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Volumn 38, Issue 1, 2012, Pages 16-20

CB2: Therapeutic target-in-waiting

Author keywords

Cannabinoid; Drug development; Functional selectivity; Tolerance

Indexed keywords

2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; 3 (2 IODO 5 NITROBENZOYL) 1 (1 METHYL 2 PIPERIDINYLMETHYL)INDOLE; 6 IODO 3 (4 METHOXYBENZOYL) 2 METHYL 1 (2 MORPHOLINOETHYL)INDOLE; CANNABINOID 2 RECEPTOR; CANNABINOID 2 RECEPTOR AGONIST; CANNABINOID RECEPTOR ANTAGONIST; G PROTEIN COUPLED RECEPTOR; RIMONABANT; SR 144258; UNCLASSIFIED DRUG;

EID: 84862875338     PISSN: 02785846     EISSN: 18784216     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2011.12.001     Document Type: Review
Times cited : (60)

References (52)
  • 2
    • 77952623444 scopus 로고    scopus 로고
    • 2: a cannabinoid receptor with an identity crisis
    • 2: a cannabinoid receptor with an identity crisis. Br J Pharmacol 2010, 160:467-479.
    • (2010) Br J Pharmacol , vol.160 , pp. 467-479
    • Atwood, B.K.1    Mackie, K.2
  • 3
    • 84872217401 scopus 로고    scopus 로고
    • Functional selectivity in CB2 cannabinoid receptor signaling and regulation: implications for the therapeutic potential of CB2 ligands
    • In press.
    • Atwood BK, Wager-Miller J, Haskins C, Straiker A, Mackie K. Functional selectivity in CB2 cannabinoid receptor signaling and regulation: implications for the therapeutic potential of CB2 ligands. Mol Pharmacol. In press.
    • Mol Pharmacol
    • Atwood, B.K.1    Wager-Miller, J.2    Haskins, C.3    Straiker, A.4    Mackie, K.5
  • 4
    • 72949117074 scopus 로고    scopus 로고
    • Cannabinoids and the skeleton: from marijuana to reversal of bone loss
    • Bab I., Zimmer A., Melamed E. Cannabinoids and the skeleton: from marijuana to reversal of bone loss. Ann Med 2009, 41:560-567.
    • (2009) Ann Med , vol.41 , pp. 560-567
    • Bab, I.1    Zimmer, A.2    Melamed, E.3
  • 5
    • 62749123023 scopus 로고    scopus 로고
    • Cannabinoid type 2 receptor as a target for chronic-pain
    • Beltramo M. Cannabinoid type 2 receptor as a target for chronic-pain. Mini Rev Med Chem 2009, 9:11-25.
    • (2009) Mini Rev Med Chem , vol.9 , pp. 11-25
    • Beltramo, M.1
  • 6
    • 0033575258 scopus 로고    scopus 로고
    • 2 phosphorylation by the inverse agonist SR 144528. Implications for receptor biological responses
    • 2 phosphorylation by the inverse agonist SR 144528. Implications for receptor biological responses. J Biol Chem 1999, 274:20397-20405.
    • (1999) J Biol Chem , vol.274 , pp. 20397-20405
    • Bouaboula, M.1    Dussossoy, D.2    Casellas, P.3
  • 8
    • 38349099590 scopus 로고    scopus 로고
    • The peripheral cannabinoid receptor knockout mice: an update
    • Buckley N.E. The peripheral cannabinoid receptor knockout mice: an update. Br J Pharmacol 2008, 153:309-318.
    • (2008) Br J Pharmacol , vol.153 , pp. 309-318
    • Buckley, N.E.1
  • 9
    • 0034685707 scopus 로고    scopus 로고
    • Immunomodulation by cannabinoids is absent in mice deficient for the cannabinoid CB(2) receptor
    • Buckley N.E., McCoy K.L., Mezey E., Bonner T., Zimmer A., Felder C.C., et al. Immunomodulation by cannabinoids is absent in mice deficient for the cannabinoid CB(2) receptor. Eur J Pharmacol 2000, 396:141-149.
    • (2000) Eur J Pharmacol , vol.396 , pp. 141-149
    • Buckley, N.E.1    McCoy, K.L.2    Mezey, E.3    Bonner, T.4    Zimmer, A.5    Felder, C.C.6
  • 11
    • 34447542824 scopus 로고    scopus 로고
    • Targeting cannabinoid agonists for inflammatory and neuropathic pain
    • Cheng Y., Hitchcock S.A. Targeting cannabinoid agonists for inflammatory and neuropathic pain. Expert Opin Investig Drugs 2007, 16:951-965.
    • (2007) Expert Opin Investig Drugs , vol.16 , pp. 951-965
    • Cheng, Y.1    Hitchcock, S.A.2
  • 12
    • 27844463517 scopus 로고    scopus 로고
    • Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia
    • Despres J.P., Golay A., Sjostrom L. Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia. N Engl J Med 2005, 353:2121-2134.
    • (2005) N Engl J Med , vol.353 , pp. 2121-2134
    • Despres, J.P.1    Golay, A.2    Sjostrom, L.3
  • 13
    • 0034717944 scopus 로고    scopus 로고
    • Localisation of cannabinoid receptors in the rat brain using antibodies to the intracellular C-terminal tail of CB
    • Egertova M., Elphick M.R. Localisation of cannabinoid receptors in the rat brain using antibodies to the intracellular C-terminal tail of CB. J Comp Neurol 2000, 422:159-171.
    • (2000) J Comp Neurol , vol.422 , pp. 159-171
    • Egertova, M.1    Elphick, M.R.2
  • 15
    • 70349128141 scopus 로고    scopus 로고
    • Cannabinoid-1 receptor inverse agonists: current understanding of mechanism of action and unanswered questions
    • Fong T.M., Heymsfield S.B. Cannabinoid-1 receptor inverse agonists: current understanding of mechanism of action and unanswered questions. Int J Obes (Lond) 2009, 33:947-955.
    • (2009) Int J Obes (Lond) , vol.33 , pp. 947-955
    • Fong, T.M.1    Heymsfield, S.B.2
  • 17
    • 0029094470 scopus 로고
    • Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations
    • Galiegue S., Mary S., Marchand J., Dussossoy D., Carriere D., Carayon P., et al. Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations. Eur J Biochem 1995, 232:54-61.
    • (1995) Eur J Biochem , vol.232 , pp. 54-61
    • Galiegue, S.1    Mary, S.2    Marchand, J.3    Dussossoy, D.4    Carriere, D.5    Carayon, P.6
  • 18
    • 79959333069 scopus 로고    scopus 로고
    • Cannabinoid receptor 2 undergoes Rab5-mediated internalization and recycles via a Rab11-dependent pathway
    • Grimsey N.L., Goodfellow C.E., Dragunow M., Glass M. Cannabinoid receptor 2 undergoes Rab5-mediated internalization and recycles via a Rab11-dependent pathway. Biochim Biophys Acta 2011, 1813:1554-1560.
    • (2011) Biochim Biophys Acta , vol.1813 , pp. 1554-1560
    • Grimsey, N.L.1    Goodfellow, C.E.2    Dragunow, M.3    Glass, M.4
  • 19
    • 38349119715 scopus 로고    scopus 로고
    • 2 receptors: a therapeutic target for the treatment of inflammatory and neuropathic pain
    • 2 receptors: a therapeutic target for the treatment of inflammatory and neuropathic pain. Br J Pharmacol 2008, 153:319-334.
    • (2008) Br J Pharmacol , vol.153 , pp. 319-334
    • Guindon, J.1    Hohmann, A.G.2
  • 20
    • 0033802583 scopus 로고    scopus 로고
    • Cannabinoids inhibit hippocampal GABAergic transmission and network oscillations
    • Hajos N., Katona I., Naiem S.S., MacKie K., Ledent C., Mody I., et al. Cannabinoids inhibit hippocampal GABAergic transmission and network oscillations. Eur J Neurosci 2000, 12:3239-3249.
    • (2000) Eur J Neurosci , vol.12 , pp. 3239-3249
    • Hajos, N.1    Katona, I.2    Naiem, S.S.3    MacKie, K.4    Ledent, C.5    Mody, I.6
  • 21
    • 18444376760 scopus 로고    scopus 로고
    • International Union of Pharmacology. XXVII. Classification of cannabinoid receptors
    • Howlett A.C., Barth F., Bonner T.I., Cabral G., Casellas P., Devane W.A., et al. International Union of Pharmacology. XXVII. Classification of cannabinoid receptors. Pharmacol Rev 2002, 54:161-202.
    • (2002) Pharmacol Rev , vol.54 , pp. 161-202
    • Howlett, A.C.1    Barth, F.2    Bonner, T.I.3    Cabral, G.4    Casellas, P.5    Devane, W.A.6
  • 22
    • 34250209535 scopus 로고    scopus 로고
    • Attenuation of allergic contact dermatitis through the endocannabinoid system
    • Karsak M., Gaffal E., Date R., Wang-Eckhardt L., Rehnelt J., Petrosino S., et al. Attenuation of allergic contact dermatitis through the endocannabinoid system. Science 2007, 316:1494-1497.
    • (2007) Science , vol.316 , pp. 1494-1497
    • Karsak, M.1    Gaffal, E.2    Date, R.3    Wang-Eckhardt, L.4    Rehnelt, J.5    Petrosino, S.6
  • 23
    • 33744948790 scopus 로고    scopus 로고
    • Effects of peripheral cannabinoid receptor ligands on motility and polarization in neutrophil-like HL60 cells and human neutrophils
    • Kurihara R., Tohyama Y., Matsusaka S., Naruse H., Kinoshita E., Tsujioka T., et al. Effects of peripheral cannabinoid receptor ligands on motility and polarization in neutrophil-like HL60 cells and human neutrophils. J Biol Chem 2006, 281:12908-12918.
    • (2006) J Biol Chem , vol.281 , pp. 12908-12918
    • Kurihara, R.1    Tohyama, Y.2    Matsusaka, S.3    Naruse, H.4    Kinoshita, E.5    Tsujioka, T.6
  • 24
    • 79955746716 scopus 로고    scopus 로고
    • Personalized medicine can pave the way for the safe use of CB receptor antagonists
    • Lazary J., Juhasz G., Hunyady L., Bagdy G. Personalized medicine can pave the way for the safe use of CB receptor antagonists. Trends Pharmacol Sci 2011, 32:270-280.
    • (2011) Trends Pharmacol Sci , vol.32 , pp. 270-280
    • Lazary, J.1    Juhasz, G.2    Hunyady, L.3    Bagdy, G.4
  • 26
    • 25844477611 scopus 로고    scopus 로고
    • Composition and function of g protein-coupled receptor signalsomes controlling mitogen-activated protein kinase activity
    • Luttrell L.M. Composition and function of g protein-coupled receptor signalsomes controlling mitogen-activated protein kinase activity. J Mol Neurosci 2005, 26:253-264.
    • (2005) J Mol Neurosci , vol.26 , pp. 253-264
    • Luttrell, L.M.1
  • 27
    • 34447626644 scopus 로고    scopus 로고
    • GPCR functional selectivity has therapeutic impact
    • Mailman R.B. GPCR functional selectivity has therapeutic impact. Trends Pharmacol Sci 2007, 28:390-396.
    • (2007) Trends Pharmacol Sci , vol.28 , pp. 390-396
    • Mailman, R.B.1
  • 28
    • 77952573550 scopus 로고    scopus 로고
    • Endocannabinoids and their role in fatty liver disease
    • Mallat A., Lotersztajn S. Endocannabinoids and their role in fatty liver disease. Dig Dis 2010, 28:261-266.
    • (2010) Dig Dis , vol.28 , pp. 261-266
    • Mallat, A.1    Lotersztajn, S.2
  • 30
    • 42949150269 scopus 로고    scopus 로고
    • Indoles and related compounds as cannabinoid ligands
    • Manera C., Tuccinardi T., Martinelli A. Indoles and related compounds as cannabinoid ligands. Mini Rev Med Chem 2008, 8:370-387.
    • (2008) Mini Rev Med Chem , vol.8 , pp. 370-387
    • Manera, C.1    Tuccinardi, T.2    Martinelli, A.3
  • 32
    • 40349101686 scopus 로고    scopus 로고
    • Recent advances in the development of selective ligands for the cannabinoid CB(2) receptor
    • Marriott K.S., Huffman J.W. Recent advances in the development of selective ligands for the cannabinoid CB(2) receptor. Curr Top Med Chem 2008, 8:187-204.
    • (2008) Curr Top Med Chem , vol.8 , pp. 187-204
    • Marriott, K.S.1    Huffman, J.W.2
  • 33
    • 33746913292 scopus 로고    scopus 로고
    • The endocannabinoid system controls key epileptogenic circuits in the hippocampus
    • Monory K., Massa F., Egertova M., Eder M., Blaudzun H., Westenbroek R., et al. The endocannabinoid system controls key epileptogenic circuits in the hippocampus. Neuron 2006, 51:455-466.
    • (2006) Neuron , vol.51 , pp. 455-466
    • Monory, K.1    Massa, F.2    Egertova, M.3    Eder, M.4    Blaudzun, H.5    Westenbroek, R.6
  • 35
    • 0027515373 scopus 로고
    • Molecular characterization of a peripheral receptor for cannabinoids
    • Munro S., Thomas K.L., Abu-Shaar M. Molecular characterization of a peripheral receptor for cannabinoids. Nature 1993, 365:61-65.
    • (1993) Nature , vol.365 , pp. 61-65
    • Munro, S.1    Thomas, K.L.2    Abu-Shaar, M.3
  • 37
    • 0001708862 scopus 로고
    • Receptor occupancy and tissue response
    • Nickerson M. Receptor occupancy and tissue response. Nature 1956, 178:697-698.
    • (1956) Nature , vol.178 , pp. 697-698
    • Nickerson, M.1
  • 38
    • 24044514656 scopus 로고    scopus 로고
    • 2 receptor and its endogenous ligand 2-arachidonoylglycerol in 12-O-tetradecanoylphorbol-13-acetate-induced acute inflammation in mouse ear
    • 2 receptor and its endogenous ligand 2-arachidonoylglycerol in 12-O-tetradecanoylphorbol-13-acetate-induced acute inflammation in mouse ear. J Biol Chem 2005, 280:18488-18497.
    • (2005) J Biol Chem , vol.280 , pp. 18488-18497
    • Oka, S.1    Yanagimoto, S.2    Ikeda, S.3    Gokoh, M.4    Kishimoto, S.5    Waku, K.6
  • 41
    • 0035487327 scopus 로고    scopus 로고
    • Classical and new roles of beta-arrestins in the regulation of G-protein-coupled receptors
    • Pierce K.L., Lefkowitz R.J. Classical and new roles of beta-arrestins in the regulation of G-protein-coupled receptors. Nat Rev Neurosci 2001, 2:727-733.
    • (2001) Nat Rev Neurosci , vol.2 , pp. 727-733
    • Pierce, K.L.1    Lefkowitz, R.J.2
  • 42
    • 79953228493 scopus 로고    scopus 로고
    • Marijuana-based drugs: innovative therapeutics or designer drugs of abuse?
    • Seely K.A., Prather P.L., James L.P., Moran J.H. Marijuana-based drugs: innovative therapeutics or designer drugs of abuse?. Mol Interv 2011, 11:36-51.
    • (2011) Mol Interv , vol.11 , pp. 36-51
    • Seely, K.A.1    Prather, P.L.2    James, L.P.3    Moran, J.H.4
  • 45
    • 0036468505 scopus 로고    scopus 로고
    • Mechanisms of inverse agonism at G-protein-coupled receptors
    • Strange P.G. Mechanisms of inverse agonism at G-protein-coupled receptors. Trends Pharmacol Sci 2002, 23:89-95.
    • (2002) Trends Pharmacol Sci , vol.23 , pp. 89-95
    • Strange, P.G.1
  • 47
    • 67650394851 scopus 로고    scopus 로고
    • Immunoprecipitation and phosphorylation of G protein-coupled receptors
    • Thomas W.G. Immunoprecipitation and phosphorylation of G protein-coupled receptors. Methods Mol Biol 2009, 552:359-371.
    • (2009) Methods Mol Biol , vol.552 , pp. 359-371
    • Thomas, W.G.1
  • 51
    • 80052213796 scopus 로고    scopus 로고
    • Brain cannabinoid CB receptors modulate cocaine's actions in mice
    • Xi Z.X., Peng X.Q., Li X., Song R., Zhang H.Y., Liu Q.R., et al. Brain cannabinoid CB receptors modulate cocaine's actions in mice. Nat Neurosci 2011, 14:1160-1166.
    • (2011) Nat Neurosci , vol.14 , pp. 1160-1166
    • Xi, Z.X.1    Peng, X.Q.2    Li, X.3    Song, R.4    Zhang, H.Y.5    Liu, Q.R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.