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Volumn 8, Issue 3, 2015, Pages 335-352

Glutamatergic agents for schizophrenia: Current evidence and perspectives

Author keywords

amino acid neurotransmission; antipsychotic; cognition; glutamate; psychosis; schizophrenia

Indexed keywords

BIOLOGICAL MARKER; CLOZAPINE; DOPAMINE; DOPAMINE RECEPTOR BLOCKING AGENT; GLYCINE; LAMOTRIGINE; METABOTROPIC RECEPTOR AGONIST; MOOD STABILIZER; N METHYL DEXTRO ASPARTIC ACID RECEPTOR STIMULATING AGENT; NEUROLEPTIC AGENT; PLACEBO; TOPIRAMATE; AMINO ACID RECEPTOR AFFECTING AGENT; GLUTAMIC ACID;

EID: 84928647586     PISSN: 17512433     EISSN: 17512441     Source Type: Journal    
DOI: 10.1586/17512433.2015.1040393     Document Type: Review
Times cited : (31)

References (201)
  • 1
    • 68949180394 scopus 로고    scopus 로고
    • Schizophrenia
    • van Os J, Kapur S. Schizophrenia. Lancet 2009;374(9690):635-45
    • (2009) Lancet , vol.374 , Issue.9690 , pp. 635-645
    • Van Os, J.1    Kapur, S.2
  • 2
    • 84920703518 scopus 로고    scopus 로고
    • Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: A systematic analysis for the Global Burden of Disease Study 2013
    • Collaborators GMaCoD. Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: A systematic analysis for the Global Burden of Disease Study 2013. The Lancet 2015;385(9963):117-71
    • (2015) The Lancet , vol.385 , Issue.9963 , pp. 117-171
    • Gmacod, C.1
  • 4
    • 84872356828 scopus 로고    scopus 로고
    • World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for Biological Treatment of Schizophrenia, Part 2: Update 2012 on the long-term treatment of schizophrenia and management of antipsychotic-induced side effects
    • Hasan A, Falkai P, Wobrock T, et al. World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for Biological Treatment of Schizophrenia, Part 2: Update 2012 on the long-term treatment of schizophrenia and management of antipsychotic-induced side effects. World J Biol Psychiatry 2012;14(1):2-44
    • (2012) World J Biol Psychiatry , vol.14 , Issue.1 , pp. 2-44
    • Hasan, A.1    Falkai, P.2    Wobrock, T.3
  • 5
    • 84881465015 scopus 로고    scopus 로고
    • A systematic review and meta-analysis of recovery in schizophrenia
    • Jääskeläinen E, Juola P, Hirvonen N, et al. A systematic review and meta-analysis of recovery in schizophrenia. Schizophr Bull 2013;39:1296-306
    • (2013) Schizophr Bull , vol.39 , pp. 1296-1306
    • Jääskeläinen, E.1    Juola, P.2    Hirvonen, N.3
  • 6
    • 84881180921 scopus 로고    scopus 로고
    • Attitudes towards psychiatric treatment and people with mental illness: Changes over two decades
    • Angermeyer MC, Matschinger H, Schomerus G. Attitudes towards psychiatric treatment and people with mental illness: changes over two decades. Br J Psychiatry 2013;203:146-51
    • (2013) Br J Psychiatry , vol.203 , pp. 146-151
    • Angermeyer, M.C.1    Matschinger, H.2    Schomerus, G.3
  • 7
    • 84878600449 scopus 로고    scopus 로고
    • Personal stigma in schizophrenia spectrum disorders: A systematic review of prevalence rates, correlates, impact and interventions
    • Gerlinger G, Hauser M, De Hert M, et al. Personal stigma in schizophrenia spectrum disorders: A systematic review of prevalence rates, correlates, impact and interventions. World Psychiatry 2013;12(2):155-64
    • (2013) World Psychiatry , vol.12 , Issue.2 , pp. 155-164
    • Gerlinger, G.1    Hauser, M.2    De Hert, M.3
  • 8
    • 84865309293 scopus 로고    scopus 로고
    • The Nature of dopamine dysfunction in schizophrenia and what this means for treatment: A meta-analysis of imaging studies
    • Howes OD, Kambeitz J, Kim E, et al. The Nature of dopamine dysfunction in schizophrenia and what this means for treatment: A meta-analysis of imaging studies. Arch Gen Psychiatry 2012;69(8): 776-86
    • (2012) Arch Gen Psychiatry , vol.69 , Issue.8 , pp. 776-786
    • Howes, O.D.1    Kambeitz, J.2    Kim, E.3
  • 9
    • 84857053838 scopus 로고    scopus 로고
    • Glutamatergic transmission in schizophrenia: From basic research to clinical practice
    • Kantrowitz J, Javitt DC. Glutamatergic transmission in schizophrenia: from basic research to clinical practice. Curr Opin Psychiatry 2013;25(2):96-102
    • (2013) Curr Opin Psychiatry , vol.25 , Issue.2 , pp. 96-102
    • Kantrowitz, J.1    Javitt, D.C.2
  • 10
    • 77954166205 scopus 로고    scopus 로고
    • From receptor pharmacology to improved outcomes: Individualising the selection, dosing, and switching of antipsychotics
    • Correll CU. From receptor pharmacology to improved outcomes: individualising the selection, dosing, and switching of antipsychotics. Eur Psychiatry 2010; 25(Suppl 2):S12-21
    • (2010) Eur Psychiatry , vol.25 , pp. S12-21
    • Correll, C.U.1
  • 11
    • 77957849121 scopus 로고    scopus 로고
    • Past and Present Progress in the Pharmacologic Treatment of Schizophrenia
    • Kane JM, Correll CU. Past and Present Progress in the Pharmacologic Treatment of Schizophrenia. J Clin Psychiatry 2010;71(9): 1115-24
    • (2010) J Clin Psychiatry , vol.71 , Issue.9 , pp. 1115-1124
    • Kane, J.M.1    Correll, C.U.2
  • 12
    • 84925229841 scopus 로고    scopus 로고
    • Thinking and acting beyond the positive: The role of the cognitive and negative symptoms in schizophrenia
    • Carbon M, Correll CU. Thinking and acting beyond the positive: the role of the cognitive and negative symptoms in schizophrenia. CNS Spectr 2014; 19(Suppl S1):35-53
    • (2014) CNS Spectr , vol.19 , pp. 35-53
    • Carbon, M.1    Correll, C.U.2
  • 13
    • 0028114486 scopus 로고
    • An overview of the mechanism of action of clozapine
    • Meltzer HY. An overview of the mechanism of action of clozapine. J Clin Psychiatry 1994;55(Suppl B):47-52
    • (1994) J Clin Psychiatry , vol.55 , pp. 47-52
    • Meltzer, H.Y.1
  • 14
    • 70349443516 scopus 로고    scopus 로고
    • Clozapine, GABA(B), and the treatment of resistant schizophrenia
    • Daskalakis ZJ, George TP. Clozapine, GABA(B), and the treatment of resistant schizophrenia. Clin Pharmacol Ther 2009; 86(4):442-6
    • (2009) Clin Pharmacol Ther , vol.86 , Issue.4 , pp. 442-446
    • Daskalakis, Z.J.1    George, T.P.2
  • 15
    • 84857082115 scopus 로고    scopus 로고
    • Clozapine, but not haloperidol, enhances glial d-serine and L-glutamate release in rat frontal cortex and primary cultured astrocytes
    • Tanahashi S, Yamamura S, Nakagawa M, et al. Clozapine, but not haloperidol, enhances glial d-serine and L-glutamate release in rat frontal cortex and primary cultured astrocytes. Br J Pharmacol 2012; 165(5):1543-55
    • (2012) Br J Pharmacol , vol.165 , Issue.5 , pp. 1543-1555
    • Tanahashi, S.1    Yamamura, S.2    Nakagawa, M.3
  • 16
    • 84881619853 scopus 로고    scopus 로고
    • Comorbid obsessive-compulsive symptoms in schizophrenia: Contributions of pharmacological and genetic factors
    • Schirmbeck F, Zink M. Comorbid obsessive-compulsive symptoms in schizophrenia: contributions of pharmacological and genetic factors. Front Pharmacol 2013;4:99
    • (2013) Front Pharmacol , vol.4 , pp. 99
    • Schirmbeck, F.1    Zink, M.2
  • 17
    • 84555202697 scopus 로고    scopus 로고
    • What are we looking for in new Antipsychotics
    • Correll CU. What are we looking for in new Antipsychotics? J Clin Psychiatry 2011; 72(Suppl 1):9-13
    • (2011) J Clin Psychiatry , vol.72 , pp. 9-13
    • Correll, C.U.1
  • 18
    • 84870057403 scopus 로고    scopus 로고
    • Pharmacological treatment of schizophrenia: A critical review of the pharmacology and clinical effects of current and future therapeutic agents
    • Miyamoto S, Miyake N, Jarskog LF, et al. Pharmacological treatment of schizophrenia: A critical review of the pharmacology and clinical effects of current and future therapeutic agents. Mol Psychiatry 2012; 17(12):1206-27
    • (2012) Mol Psychiatry , vol.17 , Issue.12 , pp. 1206-1227
    • Miyamoto, S.1    Miyake, N.2    Jarskog, L.F.3
  • 20
    • 84898737913 scopus 로고    scopus 로고
    • The endocannabinoid system and schizophrenia: Links to the underlying pathophysiology and to novel treatment approaches
    • Gupta S, Cahill JD, Ranganathan M, Correll CU. The endocannabinoid system and schizophrenia: links to the underlying pathophysiology and to novel treatment approaches. J Clini Psychiatry 2014;75(3): 285-7
    • (2014) J Clini Psychiatry , vol.75 , Issue.3 , pp. 285-287
    • Gupta, S.1    Cahill, J.D.2    Ranganathan, M.3    Correll, C.U.4
  • 21
    • 84891774415 scopus 로고    scopus 로고
    • Cognitive-behavioural therapy for the symptoms of schizophrenia: Systematic review and meta-analysis with examination of potential bias
    • Jauhar S, McKenna PJ, Radua J, et al. Cognitive-behavioural therapy for the symptoms of schizophrenia: systematic review and meta-analysis with examination of potential bias. Br J Psychiatry 2014; 204(1):20-9
    • (2014) Br J Psychiatry , vol.204 , Issue.1 , pp. 20-29
    • Jauhar, S.1    McKenna, P.J.2    Radua, J.3
  • 22
    • 79956121382 scopus 로고    scopus 로고
    • Cognitive behavior therapy for schizophrenia: A meta-analytical review of randomized controlled trials
    • Sarin F, Wallin L, Widerloev B. Cognitive behavior therapy for schizophrenia: A meta-analytical review of randomized controlled trials. Nord J Psychiatry 2011; 65(3):162-74
    • (2011) Nord J Psychiatry , vol.65 , Issue.3 , pp. 162-174
    • Sarin, F.1    Wallin, L.2    Widerloev, B.3
  • 23
    • 84912534834 scopus 로고    scopus 로고
    • Cognitive-behavioural therapy for obsessive-compulsive symptoms in schizophrenia
    • Schirmbeck F, Zink M. Cognitive-behavioural therapy for obsessive-compulsive symptoms in schizophrenia. The Cognitive Behavioural Therapist 2013;6:e7
    • (2013) The Cognitive Behavioural Therapist , vol.6 , pp. e7
    • Schirmbeck, F.1    Zink, M.2
  • 24
    • 84856740864 scopus 로고    scopus 로고
    • Randomized trial to evaluate the efficacy of cognitive therapy for low-functioning patients with schizophrenia
    • Grant PM, Huh GA, Perivoliotis D, et al. Randomized trial to evaluate the efficacy of cognitive therapy for low-functioning patients with schizophrenia. Arch Gen Psychiatry 2012;69(2):121-7
    • (2012) Arch Gen Psychiatry , vol.69 , Issue.2 , pp. 121-127
    • Grant, P.M.1    Huh, G.A.2    Perivoliotis, D.3
  • 25
    • 80054934207 scopus 로고    scopus 로고
    • Schizophrenia guidelines across the world: A selective review and comparison
    • Gaebel W, Riesbeck M, Wobrock T. Schizophrenia guidelines across the world: A selective review and comparison. Int Rev Psychiatry 2011;23(4):379-87
    • (2011) Int Rev Psychiatry , vol.23 , Issue.4 , pp. 379-387
    • Gaebel, W.1    Riesbeck, M.2    Wobrock, T.3
  • 26
    • 84901505815 scopus 로고    scopus 로고
    • Cognitive behavioural therapy (brief versus standard duration) for schizophrenia
    • Naeem F, Farooq S, Kingdom D. Cognitive behavioural therapy (brief versus standard duration) for schizophrenia. Cochrane Database Syst Rev 2014;4:CD010646
    • (2014) Cochrane Database Syst Rev , vol.4 , pp. CD010646
    • Naeem, F.1    Farooq, S.2    Kingdom, D.3
  • 27
    • 84885170937 scopus 로고    scopus 로고
    • Non-adherence to medication in patients with psychotic disorders: Epidemiology, contributing factors and management strategies
    • Kane JM, Kishimoto T, Correll CU. Non-adherence to medication in patients with psychotic disorders: epidemiology, contributing factors and management strategies. World Psychiatry 2013;12(3): 216-26
    • (2013) World Psychiatry , vol.12 , Issue.3 , pp. 216-226
    • Kane, J.M.1    Kishimoto, T.2    Correll, C.U.3
  • 28
    • 84927566479 scopus 로고    scopus 로고
    • Recognition of patients who would benefit from LAI antipsychotic treatment: How to assess adherence
    • Correll CU. Recognition of patients who would benefit from LAI antipsychotic treatment: how to assess adherence. J Clin Psychiatry 2014;75:11
    • (2014) J Clin Psychiatry , vol.75 , pp. 11
    • Correll, C.U.1
  • 29
    • 84880193278 scopus 로고    scopus 로고
    • Assessing the comparative effectiveness of long-acting injectable vs. Oral antipsychotic medications in the prevention of relapse provides a case study in comparative effectiveness research in psychiatry
    • Kane JM, Kishimoto T, Correll CU. Assessing the comparative effectiveness of long-acting injectable vs. oral antipsychotic medications in the prevention of relapse provides a case study in comparative effectiveness research in psychiatry. J Clin Epidemiol 2013;66(8 Suppl):S37-41
    • (2013) J Clin Epidemiol , vol.66 , Issue.8 , pp. S37-41
    • Kane, J.M.1    Kishimoto, T.2    Correll, C.U.3
  • 30
    • 84892639627 scopus 로고    scopus 로고
    • Long-acting injectable vs oral antipsychotics for relapse prevention in schizophrenia: A meta-analysis of randomized trials
    • Kishimoto T, Robenzadeh A, Leucht C, et al. Long-acting injectable vs oral antipsychotics for relapse prevention in schizophrenia: A meta-analysis of randomized trials. Schizophr Bull 2014; 40(1):192-213
    • (2014) Schizophr Bull , vol.40 , Issue.1 , pp. 192-213
    • Kishimoto, T.1    Robenzadeh, A.2    Leucht, C.3
  • 31
    • 84900820152 scopus 로고    scopus 로고
    • Effectiveness of Paliperidone Palmitate vs Haloperidol Decanoate for Maintenance Treatment of Schizophrenia A Randomized Clinical Trial
    • McEvoy JP, Byerly M, Hamer RM, et al. Effectiveness of Paliperidone Palmitate vs Haloperidol Decanoate for Maintenance Treatment of Schizophrenia A Randomized Clinical Trial. JAMA 2014;311(19):1978-87
    • (2014) JAMA , vol.311 , Issue.19 , pp. 1978-1987
    • McEvoy, J.P.1    Byerly, M.2    Hamer, R.M.3
  • 32
    • 84928627922 scopus 로고    scopus 로고
    • Comparative effectiveness of risperidone long-acting injectable vs first-generation antipsychotic long-acting injectables in schizophrenia: Results from a nationwide, retrospective inception cohort study
    • Nielsen J, Jensen SO, Friis RB, et al. Comparative effectiveness of risperidone long-acting injectable vs first-generation antipsychotic long-acting injectables in schizophrenia: results from a nationwide, retrospective inception cohort study. Schizophr Bull 2015;41(3):627-36
    • (2015) Schizophr Bull , vol.41 , Issue.3 , pp. 627-636
    • Nielsen, J.1    Jensen, S.O.2    Friis, R.B.3
  • 33
    • 84887080795 scopus 로고    scopus 로고
    • Long-acting injectable versus oral antipsychotics in schizophrenia: A systematic review and meta-analysis of mirror-image studies
    • Kishimoto T, Nitta M, Borenstein M, et al. Long-acting injectable versus oral antipsychotics in schizophrenia: A systematic review and meta-analysis of mirror-image studies. J Clin Psychiatry 2013;74(10): 957-65
    • (2013) J Clin Psychiatry , vol.74 , Issue.10 , pp. 957-965
    • Kishimoto, T.1    Nitta, M.2    Borenstein, M.3
  • 34
    • 77955999643 scopus 로고    scopus 로고
    • Clozapine: More side effects but still the best antipsychotic
    • Kang X, Simpson GM. Clozapine: more side effects but still the best antipsychotic. J Clin Psychiatry 2010;71(8):982-3
    • (2010) J Clin Psychiatry , vol.71 , Issue.8 , pp. 982-983
    • Kang, X.1    Simpson, G.M.2
  • 35
    • 0023812652 scopus 로고
    • Clozapine for the treatment-resistant schizophrenic. A double-blind comparison with chlorpromazine
    • Kane J, Honigfeld G, Singer J, Meltzer H. Clozapine for the treatment-resistant schizophrenic. A double-blind comparison with chlorpromazine. Arch Gen Psychiatry 1988;45(9):789-96
    • (1988) Arch Gen Psychiatry , vol.45 , Issue.9 , pp. 789-796
    • Kane, J.1    Honigfeld, G.2    Singer, J.3    Meltzer, H.4
  • 36
    • 85047698267 scopus 로고    scopus 로고
    • Effectiveness of clozapine versus olanzapine, quetiapine, and risperidone in patients with chronic schizophrenia who did not respond to prior atypical antipsychotic treatment
    • McEvoy JP, Lieberman JA, Stroup TS, et al. Effectiveness of clozapine versus olanzapine, quetiapine, and risperidone in patients with chronic schizophrenia who did not respond to prior atypical antipsychotic treatment. see comment Am J Psychiatry 2006;163(4):600-10
    • (2006) See Comment Am J Psychiatry , vol.163 , Issue.4 , pp. 600-610
    • McEvoy, J.P.1    Lieberman, J.A.2    Stroup, T.S.3
  • 37
    • 0029959401 scopus 로고    scopus 로고
    • Effects of switching inpatients with treatment-resistant schizophrenia from clozapine to risperidone
    • Still DJ, Dorson PG, Crismon ML, Pousson C. Effects of switching inpatients with treatment-resistant schizophrenia from clozapine to risperidone. Psychiatric Services 1996;47(12):1382-4
    • (1996) Psychiatric Services , vol.47 , Issue.12 , pp. 1382-1384
    • Still, D.J.1    Dorson, P.G.2    Crismon, M.L.3    Pousson, C.4
  • 38
    • 0029586907 scopus 로고
    • Cautions in the clozapine-to-risperidone switch
    • Gupta S, Daniel DG. Cautions in the clozapine-to-risperidone switch. Ann Clin Psychiatry 1995;7(3):149-9
    • (1995) Ann Clin Psychiatry , vol.7 , Issue.3 , pp. 149-159
    • Gupta, S.1    Daniel, D.G.2
  • 39
    • 0344851930 scopus 로고    scopus 로고
    • The efficacy of high-dose olanzapine versus clozapine in treatment-resistant schizophrenia: A double-blind, crossover study
    • Kelly DL, Richardson CM, Tamminga CA, Carpenter WT. The efficacy of high-dose olanzapine versus clozapine in treatment-resistant schizophrenia: A double-blind, crossover study. J Clin Psychopharmacol 2003;23(6):668-70
    • (2003) J Clin Psychopharmacol , vol.23 , Issue.6 , pp. 668-670
    • Kelly, D.L.1    Richardson, C.M.2    Tamminga, C.A.3    Carpenter, W.T.4
  • 40
  • 41
    • 84884161208 scopus 로고    scopus 로고
    • Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: A multiple-treatments meta-analysis
    • Leucht S, Cipriani A, Spineli L, et al. Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: A multiple-treatments meta-analysis. The Lancet 2013;382(9896):951-62
    • (2013) The Lancet , vol.382 , Issue.9896 , pp. 951-962
    • Leucht, S.1    Cipriani, A.2    Spineli, L.3
  • 42
    • 0037227192 scopus 로고    scopus 로고
    • Clozapine treatment for suicidality in schizophreniainternational suicide prevention trial (InterSePT)
    • Meltzer H, Alphs L, Green AI, et al. Clozapine treatment for suicidality in schizophreniainternational suicide prevention trial (InterSePT). Arch Gen Psychiatry 2003;60(1):82-91
    • (2003) Arch Gen Psychiatry , vol.60 , Issue.1 , pp. 82-91
    • Meltzer, H.1    Alphs, L.2    Green, A.I.3
  • 43
    • 68949172254 scopus 로고    scopus 로고
    • 11-year follow-up of mortality in patients with schizophrenia: A population-based cohort study (FIN11 study)
    • Tiihonen J, Lonnqvist J, Wahlbeck K, et al. 11-year follow-up of mortality in patients with schizophrenia: A population-based cohort study (FIN11 study). Lancet 2009; 374(9690):620-7
    • (2009) Lancet , vol.374 , Issue.9690 , pp. 620-627
    • Tiihonen, J.1    Lonnqvist, J.2    Wahlbeck, K.3
  • 44
    • 84928591590 scopus 로고    scopus 로고
    • "Schizophrenia past Clozapine": Reasons for Clozapine Discontinuation, Mortality, and Alternative Antipsychotic Prescribing
    • Mustafa FA, Burke JG, Abukmeil SS, et al. "Schizophrenia past Clozapine": Reasons for Clozapine Discontinuation, Mortality, and Alternative Antipsychotic Prescribing. Pharamacopsychiatry 2015;48:11-14
    • (2015) Pharamacopsychiatry , vol.48 , pp. 11-14
    • Mustafa, F.A.1    Burke, J.G.2    Abukmeil, S.S.3
  • 45
    • 84878260778 scopus 로고    scopus 로고
    • Rediscovering catatonia: The biography of a treatable syndrome
    • Fink M. Rediscovering catatonia: the biography of a treatable syndrome. Acta Psychiatr Scand Suppl 2013;127(s441):1-47
    • (2013) Acta Psychiatr Scand Suppl , vol.127 , Issue.S441 , pp. 1-47
    • Fink, M.1
  • 47
    • 84920158276 scopus 로고    scopus 로고
    • Electroconvulsive therapy augmentation in clozapine-resistant schizophrenia: A prospective, randomized study
    • Petrides G, Malur C, Braga RJ, et al. Electroconvulsive therapy augmentation in clozapine-resistant schizophrenia: A prospective, randomized study. Am J Psychiatry 2014;172(1):52-8
    • (2014) Am J Psychiatry , vol.172 , Issue.1 , pp. 52-58
    • Petrides, G.1    Malur, C.2    Braga, R.J.3
  • 48
    • 84889084513 scopus 로고    scopus 로고
    • Antipsychotic polypharmacy in a treatment-refractory schizophrenia population receiving adjunctive treatment with electroconvulsive therapy
    • Kristensen D, Hagemann I, Bauer J, et al. Antipsychotic polypharmacy in a treatment-refractory schizophrenia population receiving adjunctive treatment with electroconvulsive therapy. J ECT 2013; 29(4):271-6
    • (2013) J ECT , vol.29 , Issue.4 , pp. 271-276
    • Kristensen, D.1    Hagemann, I.2    Bauer, J.3
  • 49
    • 84893813097 scopus 로고    scopus 로고
    • Antipsychotic treatment resistance in schizophrenia associated with elevated glutamate levels but normal dopamine function
    • Demjaha A, Egerton A, Murray RM, et al. Antipsychotic treatment resistance in schizophrenia associated with elevated glutamate levels but normal dopamine function. Biol Psychiatry 2014;75(5):e11-13
    • (2014) Biol Psychiatry , vol.75 , Issue.5 , pp. e11-13
    • Demjaha, A.1    Egerton, A.2    Murray, R.M.3
  • 51
    • 84862605801 scopus 로고    scopus 로고
    • Altered Cortical GABA neurotransmission in schizophrenia: Insights into novel therapeutic strategies
    • Stan A, Lewis D. Altered Cortical GABA neurotransmission in schizophrenia: insights into novel therapeutic strategies. Curr Pharm Biotechnol 2012;13(8):1557-62
    • (2012) Curr Pharm Biotechnol , vol.13 , Issue.8 , pp. 1557-1562
    • Stan, A.1    Lewis, D.2
  • 52
    • 0033559076 scopus 로고    scopus 로고
    • The role of prefrontal cortex in the dopaminergic dysregulation of schizophrenia
    • Byne W, Davis KL. The role of prefrontal cortex in the dopaminergic dysregulation of schizophrenia. Biol Psychiatry 1999;45: 657-9
    • (1999) Biol Psychiatry , vol.45 , pp. 657-659
    • Byne, W.1    Davis, K.L.2
  • 53
    • 0037223711 scopus 로고    scopus 로고
    • Psychosis as a state of aberrant salience: A framework linking biology, phenomenology, and pharmacology in schizophrenia
    • Kapur S. Psychosis as a state of aberrant salience: A framework linking biology, phenomenology, and pharmacology in schizophrenia. Am J Psychiatry 2003; 160(1):13-23
    • (2003) Am J Psychiatry , vol.160 , Issue.1 , pp. 13-23
    • Kapur, S.1
  • 54
    • 84928642114 scopus 로고    scopus 로고
    • Mechanism of action of antipsychotic medications
    • Correll CU. Mechanism of action of antipsychotic medications. J Clin Psychiatry 2014;75(9):e23
    • (2014) J Clin Psychiatry , vol.75 , Issue.9 , pp. e23
    • Correll, C.U.1
  • 55
    • 69349089612 scopus 로고    scopus 로고
    • Aripiprazole differentially affects mesolimbic and nigrostriatal dopaminergic transmission: Implications for long-term drug efficacy and low extrapyramidal side-effects
    • Han M, Huang XF, Deng C. Aripiprazole differentially affects mesolimbic and nigrostriatal dopaminergic transmission: implications for long-term drug efficacy and low extrapyramidal side-effects. Int J Neuropsychopharmacol 2009;12(7):941-52
    • (2009) Int J Neuropsychopharmacol , vol.12 , Issue.7 , pp. 941-952
    • Han, M.1    Huang, X.F.2    Deng, C.3
  • 56
    • 84904981694 scopus 로고    scopus 로고
    • Brexpiprazole II: Antipsychotic-like and procognitive effects of a novel serotonin-dopamine activity modulator
    • Maeda K, Lerdrup L, Sugino H, et al. Brexpiprazole II: Antipsychotic-like and procognitive effects of a novel serotonin-dopamine activity modulator. J Pharmacol Exp Ther 2014;350(3):605-14
    • (2014) J Pharmacol Exp Ther , vol.350 , Issue.3 , pp. 605-614
    • Maeda, K.1    Lerdrup, L.2    Sugino, H.3
  • 57
    • 84903982078 scopus 로고    scopus 로고
    • Brexpiprazole I: In vitro and in vivo characterization of a novel serotonin-dopamine activity modulator
    • Maeda K, Sugino H, Akazawa H, et al. Brexpiprazole I: in vitro and in vivo characterization of a novel serotonin-dopamine activity modulator. J Pharmacol Exp Ther 2014;350(3):589-604
    • (2014) J Pharmacol Exp Ther , vol.350 , Issue.3 , pp. 589-604
    • Maeda, K.1    Sugino, H.2    Akazawa, H.3
  • 58
    • 84928640856 scopus 로고    scopus 로고
    • A multicenter, randomized, double-blind, controlled phase 3 trial of fixed-dose brexpiprazole for the treatment of adults with acute schizophrenia
    • [Epub ahead of print]
    • Kane JM, Skuban A, Ouyang J, et al. A multicenter, randomized, double-blind, controlled phase 3 trial of fixed-dose brexpiprazole for the treatment of adults with acute schizophrenia. Schizophr Res 2015. [Epub ahead of print]
    • (2015) Schizophr Res
    • Kane, J.M.1    Skuban, A.2    Ouyang, J.3
  • 59
    • 84888133974 scopus 로고    scopus 로고
    • Risks and benefits of Bupropion treatment in Schizophrenia: A systematic review of the current literature
    • Englisch S, Morgen K, Meyer-Lindenberg A , Zink M. Risks and benefits of Bupropion treatment in Schizophrenia: A systematic review of the current literature. Clin Neuropharmacol 2013;36(6):203-15
    • (2013) Clin Neuropharmacol , vol.36 , Issue.6 , pp. 203-215
    • Englisch, S.1    Morgen, K.2    Meyer-Lindenberg, A.3    Zink, M.4
  • 60
    • 76249120915 scopus 로고    scopus 로고
    • Bupropion for Depression in Schizophrenia: A case report
    • Englisch S, Esser A, Zink M. Bupropion for Depression in Schizophrenia: A case report. Pharmacopsychiatry 2010;43:38-9
    • (2010) Pharmacopsychiatry , vol.43 , pp. 38-39
    • Englisch, S.1    Esser, A.2    Zink, M.3
  • 61
    • 77949455392 scopus 로고    scopus 로고
    • Unraveling monoamine receptors involved in the action of typical and atypical antipsychotics on glutamatergic and serotonergic transmission in prefrontal cortex
    • Lopez-Gil X, Artigas F, Adell A. Unraveling monoamine receptors involved in the action of typical and atypical antipsychotics on glutamatergic and serotonergic transmission in prefrontal cortex. Curr Pharm Des 2010; 16(5):502-15
    • (2010) Curr Pharm des , vol.16 , Issue.5 , pp. 502-515
    • Lopez-Gil, X.1    Artigas, F.2    Adell, A.3
  • 62
    • 0034161256 scopus 로고    scopus 로고
    • Embryonic and early fetal development of the human neocortex
    • Meyer G, Schaaps JP, Moreau L, Goffinet AM. Embryonic and early fetal development of the human neocortex. J Neurosci 2000;20(5):1858-68
    • (2000) J Neurosci , vol.20 , Issue.5 , pp. 1858-1868
    • Meyer, G.1    Schaaps, J.P.2    Moreau, L.3    Goffinet, A.M.4
  • 63
    • 0033152377 scopus 로고    scopus 로고
    • Glutamate acting at NMDA receptors stimulates embryonic cortical neuronal migration
    • Behar TN, Scott CA, Greene CL, et al. Glutamate acting at NMDA receptors stimulates embryonic cortical neuronal migration. J Neurosci 1999;19(11):4449-61
    • (1999) J Neurosci , vol.19 , Issue.11 , pp. 4449-4461
    • Behar, T.N.1    Scott, C.A.2    Greene, C.L.3
  • 64
    • 0034255031 scopus 로고    scopus 로고
    • Differential modulation of proliferation in the Neocortical ventricular and subventricular zones
    • Haydar TF, Wang F, Schwartz ML, Rakic P. Differential modulation of proliferation in the Neocortical ventricular and subventricular zones. J Neurosci 2000; 20(15):5764-74
    • (2000) J Neurosci , vol.20 , Issue.15 , pp. 5764-5774
    • Haydar, T.F.1    Wang, F.2    Schwartz, M.L.3    Rakic, P.4
  • 65
    • 84920982795 scopus 로고    scopus 로고
    • Antipsychotic treatment modulates glutamate transport and NMDA receptor expression
    • Zink M, Englisch S, Schmitt A. Antipsychotic treatment modulates glutamate transport and NMDA receptor expression. Eur Archives Psychiatry Clin Neurosci 2014;264(Suppl 1):S67-82
    • (2014) Eur Archives Psychiatry Clin Neurosci , vol.264 , pp. S67-82
    • Zink, M.1    Englisch, S.2    Schmitt, A.3
  • 66
    • 0035001341 scopus 로고    scopus 로고
    • Glutamate uptake
    • Danbolt NC. Glutamate uptake. Prog Neurobiol 2001;65(1):1-105
    • (2001) Prog Neurobiol , vol.65 , Issue.1 , pp. 1-105
    • Danbolt, N.C.1
  • 67
    • 77955700847 scopus 로고    scopus 로고
    • Early Life Programming and Neurodevelopmental Disorders
    • Bale TL, Baram TZ, Brown AS, et al. Early Life Programming and Neurodevelopmental Disorders. Biol Psychiatry 2010;68(4): 314-19
    • (2010) Biol Psychiatry , vol.68 , Issue.4 , pp. 314-319
    • Bale, T.L.1    Baram, T.Z.2    Brown, A.S.3
  • 68
    • 78149428430 scopus 로고    scopus 로고
    • Rethinking schizophrenia
    • Insel TR. Rethinking schizophrenia. Nature 2010;468(7321):187-93
    • (2010) Nature , vol.468 , Issue.7321 , pp. 187-193
    • Insel, T.R.1
  • 69
    • 68449088227 scopus 로고    scopus 로고
    • Receptor mapping: Architecture of the human cerebral cortex
    • Zilles K, Amunts K. Receptor mapping: Architecture of the human cerebral cortex. Miscellaneous Article Curr Opin Neurol 2009;22(4):331-9
    • (2009) Miscellaneous Article Curr Opin Neurol , vol.22 , Issue.4 , pp. 331-339
    • Zilles, K.1    Amunts, K.2
  • 70
    • 0036328118 scopus 로고    scopus 로고
    • The validity of animal models of predisposition to depression
    • Willner P, Mitchell PJ. The validity of animal models of predisposition to depression. Behav Pharmacol 2002;13(3): 169-88
    • (2002) Behav Pharmacol , vol.13 , Issue.3 , pp. 169-188
    • Willner, P.1    Mitchell, P.J.2
  • 71
    • 72449180352 scopus 로고    scopus 로고
    • Mice with genetically altered glutamate receptors as models of schizophrenia: A comprehensive review
    • Inta D, Monyer H, Sprengel R, et al. Mice with genetically altered glutamate receptors as models of schizophrenia: A comprehensive review. Neurosci Biobehav Rev 2010;34(3): 285-94
    • (2010) Neurosci Biobehav Rev , vol.34 , Issue.3 , pp. 285-294
    • Inta, D.1    Monyer, H.2    Sprengel, R.3
  • 72
    • 82955167869 scopus 로고    scopus 로고
    • Effects of chronic oral treatment with aripiprazole on the expression of NMDA receptor subunits and binding sites in rat brain
    • Segnitz N, Ferbert T, Schmitt A, et al. Effects of chronic oral treatment with aripiprazole on the expression of NMDA receptor subunits and binding sites in rat brain. Psychopharmacology (Berl) 2011;217(1):127-42
    • (2011) Psychopharmacology (Berl) , vol.217 , Issue.1 , pp. 127-142
    • Segnitz, N.1    Ferbert, T.2    Schmitt, A.3
  • 73
    • 65249130551 scopus 로고    scopus 로고
    • Uncoupling dendrite growth and patterning: Single-cell knockout analysis of NMDA Receptor 2B
    • Espinosa JS, Wheeler DG, Tsien RW, Luo L. Uncoupling dendrite growth and patterning: single-cell knockout analysis of NMDA Receptor 2B. Neuron 2009;62: 205-17
    • (2009) Neuron , vol.62 , pp. 205-217
    • Espinosa, J.S.1    Wheeler, D.G.2    Tsien, R.W.3    Luo, L.4
  • 74
    • 66649086928 scopus 로고    scopus 로고
    • Mechanism of differential control of NMDA receptor activity by NR2 subunits
    • Gielen M, Retchless BS, Mony L, et al. Mechanism of differential control of NMDA receptor activity by NR2 subunits. Nature 2009;459:703-7
    • (2009) Nature , vol.459 , pp. 703-707
    • Gielen, M.1    Retchless, B.S.2    Mony, L.3
  • 75
    • 84885218013 scopus 로고    scopus 로고
    • Glutamate levels in the associative striatum before and after 4 weeks of antipsychotic treatment in first-episode psychosis: A longitudinal proton magnetic resonance spectroscopy study
    • Fuente-Sandoval C, León-Ortiz P, Azcárraga M, et al. Glutamate levels in the associative striatum before and after 4 weeks of antipsychotic treatment in first-episode psychosis: A longitudinal proton magnetic resonance spectroscopy study. JAMA Psychiatry 2013;70(10):1057-66
    • (2013) JAMA Psychiatry , vol.70 , Issue.10 , pp. 1057-1066
    • Fuente-Sandoval, C.1    León-Ortiz, P.2    Azcárraga, M.3
  • 76
    • 67649206083 scopus 로고    scopus 로고
    • Adding lithium or anticonvulsants to antipsychotics for the treatment of schizophrenia: Useful strategy or exercise in futility
    • Citrome L. Adding lithium or anticonvulsants to antipsychotics for the treatment of schizophrenia: useful strategy or exercise in futility? J Clin Psychiatry 2009;70(6):932-3
    • (2009) J Clin Psychiatry , vol.70 , Issue.6 , pp. 932-933
    • Citrome, L.1
  • 79
    • 62349135082 scopus 로고    scopus 로고
    • Divalproex ER combined with olanzapine or risperidone for treatment of acute exacerbations of schizophrenia
    • Casey DE, Daniel DG, Tamminga C, et al. Divalproex ER combined with olanzapine or risperidone for treatment of acute exacerbations of schizophrenia. Neuropsychopharmacology 2009;34(5): 1330-8
    • (2009) Neuropsychopharmacology , vol.34 , Issue.5 , pp. 1330-1338
    • Casey, D.E.1    Daniel, D.G.2    Tamminga, C.3
  • 81
    • 80053946160 scopus 로고    scopus 로고
    • Lamotrigine blocks repeated high-dose methamphetamine-induced behavioral sensitization to dizocilpine (MK-801), but not methamphetamine in rats
    • Nakato Y, Abekawa T, Inoue T, Koyama T. Lamotrigine blocks repeated high-dose methamphetamine-induced behavioral sensitization to dizocilpine (MK-801), but not methamphetamine in rats. Neurosci Lett 2011;504(2):131-4
    • (2011) Neurosci Lett , vol.504 , Issue.2 , pp. 131-134
    • Nakato, Y.1    Abekawa, T.2    Inoue, T.3    Koyama, T.4
  • 82
    • 0034054949 scopus 로고    scopus 로고
    • Attenuation of the neuropsychiatric effects of ketamine with lamotriginesupport for hyperglutamatergic effects of N-methyl-Daspartate Receptor Antagonists
    • Anand A, Charney DS, Oren DA, et al. Attenuation of the neuropsychiatric effects of ketamine with lamotriginesupport for hyperglutamatergic effects of N-methyl-Daspartate Receptor Antagonists. Arch Gen Psychiatry 2000;57(3):270-6
    • (2000) Arch Gen Psychiatry , vol.57 , Issue.3 , pp. 270-276
    • Anand, A.1    Charney, D.S.2    Oren, D.A.3
  • 83
    • 41649091371 scopus 로고    scopus 로고
    • Neuroprotection by lamotrigine in a rat model of neonatal hypoxic-ischaemic encephalopathy
    • Papazisis G, Kallaras K, Kaiki-Astara A, et al. Neuroprotection by lamotrigine in a rat model of neonatal hypoxic-ischaemic encephalopathy. Int J Neuropsychopharmacol 2008;11(3):321-9
    • (2008) Int J Neuropsychopharmacol , vol.11 , Issue.3 , pp. 321-329
    • Papazisis, G.1    Kallaras, K.2    Kaiki-Astara, A.3
  • 85
    • 62649086513 scopus 로고    scopus 로고
    • The efficacy of lamotrigine in clozapine-resistant schizophrenia: A systematic review and meta-analysis
    • Tiihonen J, Wahlbeck K, Kiviniemi V. The efficacy of lamotrigine in clozapine-resistant schizophrenia: A systematic review and meta-analysis. Schizophr Res 2009;109(1-3): 10-14
    • (2009) Schizophr Res , vol.109 , Issue.1-3 , pp. 10-14
    • Tiihonen, J.1    Wahlbeck, K.2    Kiviniemi, V.3
  • 86
    • 34249323746 scopus 로고    scopus 로고
    • The effect of lamotrigine augmentation of clozapine in a sample of treatment-resistant schizophrenic patients: A double-blind, placebo-controlled study
    • Zoccali R, Muscatello MR, Bruno A, et al. The effect of lamotrigine augmentation of clozapine in a sample of treatment-resistant schizophrenic patients: A double-blind, placebo-controlled study. Schizophr Res 2007;93(1-3):109-16
    • (2007) Schizophr Res , vol.93 , Issue.1-3 , pp. 109-116
    • Zoccali, R.1    Muscatello, M.R.2    Bruno, A.3
  • 87
    • 85027951368 scopus 로고    scopus 로고
    • Clozapine augmented with glutamate modulators in refractory schizophrenia: A review and metaanalysis
    • Veerman SRT, Schlulte PFJ, Begemann MJH, et al. Clozapine augmented with glutamate modulators in refractory schizophrenia: A review and metaanalysis. Pharmacopsychiatry 2014;47: 185-94
    • (2014) Pharmacopsychiatry , vol.47 , pp. 185-194
    • Veerman, S.R.T.1    Schlulte, P.F.J.2    Begemann, M.J.H.3
  • 88
    • 0142095347 scopus 로고    scopus 로고
    • Lamotrigine in treatment-resistant schizophrenia: A randomized placebo-controlled crossover trial
    • Tiihonen J, Hallikainen T, Ryynänen O-P, et al. lamotrigine in treatment-resistant schizophrenia: A randomized placebo-controlled crossover trial. Biol Psychiatry 2003;54:1241-8
    • (2003) Biol Psychiatry , vol.54 , pp. 1241-1248
    • Tiihonen, J.1    Hallikainen, T.2    Ryynänen, O.-P.3
  • 89
    • 84865334678 scopus 로고    scopus 로고
    • Pharmacological augmentation strategies for schizophrenia patients with insufficient response to clozapine: A quantitative literature review
    • Sommer IE, Begemann MJH, Temmerman A, Leucht S. pharmacological augmentation strategies for schizophrenia patients with insufficient response to clozapine: A quantitative literature review. Schizophr Bull 2012;38(5):1003-11
    • (2012) Schizophr Bull , vol.38 , Issue.5 , pp. 1003-1011
    • Sommer, I.E.1    Begemann, M.J.H.2    Temmerman, A.3    Leucht, S.4
  • 91
    • 67649274340 scopus 로고    scopus 로고
    • A double-blind randomized trial of mood stabilizer augmentation using lamotrigine and valproate for patients with schizophrenia who are stabilized and partially responsive
    • Glick ID, Bosch J, Casey DE. A double-blind randomized trial of mood stabilizer augmentation using lamotrigine and valproate for patients with schizophrenia who are stabilized and partially responsive. J Clin Psychopharmacol 2009;29(3):267-71
    • (2009) J Clin Psychopharmacol , vol.29 , Issue.3 , pp. 267-271
    • Glick, I.D.1    Bosch, J.2    Casey, D.E.3
  • 93
    • 0037008261 scopus 로고    scopus 로고
    • Topiramate antagonizes MK-801 in an animal model of schizophrenia
    • Deutsch SI, Rosse RB, Billingslea EN, et al. Topiramate antagonizes MK-801 in an animal model of schizophrenia. Eur J Pharmacol 2002;449(1-2):121-5
    • (2002) Eur J Pharmacol , vol.449 , Issue.1-2 , pp. 121-125
    • Deutsch, S.I.1    Rosse, R.B.2    Billingslea, E.N.3
  • 94
    • 33846251270 scopus 로고    scopus 로고
    • Effects of topiramate on the prepulse inhibition of the acoustic startle in rats
    • Frau R, Orru M, Fa M, et al. Effects of Topiramate on the Prepulse Inhibition of the Acoustic Startle in Rats. Neuropsychopharmacology 2006;32(2): 320-31
    • (2006) Neuropsychopharmacology , vol.32 , Issue.2 , pp. 320-331
    • Frau, R.1    Orru, M.2    Fa, M.3
  • 95
    • 70349146283 scopus 로고    scopus 로고
    • Differential effects of topiramate on prefrontal glutamatergic transmission when combined with raclopride or clozapine
    • Jardemark KE, Konradsson A, Schilström BÂ., et al. Differential effects of topiramate on prefrontal glutamatergic transmission when combined with raclopride or clozapine. Synapse 2009; 63(10):913-20
    • (2009) Synapse , vol.63 , Issue.10 , pp. 913-920
    • Jardemark, K.E.1    Konradsson, A.2    Schilström B.Â.3
  • 96
    • 0035663840 scopus 로고    scopus 로고
    • Augmenting antipsychotic treatment with lamotrigine or topiramate in patients with treatment-resistant schizophrenia: A naturalistic case-series outcome study
    • Dursun SM, Deakin JF. Augmenting antipsychotic treatment with lamotrigine or topiramate in patients with treatment-resistant schizophrenia: A naturalistic case-series outcome study. J Psychopharmacol 2001;15(4):297-301
    • (2001) J Psychopharmacol , vol.15 , Issue.4 , pp. 297-301
    • Dursun, S.M.1    Deakin, J.F.2
  • 97
    • 67649177544 scopus 로고    scopus 로고
    • Topiramate add-on treatment in schizophrenia: A randomised, double-blind, placebo-controlled clinical trial
    • Afshar H, Roohafza H, Mousavi G, et al. Topiramate add-on treatment in schizophrenia: A randomised, double-blind, placebo-controlled clinical trial. J Psychopharmacol 2009;23(2):157-62
    • (2009) J Psychopharmacol , vol.23 , Issue.2 , pp. 157-162
    • Afshar, H.1    Roohafza, H.2    Mousavi, G.3
  • 98
    • 78649362141 scopus 로고    scopus 로고
    • Topiramate augmentation in clozapine-treated patients with schizophrenia: Clinical and metabolic effects
    • Hahn MK, Remington G, Bois D, Cohn T. Topiramate augmentation in clozapine-treated patients with schizophrenia: clinical and metabolic effects. J Clin Psychopharmacol 2010;30(6):706-10
    • (2010) J Clin Psychopharmacol , vol.30 , Issue.6 , pp. 706-710
    • Hahn, M.K.1    Remington, G.2    Bois, D.3    Cohn, T.4
  • 99
    • 79955375973 scopus 로고    scopus 로고
    • Topiramate augmentation of clozapine in schizophrenia: A double-blind, placebo-controlled study
    • Muscatello MR, Bruno A, Pandolfo G, et al. Topiramate augmentation of clozapine in schizophrenia: A double-blind, placebo-controlled study. J Psychopharmacol 2011;25(5):667-74
    • (2011) J Psychopharmacol , vol.25 , Issue.5 , pp. 667-674
    • Muscatello, M.R.1    Bruno, A.2    Pandolfo, G.3
  • 100
    • 3242723180 scopus 로고    scopus 로고
    • Effects on weight and outcome of long-term olanzapine-topiramate combination treatment in bipolar disorder
    • Vieta E, Sanchez-Moreno J, Goikolea JM, et al. Effects on weight and outcome of long-term olanzapine-topiramate combination treatment in bipolar disorder. J Clin Psychopharmacol 2004;24(4):374-8
    • (2004) J Clin Psychopharmacol , vol.24 , Issue.4 , pp. 374-378
    • Vieta, E.1    Sanchez-Moreno, J.2    Goikolea, J.M.3
  • 101
    • 84873587102 scopus 로고    scopus 로고
    • Topiramate in schizophrenia: A review of effects on psychopathology and metabolic parameters
    • Hahn MK, Cohn T, Teo C, Remington G. Topiramate in schizophrenia: A review of effects on psychopathology and metabolic parameters. Clin Schizophr Relat Psychoses 2013;6(4):186-96
    • (2013) Clin Schizophr Relat Psychoses , vol.6 , Issue.4 , pp. 186-196
    • Hahn, M.K.1    Cohn, T.2    Teo, C.3    Remington, G.4
  • 102
    • 58549117463 scopus 로고    scopus 로고
    • Anxiolytic profile of pregabalin on elicited hippocampal theta oscillation
    • Siok CJ, Taylor CP, Hajos M. Anxiolytic profile of pregabalin on elicited hippocampal theta oscillation. Neuropharmacology 2009;56(2):379-85
    • (2009) Neuropharmacology , vol.56 , Issue.2 , pp. 379-385
    • Siok, C.J.1    Taylor, C.P.2    Hajos, M.3
  • 103
    • 33947254401 scopus 로고    scopus 로고
    • Pregabalin: A novel gamma-aminobutyric acid analogue in the treatment of neuropathic pain, partial-onset seizures, and anxiety disorders
    • Tassone DM, Boyce E, Guyer J, et al. Pregabalin: A novel gamma-aminobutyric acid analogue in the treatment of neuropathic pain, partial-onset seizures, and anxiety disorders. Clin Ther 2007;29(1): 26-48
    • (2007) Clin Ther , vol.29 , Issue.1 , pp. 26-48
    • Tassone, D.M.1    Boyce, E.2    Guyer, J.3
  • 104
    • 34447115669 scopus 로고    scopus 로고
    • Pregabalin for the treatment of generalized anxiety disorder: A novel pharmacologic intervention
    • Bandelow B, Wedekind D, Leon T, et al. Pregabalin for the treatment of generalized anxiety disorder: A novel pharmacologic intervention. Expert Rev Neurother 2007; 7(7):769-81
    • (2007) Expert Rev Neurother , vol.7 , Issue.7 , pp. 769-781
    • Bandelow, B.1    Wedekind, D.2    Leon, T.3
  • 105
    • 84871453849 scopus 로고    scopus 로고
    • Effects of pregabalin on behavioral alterations induced by ketamine in rats
    • Nunes EA, Canever L, Oliveira L, et al. Effects of pregabalin on behavioral alterations induced by ketamine in rats. Revista Brasileira de Psiquiatria 2012;34(3): 329-33
    • (2012) Revista Brasileira de Psiquiatria , vol.34 , Issue.3 , pp. 329-333
    • Nunes, E.A.1    Canever, L.2    Oliveira, L.3
  • 106
    • 84862023125 scopus 로고    scopus 로고
    • The effect of pregabalin on sensorimotor gating in low' gating humans and mice
    • Acheson DT, Stein MB, Paulus MP, et al. The effect of pregabalin on sensorimotor gating in 'low' gating humans and mice. Neuropharmacology 2015;63(3):480-5
    • (2015) Neuropharmacology , vol.63 , Issue.3 , pp. 480-485
    • Acheson, D.T.1    Stein, M.B.2    Paulus, M.P.3
  • 108
    • 77955172849 scopus 로고    scopus 로고
    • Augmentation with pregabalin in schizophrenia
    • Englisch S, Esser A, Enning F, et al. Augmentation with pregabalin in schizophrenia. J Clin Psychopharmacol 2010;30(4):437-40
    • (2010) J Clin Psychopharmacol , vol.30 , Issue.4 , pp. 437-440
    • Englisch, S.1    Esser, A.2    Enning, F.3
  • 109
    • 84924680704 scopus 로고    scopus 로고
    • Investigational drugs for anxiety in patients with schizophrenia
    • Garay RP, Samalin L, Hameg A, Llorca PM. Investigational drugs for anxiety in patients with schizophrenia. Expe Opin Investig Drugs 2015;24(4):507-17
    • (2015) Expe Opin Investig Drugs , vol.24 , Issue.4 , pp. 507-517
    • Garay, R.P.1    Samalin, L.2    Hameg, A.3    Llorca, P.M.4
  • 111
    • 84881313914 scopus 로고    scopus 로고
    • Glutamate modulators as potential therapeutic drugs in schizophrenia and affective disorders
    • Hashimoto K, Malchow B, Falkai P, Schmitt A. Glutamate modulators as potential therapeutic drugs in schizophrenia and affective disorders. Eur Arch Psychiatry Clin Neurosci 2013;263(5):367-77
    • (2013) Eur Arch Psychiatry Clin Neurosci , vol.263 , Issue.5 , pp. 367-377
    • Hashimoto, K.1    Malchow, B.2    Falkai, P.3    Schmitt, A.4
  • 112
    • 84873455187 scopus 로고    scopus 로고
    • When the drugs do not work: The potential of glutamatergic antipsychotics in schizophrenia
    • Papanastasiou E, Stone JM, Shergill S. When the drugs do not work: the potential of glutamatergic antipsychotics in schizophrenia. Br J Psychiatry 2013;202(2): 91-3
    • (2013) Br J Psychiatry , vol.202 , Issue.2 , pp. 91-93
    • Papanastasiou, E.1    Stone, J.M.2    Shergill, S.3
  • 113
    • 0034727878 scopus 로고    scopus 로고
    • Gene expression of metabotropic glutamate receptor 5 and excitatory amino acid transporter 2 in the schizophrenic hippocampus
    • Ohnuma T, Tessler S, Arai H, et al. Gene expression of metabotropic glutamate receptor 5 and excitatory amino acid transporter 2 in the schizophrenic hippocampus. Mol Brain Res 2000;85(1-2): 24-31
    • (2000) Mol Brain Res , vol.85 , Issue.1-2 , pp. 24-31
    • Ohnuma, T.1    Tessler, S.2    Arai, H.3
  • 114
    • 0037665283 scopus 로고    scopus 로고
    • Metabotropic glutamate subtype 5 receptors modulate locomotor activity and sensorimotor gating in rodents
    • Kinney GG, Burno M, Campbell UC, et al. Metabotropic glutamate subtype 5 receptors modulate locomotor activity and sensorimotor gating in rodents. J Pharmacol Exper Ther 2003;306(1):116-23
    • (2003) J Pharmacol Exper Ther , vol.306 , Issue.1 , pp. 116-123
    • Kinney, G.G.1    Burno, M.2    Campbell, U.C.3
  • 115
    • 34547637452 scopus 로고    scopus 로고
    • Epistasis between catechol-O-methyltransferase and type II metabotropic glutamate receptor 3 genes on working memory brain function
    • Tan HY, Chen Q, Sust S, et al. Epistasis between catechol-O-methyltransferase and type II metabotropic glutamate receptor 3 genes on working memory brain function. Proc Natl Acad Sci USA 2007;104(30): 12536-41
    • (2007) Proc Natl Acad Sci USA , vol.104 , Issue.30 , pp. 12536-12541
    • Tan, H.Y.1    Chen, Q.2    Sust, S.3
  • 116
    • 84883546610 scopus 로고    scopus 로고
    • The reversal of cognitive, but not negative or positive symptoms of schizophrenia, by the mGlu2/3 receptor agonist, LY379268, is 5-HT1A dependent
    • Wieronska JM, Slawinska A, Stachowicz K, et al. The reversal of cognitive, but not negative or positive symptoms of schizophrenia, by the mGlu2/3 receptor agonist, LY379268, is 5-HT1A dependent. Behav Brain Res 2013;256(0):298-304
    • (2013) Behav Brain Res , vol.256 , Issue.0 , pp. 298-304
    • Wieronska, J.M.1    Slawinska, A.2    Stachowicz, K.3
  • 117
    • 82955198514 scopus 로고    scopus 로고
    • Interaction of mGlu2/3 agonism with clozapine and lurasidone to restore novel object recognition in subchronic phencyclidine-treated rats
    • Horiguchi M, Huang M, Meltzer H. Interaction of mGlu2/3 agonism with clozapine and lurasidone to restore novel object recognition in subchronic phencyclidine-treated rats. Psychopharmacology (Berl) 2011;217(1): 13-24
    • (2011) Psychopharmacology (Berl) , vol.217 , Issue.1 , pp. 13-24
    • Horiguchi, M.1    Huang, M.2    Meltzer, H.3
  • 119
    • 84872735105 scopus 로고    scopus 로고
    • Metabotropic glutamate receptor 5 in the pathology and treatment of schizophrenia
    • Matosin N, Newell KA. Metabotropic glutamate receptor 5 in the pathology and treatment of schizophrenia. Neurosci Biobehav Rev 2013;37(3):256-68
    • (2013) Neurosci Biobehav Rev , vol.37 , Issue.3 , pp. 256-268
    • Matosin, N.1    Newell, K.A.2
  • 120
    • 34948858402 scopus 로고    scopus 로고
    • Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: A randomized Phase 2 clinical trial
    • Patil ST, Zhang L, Martenyi F, et al. Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: A randomized Phase 2 clinical trial. Nat Med 2007;13(9):1102-7
    • (2007) Nat Med , vol.13 , Issue.9 , pp. 1102-1107
    • Patil, S.T.1    Zhang, L.2    Martenyi, F.3
  • 121
    • 84886304673 scopus 로고    scopus 로고
    • Pomaglumetad methionil: No significant difference as an adjunctive treatment for patients with prominent negative symptoms of schizophrenia compared to placebo
    • Stauffer VL, Millen BA, Andersen S, et al. Pomaglumetad methionil: No significant difference as an adjunctive treatment for patients with prominent negative symptoms of schizophrenia compared to placebo. Schizophr Res 2013;150(2-3):434-41
    • (2013) Schizophr Res , vol.150 , Issue.2-3 , pp. 434-441
    • Stauffer, V.L.1    Millen, B.A.2    Andersen, S.3
  • 122
    • 79955594301 scopus 로고    scopus 로고
    • A multicenter, inpatient, phase 2, double-blind, placebo-controlled doseranging study of LY2140023 monohydrate in patients with DSM-IV schizophrenia
    • Kinon BJ, Zhang L, Millen BA, et al. A multicenter, inpatient, phase 2, double-blind, placebo-controlled doseranging study of LY2140023 monohydrate in patients with DSM-IV schizophrenia. J Clin Psychopharmacol 2011;31(3):349-55
    • (2011) J Clin Psychopharmacol , vol.31 , Issue.3 , pp. 349-355
    • Kinon, B.J.1    Zhang, L.2    Millen, B.A.3
  • 123
    • 84928644124 scopus 로고    scopus 로고
    • Clinicaltrials.gov
    • Clinicaltrials.gov. Available from: www. clinicaltrials.gov
  • 125
    • 77949447469 scopus 로고    scopus 로고
    • Strategies to enhance Nmethyl-D-aspartate receptor-mediated neurotransmission in schizophrenia, a critical review and meta-analysis
    • Tsai GE, Lin PY. Strategies to enhance Nmethyl-D-aspartate receptor-mediated neurotransmission in schizophrenia, a critical review and meta-analysis. Curr Pharm Des 2010;16(5):522-37
    • (2010) Curr Pharm des , vol.16 , Issue.5 , pp. 522-537
    • Tsai, G.E.1    Lin, P.Y.2
  • 126
    • 80052996482 scopus 로고    scopus 로고
    • Meta-analysis of the efficacy of adjunctive NMDA receptor modulators in chronic schizophrenia
    • Singh S, Singh V. Meta-Analysis of the Efficacy of Adjunctive NMDA Receptor Modulators in Chronic Schizophrenia. CNS Drugs; 2011;25(10):859-85
    • (2011) CNS Drugs , vol.25 , Issue.10 , pp. 859-885
    • Singh, S.1    Singh, V.2
  • 127
    • 0035340978 scopus 로고    scopus 로고
    • Glial transporters for glutamate, glycine, and GABA III. Glycine transporters
    • Gadea A, Lopez-Colome AM. Glial transporters for glutamate, glycine, and GABA III. Glycine transporters. J Neurosci Res 2001;64(3):218-22
    • (2001) J Neurosci Res , vol.64 , Issue.3 , pp. 218-222
    • Gadea, A.1    Lopez-Colome, A.M.2
  • 128
    • 2942590366 scopus 로고    scopus 로고
    • Gene knockout of glycine transporter 1: Characterization of the behavioral phenotype
    • Tsai G, Ralph-Williams RJ, Martina M, et al. Gene knockout of glycine transporter 1: characterization of the behavioral phenotype. Proc Natl Acad Sci USA 2004; 101(22):8485-90
    • (2004) Proc Natl Acad Sci USA , vol.101 , Issue.22 , pp. 8485-8490
    • Tsai, G.1    Ralph-Williams, R.J.2    Martina, M.3
  • 129
    • 33645214436 scopus 로고    scopus 로고
    • Disruption of glycine transporter 1 restricted to forebrain neurons is associated with a procognitive and antipsychotic phenotypic profile
    • Yee BK, Balic E, Singer P, et al. Disruption of glycine transporter 1 restricted to forebrain neurons is associated with a procognitive and antipsychotic phenotypic profile. J Neurosci 2006;26(12):3169-81
    • (2006) J Neurosci , vol.26 , Issue.12 , pp. 3169-3181
    • Yee, B.K.1    Balic, E.2    Singer, P.3
  • 130
    • 84859648778 scopus 로고    scopus 로고
    • Differential effects of AMPA receptor potentiators and glycine reuptake inhibitors on antipsychotic efficacy and prefrontal glutamatergic transmission
    • Jardemark K, Marcus M, Malmerfelt A, et al. Differential effects of AMPA receptor potentiators and glycine reuptake inhibitors on antipsychotic efficacy and prefrontal glutamatergic transmission. Psychopharmacology (Berl) 2012;221(1): 115-31
    • (2012) Psychopharmacology (Berl) , vol.221 , Issue.1 , pp. 115-131
    • Jardemark, K.1    Marcus, M.2    Malmerfelt, A.3
  • 131
    • 79957791056 scopus 로고    scopus 로고
    • Blockade of glycine transporter 1 by SSR-504734 promotes cognitive flexibility in glycine/NMDA receptor-dependent manner
    • Nikiforuk A, Kos T, Rafa D, et al. Blockade of glycine transporter 1 by SSR-504734 promotes cognitive flexibility in glycine/NMDA receptor-dependent manner. Neuropharmacology 2011;61(1-2): 262-7
    • (2011) Neuropharmacology , vol.61 , Issue.1-2 , pp. 262-267
    • Nikiforuk, A.1    Kos, T.2    Rafa, D.3
  • 132
    • 46249094959 scopus 로고    scopus 로고
    • Expression of D-serine and glycine transporters in the prefrontal cortex and cerebellum in schizophrenia
    • Burnet PWJ, Hutchinson L, von Hesling M , et al. Expression of D-serine and glycine transporters in the prefrontal cortex and cerebellum in schizophrenia. Schizophr Res 2008;102(1-3):283-94
    • (2008) Schizophr Res , vol.102 , Issue.1-3 , pp. 283-294
    • Burnet, P.W.J.1    Hutchinson, L.2    Von Hesling, M.3
  • 133
    • 33748936348 scopus 로고    scopus 로고
    • Association study of polymorphisms in glycine transporter with schizophrenia
    • Tsai SJ, Cheng CY, Hong CJ, et al. Association study of polymorphisms in glycine transporter with schizophrenia. J Neural Transm 2006;113(10):1545-9
    • (2006) J Neural Transm , vol.113 , Issue.10 , pp. 1545-1549
    • Tsai, S.J.1    Cheng, C.Y.2    Hong, C.J.3
  • 134
    • 84857039780 scopus 로고    scopus 로고
    • Glycine transporter inhibitor attenuates the psychotomimetic effects of ketamine in healthy males: Preliminary evidence
    • D'Souza DC, Singh N, Elander J, et al. Glycine Transporter Inhibitor Attenuates the Psychotomimetic Effects of Ketamine in Healthy Males: Preliminary Evidence. Neuropsychopharmacology 2012;37(4): 1036-46
    • (2012) Neuropsychopharmacology , vol.37 , Issue.4 , pp. 1036-1046
    • D'souza, D.C.1    Singh, N.2    Elander, J.3
  • 135
    • 78650114987 scopus 로고    scopus 로고
    • The effects of the glycine reuptake inhibitor R213129 on the central nervous system and on scopolamine-induced impairments in psychomotor and cognitive function in healthy subjects
    • Liem-Moolenaar M, Zoethout RWM, de Boer P, et al. The effects of the glycine reuptake inhibitor R213129 on the central nervous system and on scopolamine-induced impairments in psychomotor and cognitive function in healthy subjects. J Psychopharmacol 2010;24(11):1671-9
    • (2010) J Psychopharmacol , vol.24 , Issue.11 , pp. 1671-1679
    • Liem-Moolenaar, M.1    Zoethout, R.W.M.2    De Boer, P.3
  • 136
    • 2642557822 scopus 로고    scopus 로고
    • The therapeutic potential of glycine transporter-1 inhibitors
    • Sur C, Kinney GG. The therapeutic potential of glycine transporter-1 inhibitors. Expert Opin Investig Drugs 2004;13(5): 515-21
    • (2004) Expert Opin Investig Drugs , vol.13 , Issue.5 , pp. 515-521
    • Sur, C.1    Kinney, G.G.2
  • 137
    • 17744399498 scopus 로고    scopus 로고
    • N-Methyl-D-aspartate receptors as a target for improved antipsychotic agents: Novel insights and clinical perspectives
    • Millan MJ. N-Methyl-D-aspartate receptors as a target for improved antipsychotic agents: novel insights and clinical perspectives. Psychopharmacology (Berl) 2005;179(1):30-53
    • (2005) Psychopharmacology (Berl) , vol.179 , Issue.1 , pp. 30-53
    • Millan, M.J.1
  • 138
    • 56049092225 scopus 로고    scopus 로고
    • Allosteric modulation of NMDA receptor via elevation of brain glycine and D-serine: The therapeutic potentials for schizophrenia
    • Yang CR, Svensson KA. Allosteric modulation of NMDA receptor via elevation of brain glycine and D-serine: the therapeutic potentials for schizophrenia. Pharmacol Ther 2008;120(3):317-32
    • (2008) Pharmacol Ther , vol.120 , Issue.3 , pp. 317-332
    • Yang, C.R.1    Svensson, K.A.2
  • 139
    • 38849147799 scopus 로고    scopus 로고
    • Potentiation of the NMDA receptor in the treatment of schizophrenia: Focused on the glycine site
    • Shim SS, Hammonds MD, Kee BS. Potentiation of the NMDA receptor in the treatment of schizophrenia: focused on the glycine site. Eur Archives Psychiatry Clin Neurosci 2008;258(1):16-27
    • (2008) Eur Archives Psychiatry Clin Neurosci , vol.258 , Issue.1 , pp. 16-27
    • Shim, S.S.1    Hammonds, M.D.2    Kee, B.S.3
  • 140
    • 77952419003 scopus 로고    scopus 로고
    • The neuropsychology of the schizo-obsessive subtype of schizophrenia: A new analysis
    • Patel DD, Laws KR, Padhi A, et al. The neuropsychology of the schizo-obsessive subtype of schizophrenia: A new analysis. Psychol Med 2010;40(6):921-33
    • (2010) Psychol Med , vol.40 , Issue.6 , pp. 921-933
    • Patel, D.D.1    Laws, K.R.2    Padhi, A.3
  • 141
    • 84900411478 scopus 로고    scopus 로고
    • Effect of bitopertin, a glycine reuptake inhibitor, on negative symptoms of schizophrenia: A randomized, double-blind, proof-of-concept study
    • Umbricht D, Alberati D, Martin-Facklam M. Effect of bitopertin, a glycine reuptake inhibitor, on negative symptoms of schizophrenia: A randomized, double-blind, proof-of-concept study. JAMA Psychiatry 2014;71(6):637-46
    • (2014) JAMA Psychiatry , vol.71 , Issue.6 , pp. 637-646
    • Umbricht, D.1    Alberati, D.2    Martin-Facklam, M.3
  • 142
    • 84902305515 scopus 로고    scopus 로고
    • A phase II/III trial of bitopertin monotherapy compared with placebo in patients with an acute exacerbation of schizophrenia-Results from the CandleLyte study
    • Bugarski-Kirola D, Wang A, Abi-Saab D, Blüttler T. A phase II/III trial of bitopertin monotherapy compared with placebo in patients with an acute exacerbation of schizophrenia-Results from the CandleLyte study. Eur Neuropsychopharmacol 2014;24(7):1024-36
    • (2014) Eur Neuropsychopharmacol , vol.24 , Issue.7 , pp. 1024-1036
    • Bugarski-Kirola, D.1    Wang, A.2    Abi-Saab, D.3    Blüttler, T.4
  • 143
    • 84928608411 scopus 로고    scopus 로고
    • Roche. Available from: www.roche.com/ media/mediáreleases/med-cor-2014-01-21. htm
  • 144
    • 84928602139 scopus 로고    scopus 로고
    • Roche. Available from: www.roche.com/ irp101209.pdf
  • 145
    • 84929492566 scopus 로고    scopus 로고
    • Sarcosine-based glycine transporter type-1 (GlyT-1) inhibitors containing pyridazine moiety: A further search for drugs with potential to influence schizophrenia negative symptoms
    • Epub ahead of print
    • Harsing LG, Timar J, Szabo G, et al. Sarcosine-based glycine transporter type-1 (GlyT-1) inhibitors containing pyridazine moiety: A further search for drugs with potential to influence schizophrenia negative symptoms. Curr Pharm Des 2015. [Epub ahead of print]
    • (2015) Curr Pharm des
    • Harsing, L.G.1    Timar, J.2    Szabo, G.3
  • 146
    • 60849097905 scopus 로고    scopus 로고
    • Minocycline as adjunctive therapy for schizophrenia: An open-label study
    • Miyaoka T, Yasukawa R, Yasuda H, et al. Minocycline as adjunctive therapy for schizophrenia: An open-label study. Clin Neuropharmacol 2008;31(5):287-92
    • (2008) Clin Neuropharmacol , vol.31 , Issue.5 , pp. 287-292
    • Miyaoka, T.1    Yasukawa, R.2    Yasuda, H.3
  • 147
    • 60549086674 scopus 로고    scopus 로고
    • Clinical potential of minocycline for schizophrenia
    • Miyaoka T. Clinical potential of minocycline for schizophrenia. CNS Neurol Disorders Drug Targets 2008;7(4):376-81
    • (2008) CNS Neurol Disorders Drug Targets , vol.7 , Issue.4 , pp. 376-381
    • Miyaoka, T.1
  • 148
    • 77649112679 scopus 로고    scopus 로고
    • A double-blind, randomized study of minocycline for the treatment of negative and cognitive symptoms in early-phase schizophrenia
    • Levkovitz Y, Mendlovich S, Riwkes S, et al. A double-blind, randomized study of minocycline for the treatment of negative and cognitive symptoms in early-phase schizophrenia. J Clin Psychiatry 2010;71(2): 138-49
    • (2010) J Clin Psychiatry , vol.71 , Issue.2 , pp. 138-149
    • Levkovitz, Y.1    Mendlovich, S.2    Riwkes, S.3
  • 149
    • 84922705265 scopus 로고    scopus 로고
    • Efficacy and tolerability of minocycline augmentation therapy in schizophrenia: A systematic review and meta-analysis of randomized controlled trials
    • Oya K, Kishi T, Iwata N. Efficacy and tolerability of minocycline augmentation therapy in schizophrenia: A systematic review and meta-analysis of randomized controlled trials. Hum Psychopharmacol 2014;29(5): 483-91
    • (2014) Hum Psychopharmacol , vol.29 , Issue.5 , pp. 483-491
    • Oya, K.1    Kishi, T.2    Iwata, N.3
  • 150
    • 84928608134 scopus 로고    scopus 로고
    • Addex. Available from: www. Addextherapeutics.com/investors/pressreleases/ news-details/article/addex-reportstopline-data-from-a-successful-phase-2aclinicalstudy-with-adx71149-inschizophrenia
  • 151
    • 37349021411 scopus 로고    scopus 로고
    • Addition of memantine to antipsychotic treatment in schizophrenia inpatients with residual symptoms: A preliminary study
    • Krivoy A, Weizman A, Laor L, et al. Addition of memantine to antipsychotic treatment in schizophrenia inpatients with residual symptoms: A preliminary study. Eur Neuropsychopharmacol 2008;18(2): 117-21
    • (2008) Eur Neuropsychopharmacol , vol.18 , Issue.2 , pp. 117-121
    • Krivoy, A.1    Weizman, A.2    Laor, L.3
  • 152
    • 62349116484 scopus 로고    scopus 로고
    • A randomized, placebo-controlled study of memantine as adjunctive treatment in patients with schizophrenia
    • Lieberman JA, Papadakis K, Csernansky J, et al. A randomized, placebo-controlled study of memantine as adjunctive treatment in patients with schizophrenia. Neuropsychopharmacology 2009;34(5): 1322-9
    • (2009) Neuropsychopharmacology , vol.34 , Issue.5 , pp. 1322-1329
    • Lieberman, J.A.1    Papadakis, K.2    Csernansky, J.3
  • 153
    • 84855557361 scopus 로고    scopus 로고
    • Glutamate signaling in the pathophysiology and therapy of schizophrenia
    • Lin CH, Lane HY, Tsai GE. Glutamate signaling in the pathophysiology and therapy of schizophrenia. Pharmacol Biochem Behav 2012;100(4):665-77
    • (2012) Pharmacol Biochem Behav , vol.100 , Issue.4 , pp. 665-677
    • Lin, C.H.1    Lane, H.Y.2    Tsai, G.E.3
  • 155
    • 43949112985 scopus 로고    scopus 로고
    • Mice lacking the AMPA GluR1 receptor exhibit striatal hyperdopaminergia and schizophrenia-related' behaviors
    • Wiedholz LM, Owens WA, Horton RE, et al. Mice lacking the AMPA GluR1 receptor exhibit striatal hyperdopaminergia and 'schizophrenia-related' behaviors. Mol Psychiatry 2008;13(6):631-40
    • (2008) Mol Psychiatry , vol.13 , Issue.6 , pp. 631-640
    • Wiedholz, L.M.1    Owens, W.A.2    Horton, R.E.3
  • 156
    • 0034796599 scopus 로고    scopus 로고
    • A placebo-controlled pilot study of the ampakine CX516 added to clozapine in schizophrenia
    • Goff DC, Leahy L, Berman I, et al. A placebo-controlled pilot study of the ampakine CX516 added to clozapine in schizophrenia. J Clin Psychopharmacol 2001;21(5):484-7
    • (2001) J Clin Psychopharmacol , vol.21 , Issue.5 , pp. 484-487
    • Goff, D.C.1    Leahy, L.2    Berman, I.3
  • 157
    • 38149132338 scopus 로고    scopus 로고
    • A placebo-controlled add-on trial of the Ampakine, CX516, for cognitive deficits in schizophrenia
    • Goff DC, Lamberti JS, Leon AC, et al. A placebo-controlled add-on trial of the Ampakine, CX516, for cognitive deficits in schizophrenia. Neuropsychopharmacology 2008;33(3):465-72
    • (2008) Neuropsychopharmacology , vol.33 , Issue.3 , pp. 465-472
    • Goff, D.C.1    Lamberti, J.S.2    Leon, A.C.3
  • 158
    • 77950627538 scopus 로고    scopus 로고
    • Antipsychotic-like effects of the N-methyl-daspartate receptor modulator neboglamine: An immunohistochemical and behavioural study in the rat
    • Chiusaroli R, Garofalo P, Espinoza S, et al. Antipsychotic-like effects of the N-methyl-daspartate receptor modulator neboglamine: An immunohistochemical and behavioural study in the rat. Pharmacol Res 2010;61(5): 430-6
    • (2010) Pharmacol Res , vol.61 , Issue.5 , pp. 430-436
    • Chiusaroli, R.1    Garofalo, P.2    Espinoza, S.3
  • 159
    • 84907987116 scopus 로고    scopus 로고
    • Juvenile antioxidant treatment prevents adult deficits in a developmental model of schizophrenia
    • Cabungcal JH, Counotte D-A, Lewis EM, et al. Juvenile antioxidant treatment prevents adult deficits in a developmental model of schizophrenia. Neuron. 2014; 83(5):1073-84
    • (2014) Neuron. , vol.83 , Issue.5 , pp. 1073-1084
    • Cabungcal, J.H.1    Counotte, D.-A.2    Lewis, E.M.3
  • 160
    • 84887256413 scopus 로고    scopus 로고
    • N-acetyl cysteine reverses social isolation rearing induced changes in cortico-striatal monoamines in rats
    • Moeller M, Du Preez J, Viljoen F, et al. N-acetyl cysteine reverses social isolation rearing induced changes in cortico-striatal monoamines in rats. Metab Brain Dis 2013; 28(4):687-96
    • (2013) Metab Brain Dis , vol.28 , Issue.4 , pp. 687-696
    • Moeller, M.1    Du Preez, J.2    Viljoen, F.3
  • 161
    • 84876865351 scopus 로고    scopus 로고
    • Social isolation rearing induces mitochondrial, immunological, neurochemical and behavioural deficits in rats, and is reversed by clozapine or N-acetyl cysteine
    • Moeller M, Du Preez JL, Viljoen FP, et al. Social isolation rearing induces mitochondrial, immunological, neurochemical and behavioural deficits in rats, and is reversed by clozapine or N-acetyl cysteine. Brain Beha Immun 2013; 30(0):156-67
    • (2013) Brain Beha Immun , vol.30 , Issue.0 , pp. 156-167
    • Moeller, M.1    Du Preez, J.L.2    Viljoen, F.P.3
  • 162
    • 84857482073 scopus 로고    scopus 로고
    • Glutathione Precursor N-Acetyl-Cysteine Modulates EEG synchronization in schizophrenia patients: A double-blind, randomized, placebo-controlled trial
    • Carmeli C, Knyazeva MG, Cünod M, Do KQ. Glutathione Precursor N-Acetyl-Cysteine Modulates EEG synchronization in schizophrenia patients: A double-blind, randomized, placebo-controlled trial. PLoS One 2012; 7(2):e29341
    • (2012) PLoS One , vol.7 , Issue.2 , pp. e29341
    • Carmeli, C.1    Knyazeva, M.G.2    Cünod, M.3    Do, K.Q.4
  • 163
    • 47249165587 scopus 로고    scopus 로고
    • Glutathione Precursor, N-Acetyl-cysteine, improves mismatch negativity in schizophrenia patients
    • Lavoie S, Murray MM, Deppen P, et al. Glutathione Precursor, N-Acetyl-cysteine, improves mismatch negativity in schizophrenia patients. Neuropsychopharmacology 2007;33(9): 2187-99
    • (2007) Neuropsychopharmacology , vol.33 , Issue.9 , pp. 2187-2199
    • Lavoie, S.1    Murray, M.M.2    Deppen, P.3
  • 164
    • 48749112603 scopus 로고    scopus 로고
    • N-Acetyl cysteine as a glutathione precursor for schizophrenia-A double-blind, randomized, placebo-controlled trial
    • Berk M, Copolov D, Dean O, et al. N-Acetyl cysteine as a glutathione precursor for schizophrenia-A double-blind, randomized, placebo-controlled trial. Biol Psychiatry 2008;64(5):361-8
    • (2008) Biol Psychiatry , vol.64 , Issue.5 , pp. 361-368
    • Berk, M.1    Copolov, D.2    Dean, O.3
  • 165
    • 84885194908 scopus 로고    scopus 로고
    • Adjunctive use of nonsteroidal anti-inflammatory drugs for schizophrenia: a meta-analytic investigation of randomized controlled trials
    • Nitta M, Kishimoto T, Mueller N, et al. Adjunctive Use of Nonsteroidal Anti-inflammatory Drugs for Schizophrenia: A Meta-analytic Investigation of Randomized Controlled Trials. Schizophr Bull 2013;39(6):1230-41
    • (2013) Schizophr Bull , vol.39 , Issue.6 , pp. 1230-1241
    • Nitta, M.1    Kishimoto, T.2    Mueller, N.3
  • 166
    • 84911092120 scopus 로고    scopus 로고
    • Towards stage specific treatments: Effects of duration of illness on therapeutic response to adjunctive treatment with N-acetyl cysteine in schizophrenia
    • Rapado-Castro M, Berk M, Venugopal K, et al. Towards stage specific treatments: Effects of duration of illness on therapeutic response to adjunctive treatment with N-acetyl cysteine in schizophrenia. Prog Neuro-Psychopharmacol Biol Psychiatry 2015;57(0):69-75
    • (2015) Prog Neuro-Psychopharmacol Biol Psychiatry , vol.57 , Issue.0 , pp. 69-75
    • Rapado-Castro, M.1    Berk, M.2    Venugopal, K.3
  • 167
    • 84881665236 scopus 로고    scopus 로고
    • Glycine treatment of the risk syndrome for psychosis: Report of two pilot studies
    • Woods SW, Walsh BC, Hawkins KA, et al. Glycine treatment of the risk syndrome for psychosis: Report of two pilot studies. Eur Neuropsychopharmacol 2013;23(8):931-40
    • (2013) Eur Neuropsychopharmacol , vol.23 , Issue.8 , pp. 931-940
    • Woods, S.W.1    Walsh, B.C.2    Hawkins, K.A.3
  • 168
    • 30544442928 scopus 로고    scopus 로고
    • DARPP-32 mediates the actions of multiple drugs of abuse
    • Svenningsson P, Nairn AC, Greengard P. DARPP-32 mediates the actions of multiple drugs of abuse. AAPS J 2005;7(2):E353-60
    • (2005) AAPS J , vol.7 , Issue.2 , pp. E353-E360
    • Svenningsson, P.1    Nairn, A.C.2    Greengard, P.3
  • 169
    • 0028018276 scopus 로고
    • Amphetamine regulates gene expression in rat striatum via transcription factor CREB
    • Konradi C, Cole RL, Heckers S, Hyman SE . Amphetamine regulates gene expression in rat striatum via transcription factor CREB. J Neurosci 1994;14(9):5623-34
    • (1994) J Neurosci , vol.14 , Issue.9 , pp. 5623-5634
    • Konradi, C.1    Cole, R.L.2    Heckers, S.3    Hyman, S.E.4
  • 170
    • 84871989449 scopus 로고    scopus 로고
    • The psychosis high-risk state: A comprehensive state-of-the-art review
    • Fusar-Poli P, Borgwardt S, Bechdolf A, et al. The psychosis high-risk state: A comprehensive state-of-the-art review. JAMA Psychiatry 2013;70(1):107-20
    • (2013) JAMA Psychiatry , vol.70 , Issue.1 , pp. 107-120
    • Fusar-Poli, P.1    Borgwardt, S.2    Bechdolf, A.3
  • 171
    • 77949404965 scopus 로고    scopus 로고
    • Research in people with psychosis risk syndrome: A review of the current evidence and future directions
    • Correll CU, Hauser M, Auther AM, Cornblatt BA. Research in people with psychosis risk syndrome: A review of the current evidence and future directions. J Child Psychol Psychiatry 2010;51(4): 390-431
    • (2010) J Child Psychol Psychiatry , vol.51 , Issue.4 , pp. 390-431
    • Correll, C.U.1    Hauser, M.2    Auther, A.M.3    Cornblatt, B.A.4
  • 172
    • 84903988963 scopus 로고    scopus 로고
    • Effects of brexpiprazole, a novel serotonin-dopamine activity modulator, on phencyclidine-induced cognitive deficits in mice: A role for serotonin 5-HT1A receptors
    • Yoshimi N, Fujita Y, Ohgi Y, et al. Effects of brexpiprazole, a novel serotonin-dopamine activity modulator, on phencyclidine-induced cognitive deficits in mice: A role for serotonin 5-HT1A receptors. Pharmacol Biochem Behave 2014;124:245-9
    • (2014) Pharmacol Biochem Behave , vol.124 , pp. 245-249
    • Yoshimi, N.1    Fujita, Y.2    Ohgi, Y.3
  • 173
    • 84925944263 scopus 로고    scopus 로고
    • Improvement of dizocilpine-induced social recognition deficits in mice by brexpiprazole, a novel serotonin-dopamine activity modulator
    • Yoshimi N, Futamura T, Hashimoto K. Improvement of dizocilpine-induced social recognition deficits in mice by brexpiprazole, a novel serotonin-dopamine activity modulator. Eur Neuropsychopharmacol 2015;25(3):356-64
    • (2015) Eur Neuropsychopharmacol , vol.25 , Issue.3 , pp. 356-364
    • Yoshimi, N.1    Futamura, T.2    Hashimoto, K.3
  • 174
    • 84879080531 scopus 로고    scopus 로고
    • Aripiprazole differentially regulates the expression of Gad67 and ã-amino-butyric acid transporters in rat brain
    • Peselmann N, Schmitt A, Gebicke-Haerter P, Zink M. Aripiprazole differentially regulates the expression of Gad67 and ã-amino-butyric acid transporters in rat brain. Eur Arch Psychiatry Clin Neurosci 2013;263(4): 285-97
    • (2013) Eur Arch Psychiatry Clin Neurosci , vol.263 , Issue.4 , pp. 285-297
    • Peselmann, N.1    Schmitt, A.2    Gebicke-Haerter, P.3    Zink, M.4
  • 175
    • 69349084556 scopus 로고    scopus 로고
    • Differential expression of glutamate transporter genes after chronic oral treatment with aripiprazole in rats
    • Segnitz N, Schmitt A, Gebicke-Härter P, Zink M. Differential expression of glutamate transporter genes after chronic oral treatment with aripiprazole in rats. Neurochem Int 2009;55(7):619-28
    • (2009) Neurochem Int , vol.55 , Issue.7 , pp. 619-628
    • Segnitz, N.1    Schmitt, A.2    Gebicke-Härter, P.3    Zink, M.4
  • 176
    • 84886286165 scopus 로고    scopus 로고
    • Neural basis for the ability of atypical antipsychotic drugs to improve cognition in schizophrenia
    • Sumiyoshi T, Higuchi Y, Uehara T. Neural Basis for the Ability of Atypical Antipsychotic Drugs to Improve Cognition in Schizophrenia. Frontiers in Behav Neurosci 2013;7:140
    • (2013) Frontiers in Behav Neurosci , vol.7 , pp. 140
    • Sumiyoshi, T.1    Higuchi, Y.2    Uehara, T.3
  • 177
    • 84877954714 scopus 로고    scopus 로고
    • Facilitative effect of serotonin (1A) receptor agonists on cognition in patients with schizophrenia
    • Sumiyoshi T, Higuchi Y. Facilitative effect of serotonin(1A) receptor agonists on cognition in patients with schizophrenia. Curr Med Chem 2013;20(3):357-62
    • (2013) Curr Med Chem , vol.20 , Issue.3 , pp. 357-362
    • Sumiyoshi, T.1    Higuchi, Y.2
  • 178
    • 79953689886 scopus 로고    scopus 로고
    • The role of serotonin receptors in the action of atypical antipsychotic drugs
    • Meltzer HY, Massey BW. The role of serotonin receptors in the action of atypical antipsychotic drugs. Curr Opin Pharmacol Neurosci 2011;11(1):59-67
    • (2011) Curr Opin Pharmacol Neurosci , vol.11 , Issue.1 , pp. 59-67
    • Meltzer, H.Y.1    Massey, B.W.2
  • 179
    • 80052149754 scopus 로고    scopus 로고
    • Randomized controlled trials in schizophrenia: Opportunities, limitations, and trial design alternatives
    • Correll CU. Randomized controlled trials in schizophrenia: opportunities, limitations, and trial design alternatives. Dialogues Clin Neurosci 2011;13(2):155-72
    • (2011) Dialogues Clin Neurosci , vol.13 , Issue.2 , pp. 155-172
    • Correll, C.U.1
  • 180
    • 84904804929 scopus 로고    scopus 로고
    • Biological insights from 108 schizophrenia-associated genetic loci
    • Consortium SWGotPG. Biological insights from 108 schizophrenia-associated genetic loci. Nature 2014;511(7510):421-7
    • (2014) Nature , vol.511 , Issue.7510 , pp. 421-427
    • Swgotpg, C.1
  • 181
    • 0027251058 scopus 로고
    • Chronic haloperidol treatment enhances binding to NMDA receptors in rat cortex
    • Ulas J, Nguyen L, Cotman CW. Chronic haloperidol treatment enhances binding to NMDA receptors in rat cortex. Neuroreport 1993;4(8):1049-51
    • (1993) Neuroreport , vol.4 , Issue.8 , pp. 1049-1051
    • Ulas, J.1    Nguyen, L.2    Cotman, C.W.3
  • 182
    • 0028947052 scopus 로고
    • Regulation of cortical and subcortical glutamate receptor subunit expression by antipsychotic drugs
    • Fitzgerald LW, Deutch AY, Gasic G, et al. Regulation of cortical and subcortical glutamate receptor subunit expression by antipsychotic drugs. J Neurosci 1995; 15(3 Pt 2):2453-61
    • (1995) J Neurosci , vol.15 , Issue.3 , pp. 2453-2461
    • Fitzgerald, L.W.1    Deutch, A.Y.2    Gasic, G.3
  • 183
    • 0029030343 scopus 로고
    • Antipsychotic agents antagonize non-competitive N-methyl-D-aspartate antagonist-induced behaviors
    • Corbett R, Camacho F, Woods AT, et al. Antipsychotic agents antagonize non-competitive N-methyl-D-aspartate antagonist-induced behaviors. Psychopharmacology (Berl) 1995;120(1): 67-74
    • (1995) Psychopharmacology (Berl) , vol.120 , Issue.1 , pp. 67-74
    • Corbett, R.1    Camacho, F.2    Woods, A.T.3
  • 184
    • 0037321715 scopus 로고    scopus 로고
    • Effects of long-term antipsychotic treatment on NMDA receptor binding and gene expression of subunits
    • Schmitt A, Zink M, Mueller B, et al. Effects of long-term antipsychotic treatment on NMDA receptor binding and gene expression of subunits. Neurochem Res 2003;28(2):235-41
    • (2003) Neurochem Res , vol.28 , Issue.2 , pp. 235-241
    • Schmitt, A.1    Zink, M.2    Mueller, B.3
  • 185
    • 18044365379 scopus 로고    scopus 로고
    • Clozapine, ziprasidone and aripiprazole but not haloperidol protect against kainic acid-induced lesion of the striatum in mice, in vivo: Role of 5-HT1A receptor activation
    • Cosi C, Waget A, Rollet K, et al. Clozapine, ziprasidone and aripiprazole but not haloperidol protect against kainic acid-induced lesion of the striatum in mice, in vivo: role of 5-HT1A receptor activation. Brain Res 2005;1043(1-2):32-41
    • (2005) Brain Res , vol.1043 , Issue.1-2 , pp. 32-41
    • Cosi, C.1    Waget, A.2    Rollet, K.3
  • 186
    • 27144443377 scopus 로고    scopus 로고
    • Effects of novel antipsychotics with mixed D(2) antagonist/ 5-HT(1A) agonist properties on PCP-induced social interaction deficits in the rat
    • Bruins Slot LA, Kleven MS, Newman-Tancredi A. Effects of novel antipsychotics with mixed D(2) antagonist/ 5-HT(1A) agonist properties on PCP-induced social interaction deficits in the rat. Neuropharmacology 2005;49(7): 996-1006
    • (2005) Neuropharmacology , vol.49 , Issue.7 , pp. 996-1006
    • Bruins Slot, L.A.1    Kleven, M.S.2    Newman-Tancredi, A.3
  • 187
    • 33847653333 scopus 로고    scopus 로고
    • The atypical antipsychotic, aripiprazole, blocks phencyclidine-induced disruption of prepulse inhibition in mice
    • Fejgin K, Safonov S, Palsson E, et al. The atypical antipsychotic, aripiprazole, blocks phencyclidine-induced disruption of prepulse inhibition in mice. Psychopharmacology (Berl) 2007;191: 377-85
    • (2007) Psychopharmacology (Berl) , vol.191 , pp. 377-385
    • Fejgin, K.1    Safonov, S.2    Palsson, E.3
  • 188
    • 37349036431 scopus 로고    scopus 로고
    • Aripiprazole, an atypical antipsychotic, prevents the motor hyperactivity induced by psychotomimetics and psychostimulants in mice
    • Leite JV, Guimaraes FS, Moreira FA. Aripiprazole, an atypical antipsychotic, prevents the motor hyperactivity induced by psychotomimetics and psychostimulants in mice. Eur J Pharmacol 2008;578(2-3):222-7
    • (2008) Eur J Pharmacol , vol.578 , Issue.2-3 , pp. 222-227
    • Leite, J.V.1    Guimaraes, F.S.2    Moreira, F.A.3
  • 189
    • 38149001461 scopus 로고    scopus 로고
    • Effects of aripiprazole/OPC-14597 on motor activity, pharmacological models of psychosis, and brain activity in rats
    • Nordquist RE, Risterucci C, Moreau JL, et al. Effects of aripiprazole/OPC-14597 on motor activity, pharmacological models of psychosis, and brain activity in rats. Neuropharmacology 2008;54(2):405-16
    • (2008) Neuropharmacology , vol.54 , Issue.2 , pp. 405-416
    • Nordquist, R.E.1    Risterucci, C.2    Moreau, J.L.3
  • 190
    • 43249099229 scopus 로고    scopus 로고
    • Improvement of phencyclidine-induced social behaviour deficits in rats: Involvement of 5-HT1A receptors
    • Snigdha S, Neill JC. Improvement of phencyclidine-induced social behaviour deficits in rats: involvement of 5-HT1A receptors. Behav Brain Res 2008; 191(1):26-31
    • (2008) Behav Brain Res , vol.191 , Issue.1 , pp. 26-31
    • Snigdha, S.1    Neill, J.C.2
  • 191
    • 35548983971 scopus 로고    scopus 로고
    • Antipsychotic drugs reverse the disruption in prefrontal cortex function produced by NMDA receptor blockade with phencyclidine
    • Kargieman L, Santana N, Mengod G, et al. Antipsychotic drugs reverse the disruption in prefrontal cortex function produced by NMDA receptor blockade with phencyclidine. Proc Natl Acad Sci USA 2007;104(37):14843-8
    • (2007) Proc Natl Acad Sci USA , vol.104 , Issue.37 , pp. 14843-14848
    • Kargieman, L.1    Santana, N.2    Mengod, G.3
  • 192
    • 56649111297 scopus 로고    scopus 로고
    • Orbitofrontal cortex neurons as a common target for classic and glutamatergic antipsychotic drugs
    • Homayoun H, Moghaddam B. Orbitofrontal cortex neurons as a common target for classic and glutamatergic antipsychotic drugs. Proc Natil Acad Sci USA 2008;105(46):18041-6
    • (2008) Proc Natil Acad Sci USA , vol.105 , Issue.46 , pp. 18041-18046
    • Homayoun, H.1    Moghaddam, B.2
  • 193
    • 65049085795 scopus 로고    scopus 로고
    • D1-like receptor activation improves PCP-induced cognitive deficits in animal models: Implications for mechanisms of improved cognitive function in schizophrenia
    • McLean SL, Idris NF, Woolley ML, Neill JC. D1-like receptor activation improves PCP-induced cognitive deficits in animal models: Implications for mechanisms of improved cognitive function in schizophrenia. Eur Neuropsychopharmacol 2009;19(6):440-50
    • (2009) Eur Neuropsychopharmacol , vol.19 , Issue.6 , pp. 440-450
    • McLean, S.L.1    Idris, N.F.2    Woolley, M.L.3    Neill, J.C.4
  • 194
    • 57749175518 scopus 로고    scopus 로고
    • Effects of risperidone on glutamate receptor subtypes in developing rat brain
    • Choi YK, Gardner MP, Tarazi FI. Effects of risperidone on glutamate receptor subtypes in developing rat brain. Eur Neuropsychopharmacol 2009;19(2):77-84
    • (2009) Eur Neuropsychopharmacol , vol.19 , Issue.2 , pp. 77-84
    • Choi, Y.K.1    Gardner, M.P.2    Tarazi, F.I.3
  • 195
    • 66049107219 scopus 로고    scopus 로고
    • Asenapine exerts distinctive regional effects on ionotropic glutamate receptor subtypes in rat brain
    • Tarazi FI, Choi YK, Gardner M, et al. Asenapine exerts distinctive regional effects on ionotropic glutamate receptor subtypes in rat brain. Synapse 2009;63(5):413-20
    • (2009) Synapse , vol.63 , Issue.5 , pp. 413-420
    • Tarazi, F.I.1    Choi, Y.K.2    Gardner, M.3
  • 196
    • 59449096993 scopus 로고    scopus 로고
    • Aripiprazole ameliorates phencyclidine-induced impairment of recognition memory through dopamine D1 and serotonin 5-HT1A receptors
    • Nagai T, Murai R, Matsui K, et al. Aripiprazole ameliorates phencyclidine-induced impairment of recognition memory through dopamine D1 and serotonin 5-HT1A receptors. Psychopharmacology (Berl) 2009;202(1-3): 315-28
    • (2009) Psychopharmacology (Berl) , vol.202 , Issue.1-3 , pp. 315-328
    • Nagai, T.1    Murai, R.2    Matsui, K.3
  • 197
    • 77955274181 scopus 로고    scopus 로고
    • Antipsychotic drugs prevent the motor hyperactivity induced by psychotomimetic MK-801 in zebrafish (Danio rerio)
    • Seibt KJ, Oliveira Rda L, Zimmermann FF, et al. Antipsychotic drugs prevent the motor hyperactivity induced by psychotomimetic MK-801 in zebrafish (Danio rerio). Behav Brain Res 2010;214(2):417-22
    • (2010) Behav Brain Res , vol.214 , Issue.2 , pp. 417-422
    • Seibt, K.J.1    Oliveira Rda, L.2    Zimmermann, F.F.3
  • 198
    • 79953645758 scopus 로고    scopus 로고
    • Sertindole restores attentional performance and suppresses glutamate release induced by the NMDA receptor antagonist CPP
    • Carli M, Calcagno E, Mainini E, et al. Sertindole restores attentional performance and suppresses glutamate release induced by the NMDA receptor antagonist CPP. Psychopharmacology (Berl) 2011;214(3): 625-37
    • (2011) Psychopharmacology (Berl) , vol.214 , Issue.3 , pp. 625-637
    • Carli, M.1    Calcagno, E.2    Mainini, E.3
  • 199
    • 84885415461 scopus 로고    scopus 로고
    • Atypical antipsychotic olanzapine reversed deficit on prepulse inhibition of the acoustic startle reflex produced by microinjection of dizocilpine (MK-801) into the inferior colliculus in rats
    • Zangrando J, Carvalheira R, Labbate G, et al. Atypical antipsychotic olanzapine reversed deficit on prepulse inhibition of the acoustic startle reflex produced by microinjection of dizocilpine (MK-801) into the inferior colliculus in rats. Behav Brain Res 2013;257(0):77-82
    • (2013) Behav Brain Res , vol.257 , Issue.0 , pp. 77-82
    • Zangrando, J.1    Carvalheira, R.2    Labbate, G.3
  • 200
    • 84895923611 scopus 로고    scopus 로고
    • Comparative effect of lurasidone and blonanserin on cortical glutamate, dopamine, and acetylcholine efflux: Role of relative serotonin (5-HT)2A and da D2 antagonism and 5-HT1A partial agonism
    • Huang M, Panos JJ, Kwon S, et al. Comparative effect of lurasidone and blonanserin on cortical glutamate, dopamine, and acetylcholine efflux: role of relative serotonin (5-HT)2A and DA D2 antagonism and 5-HT1A partial agonism. J Neurochem 2014;128(6):938-49
    • (2014) J Neurochem , vol.128 , Issue.6 , pp. 938-949
    • Huang, M.1    Panos, J.J.2    Kwon, S.3
  • 201
    • 84922461418 scopus 로고    scopus 로고
    • Glutamate receptor 1 phosphorylation at serine 845 contributes to the therapeutic effect of olanzapine on schizophrenia-like cognitive impairments
    • Zhang C, Fang Y, Xu L. Glutamate receptor 1 phosphorylation at serine 845 contributes to the therapeutic effect of olanzapine on schizophrenia-like cognitive impairments. Schizophr Res 2014;159(2-3): 376-84
    • (2014) Schizophr Res , vol.159 , Issue.2-3 , pp. 376-384
    • Zhang, C.1    Fang, Y.2    Xu, L.3


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