Schizophrenia past Clozapine: Reasons for Clozapine Discontinuation, Mortality, and Alternative Antipsychotic Prescribing

Pharmacopsychiatry

Volumn 45, Issue 1, 2014, Pages 11-14

  Mustafa, F A ^a   Burke, J G ^a   Abukmeil, S S ^a   Scanlon, J J ^a   Cox, M ^a  

^a Northamptonshire Healthcare NHS Foundation Trust   (United Kingdom)

Author keywords

alternative to clozapine; clozapine discontinuation; clozapine mortality; olanzapine; schizophrenia past clozapine

Indexed keywords

CLOZAPINE; OLANZAPINE; BENZODIAZEPINE DERIVATIVE; NEUROLEPTIC AGENT; PRESCRIPTION DRUG;

ADULT; AGED; ARTICLE; BIOLOGICAL MONITORING; DRUG FATALITY; DRUG WITHDRAWAL; FEMALE; HUMAN; LEUKOCYTE; MAJOR CLINICAL STUDY; MALE; MENTAL HEALTH SERVICE; MIDDLE AGED; MORTALITY; NEUTROPENIA; PATIENT COMPLIANCE; PRESCRIPTION; RESPIRATORY TRACT INFECTION; SCHIZOPHRENIA; TREATMENT REFUSAL; TREATMENT RESPONSE; YOUNG ADULT; CHEMICALLY INDUCED; CONSTIPATION; ELECTRONIC MEDICAL RECORD; HYPERSALIVATION; RETROSPECTIVE STUDY; STATISTICS AND NUMERICAL DATA; ACUTE PANCREATITIS; ALCOHOL INTOXICATION; BRAIN ABSCESS; CAUSE OF DEATH; CONTROLLED STUDY; DATA EXTRACTION; DESCRIPTIVE RESEARCH; DRUG EFFICACY; DRUG INTOXICATION; DRUG SAFETY; FECES IMPACTION; LUNG EMBOLISM; MENTAL PATIENT; MONOTHERAPY; NEOPLASM; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; PSYCHOPHARMACOTHERAPY; SCHIZOAFFECTIVE PSYCHOSIS; SEPTICEMIA; STATISTICAL ANALYSIS; SUICIDE; UNITED KINGDOM;

ADULT; AGED; ANTIPSYCHOTIC AGENTS; BENZODIAZEPINES; CLOZAPINE; CONSTIPATION; ELECTRONIC HEALTH RECORDS; FEMALE; HUMANS; MALE; MIDDLE AGED; PRESCRIPTION DRUGS; RETROSPECTIVE STUDIES; SCHIZOPHRENIA; SIALORRHEA;

EID: 84928591590     PISSN: 01763679     EISSN: 14390795     Source Type: Journal    
DOI: 10.1055/s-0034-1394397     Document Type: Article

References (20)

1. Kane J., Honigfeld G., Singer J. et al. Clozapine for the treatment-resistant schizophrenic. A double-blind comparison with chlorpromazine. Arch Gen Psychiatry: 1988; 45 789 796
2. McEvoy J. P., Lieberman J. A., Stoup T. S. et al. Effectiveness of clozapine versus olanzapine, quetiapine, and risperidone in patients with chronic schizophrenia who did not respond to prior atypical antipsychotic treatment. Am J Psychiatry: 2006; 163 600 610
3. Buchanan R. W. Clozapine: efficacy and safety. Schizophr Bull: 1995; 21 579 591
4. Mustafa F. A. Schizophrenia past clozapine: what works? J Clin Psychopharmacol: 2013; 33 63 68
5. Davis M. C., Fuller M. A., Strauss M. E. et al. A 15-year naturalistic retrospective study of 320 patients. Acta Psychiatr Scand: 2013; 10.1111/acps.12233
6. Pai N. B., Vella S. C. Reason for clozapine cessation. Acta Psychiatr Scand: 2012; 125 39 44
7. Taylor D. M., Douglas-Hall P., Olofinjana B. et al. Reasons for discontinuing clozapine: matched, case-control comparison with risperidone long-acting injection. Br J Psychiatry: 2009; 194 165 167
8. Bastiampillai T., Avina P., Malalagama G. et al. 2012;Gender differences in clozapine prescription in Australia. Curr Psychopharmacol 2012; 6 111 116
9. Mustafa F., Abdelmawla N., Chikodzore LM D. et al. Gender differences in clozapine prescription for patients with treatment resistant schizophrenia: A case note survey. J Psychopharmacol: 2009; 23 6 A60
10. Meltzer H. Y. Clozapine: balancing safety with superior antipsychotic efficacy. Clin Schizophr Relat Psychoses: 2012; 6 134 144
11. Tiihonen J., Lönnqvist J., Wahlbeck K. et al. 11-year follow-up of mortality in patients with schizophrenia: a population-based cohort study (FIN11 study). Lancet: 2009; 374 620 627
12. Hinkes R., Quesada T. V., Currier M. B. et al. Aspiration pneumonia possibly secondary to clozapine-induced sialorrhea. J Clin Psychopharmacol: 1996; 16 462 463
13. Maddalena A. S., Fox M., Hofmann M. et al. Esophageal dysfunction on psychotropic medication. A case report and literature review. Pharmacopsychiatry: 2004; 37 134 138
14. Levin T. T., Barrett J., Mendelowitz A. Death from clozapine-induced constipation: case report and literature review. Psychosomatics: 2002; 43 71 73
15. Hayes G., Gibler B. Clozapine-induced constipation. Am J Psychiatry: 1995; 152 298
16. Wahlbeck K., Westman J., Nordentoft M. et al. Outcomes of Nordic mental health systems: life expectancy of patients with mental disorders. Br J Psychiatry: 2011; 199 453 458
17. Crump C., Winkleby M. A., Sundquist K. et al. Comorbidities and mortality in persons with schizophrenia: a Swedish national cohort study. Am J Psychiatry: 2013; 170 324 333
18. Chakos M., Lieberman J., Hoffman E. et al. Effectiveness of second-generation antipsychotics in patients with treatment-resistant schizophrenia: a review and meta-analysis of randomized trials. Am J Psychiatry: 2001; 158 518 526
19. Leucht S., Tardy M., Komossa K. et al. Antipsychotic drugs versus placebo for relapse prevention in schizophrenia: a systematic review and meta-analysis. Lancet: 2012; 379 2063 2071
20. Remington G., Agid O., Foussias G. et al. Clozapine's role in the treatment of first-episode schizophrenia. Am J Psychiatry: 2013; 170 146 151