Adding lithium or anticonvulsants to antipsychotics for the treatment of schizophrenia: Useful strategy or exercise in futility?

Journal of Clinical Psychiatry

Volumn 70, Issue 6, 2009, Pages 932-933

  Citrome, Leslie ^a,b  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATHAN S KLINE INSTITUTE FOR PSYCHIATRIC RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICONVULSIVE AGENT; CARBAMAZEPINE; CLOZAPINE; LAMOTRIGINE; LITHIUM; MOOD STABILIZER; NEUROLEPTIC AGENT; OLANZAPINE; PLACEBO; RISPERIDONE; TOPIRAMATE; VALPROATE SEMISODIUM; VALPROIC ACID;

AGGRESSION; ALOPECIA; ATAXIA; BIPOLAR MANIA; BLURRED VISION; CLINICAL TRIAL; COGNITIVE DEFECT; DIARRHEA; DIPLOPIA; DIZZINESS; DROWSINESS; DRUG APPROVAL; DRUG EFFECT; DRUG EFFICACY; DRUG ERUPTION; DRUG SAFETY; FATIGUE; FOOD AND DRUG ADMINISTRATION; GASTROINTESTINAL SYMPTOM; HEADACHE; HOSPITAL PATIENT; HUMAN; HYPERAMMONEMIA; LEUKOPENIA; MENSTRUATION DISORDER; MUSCLE WEAKNESS; NAUSEA; NAUSEA AND VOMITING; NEUTROPENIA; PARESTHESIA; POLYURIA; PRIORITY JOURNAL; QUALITY OF LIFE; RASH; RATING SCALE; RHINITIS; SCHIZOAFFECTIVE PSYCHOSIS; SCHIZOPHRENIA; SCORING SYSTEM; SEDATION; SHORT SURVEY; SIDE EFFECT; SOMNOLENCE; THROMBOCYTOPENIA; TREATMENT RESPONSE; TREMOR; WEIGHT GAIN;

ANTICONVULSANTS; ANTIMANIC AGENTS; ANTIPSYCHOTIC AGENTS; DELAYED-ACTION PREPARATIONS; DRUG THERAPY, COMBINATION; HUMANS; LITHIUM CARBONATE; MEDICAL FUTILITY; MULTICENTER STUDIES AS TOPIC; RANDOMIZED CONTROLLED TRIALS AS TOPIC; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; TREATMENT FAILURE; TRIAZINES; VALPROIC ACID;

EID: 67649206083     PISSN: 01606689     EISSN: None     Source Type: Journal    
DOI: 10.4088/JCP.09ac05289     Document Type: Short Survey

References (25)

1. Citrome L, Goldberg JF, Stahl SM. Toward convergence in the medication treatment of bipolar disorder and schizophrenia. Harv Rev Psychiatry 2005;13:28-42 (Pubitemid 40446363)
2. Citrome L. Use of lithium, carbamazepine, and valproic acid in a state-operated psychiatric hospital. J Pharm Technol 1995;11:55-59
3. Citrome L. Adjunctive lithium and anticonvulsants for the treatment of schizophrenia: what is the evidence? Expert Rev Neurother 2009; 9:55-71
4. Citrome L, Levine J, Allingham B. Changes in use of valproate and other mood stabilizers for patients with schizophrenia from 1994 to 1998. Psychiatr Serv 2000;51:634-638
5. Malhi GS, Green M, Fagiolini A, et al. Schizoaffective disorder: diagnostic issues and future recommendations. Bipolar Disord 2008; 10:215-230
6. Casey DE, Daniel DG, Tamminga C, et al. Divalproex ER combined with olanzapine or risperidone for treatment of acute exacerbations of schizophrenia. Neuropsychopharmacology 2009;34:1330-1338
7. Casey DE, Daniel DG, Wassef AA, et al. Effect of divalproex combined with olanzapine or risperidone in patients with an acute exacerbation of schizophrenia. Neuropsychopharmacology 2003;28:182-192 (Pubitemid 37412115)
8. Schwarz C, Volz A, Li C, et al. Valproate for schizophrenia. Cochrane Database Syst Rev 2008;(3):CD004028
9. Goff DC, Keefe R, Citrome L, et al. Lamotrigine as add-on therapy in schizophrenia: results of two placebo-controlled trials. J Clin Psychopharmacol 2007;27:582-589 (Pubitemid 351339444)
10. Tiihonen J, Wahlbeck K, Kiviniemi V. The efficacy of lamotrigine in clozapine-resistant schizophrenia: a systematic review and metaanalysis. Schizophr Res 2009;109:10-14
11. Okuma T, Yamashita I, Takahashi R, et al. A double-blind study of adjunctive carbamazepine versus placebo on excited states of schizophrenic and schizoaffective disorders. Acta Psychiatr Scand 1989;80:250-259 (Pubitemid 19249936)
12. Leucht S, Kissling W, McGrath J, et al. Carbamazepine for schizophrenia. Cochrane Database Syst Rev 2007;(3):CD001258 (Pubitemid 351805455)
13. Citrome L, Vreeland B. Schizophrenia, obesity, and antipsychotic medications: what can we do? Postgrad Med 2008;120 (Jul):18-33
14. Tiihonen J, Halonen P, Wahlbeck K, et al. Topiramate add-on in treatment- resistant schizophrenia: a randomized, double-blind, placebocontrolled, crossover trial. J Clin Psychiatry 2005;66:1012-1015 (Pubitemid 41191793)
15. Afshar H, Roohafza H, Mousavi G, et al. Topiramate add-on treatment in schizophrenia: a randomised, double-blind, placebo-controlled clinical trial. J Psychopharmacol 2009;23:157-162
16. Arnone D. Review of the use of topiramate for treatment of psychiatric disorders. Ann Gen Psychiatry 2005;4(1):5 (Pubitemid 40854397)
17. Leucht S, Kissling W, McGrath J. Lithium for schizophrenia. Cochrane Database Syst Rev 2007;(3):CD003834 (Pubitemid 351805547)
18. Kanaan RA, Kerwin RW. Lithium and clozapine rechallenge: a retrospective case analysis. J Clin Psychiatry 2006;67:756-760 (Pubitemid 43946182)
19. Kanner AM, Balabanov A. Valproate: a practical review of its uses in neurological and psychiatric disorders. Expert Rev Neurother 2002;2:151-165 (Pubitemid 34638824)
20. Bowden CL, Karren NU. Anticonvulsants in bipolar disorder. Aust N Z J Psychiatry 2006;40:386-393
21. Malik S, Arif H, Hirsch LJ. Lamotrigine and its applications in the treatment of epilepsy and other neurological and psychiatric disorders. Expert Rev Neurother 2006;6:1609-1627 (Pubitemid 44904008)
22. Ferrier IN, Ferrie LJ, Macritchie KA. Old drug, new data: revisiting lithium therapy. Adv Psychiatr Treat 2006;12:256-264
23. Guyatt GH, Rennie D. Users' Guides to the Medical Literature: Essentials of Evidence-Based Clinical Practice. Chicago, Ill: American Medical Association; 2001:7
24. McEvoy JP, Lieberman JA, Stroup TS, et al. Effectiveness of clozapine versus olanzapine, quetiapine, and risperidone in patients with chronic schizophrenia who did not respond to prior atypical antipsychotic treatment. Am J Psychiatry 2006;163:600-610 (Pubitemid 44464569)
25. Krakowski MI, Czobor P, Citrome L, et al. Atypical antipsychotic agents in the treatment of violent patients with schizophrenia and schizoaffective disorder. Arch Gen Psychiatry 2006;63:622-629 (Pubitemid 43848293)