid 46641555)
20. MC Pascual-Martí A Salvador A Chafer A Berna 2001 Supercritical fluid extraction of resveratrol from grape skin of Vitis vinifera and determination by HPLC Talanta 54 735 740 18968296 10.1016/S0039-9140(01)00319-8 (Pubitemid 32458494)
21. KJ Pearson JA Baur KN Lewis L Peshkin NL Price N Labinskyy WR Swindell D Kamara RK Minor E Perez HA Jamieson Y Zhang SR Dunn K Sharma N Pleshko LA Woollett A Csiszar Y Ikeno D Le Couteur PJ Elliott KG Becker P Navas DK Ingram NS Wolf Z Ungvari DA Sinclair R de Cabo 2008 Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span Cell Metab 8 2 157 168 18599363 10.1016/j.cmet.2008.06.011 1:CAS:528:DC%2BD1cXpvVKrs74%3D
22. M Rusin A Zajkowicz D Butkiewicz 2009 Resveratrol induces senescence-like growth inhibition of U-2 OS cells associated with the instability of telomeric DNA and upregulation of BRCA1 Mech Ageing Dev 30 8 528 537 10.1016/j.mad.2009. 06.005
23. Saiko P, Szakmary A, Jaeger W, Szekeres T. (2008) Resveratrol and its analogs: defense against cancer, coronary disease and neurodegenerative maladies or just a fad? Mutat Res. 658:68-94 (Pubitemid 351172881)
24. LA Stivala M Savio F Carafoli P Perucca L Bianchi G Maga L Forti UM Pagnon A Albini E Prosper 2001 Specific structural determinants are responsible for the antioxidant activity and the cell cycle of resveratrol J Biol Chem 276 22586 22594 11316812 10.1074/jbc.M101846200 1:CAS:528:DC%2BD3MXkvVamsbw%3D
25. S Ulrich A Huwiler S Loitsch H Schmidt JM Stein 2007 De novo ceramide biosynthesis is associated with resveratrol-induced inhibition of ornithine decarboxylase activity Biochem Pharmacol 74 281 289 17521618 10.1016/j.bcp.2007.04.001 1:CAS:528:DC%2BD2sXmsFKgtLs%3D (Pubitemid 46890810)
26. Valenzano DR, Terzibasi E, Genade T, Cattaneo A, Domenici L, Cellerino A. (2006) Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate. Curr Biol. 16(3):296-300 (Pubitemid 43190229)
27. ME Venable JY Lee MJ Smyth A Bielawska LM Obeid 1995 Role of ceramide in cellular senescence J Biol Chem 270 30701 30708 8530509 10.1074/jbc.270.51.30701 1:CAS:528:DyaK28XhtFKksw%3D%3D (Pubitemid 26005136)
28. ME Venable X Yin 2009 Ceramide induces endothelial cell senescence Cell Biochem Funct 27 547 551 19842094 10.1002/cbf.1605 1:CAS:528:DC%2BD1MXhsV2mtbzI
29. Wakeling LA, Ions LJ, Ford D (2009) Could Sirt1-mediated epigenetic effects contribute to the longevity response to dietary restriction and be mimicked by other dietary interventions? Age (Dordr) (in press)
30. T Walle F Hsieh MH DeLegge JE Oatis Jr UK Walle 2004 High absorption but very low bioavailability of oral resveratrol in humans Drug Metab Dispos 32 1377 1382 15333514 10.1124/dmd.104.000885 1:CAS:528:DC%2BD2cXhtFGitrfE (Pubitemid 39564557)
31. JG Wood B Rogina S Lavu K Howitz SL Helfand M Tatar D Sinclair 2004 Sirtuin activators mimic caloric restriction and delay ageing in metazoans Nature 430 686 689 15254550 10.1038/nature02789 1:CAS:528:DC%2BD2cXmt1Gisb4%3D (Pubitemid 39061685)
32. 2-induced premature senescence of IMR-90 hTERT human fibroblasts FEBS Lett 580 6455 6463 17101135 10.1016/j.febslet.2006.10.064 1:CAS:528: DC%2BD28Xht1els7zP (Pubitemid 44750937)