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Volumn 171, Issue 23, 2014, Pages 5387-5406

Heteromerization of GPR55 and cannabinoid CB2 receptors modulates signalling

Author keywords

[No Author keywords available]

Indexed keywords

CANNABINOID 2 RECEPTOR; G PROTEIN COUPLED RECEPTOR; GPR55 PROTEIN, HUMAN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3;

EID: 84928502303     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.12850     Document Type: Article
Times cited : (106)

References (75)
  • 3
    • 78651393400 scopus 로고    scopus 로고
    • The orphan G protein-coupled receptor GPR55 promotes cancer cell proliferation via ERK
    • Andradas C, Caffarel MM, Perez-Gomez E, Salazar M, Lorente M, Velasco G, et al. (2011). The orphan G protein-coupled receptor GPR55 promotes cancer cell proliferation via ERK. Oncogene 30: 245-252.
    • (2011) Oncogene , vol.30 , pp. 245-252
    • Andradas, C.1    Caffarel, M.M.2    Perez-Gomez, E.3    Salazar, M.4    Lorente, M.5    Velasco, G.6
  • 5
    • 80053652832 scopus 로고    scopus 로고
    • GPR55 regulates cannabinoid 2 receptor-mediated responses in human neutrophils
    • Balenga NA, Aflaki E, Kargl J, Platzer W, Schroder R, Blattermann S, et al. (2011a). GPR55 regulates cannabinoid 2 receptor-mediated responses in human neutrophils. Cell Res 21: 1452-1469.
    • (2011) Cell Res , vol.21 , pp. 1452-1469
    • Balenga, N.A.1    Aflaki, E.2    Kargl, J.3    Platzer, W.4    Schroder, R.5    Blattermann, S.6
  • 6
    • 80052661509 scopus 로고    scopus 로고
    • Pharmacology, signaling and physiological relevance of the G protein-coupled receptor 55
    • Balenga NA, Henstridge CM, Kargl J, Waldhoer M, (2011b). Pharmacology, signaling and physiological relevance of the G protein-coupled receptor 55. Adv Pharmacol 62: 251-277.
    • (2011) Adv Pharmacol , vol.62 , pp. 251-277
    • Balenga, N.A.1    Henstridge, C.M.2    Kargl, J.3    Waldhoer, M.4
  • 7
    • 84879518676 scopus 로고    scopus 로고
    • Cannabinoid receptor 2 (CB2) plays a role in the generation of germinal center and memory B cells, but not in the production of antigen-specific IgG and IgM, in response to T-dependent antigens
    • Basu S, Ray A, Dittel BN, (2013). Cannabinoid receptor 2 (CB2) plays a role in the generation of germinal center and memory B cells, but not in the production of antigen-specific IgG and IgM, in response to T-dependent antigens. PLoS ONE 8: e67587.
    • (2013) PLoS ONE , vol.8 , pp. e67587
    • Basu, S.1    Ray, A.2    Dittel, B.N.3
  • 8
    • 84862895073 scopus 로고    scopus 로고
    • A biased ligand for OXE-R uncouples Galpha and Gbetagamma signaling within a heterotrimer
    • Blattermann S, Peters L, Ottersbach PA, Bock A, Konya V, Weaver CD, et al. (2012). A biased ligand for OXE-R uncouples Galpha and Gbetagamma signaling within a heterotrimer. Nat Chem Biol 8: 631-638.
    • (2012) Nat Chem Biol , vol.8 , pp. 631-638
    • Blattermann, S.1    Peters, L.2    Ottersbach, P.A.3    Bock, A.4    Konya, V.5    Weaver, C.D.6
  • 9
    • 67749114412 scopus 로고    scopus 로고
    • Is GPR55 an anandamide receptor?
    • Brown AJ, Robin Hiley C, (2009). Is GPR55 an anandamide receptor? Vitam Horm 81: 111-137.
    • (2009) Vitam Horm , vol.81 , pp. 111-137
    • Brown, A.J.1    Robin Hiley, C.2
  • 10
    • 79953006067 scopus 로고    scopus 로고
    • Pharmacology of GPR55 in yeast and identification of GSK494581A as a mixed-activity glycine transporter subtype 1 inhibitor and GPR55 agonist
    • Brown AJ, Daniels DA, Kassim M, Brown S, Haslam CP, Terrell VR, et al. (2011). Pharmacology of GPR55 in yeast and identification of GSK494581A as a mixed-activity glycine transporter subtype 1 inhibitor and GPR55 agonist. J Pharmacol Exp Ther 337: 236-246.
    • (2011) J Pharmacol Exp Ther , vol.337 , pp. 236-246
    • Brown, A.J.1    Daniels, D.A.2    Kassim, M.3    Brown, S.4    Haslam, C.P.5    Terrell, V.R.6
  • 11
    • 0348049997 scopus 로고    scopus 로고
    • Ets ternary complex transcription factors
    • Buchwalter G, Gross C, Wasylyk B, (2004). Ets ternary complex transcription factors. Gene 324: 1-14.
    • (2004) Gene , vol.324 , pp. 1-14
    • Buchwalter, G.1    Gross, C.2    Wasylyk, B.3
  • 13
    • 34447542824 scopus 로고    scopus 로고
    • Targeting cannabinoid agonists for inflammatory and neuropathic pain
    • Cheng Y, Hitchcock SA, (2007). Targeting cannabinoid agonists for inflammatory and neuropathic pain. Expert Opin Investig Drugs 16: 951-965.
    • (2007) Expert Opin Investig Drugs , vol.16 , pp. 951-965
    • Cheng, Y.1    Hitchcock, S.A.2
  • 14
    • 0029118444 scopus 로고
    • Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptors
    • Felder CC, Joyce KE, Briley EM, Mansouri J, Mackie K, Blond O, et al. (1995). Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptors. Mol Pharmacol 48: 443-450.
    • (1995) Mol Pharmacol , vol.48 , pp. 443-450
    • Felder, C.C.1    Joyce, K.E.2    Briley, E.M.3    Mansouri, J.4    Mackie, K.5    Blond, O.6
  • 16
    • 0038024615 scopus 로고    scopus 로고
    • The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints
    • Fredriksson R, Lagerstrom MC, Lundin LG, Schioth HB, (2003). The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints. Mol Pharmacol 63: 1256-1272.
    • (2003) Mol Pharmacol , vol.63 , pp. 1256-1272
    • Fredriksson, R.1    Lagerstrom, M.C.2    Lundin, L.G.3    Schioth, H.B.4
  • 18
    • 79960336157 scopus 로고    scopus 로고
    • The endocannabinoid system and cancer: Therapeutic implication
    • Guindon J, Hohmann AG, (2011). The endocannabinoid system and cancer: therapeutic implication. Br J Pharmacol 163: 1447-1463.
    • (2011) Br J Pharmacol , vol.163 , pp. 1447-1463
    • Guindon, J.1    Hohmann, A.G.2
  • 19
    • 58249109364 scopus 로고    scopus 로고
    • The GPR55 ligand L-alpha-lysophosphatidylinositol promotes RhoA-dependent Ca2+ signaling and NFAT activation
    • Henstridge CM, Balenga NA, Ford LA, Ross RA, Waldhoer M, Irving AJ, (2009). The GPR55 ligand L-alpha-lysophosphatidylinositol promotes RhoA-dependent Ca2+ signaling and NFAT activation. FASEB J 23: 183-193.
    • (2009) FASEB J , vol.23 , pp. 183-193
    • Henstridge, C.M.1    Balenga, N.A.2    Ford, L.A.3    Ross, R.A.4    Waldhoer, M.5    Irving, A.J.6
  • 21
    • 35648944276 scopus 로고    scopus 로고
    • GPR55 and the vascular receptors for cannabinoids
    • Hiley CR, Kaup SS, (2007). GPR55 and the vascular receptors for cannabinoids. Br J Pharmacol 152: 559-561.
    • (2007) Br J Pharmacol , vol.152 , pp. 559-561
    • Hiley, C.R.1    Kaup, S.S.2
  • 22
    • 0037124032 scopus 로고    scopus 로고
    • Coaggregation, cointernalization, and codesensitization of adenosine A2A receptors and dopamine D2 receptors
    • Hillion J, Canals M, Torvinen M, Casado V, Scott R, Terasmaa A, et al. (2002). Coaggregation, cointernalization, and codesensitization of adenosine A2A receptors and dopamine D2 receptors. J Biol Chem 277: 18091-18097.
    • (2002) J Biol Chem , vol.277 , pp. 18091-18097
    • Hillion, J.1    Canals, M.2    Torvinen, M.3    Casado, V.4    Scott, R.5    Terasmaa, A.6
  • 23
    • 33645796477 scopus 로고    scopus 로고
    • Cannabinoid receptor signaling
    • Howlett AC, (2005). Cannabinoid receptor signaling. Handb Exp Pharmacol 168: 53-79.
    • (2005) Handb Exp Pharmacol , vol.168 , pp. 53-79
    • Howlett, A.C.1
  • 24
    • 78651381618 scopus 로고    scopus 로고
    • The putative cannabinoid receptor GPR55 promotes cancer cell proliferation
    • Hu G, Ren G, Shi Y, (2011). The putative cannabinoid receptor GPR55 promotes cancer cell proliferation. Oncogene 30: 139-141.
    • (2011) Oncogene , vol.30 , pp. 139-141
    • Hu, G.1    Ren, G.2    Shi, Y.3
  • 25
    • 35648959293 scopus 로고    scopus 로고
    • The novel endocannabinoid receptor GPR55 is activated by atypical cannabinoids but does not mediate their vasodilator effects
    • Johns DG, Behm DJ, Walker DJ, Ao Z, Shapland EM, Daniels DA, et al. (2007). The novel endocannabinoid receptor GPR55 is activated by atypical cannabinoids but does not mediate their vasodilator effects. Br J Pharmacol 152: 825-831.
    • (2007) Br J Pharmacol , vol.152 , pp. 825-831
    • Johns, D.G.1    Behm, D.J.2    Walker, D.J.3    Ao, Z.4    Shapland, E.M.5    Daniels, D.A.6
  • 26
    • 70350376735 scopus 로고    scopus 로고
    • Atypical responsiveness of the orphan receptor GPR55 to cannabinoid ligands
    • Kapur A, Zhao P, Sharir H, Bai Y, Caron MG, Barak LS, et al. (2009). Atypical responsiveness of the orphan receptor GPR55 to cannabinoid ligands. J Biol Chem 284: 29817-29827.
    • (2009) J Biol Chem , vol.284 , pp. 29817-29827
    • Kapur, A.1    Zhao, P.2    Sharir, H.3    Bai, Y.4    Caron, M.G.5    Barak, L.S.6
  • 27
    • 84871793022 scopus 로고    scopus 로고
    • The cannabinoid receptor CB1 modulates the signaling properties of the lysophosphatidylinositol receptor GPR55
    • Kargl J, Balenga N, Parzmair GP, Brown AJ, Heinemann A, Waldhoer M, (2012). The cannabinoid receptor CB1 modulates the signaling properties of the lysophosphatidylinositol receptor GPR55. J Biol Chem 287: 44234-44248.
    • (2012) J Biol Chem , vol.287 , pp. 44234-44248
    • Kargl, J.1    Balenga, N.2    Parzmair, G.P.3    Brown, A.J.4    Heinemann, A.5    Waldhoer, M.6
  • 28
    • 84879314553 scopus 로고    scopus 로고
    • A selective antagonist reveals a potential role of G protein-coupled receptor 55 in platelet and endothelial cell function
    • Kargl J, Brown AJ, Andersen L, Dorn G, Schicho R, Waldhoer M, et al. (2013). A selective antagonist reveals a potential role of G protein-coupled receptor 55 in platelet and endothelial cell function. J Pharmacol Exp Ther 346: 54-66.
    • (2013) J Pharmacol Exp Ther , vol.346 , pp. 54-66
    • Kargl, J.1    Brown, A.J.2    Andersen, L.3    Dorn, G.4    Schicho, R.5    Waldhoer, M.6
  • 29
    • 16244382549 scopus 로고    scopus 로고
    • Muscle-specific signaling mechanism that links actin dynamics to serum response factor
    • Kuwahara K, Barrientos T, Pipes GC, Li S, Olson EN, (2005). Muscle-specific signaling mechanism that links actin dynamics to serum response factor. Mol Cell Biol 25: 3173-3181.
    • (2005) Mol Cell Biol , vol.25 , pp. 3173-3181
    • Kuwahara, K.1    Barrientos, T.2    Pipes, G.C.3    Li, S.4    Olson, E.N.5
  • 30
    • 21744448695 scopus 로고    scopus 로고
    • Mutation of the DRY motif reveals different structural requirements for the CC chemokine receptor 5-mediated signaling and receptor endocytosis
    • Lagane B, Ballet S, Planchenault T, Balabanian K, Le Poul E, Blanpain C, et al. (2005). Mutation of the DRY motif reveals different structural requirements for the CC chemokine receptor 5-mediated signaling and receptor endocytosis. Mol Pharmacol 67: 1966-1976.
    • (2005) Mol Pharmacol , vol.67 , pp. 1966-1976
    • Lagane, B.1    Ballet, S.2    Planchenault, T.3    Balabanian, K.4    Le Poul, E.5    Blanpain, C.6
  • 33
    • 33847403181 scopus 로고    scopus 로고
    • Ligand-induced down-regulation of the cannabinoid 1 receptor is mediated by the G-protein-coupled receptor-associated sorting protein GASP1
    • Martini L, Waldhoer M, Pusch M, Kharazia V, Fong J, Lee JH, et al. (2007). Ligand-induced down-regulation of the cannabinoid 1 receptor is mediated by the G-protein-coupled receptor-associated sorting protein GASP1. FASEB J 21: 802-811.
    • (2007) FASEB J , vol.21 , pp. 802-811
    • Martini, L.1    Waldhoer, M.2    Pusch, M.3    Kharazia, V.4    Fong, J.5    Lee, J.H.6
  • 34
    • 0025325535 scopus 로고
    • Structure of a cannabinoid receptor and functional expression of the cloned cDNA
    • Matsuda LA, Lolait SJ, Brownstein MJ, Young AC, Bonner TI, (1990). Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature 346: 561-564.
    • (1990) Nature , vol.346 , pp. 561-564
    • Matsuda, L.A.1    Lolait, S.J.2    Brownstein, M.J.3    Young, A.C.4    Bonner, T.I.5
  • 35
    • 33846301667 scopus 로고    scopus 로고
    • Serum response factor: Master regulator of the actin cytoskeleton and contractile apparatus
    • Miano JM, Long X, Fujiwara K, (2007). Serum response factor: master regulator of the actin cytoskeleton and contractile apparatus. Am J Physiol Cell Physiol 292: C70-C81.
    • (2007) Am J Physiol Cell Physiol , vol.292 , pp. C70-C81
    • Miano, J.M.1    Long, X.2    Fujiwara, K.3
  • 36
    • 0038737042 scopus 로고    scopus 로고
    • Actin dynamics control SRF activity by regulation of its coactivator MAL
    • Miralles F, Posern G, Zaromytidou AI, Treisman R, (2003). Actin dynamics control SRF activity by regulation of its coactivator MAL. Cell 113: 329-342.
    • (2003) Cell , vol.113 , pp. 329-342
    • Miralles, F.1    Posern, G.2    Zaromytidou, A.I.3    Treisman, R.4
  • 37
    • 84877757564 scopus 로고    scopus 로고
    • Molecular basis of NF-kappaB signaling
    • Napetschnig J, Wu H, (2013). Molecular basis of NF-kappaB signaling. Annu Rev Biophys 42: 443-468.
    • (2013) Annu Rev Biophys , vol.42 , pp. 443-468
    • Napetschnig, J.1    Wu, H.2
  • 38
    • 78649689791 scopus 로고    scopus 로고
    • GPR55, a lysophosphatidylinositol receptor with cannabinoid sensitivity?
    • Nevalainen T, Irving AJ, (2010). GPR55, a lysophosphatidylinositol receptor with cannabinoid sensitivity? Curr Top Med Chem 10: 799-813.
    • (2010) Curr Top Med Chem , vol.10 , pp. 799-813
    • Nevalainen, T.1    Irving, A.J.2
  • 39
    • 80052326134 scopus 로고    scopus 로고
    • Lysophosphatidylinositol causes neurite retraction via GPR55, G13 and RhoA in PC12 cells
    • Obara Y, Ueno S, Yanagihata Y, Nakahata N, (2011). Lysophosphatidylinositol causes neurite retraction via GPR55, G13 and RhoA in PC12 cells. PLoS ONE 6: e24284.
    • (2011) PLoS ONE , vol.6 , pp. e24284
    • Obara, Y.1    Ueno, S.2    Yanagihata, Y.3    Nakahata, N.4
  • 41
    • 58149138962 scopus 로고    scopus 로고
    • 2-Arachidonoyl-sn-glycero-3-phosphoinositol: A possible natural ligand for GPR55
    • Oka S, Toshida T, Maruyama K, Nakajima K, Yamashita A, Sugiura T, (2009). 2-Arachidonoyl-sn-glycero-3-phosphoinositol: a possible natural ligand for GPR55. J Biochem 145: 13-20.
    • (2009) J Biochem , vol.145 , pp. 13-20
    • Oka, S.1    Toshida, T.2    Maruyama, K.3    Nakajima, K.4    Yamashita, A.5    Sugiura, T.6
  • 42
    • 77952954092 scopus 로고    scopus 로고
    • Lysophosphatidylinositol induces rapid phosphorylation of p38 mitogen-activated protein kinase and activating transcription factor 2 in HEK293 cells expressing GPR55 and IM-9 lymphoblastoid cells
    • Oka S, Kimura S, Toshida T, Ota R, Yamashita A, Sugiura T, (2010). Lysophosphatidylinositol induces rapid phosphorylation of p38 mitogen-activated protein kinase and activating transcription factor 2 in HEK293 cells expressing GPR55 and IM-9 lymphoblastoid cells. J Biochem 147: 671-678.
    • (2010) J Biochem , vol.147 , pp. 671-678
    • Oka, S.1    Kimura, S.2    Toshida, T.3    Ota, R.4    Yamashita, A.5    Sugiura, T.6
  • 43
    • 84876930960 scopus 로고    scopus 로고
    • Modulating the endocannabinoid system in human health and disease-successes and failures
    • Pacher P, Kunos G, (2013). Modulating the endocannabinoid system in human health and disease-successes and failures. FEBS J 280: 1918-1943.
    • (2013) FEBS J , vol.280 , pp. 1918-1943
    • Pacher, P.1    Kunos, G.2
  • 44
    • 33748703859 scopus 로고    scopus 로고
    • The endocannabinoid system as an emerging target of pharmacotherapy
    • Pacher P, Batkai S, Kunos G, (2006). The endocannabinoid system as an emerging target of pharmacotherapy. Pharmacol Rev 58: 389-462.
    • (2006) Pharmacol Rev , vol.58 , pp. 389-462
    • Pacher, P.1    Batkai, S.2    Kunos, G.3
  • 45
    • 84891791940 scopus 로고    scopus 로고
    • The IUPHAR/BPS Guide to PHARMACOLOGY: An expert-driven knowledgebase of drug targets and their ligands
    • NC-IUPHAR.
    • Pawson AJ, Sharman JL, Benson HE, Faccenda E, Alexander SP, Buneman OP, et al.; NC-IUPHAR (2014). The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands. Nucl. Acids Res. 42 (Database Issue): D1098-1106.
    • (2014) Nucl. Acids Res. , vol.42 , Issue.DATABASE ISSUE , pp. D1098-D1106
    • Pawson, A.J.1    Sharman, J.L.2    Benson, H.E.3    Faccenda, E.4    Alexander, S.P.5    Buneman, O.P.6
  • 46
    • 84878019365 scopus 로고    scopus 로고
    • The orphan receptor GPR55 drives skin carcinogenesis and is upregulated in human squamous cell carcinomas
    • Perez-Gomez E, Andradas C, Flores JM, Quintanilla M, Paramio JM, Guzman M, et al. (2013). The orphan receptor GPR55 drives skin carcinogenesis and is upregulated in human squamous cell carcinomas. Oncogene 32: 2534-2542.
    • (2013) Oncogene , vol.32 , pp. 2534-2542
    • Perez-Gomez, E.1    Andradas, C.2    Flores, J.M.3    Quintanilla, M.4    Paramio, J.M.5    Guzman, M.6
  • 47
    • 36448995830 scopus 로고    scopus 로고
    • GPR55: A new member of the cannabinoid receptor clan?
    • Pertwee RG, (2007). GPR55: a new member of the cannabinoid receptor clan? Br J Pharmacol 152: 984-986.
    • (2007) Br J Pharmacol , vol.152 , pp. 984-986
    • Pertwee, R.G.1
  • 48
    • 78650120798 scopus 로고    scopus 로고
    • International union of basic and clinical pharmacology. LXXIX. Cannabinoid receptors and their ligands: Beyond CB(1) and CB(2)
    • Pertwee RG, Howlett AC, Abood ME, Alexander SP, Di Marzo V, Elphick MR, et al. (2010). International union of basic and clinical pharmacology. LXXIX. Cannabinoid receptors and their ligands: beyond CB(1) and CB(2). Pharmacol Rev 62: 588-631.
    • (2010) Pharmacol Rev , vol.62 , pp. 588-631
    • Pertwee, R.G.1    Howlett, A.C.2    Abood, M.E.3    Alexander, S.P.4    Di Marzo, V.5    Elphick, M.R.6
  • 49
    • 77952067930 scopus 로고    scopus 로고
    • Comparing label-free biosensors for pharmacological screening with cell-based functional assays
    • Peters MF, Vaillancourt F, Heroux M, Valiquette M, Scott CW, (2010). Comparing label-free biosensors for pharmacological screening with cell-based functional assays. Assay Drug Dev Technol 8: 219-227.
    • (2010) Assay Drug Dev Technol , vol.8 , pp. 219-227
    • Peters, M.F.1    Vaillancourt, F.2    Heroux, M.3    Valiquette, M.4    Scott, C.W.5
  • 50
    • 33645323225 scopus 로고    scopus 로고
    • GPR55 as a new cannabinoid receptor: Still a long way to prove it
    • Petitet F, Donlan M, Michel A, (2006). GPR55 as a new cannabinoid receptor: still a long way to prove it. Chem Biol Drug Des 67: 252-253.
    • (2006) Chem Biol Drug des , vol.67 , pp. 252-253
    • Petitet, F.1    Donlan, M.2    Michel, A.3
  • 51
    • 78651383853 scopus 로고    scopus 로고
    • The putative cannabinoid receptor GPR55 defines a novel autocrine loop in cancer cell proliferation
    • Pineiro R, Maffucci T, Falasca M, (2011). The putative cannabinoid receptor GPR55 defines a novel autocrine loop in cancer cell proliferation. Oncogene 30: 142-152.
    • (2011) Oncogene , vol.30 , pp. 142-152
    • Pineiro, R.1    Maffucci, T.2    Falasca, M.3
  • 52
    • 84877065224 scopus 로고    scopus 로고
    • Attenuation of HIV-1 replication in macrophages by cannabinoid receptor 2 agonists
    • Ramirez SH, Reichenbach NL, Fan S, Rom S, Merkel SF, Wang X, et al. (2013). Attenuation of HIV-1 replication in macrophages by cannabinoid receptor 2 agonists. J Leukoc Biol 93: 801-810.
    • (2013) J Leukoc Biol , vol.93 , pp. 801-810
    • Ramirez, S.H.1    Reichenbach, N.L.2    Fan, S.3    Rom, S.4    Merkel, S.F.5    Wang, X.6
  • 53
    • 84864828374 scopus 로고    scopus 로고
    • Heterodimerization of serotonin receptors 5-HT1A and 5-HT7 differentially regulates receptor signalling and trafficking
    • Renner U, Zeug A, Woehler A, Niebert M, Dityatev A, Dityateva G, et al. (2012). Heterodimerization of serotonin receptors 5-HT1A and 5-HT7 differentially regulates receptor signalling and trafficking. J Cell Sci 125 (Pt 10): 2486-2499.
    • (2012) J Cell Sci , vol.125 , pp. 2486-2499
    • Renner, U.1    Zeug, A.2    Woehler, A.3    Niebert, M.4    Dityatev, A.5    Dityateva, G.6
  • 55
    • 84878105216 scopus 로고    scopus 로고
    • The transcription factor NFAT1 induces apoptosis through cooperation with Ras/Raf/MEK/ERK pathway and upregulation of TNF-alpha expression
    • Robbs BK, Lucena PI, Viola JP, (2013). The transcription factor NFAT1 induces apoptosis through cooperation with Ras/Raf/MEK/ERK pathway and upregulation of TNF-alpha expression. Biochim Biophys Acta 1833: 2016-2028.
    • (2013) Biochim Biophys Acta , vol.1833 , pp. 2016-2028
    • Robbs, B.K.1    Lucena, P.I.2    Viola, J.P.3
  • 56
    • 84873899865 scopus 로고    scopus 로고
    • Mining the potential of label-free biosensors for seven-transmembrane receptor drug discovery
    • Rocheville M, Martin J, Jerman J, Kostenis E, (2013). Mining the potential of label-free biosensors for seven-transmembrane receptor drug discovery. Prog Mol Biol Transl Sci 115: 123-142.
    • (2013) Prog Mol Biol Transl Sci , vol.115 , pp. 123-142
    • Rocheville, M.1    Martin, J.2    Jerman, J.3    Kostenis, E.4
  • 57
    • 79551485761 scopus 로고    scopus 로고
    • Exploring a role for heteromerization in GPCR signalling specificity
    • Rozenfeld R, Devi LA, (2011). Exploring a role for heteromerization in GPCR signalling specificity. Biochem J 433: 11-18.
    • (2011) Biochem J , vol.433 , pp. 11-18
    • Rozenfeld, R.1    Devi, L.A.2
  • 59
    • 77956657852 scopus 로고    scopus 로고
    • Deconvolution of complex G protein-coupled receptor signaling in live cells using dynamic mass redistribution measurements
    • Schroder R, Janssen N, Schmidt J, Kebig A, Merten N, Hennen S, et al. (2010). Deconvolution of complex G protein-coupled receptor signaling in live cells using dynamic mass redistribution measurements. Nat Biotechnol 28: 943-949.
    • (2010) Nat Biotechnol , vol.28 , pp. 943-949
    • Schroder, R.1    Janssen, N.2    Schmidt, J.3    Kebig, A.4    Merten, N.5    Hennen, S.6
  • 60
    • 77956486698 scopus 로고    scopus 로고
    • Label-free whole-cell assays: Expanding the scope of GPCR screening
    • Scott CW, Peters MF, (2010). Label-free whole-cell assays: expanding the scope of GPCR screening. Drug Discov Today 15: 704-716.
    • (2010) Drug Discov Today , vol.15 , pp. 704-716
    • Scott, C.W.1    Peters, M.F.2
  • 61
    • 84856470165 scopus 로고    scopus 로고
    • D-type prostanoid receptor enhances the signaling of chemoattractant receptor-homologous molecule expressed on T(H)2 cells
    • 500 e491-499.
    • Sedej M, Schroder R, Bell K, Platzer W, Vukoja A, Kostenis E, et al. (2012). D-type prostanoid receptor enhances the signaling of chemoattractant receptor-homologous molecule expressed on T(H)2 cells. J Allergy Clin Immunol 129: 492-500, 500 e491-499.
    • (2012) J Allergy Clin Immunol , vol.129 , pp. 492-500
    • Sedej, M.1    Schroder, R.2    Bell, K.3    Platzer, W.4    Vukoja, A.5    Kostenis, E.6
  • 62
    • 0030425575 scopus 로고    scopus 로고
    • Evaluation of binding in a transfected cell line expressing a peripheral cannabinoid receptor (CB2): Identification of cannabinoid receptor subtype selective ligands
    • Showalter VM, Compton DR, Martin BR, Abood ME, (1996). Evaluation of binding in a transfected cell line expressing a peripheral cannabinoid receptor (CB2): identification of cannabinoid receptor subtype selective ligands. J Pharmacol Exp Ther 278: 989-999.
    • (1996) J Pharmacol Exp Ther , vol.278 , pp. 989-999
    • Showalter, V.M.1    Compton, D.R.2    Martin, B.R.3    Abood, M.E.4
  • 63
    • 51549099779 scopus 로고    scopus 로고
    • The putative cannabinoid receptor GPR55 plays a role in mechanical hyperalgesia associated with inflammatory and neuropathic pain
    • Staton PC, Hatcher JP, Walker DJ, Morrison AD, Shapland EM, Hughes JP, et al. (2008). The putative cannabinoid receptor GPR55 plays a role in mechanical hyperalgesia associated with inflammatory and neuropathic pain. Pain 139: 225-236.
    • (2008) Pain , vol.139 , pp. 225-236
    • Staton, P.C.1    Hatcher, J.P.2    Walker, D.J.3    Morrison, A.D.4    Shapland, E.M.5    Hughes, J.P.6
  • 64
    • 84879374129 scopus 로고    scopus 로고
    • NGF upregulates the plasminogen activation inhibitor-1 in neurons via the calcineurin/NFAT pathway and the down syndrome-related proteins DYRK1A and RCAN1 attenuate this effect
    • Stefos GC, Soppa U, Dierssen M, Becker W, (2013). NGF upregulates the plasminogen activation inhibitor-1 in neurons via the calcineurin/NFAT pathway and the down syndrome-related proteins DYRK1A and RCAN1 attenuate this effect. PLoS ONE 8: e67470.
    • (2013) PLoS ONE , vol.8 , pp. e67470
    • Stefos, G.C.1    Soppa, U.2    Dierssen, M.3    Becker, W.4
  • 65
    • 0033614020 scopus 로고    scopus 로고
    • Evidence that the cannabinoid CB1 receptor is a 2-arachidonoylglycerol receptor. Structure-activity relationship of 2-arachidonoylglycerol, ether-linked analogues, and related compounds
    • Sugiura T, Kodaka T, Nakane S, Miyashita T, Kondo S, Suhara Y, et al. (1999). Evidence that the cannabinoid CB1 receptor is a 2-arachidonoylglycerol receptor. Structure-activity relationship of 2-arachidonoylglycerol, ether-linked analogues, and related compounds. J Biol Chem 274: 2794-2801.
    • (1999) J Biol Chem , vol.274 , pp. 2794-2801
    • Sugiura, T.1    Kodaka, T.2    Nakane, S.3    Miyashita, T.4    Kondo, S.5    Suhara, Y.6
  • 66
    • 84860741916 scopus 로고    scopus 로고
    • History and biological significance of GPCR heteromerization in the neuroendocrine system
    • Tadagaki K, Jockers R, Kamal M, (2012). History and biological significance of GPCR heteromerization in the neuroendocrine system. Neuroendocrinology 95: 223-231.
    • (2012) Neuroendocrinology , vol.95 , pp. 223-231
    • Tadagaki, K.1    Jockers, R.2    Kamal, M.3
  • 68
    • 8644243021 scopus 로고    scopus 로고
    • Ternary complex factor-serum response factor complex-regulated gene activity is required for cellular proliferation and inhibition of apoptotic cell death
    • Vickers ER, Kasza A, Kurnaz IA, Seifert A, Zeef LA, O'Donnell A, et al. (2004). Ternary complex factor-serum response factor complex-regulated gene activity is required for cellular proliferation and inhibition of apoptotic cell death. Mol Cell Biol 24: 10340-10351.
    • (2004) Mol Cell Biol , vol.24 , pp. 10340-10351
    • Vickers, E.R.1    Kasza, A.2    Kurnaz, I.A.3    Seifert, A.4    Zeef, L.A.5    O'Donnell, A.6
  • 69
    • 0037207071 scopus 로고    scopus 로고
    • Dimerization of G protein-coupled receptors: CB1 cannabinoid receptors as an example
    • Wager-Miller J, Westenbroek R, Mackie K, (2002). Dimerization of G protein-coupled receptors: CB1 cannabinoid receptors as an example. Chem Phys Lipids 121: 83-89.
    • (2002) Chem Phys Lipids , vol.121 , pp. 83-89
    • Wager-Miller, J.1    Westenbroek, R.2    Mackie, K.3
  • 70
    • 46249108439 scopus 로고    scopus 로고
    • Integrin clustering enables anandamide-induced Ca2+ signaling in endothelial cells via GPR55 by protection against CB1-receptor-triggered repression
    • Waldeck-Weiermair M, Zoratti C, Osibow K, Balenga N, Goessnitzer E, Waldhoer M, et al. (2008). Integrin clustering enables anandamide-induced Ca2+ signaling in endothelial cells via GPR55 by protection against CB1-receptor-triggered repression. J Cell Sci 121 (Pt 10): 1704-1717.
    • (2008) J Cell Sci , vol.121 , pp. 1704-1717
    • Waldeck-Weiermair, M.1    Zoratti, C.2    Osibow, K.3    Balenga, N.4    Goessnitzer, E.5    Waldhoer, M.6
  • 72
    • 0033570227 scopus 로고    scopus 로고
    • The mechanism of phosphorylation-inducible activation of the ETS-domain transcription factor Elk-1
    • Yang SH, Shore P, Willingham N, Lakey JH, Sharrocks AD, (1999). The mechanism of phosphorylation-inducible activation of the ETS-domain transcription factor Elk-1. EMBO J 18: 5666-5674.
    • (1999) EMBO J , vol.18 , pp. 5666-5674
    • Yang, S.H.1    Shore, P.2    Willingham, N.3    Lakey, J.H.4    Sharrocks, A.D.5
  • 73
    • 38349177841 scopus 로고    scopus 로고
    • In vitro and in vivo characterization of A-796260: A selective cannabinoid CB2 receptor agonist exhibiting analgesic activity in rodent pain models
    • Yao BB, Hsieh GC, Frost JM, Fan Y, Garrison TR, Daza AV, et al. (2008). In vitro and in vivo characterization of A-796260: a selective cannabinoid CB2 receptor agonist exhibiting analgesic activity in rodent pain models. Br J Pharmacol 153: 390-401.
    • (2008) Br J Pharmacol , vol.153 , pp. 390-401
    • Yao, B.B.1    Hsieh, G.C.2    Frost, J.M.3    Fan, Y.4    Garrison, T.R.5    Daza, A.V.6
  • 74
    • 59149090322 scopus 로고    scopus 로고
    • Characterization of a cannabinoid CB2 receptor-selective agonist, A-836339 [2,2,3,3-tetramethyl-cyclopropanecarboxylic acid [3-(2-methoxy-ethyl)-4,5-dimethyl-3H-thiazol-(2Z)-ylidene]-amide], using in vitro pharmacological assays, in vivo pain models, and pharmacological magnetic resonance imaging
    • Yao BB, Hsieh G, Daza AV, Fan Y, Grayson GK, Garrison TR, et al. (2009). Characterization of a cannabinoid CB2 receptor-selective agonist, A-836339 [2,2,3,3-tetramethyl-cyclopropanecarboxylic acid [3-(2-methoxy-ethyl)-4,5-dimethyl-3H-thiazol-(2Z)-ylidene]-amide], using in vitro pharmacological assays, in vivo pain models, and pharmacological magnetic resonance imaging. J Pharmacol Exp Ther 328: 141-151.
    • (2009) J Pharmacol Exp Ther , vol.328 , pp. 141-151
    • Yao, B.B.1    Hsieh, G.2    Daza, A.V.3    Fan, Y.4    Grayson, G.K.5    Garrison, T.R.6
  • 75


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