Neferine attenuates the protein level and toxicity of mutant huntingtin in PC-12 cells via induction of autophagy

Molecules

Volumn 20, Issue 3, 2015, Pages 3496-3514

  Wong, Vincent Kam Wai ^a   Wu, An Guo ^a   Wang, Jing Rong ^a   Liu, Liang ^a   Law, Betty Yuen Kwan ^a  

^a MACAU UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Macao)

Author keywords

AMPK; Autophagy; Bioactivity; Huntingtin; Mechanism of action; MTOR; Natural products; Neferine; Nelumbo nucifera; PC 12; synuclein

Indexed keywords

BENZYLISOQUINOLINE DERIVATIVE; HERBACEOUS AGENT; HTT PROTEIN, HUMAN; MESSENGER RNA; MTOR PROTEIN, HUMAN; MUTANT PROTEIN; NEFERINE; NERVE PROTEIN; TARGET OF RAPAMYCIN KINASE;

ADULT; ANIMAL; APOPTOSIS; AUTOPHAGY; CELL PROLIFERATION; CHEMISTRY; DRUG EFFECTS; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GENETICS; HUMAN; HUNTINGTON DISEASE; METABOLISM; PATHOLOGY; PC12 CELL LINE; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ADULT; ANIMALS; APOPTOSIS; AUTOPHAGY; BENZYLISOQUINOLINES; BLOTTING, WESTERN; CELL PROLIFERATION; DRUGS, CHINESE HERBAL; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; HUMANS; HUNTINGTON DISEASE; MUTANT PROTEINS; NERVE TISSUE PROTEINS; PC12 CELLS; RATS; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TOR SERINE-THREONINE KINASES;

EID: 84928492237     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules20033496     Document Type: Article

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