The putative cannabinoid receptor GPR55 promotes cancer cell proliferation

Oncogene

Volumn 30, Issue 2, 2011, Pages 139-141

  Hu, G ^a   Ren, G ^b   Shi, Y ^a,b  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; ANANDAMIDE; CANNABINOID RECEPTOR; G PROTEIN COUPLED RECEPTOR 55; TUMOR MARKER; UNCLASSIFIED DRUG;

CANCER CELL; CELL PROLIFERATION; HUMAN; NONHUMAN; PRIORITY JOURNAL; REVIEW;

ANIMALS; CANNABINOIDS; CELL PROLIFERATION; FEMALE; HUMANS; MALE; MICE; NEOPLASMS; RECEPTORS, CANNABINOID; RECEPTORS, G-PROTEIN-COUPLED;

CANNABIS SATIVA; VERTEBRATA;

EID: 78651381618     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2010.502     Document Type: Review

References (14)

1. Alexander A, Smith PF, Rosengren RJ. (2009). Cannabinoids in the treatment of cancer. Cancer Lett 285: 6-12.
2. Andradas C, Caffarel MM, Perez-Gomez E, Salazar M, Lorente M, Velasco G et al. (2011). The orphan G protein-coupled receptor GPR55 promotes cancer cell proliferation via ERK. Oncogene 30: 245-252.
3. Das SK, Paria BC, Chakraborty I, Dey SK. (1995). Cannabinoid ligand-receptor signaling in the mouse uterus. Proc Natl Acad Sci USA 92: 4332-4336.
4. Devane WA, Hanus L, Breuer A, Pertwee RG, Stevenson LA, Griffin G et al. (1992). Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science 258: 1946-1949.
5. Ford LA, Roelofs AJ, Anavi-Goffer S, Mowat L, Simpson DG, Irving AJ et al. (2010). A role for L-alpha-lysophosphati-dylinositol and GPR55 in the modulation of migration, orientation and polarization of human breast cancer cells. Br J Pharmacol 160: 762-771.
6. Lauckner JE, Jensen JB, Chen HY, Lu HC, Hille B, Mackie K. (2008). GPR55 is a cannabinoid receptor that increases intra-cellular calcium and inhibits M current. Proc Natl Acad Sci USA 105: 2699-2704.
7. Mechoulam R, Ben-Shabat S, Hanus L, Ligumsky M, Kaminski NE, Schatz AR et al. (1995). Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors. Biochem Pharmacol 50: 83-90.
8. Oesch S, Gertsch J. (2009). Cannabinoid receptor ligands as potential anticancer agents-high hopes for new therapies? J Pharm Pharmacol 61: 839-853.
9. Oka S, Kimura S, Toshida T, Ota R, Yamashita A, Sugiura T. (2010). Lysopho-sphatidylinositol induces rapid phosphor-ylation of p38 mitogen-activated protein kinase and activating transcription factor 2 in HEK293 cells expressing GPR55 and IM-9 lymphoblastoid cells. J Biochem 147: 671-678.
10. Pineiro R, Maffucci T, Falasca M. (2011). The putative cannabinoid receptor GPR55 defines a novel autocrine loop in cancer cell proliferation. Oncogene 30: 142-152.
11. Sharir H, Abood ME. (2010). Pharmacological characterization of GPR55, a putative cannabinoid receptor. Pharmacol Ther 126: 301-313.
12. Staton PC, Hatcher JP, Walker DJ, Morrison AD, Shapland EM, Hughes JP et al. (2008). The putative cannabinoid receptor GPR55 plays a role in mechanical hyperalgesia associated with inflammatory and neuropathic pain. Pain 139: 225-236.
13. Sugiura T, Kodaka T, Kondo S, Tonegawa T, Nakane S, Kishimoto S et al. (1996). 2-Arachidonoylglycerol, a putative endogenous cannabinoid receptor ligand, induces rapid, transient elevation of intracellular free Ca2+ in neuroblastoma x glioma hybrid NG108-15 cells. Biochem Biophys Res Commun 229: 58-64.
14. Whyte LS, Ryberg E, Sims NA, Ridge SA, Mackie K, Greasley PJ et al. (2009). The putative cannabinoid receptor GPR55 affects osteoclast function in vitro and bone mass in vivo. Proc Natl Acad Sci USA 106: 16511-16516.