메뉴 건너뛰기




Volumn 34, Issue 4, 2015, Pages

Pharmacogenomics of EGFR-targeted therapies in non–small cell lung cancer: EGFR and beyond

Author keywords

Cetuximab; Epidermal growth factor receptor (EGFR); Erlotinib; Non small cell lung cancer (NSCLC); Pharmacogenomics

Indexed keywords

CETUXIMAB; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIDERMAL GROWTH FACTOR RECEPTOR 3; ERLOTINIB; FIBROBLAST GROWTH FACTOR RECEPTOR; GEFITINIB; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE 3 KINASE; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROTEIN KINASE B; PROTEIN TYROSINE KINASE; SCATTER FACTOR RECEPTOR; SOMATOMEDIN C RECEPTOR; SOS PROTEIN; STAT PROTEIN; VASCULOTROPIN RECEPTOR; ANTINEOPLASTIC AGENT; EGFR PROTEIN, HUMAN; QUINAZOLINE DERIVATIVE;

EID: 84928406899     PISSN: None     EISSN: 1944446X     Source Type: Journal    
DOI: 10.1186/s40880-015-0007-9     Document Type: Article
Times cited : (22)

References (115)
  • 3
    • 84896457207 scopus 로고    scopus 로고
    • EGFR inhibition in non-small cell lung cancer: Current evidence and future directions
    • Chi A, Remick S, Tse W. EGFR inhibition in non-small cell lung cancer: current evidence and future directions. Biomark Res. 2013;1:2.
    • (2013) Biomark Res , vol.1 , pp. 2
    • Chi, A.1    Remick, S.2    Tse, W.3
  • 4
    • 84866766267 scopus 로고    scopus 로고
    • Epidermal growth factor receptor (EGFR) inhibitors and derived treatments
    • Dziadziuszko R, Jassem J. Epidermal growth factor receptor (EGFR) inhibitors and derived treatments. Ann Oncol. 2012;23:x193-6.
    • (2012) Ann Oncol , vol.23 , pp. x193-x196
    • Dziadziuszko, R.1    Jassem, J.2
  • 5
    • 84866756037 scopus 로고    scopus 로고
    • Epidermal growth factor receptor (EGFR) signaling and covalent EGFR inhibition in lung cancer
    • Heuckmann JM, Rauh D, Thomas RK. Epidermal growth factor receptor (EGFR) signaling and covalent EGFR inhibition in lung cancer. J Clin Oncol. 2012;30:3417-20.
    • (2012) J Clin Oncol , vol.30 , pp. 3417-3420
    • Heuckmann, J.M.1    Rauh, D.2    Thomas, R.K.3
  • 6
    • 84888135317 scopus 로고    scopus 로고
    • Cetuximab and non-small-cell lung cancer: End of the story?
    • Rossi A. Cetuximab and non-small-cell lung cancer: end of the story? Lancet Oncol. 2013;14:1251-3.
    • (2013) Lancet Oncol , vol.14 , pp. 1251-1253
    • Rossi, A.1
  • 7
    • 84867648343 scopus 로고    scopus 로고
    • Cetuximab in combination with anti-human IgG antibodies efficiently down-regulates the EGF receptor by macropinocytosis
    • Berger C, Madshus IH, Stang E. Cetuximab in combination with anti-human IgG antibodies efficiently down-regulates the EGF receptor by macropinocytosis. Exp Cell Res. 2012;318:2578-91.
    • (2012) Exp Cell Res , vol.318 , pp. 2578-2591
    • Berger, C.1    Madshus, I.H.2    Stang, E.3
  • 9
    • 84904466368 scopus 로고    scopus 로고
    • Erlotinib and gefitinib for elderly patients with advanced non-small-cell lung cancer
    • Passaro A, Alesini D, Pochesci A, Cortesi E. Erlotinib and gefitinib for elderly patients with advanced non-small-cell lung cancer. Anticancer Agents Med Chem. 2014;14:646-50.
    • (2014) Anticancer Agents Med Chem , vol.14 , pp. 646-650
    • Passaro, A.1    Alesini, D.2    Pochesci, A.3    Cortesi, E.4
  • 10
    • 84901263119 scopus 로고    scopus 로고
    • The efficacy and safety of EGFR inhibitor monotherapy in non-small cell lung cancer: A systematic review
    • Yang X, Yang K, Kuang K. The efficacy and safety of EGFR inhibitor monotherapy in non-small cell lung cancer: a systematic review. Curr Oncol Rep. 2014;16:390.
    • (2014) Curr Oncol Rep , vol.16 , pp. 390
    • Yang, X.1    Yang, K.2    Kuang, K.3
  • 11
    • 84899475126 scopus 로고    scopus 로고
    • Relationship between EGFR expression, EGFR mutation status, and the efficacy of chemotherapy plus cetuximab in FLEX study patients with advanced non-small-cell lung cancer
    • Douillard JY, Pirker R, O'Byrne KJ, Kerr KM, Storkel S, Von Heydebreck A, et al. Relationship between EGFR expression, EGFR mutation status, and the efficacy of chemotherapy plus cetuximab in FLEX study patients with advanced non-small-cell lung cancer. J Thorac Oncol. 2014;9:717-24.
    • (2014) J Thorac Oncol , vol.9 , pp. 717-724
    • Douillard, J.Y.1    Pirker, R.2    O'Byrne, K.J.3    Kerr, K.M.4    Storkel, S.5    Von Heydebreck, A.6
  • 12
    • 84879188682 scopus 로고    scopus 로고
    • Expression of epidermal growth factor receptor detected by cetuximab indicates its efficacy to inhibit and proliferation of colorectal cancer cells
    • Shigeta K, Hayashida T, Hoshino Y, Okabayashi K, Endo T, Ishii Y, et al. Expression of epidermal growth factor receptor detected by cetuximab indicates its efficacy to inhibit and proliferation of colorectal cancer cells. PLoS One. 2013;8:e66302.
    • (2013) PLoS One , vol.8
    • Shigeta, K.1    Hayashida, T.2    Hoshino, Y.3    Okabayashi, K.4    Endo, T.5    Ishii, Y.6
  • 13
    • 84874933609 scopus 로고    scopus 로고
    • EGFR-directed monoclonal antibodies in non-small cell lung cancer
    • Pirker R. EGFR-directed monoclonal antibodies in non-small cell lung cancer. Target Oncol. 2013;8:47-53.
    • (2013) Target Oncol , vol.8 , pp. 47-53
    • Pirker, R.1
  • 14
    • 84863062587 scopus 로고    scopus 로고
    • Erlotinib in the treatment of advanced non-small cell lung cancer: An update for clinicians
    • Wang Y, Schmid-Bindert G, Zhou C. Erlotinib in the treatment of advanced non-small cell lung cancer: an update for clinicians. Ther Adv Med Oncol. 2012;4:19-29.
    • (2012) Ther Adv Med Oncol , vol.4 , pp. 19-29
    • Wang, Y.1    Schmid-Bindert, G.2    Zhou, C.3
  • 15
    • 33646228635 scopus 로고    scopus 로고
    • KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer
    • Lievre A, Bachet JB, Le Corre D, Boige V, Landi B, Emile JF, et al. KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer. Cancer Res. 2006;66:3992-5.
    • (2006) Cancer Res , vol.66 , pp. 3992-3995
    • Lievre, A.1    Bachet, J.B.2    Le Corre, D.3    Boige, V.4    Landi, B.5    Emile, J.F.6
  • 16
    • 84862571677 scopus 로고    scopus 로고
    • Prognostic and predictive value of K-RAS mutations in non-small cell lung cancer
    • Califano R, Landi L, Cappuzzo F. Prognostic and predictive value of K-RAS mutations in non-small cell lung cancer. Drugs. 2012;72:28-36.
    • (2012) Drugs , vol.72 , pp. 28-36
    • Califano, R.1    Landi, L.2    Cappuzzo, F.3
  • 17
    • 15744372810 scopus 로고    scopus 로고
    • KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib
    • Pao W, Wang TY, Riely GJ, Miller VA, Pan Q, Ladanyi M, et al. KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib. PLoS Med. 2005;2:e17.
    • (2005) PLoS Med , vol.2
    • Pao, W.1    Wang, T.Y.2    Riely, G.J.3    Miller, V.A.4    Pan, Q.5    Ladanyi, M.6
  • 18
    • 63749086305 scopus 로고    scopus 로고
    • ErbB receptors and signaling pathways in cancer
    • Hynes NE, MacDonald G. ErbB receptors and signaling pathways in cancer. Curr Opin Cell Biol. 2009;21:177-84.
    • (2009) Curr Opin Cell Biol , vol.21 , pp. 177-184
    • Hynes, N.E.1    MacDonald, G.2
  • 19
    • 77953896432 scopus 로고    scopus 로고
    • Cell signaling by receptor tyrosine kinases
    • Lemmon MA, Schlessinger J. Cell signaling by receptor tyrosine kinases. Cell. 2010;141:1117-34.
    • (2010) Cell , vol.141 , pp. 1117-1134
    • Lemmon, M.A.1    Schlessinger, J.2
  • 20
    • 77956141521 scopus 로고    scopus 로고
    • Phosphotyrosine signaling: Evolving a new cellular communication system
    • Lim WA, Pawson T. Phosphotyrosine signaling: evolving a new cellular communication system. Cell. 2010;142:661-7.
    • (2010) Cell , vol.142 , pp. 661-667
    • Lim, W.A.1    Pawson, T.2
  • 21
    • 58149376976 scopus 로고    scopus 로고
    • The epidermal growth factor receptor ligands at a glance
    • Schneider MR, Wolf E. The epidermal growth factor receptor ligands at a glance. J Cell Physio. 2009;218:460-6.
    • (2009) J Cell Physio , vol.218 , pp. 460-466
    • Schneider, M.R.1    Wolf, E.2
  • 22
    • 84859355565 scopus 로고    scopus 로고
    • Complexity in the signaling network: Insights from the use of targeted inhibitors in cancer therapy
    • Logue JS, Morrison DK. Complexity in the signaling network: insights from the use of targeted inhibitors in cancer therapy. Genes Dev. 2012;26:641-50.
    • (2012) Genes Dev , vol.26 , pp. 641-650
    • Logue, J.S.1    Morrison, D.K.2
  • 23
    • 22144431886 scopus 로고    scopus 로고
    • Autocrine, paracrine and juxtacrine signaling by EGFR ligands
    • Singh AB, Harris RC. Autocrine, paracrine and juxtacrine signaling by EGFR ligands. Cell Signal. 2005;17:1183-93.
    • (2005) Cell Signal , vol.17 , pp. 1183-1193
    • Singh, A.B.1    Harris, R.C.2
  • 26
    • 63749113783 scopus 로고    scopus 로고
    • Tyrosine phosphorylation: Thirty years and counting
    • Hunter T. Tyrosine phosphorylation: thirty years and counting. Curr Opin Cell Biol. 2009;21:140-6.
    • (2009) Curr Opin Cell Biol , vol.21 , pp. 140-146
    • Hunter, T.1
  • 27
    • 0842346438 scopus 로고    scopus 로고
    • Specificity in signal transduction: From phosphotyrosine-SH2 domain interactions to complex cellular systems
    • Pawson T. Specificity in signal transduction: from phosphotyrosine-SH2 domain interactions to complex cellular systems. Cell. 2004;116:191-203.
    • (2004) Cell , vol.116 , pp. 191-203
    • Pawson, T.1
  • 28
    • 0037453510 scopus 로고    scopus 로고
    • Assembly of cell regulatory systems through protein interaction domains
    • Pawson T, Nash P. Assembly of cell regulatory systems through protein interaction domains. Science. 2003;300:445-52.
    • (2003) Science , vol.300 , pp. 445-452
    • Pawson, T.1    Nash, P.2
  • 29
    • 33745828702 scopus 로고    scopus 로고
    • EGF-ERBB signalling: Towards the systems level
    • Citri A, Yarden Y. EGF-ERBB signalling: towards the systems level. Nat Rev Mol Cell Biol. 2006;7:505-16.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 505-516
    • Citri, A.1    Yarden, Y.2
  • 31
    • 84863337700 scopus 로고    scopus 로고
    • PI3K: A potential therapeutic target for cancer
    • Chen Y, Wang BC, Xiao Y. PI3K: a potential therapeutic target for cancer. J Cell Physio. 2012;227:2818-21.
    • (2012) J Cell Physio , vol.227 , pp. 2818-2821
    • Chen, Y.1    Wang, B.C.2    Xiao, Y.3
  • 32
    • 17144395975 scopus 로고    scopus 로고
    • The activation of Akt/PKB signaling pathway and cell survival
    • Song G, Ouyang G, Bao S. The activation of Akt/PKB signaling pathway and cell survival. J Cell Mol Med. 2005;9:59-71.
    • (2005) J Cell Mol Med , vol.9 , pp. 59-71
    • Song, G.1    Ouyang, G.2    Bao, S.3
  • 33
    • 84860217431 scopus 로고    scopus 로고
    • The functions and regulation of the PTEN tumour suppressor
    • Song MS, Salmena L, Pandolfi PP. The functions and regulation of the PTEN tumour suppressor. Nat Rev Mol Cell Biol. 2012;13:283-96.
    • (2012) Nat Rev Mol Cell Biol , vol.13 , pp. 283-296
    • Song, M.S.1    Salmena, L.2    Pandolfi, P.P.3
  • 35
    • 69949126786 scopus 로고    scopus 로고
    • Personalized medicine and inhibition of EGFR signaling in lung cancer
    • Gazdar AF. Personalized medicine and inhibition of EGFR signaling in lung cancer. N Engl J Med. 2009;361:1018-20.
    • (2009) N Engl J Med , vol.361 , pp. 1018-1020
    • Gazdar, A.F.1
  • 37
    • 10844231985 scopus 로고    scopus 로고
    • Mutations of the epidermal growth factor receptor gene in lung cancer: Biological and clinical implications
    • Kosaka T, Yatabe Y, Endoh H, Kuwano H, Takahashi T, Mitsudomi T. Mutations of the epidermal growth factor receptor gene in lung cancer: biological and clinical implications. Cancer Res. 2004;64:8919-23.
    • (2004) Cancer Res , vol.64 , pp. 8919-8923
    • Kosaka, T.1    Yatabe, Y.2    Endoh, H.3    Kuwano, H.4    Takahashi, T.5    Mitsudomi, T.6
  • 39
    • 33747605594 scopus 로고    scopus 로고
    • Stochastic models of receptor oligomerization by bivalent ligand
    • Alarcon T, Page KM. Stochastic models of receptor oligomerization by bivalent ligand. J R Soc Interface. 2006;3:545-59.
    • (2006) J R Soc Interface , vol.3 , pp. 545-559
    • Alarcon, T.1    Page, K.M.2
  • 40
    • 84867621201 scopus 로고    scopus 로고
    • Target binding properties and cellular activity of afatinib (BIBW 2992), an irreversible ErbB family blocker
    • Solca F, Dahl G, Zoephel A, Bader G, Sanderson M, Klein C, et al. Target binding properties and cellular activity of afatinib (BIBW 2992), an irreversible ErbB family blocker. J Pharm Exp Ther. 2012;343:342-50.
    • (2012) J Pharm Exp Ther , vol.343 , pp. 342-350
    • Solca, F.1    Dahl, G.2    Zoephel, A.3    Bader, G.4    Sanderson, M.5    Klein, C.6
  • 41
    • 84901983989 scopus 로고    scopus 로고
    • Comparison of clinical outcomes following gefitinib and erlotinib treatment in non-small-cell lung cancer patients harboring an epidermal growth factor receptor mutation in either exon 19 or 21
    • Lim SH, Lee JY, Sun JM, Ahn JS, Park K, Ahn MJ. Comparison of clinical outcomes following gefitinib and erlotinib treatment in non-small-cell lung cancer patients harboring an epidermal growth factor receptor mutation in either exon 19 or 21. J Thorac Oncol. 2014;9:506-11.
    • (2014) J Thorac Oncol , vol.9 , pp. 506-511
    • Lim, S.H.1    Lee, J.Y.2    Sun, J.M.3    Ahn, J.S.4    Park, K.5    Ahn, M.J.6
  • 42
    • 84892551057 scopus 로고    scopus 로고
    • Are erlotinib and gefitinib interchangeable, opposite or complementary for non-small cell lung cancer treatment? Biological, pharmacological and clinical aspects
    • Bronte G, Rolfo C, Giovannetti E, Cicero G, Pauwels P, Passiglia F, et al. Are erlotinib and gefitinib interchangeable, opposite or complementary for non-small cell lung cancer treatment? Biological, pharmacological and clinical aspects. Crit Rev Oncol Hemat. 2014;89:300-13.
    • (2014) Crit Rev Oncol Hemat , vol.89 , pp. 300-313
    • Bronte, G.1    Rolfo, C.2    Giovannetti, E.3    Cicero, G.4    Pauwels, P.5    Passiglia, F.6
  • 43
    • 77953541527 scopus 로고    scopus 로고
    • Erlotinib as maintenance treatment in advanced non-small-cell lung cancer: A multicentre, randomised, placebo-controlled phase 3 study
    • Cappuzzo F, Ciuleanu T, Stelmakh L, Cicenas S, Szczesna A, Juhasz E, et al. Erlotinib as maintenance treatment in advanced non-small-cell lung cancer: a multicentre, randomised, placebo-controlled phase 3 study. Lancet Oncol. 2010;11:521-9.
    • (2010) Lancet Oncol , vol.11 , pp. 521-529
    • Cappuzzo, F.1    Ciuleanu, T.2    Stelmakh, L.3    Cicenas, S.4    Szczesna, A.5    Juhasz, E.6
  • 44
    • 84865154870 scopus 로고    scopus 로고
    • First-line erlotinib followed by second-line cisplatin-gemcitabine chemotherapy in advanced non-small-cell lung cancer: The TORCH randomized trial
    • Gridelli C, Ciardiello F, Gallo C, Feld R, Butts C, Gebbia V, et al. First-line erlotinib followed by second-line cisplatin-gemcitabine chemotherapy in advanced non-small-cell lung cancer: the TORCH randomized trial. J Clin Oncol. 2012;30:3002-11.
    • (2012) J Clin Oncol , vol.30 , pp. 3002-3011
    • Gridelli, C.1    Ciardiello, F.2    Gallo, C.3    Feld, R.4    Butts, C.5    Gebbia, V.6
  • 45
    • 84872707092 scopus 로고    scopus 로고
    • Gefitinib in selected patients with pre-treated non-small-cell lung cancer: Results from a phase IV, multicenter, non-randomized study (SELINE)
    • Lee KH, Lee KY, Jeon YJ, Jung MH, Son C, Lee MK, et al. Gefitinib in selected patients with pre-treated non-small-cell lung cancer: results from a phase IV, multicenter, non-randomized study (SELINE). Tuberc Respir Dis. 2012;73:303-11.
    • (2012) Tuberc Respir Dis , vol.73 , pp. 303-311
    • Lee, K.H.1    Lee, K.Y.2    Jeon, Y.J.3    Jung, M.H.4    Son, C.5    Lee, M.K.6
  • 46
    • 69949186250 scopus 로고    scopus 로고
    • Screening for epidermal growth factor receptor mutations in lung cancer
    • Rosell R, Moran T, Queralt C, Porta R, Cardenal F, Camps C, et al. Screening for epidermal growth factor receptor mutations in lung cancer. N Engl J Med. 2009;361:958-67.
    • (2009) N Engl J Med , vol.361 , pp. 958-967
    • Rosell, R.1    Moran, T.2    Queralt, C.3    Porta, R.4    Cardenal, F.5    Camps, C.6
  • 47
    • 33751292685 scopus 로고    scopus 로고
    • Novel D761Y and common secondary T790M mutations in epidermal growth factor receptor-mutant lung adenocarcinomas with acquired resistance to kinase inhibitors
    • Balak MN, Gong Y, Riely GJ, Somwar R, Li AR, Zakowski MF, et al. Novel D761Y and common secondary T790M mutations in epidermal growth factor receptor-mutant lung adenocarcinomas with acquired resistance to kinase inhibitors. Clin Cancer Res. 2006;12:6494-501.
    • (2006) Clin Cancer Res , vol.12 , pp. 6494-6501
    • Balak, M.N.1    Gong, Y.2    Riely, G.J.3    Somwar, R.4    Li, A.R.5    Zakowski, M.F.6
  • 48
    • 43749107912 scopus 로고    scopus 로고
    • Acquired resistance to tyrosine kinase inhibitors during cancer therapy
    • Engelman JA, Settleman J. Acquired resistance to tyrosine kinase inhibitors during cancer therapy. Curr Opin Genet Dev. 2008;18:73-9.
    • (2008) Curr Opin Genet Dev , vol.18 , pp. 73-79
    • Engelman, J.A.1    Settleman, J.2
  • 49
    • 18244371651 scopus 로고    scopus 로고
    • Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain
    • Pao W, Miller VA, Politi KA, Riely GJ, Somwar R, Zakowski MF, et al. Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. PLoS Med. 2005;2:e73.
    • (2005) PLoS Med , vol.2
    • Pao, W.1    Miller, V.A.2    Politi, K.A.3    Riely, G.J.4    Somwar, R.5    Zakowski, M.F.6
  • 50
    • 84876350673 scopus 로고    scopus 로고
    • Further advances in genetically informed lung cancer medicine
    • Nebhan C, Pao W. Further advances in genetically informed lung cancer medicine. J Thorac Oncol. 2013;8:521-2.
    • (2013) J Thorac Oncol , vol.8 , pp. 521-522
    • Nebhan, C.1    Pao, W.2
  • 51
    • 78650034175 scopus 로고    scopus 로고
    • Genetically informed lung cancer medicine
    • Pao W, Iafrate AJ, Su Z. Genetically informed lung cancer medicine. J Pathol. 2011;223:230-40.
    • (2011) J Pathol , vol.223 , pp. 230-240
    • Pao, W.1    Iafrate, A.J.2    Su, Z.3
  • 52
    • 84895766506 scopus 로고    scopus 로고
    • Afatinib: A review of its use in the treatment of advanced non-small cell lung cancer
    • Keating GM. Afatinib: a review of its use in the treatment of advanced non-small cell lung cancer. Drugs. 2014;74:207-21.
    • (2014) Drugs , vol.74 , pp. 207-221
    • Keating, G.M.1
  • 53
    • 84904898065 scopus 로고    scopus 로고
    • AZD9291, an irreversible EGFR TKI, overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer
    • Cross DA, Ashton SE, Ghiorghiu S, Eberlein C, Nebhan CA, Spitzler PJ, et al. AZD9291, an irreversible EGFR TKI, overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer. Cancer Discov. 2014;4:1046-61.
    • (2014) Cancer Discov , vol.4 , pp. 1046-1061
    • Cross, D.A.1    Ashton, S.E.2    Ghiorghiu, S.3    Eberlein, C.4    Nebhan, C.A.5    Spitzler, P.J.6
  • 54
    • 49149118719 scopus 로고    scopus 로고
    • BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models
    • Li D, Ambrogio L, Shimamura T, Kubo S, Takahashi M, Chirieac LR, et al. BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models. Oncogene. 2008;27:4702-11.
    • (2008) Oncogene , vol.27 , pp. 4702-4711
    • Li, D.1    Ambrogio, L.2    Shimamura, T.3    Kubo, S.4    Takahashi, M.5    Chirieac, L.R.6
  • 55
    • 37549061078 scopus 로고    scopus 로고
    • PF00299804, an irreversible pan-ERBB inhibitor, is effective in lung cancer models with EGFR and ERBB2 mutations that are resistant to gefitinib
    • Engelman JA, Zejnullahu K, Gale CM, Lifshits E, Gonzales AJ, Shimamura T, et al. PF00299804, an irreversible pan-ERBB inhibitor, is effective in lung cancer models with EGFR and ERBB2 mutations that are resistant to gefitinib. Cancer Res. 2007;67:11924-32.
    • (2007) Cancer Res , vol.67 , pp. 11924-11932
    • Engelman, J.A.1    Zejnullahu, K.2    Gale, C.M.3    Lifshits, E.4    Gonzales, A.J.5    Shimamura, T.6
  • 56
    • 34548484397 scopus 로고    scopus 로고
    • Pooled analysis of the prospective trials of gefitinib monotherapy for EGFR-mutant non-small cell lung cancers
    • Costa DB, Kobayashi S, Tenen DG, Huberman MS. Pooled analysis of the prospective trials of gefitinib monotherapy for EGFR-mutant non-small cell lung cancers. Lung Cancer. 2007;58:95-103.
    • (2007) Lung Cancer , vol.58 , pp. 95-103
    • Costa, D.B.1    Kobayashi, S.2    Tenen, D.G.3    Huberman, M.S.4
  • 57
    • 84862271634 scopus 로고    scopus 로고
    • A phase II trial of erlotinib in patients with EGFR wild-type advanced non-small-cell lung cancer
    • Kobayashi T, Koizumi T, Agatsuma T, Yasuo M, Tsushima K, Kubo K, et al. A phase II trial of erlotinib in patients with EGFR wild-type advanced non-small-cell lung cancer. Cancer Chemother Pharm. 2012;69:1241-6.
    • (2012) Cancer Chemother Pharm , vol.69 , pp. 1241-1246
    • Kobayashi, T.1    Koizumi, T.2    Agatsuma, T.3    Yasuo, M.4    Tsushima, K.5    Kubo, K.6
  • 58
    • 79251490374 scopus 로고    scopus 로고
    • New driver mutations in non-small-cell lung cancer
    • Pao W, Girard N. New driver mutations in non-small-cell lung cancer. Lancet Oncol. 2011;12:175-80.
    • (2011) Lancet Oncol , vol.12 , pp. 175-180
    • Pao, W.1    Girard, N.2
  • 59
    • 84883769389 scopus 로고    scopus 로고
    • EGFR exon-level biomarkers of the response to bevacizumab/erlotinib in non-small cell lung cancer
    • Baty F, Rothschild S, Fruh M, Betticher D, Droge C, Cathomas R, et al. EGFR exon-level biomarkers of the response to bevacizumab/erlotinib in non-small cell lung cancer. PLoS One. 2013;8:e72966.
    • (2013) PLoS One , vol.8
    • Baty, F.1    Rothschild, S.2    Fruh, M.3    Betticher, D.4    Droge, C.5    Cathomas, R.6
  • 60
    • 65349116059 scopus 로고    scopus 로고
    • Cetuximab plus chemotherapy in patients with advanced non-small-cell lung cancer (FLEX): An open-label randomised phase III trial
    • Pirker R, Pereira JR, Szczesna A, Von Pawel J, Krzakowski M, Ramlau R, et al. Cetuximab plus chemotherapy in patients with advanced non-small-cell lung cancer (FLEX): an open-label randomised phase III trial. Lancet Oncol. 2009;373:1525-31.
    • (2009) Lancet Oncol , vol.373 , pp. 1525-1531
    • Pirker, R.1    Pereira, J.R.2    Szczesna, A.3    Von Pawel, J.4    Krzakowski, M.5    Ramlau, R.6
  • 61
    • 84855311144 scopus 로고    scopus 로고
    • EGFR expression as a predictor of survival for first-line chemotherapy plus cetuximab in patients with advanced non-small-cell lung cancer: Analysis of data from the phase 3 FLEX study
    • Pirker R, Pereira JR, Von Pawel J, Krzakowski M, Ramlau R, Park K, et al. EGFR expression as a predictor of survival for first-line chemotherapy plus cetuximab in patients with advanced non-small-cell lung cancer: analysis of data from the phase 3 FLEX study. Lancet Oncol. 2012;13:33-42.
    • (2012) Lancet Oncol , vol.13 , pp. 33-42
    • Pirker, R.1    Pereira, J.R.2    Von Pawel, J.3    Krzakowski, M.4    Ramlau, R.5    Park, K.6
  • 62
    • 76149126918 scopus 로고    scopus 로고
    • K-Ras mutation (mut), EGFR-related, and exploratory markers as response predictors of cetuximab in first-line advanced NSCLC: Retrospective analyses of the BMS099 trial
    • Khambata-Ford S, Harbison C, Woytowitz D, Awad M, Horak C, Xu LA, et al. K-Ras mutation (mut), EGFR-related, and exploratory markers as response predictors of cetuximab in first-line advanced NSCLC: Retrospective analyses of the BMS099 trial. J Clin Oncol. (Meeting Abstracts) 2009;27:no.15S: 8021.
    • (2009) J Clin Oncol (Meeting Abstracts) , vol.27 , Issue.15 S , pp. 8021
    • Khambata-Ford, S.1    Harbison, C.2    Woytowitz, D.3    Awad, M.4    Horak, C.5    Xu, L.A.6
  • 63
    • 77949886293 scopus 로고    scopus 로고
    • Analysis of potential predictive markers of cetuximab benefit in BMS099, a phase III study of cetuximab and first-line taxane/carboplatin in advanced non-small-cell lung cancer
    • Khambata-Ford S, Harbison CT, Hart LL, Awad M, Xu LA, Horak CE, et al. Analysis of potential predictive markers of cetuximab benefit in BMS099, a phase III study of cetuximab and first-line taxane/carboplatin in advanced non-small-cell lung cancer. J Clin Oncol. 2010;28:918-27.
    • (2010) J Clin Oncol , vol.28 , pp. 918-927
    • Khambata-Ford, S.1    Harbison, C.T.2    Hart, L.L.3    Awad, M.4    Xu, L.A.5    Horak, C.E.6
  • 64
    • 84888129994 scopus 로고    scopus 로고
    • Docetaxel or pemetrexed with or without cetuximab in recurrent or progressive non-small-cell lung cancer after platinum-based therapy: A phase 3, open-label, randomised trial
    • Kim ES, Neubauer M, Cohn A, Schwartzberg L, Garbo L, Caton J, et al. Docetaxel or pemetrexed with or without cetuximab in recurrent or progressive non-small-cell lung cancer after platinum-based therapy: a phase 3, open-label, randomised trial. Lancet Oncol. 2013;14:1326-36.
    • (2013) Lancet Oncol , vol.14 , pp. 1326-1336
    • Kim, E.S.1    Neubauer, M.2    Cohn, A.3    Schwartzberg, L.4    Garbo, L.5    Caton, J.6
  • 65
    • 77949891126 scopus 로고    scopus 로고
    • Cetuximab and first-line taxane/carboplatin chemotherapy in advanced non-small-cell lung cancer: Results of the randomized multicenter phase III trial BMS099
    • Lynch TJ, Patel T, Dreisbach L, McCleod M, Heim WJ, Hermann RC, et al. Cetuximab and first-line taxane/carboplatin chemotherapy in advanced non-small-cell lung cancer: results of the randomized multicenter phase III trial BMS099. J Clin Oncol. 2010;28:911-7.
    • (2010) J Clin Oncol , vol.28 , pp. 911-917
    • Lynch, T.J.1    Patel, T.2    Dreisbach, L.3    McCleod, M.4    Heim, W.J.5    Hermann, R.C.6
  • 66
    • 52049090365 scopus 로고    scopus 로고
    • Role of KRAS and EGFR as biomarkers of response to erlotinib in National Cancer Institute of Canada Clinical Trials Group Study BR.21
    • Zhu CQ, Da Cunha SG, Ding K, Sakurada A, Cutz JC, Liu N, et al. Role of KRAS and EGFR as biomarkers of response to erlotinib in National Cancer Institute of Canada Clinical Trials Group Study BR.21. J Clin Oncol. 2008;26:4268-75.
    • (2008) J Clin Oncol , vol.26 , pp. 4268-4275
    • Zhu, C.Q.1    Da Cunha, S.G.2    Ding, K.3    Sakurada, A.4    Cutz, J.C.5    Liu, N.6
  • 67
    • 78650372656 scopus 로고    scopus 로고
    • Different types of K-Ras mutations could affect drug sensitivity and tumour behaviour in non-small-cell lung cancer
    • Garassino MC, Marabese M, Rusconi P, Rulli E, Martelli O, Farina G, et al. Different types of K-Ras mutations could affect drug sensitivity and tumour behaviour in non-small-cell lung cancer. Ann Oncol. 2011;22:235-7.
    • (2011) Ann Oncol , vol.22 , pp. 235-237
    • Garassino, M.C.1    Marabese, M.2    Rusconi, P.3    Rulli, E.4    Martelli, O.5    Farina, G.6
  • 68
    • 84892859492 scopus 로고    scopus 로고
    • KRAS mutations in non-small-cell lung cancer and colorectal cancer: Implications for EGFR-targeted therapies
    • Maus MKH, Grimminger PP, Mack PC, Astrow SH, Stephens C, Zeger G, et al. KRAS mutations in non-small-cell lung cancer and colorectal cancer: implications for EGFR-targeted therapies. Lung Cancer. 2014;83:163-7.
    • (2014) Lung Cancer , vol.83 , pp. 163-167
    • Maus, M.K.H.1    Grimminger, P.P.2    Mack, P.C.3    Astrow, S.H.4    Stephens, C.5    Zeger, G.6
  • 69
    • 77954012635 scopus 로고    scopus 로고
    • Durable responses to Erlotinib despite KRAS mutations in two patients with metastatic lung adenocarcinoma
    • Ferte C, Besse B, Dansin E, Parent F, Buisine MP, Copin MC, et al. Durable responses to Erlotinib despite KRAS mutations in two patients with metastatic lung adenocarcinoma. Ann Oncol. 2010;21:1385-7.
    • (2010) Ann Oncol , vol.21 , pp. 1385-1387
    • Ferte, C.1    Besse, B.2    Dansin, E.3    Parent, F.4    Buisine, M.P.5    Copin, M.C.6
  • 70
    • 79551536656 scopus 로고    scopus 로고
    • KRAS mutations (MTs) in non-small cell lung cancer (NSCLC) versus colorectal cancer (CRC): Implications for cetuximab therapy
    • Danenberg KD, Grimminger PP, Mack PC, Danenberg PV, Cooc J, Stephens C, et al. KRAS mutations (MTs) in non-small cell lung cancer (NSCLC) versus colorectal cancer (CRC): implications for cetuximab therapy. J Clin Oncol. 2010;28:10529.
    • (2010) J Clin Oncol , vol.28
    • Danenberg, K.D.1    Grimminger, P.P.2    Mack, P.C.3    Danenberg, P.V.4    Cooc, J.5    Stephens, C.6
  • 71
    • 58749102224 scopus 로고    scopus 로고
    • High concordance of KRAS status between primary colorectal tumors and related metastatic sites: Implications for clinical practice
    • Santini D, Loupakis F, Vincenzi B, Floriani I, Stasi I, Canestrari E, et al. High concordance of KRAS status between primary colorectal tumors and related metastatic sites: implications for clinical practice. Oncologist. 2008;13:1270-5.
    • (2008) Oncologist , vol.13 , pp. 1270-1275
    • Santini, D.1    Loupakis, F.2    Vincenzi, B.3    Floriani, I.4    Stasi, I.5    Canestrari, E.6
  • 72
    • 84895788351 scopus 로고    scopus 로고
    • PIK3CA mutations frequently coexist with EGFR/KRAS mutations in non-small cell lung cancer and suggest poor prognosis in EGFR/KRAS wildtype subgroup
    • Wang L, Hu H, Pan Y, Wang R, Li Y, Shen L, et al. PIK3CA mutations frequently coexist with EGFR/KRAS mutations in non-small cell lung cancer and suggest poor prognosis in EGFR/KRAS wildtype subgroup. PLoS One. 2014;9:e88291.
    • (2014) PLoS One , vol.9
    • Wang, L.1    Hu, H.2    Pan, Y.3    Wang, R.4    Li, Y.5    Shen, L.6
  • 74
    • 77958478674 scopus 로고    scopus 로고
    • Rational, biologically based treatment of EGFR-mutant non-small-cell lung cancer
    • Pao W, Chmielecki J. Rational, biologically based treatment of EGFR-mutant non-small-cell lung cancer. Nat Rev Cancer. 2010;10:760-74.
    • (2010) Nat Rev Cancer , vol.10 , pp. 760-774
    • Pao, W.1    Chmielecki, J.2
  • 75
    • 31944444234 scopus 로고    scopus 로고
    • Cancer-specific mutations in PIK3CA are oncogenic in vivo
    • Bader AG, Kang S, Vogt PK. Cancer-specific mutations in PIK3CA are oncogenic in vivo. Proc Natl Acad Sci U S A. 2006;103:1475-9.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 1475-1479
    • Bader, A.G.1    Kang, S.2    Vogt, P.K.3
  • 76
    • 33749435816 scopus 로고    scopus 로고
    • Allelic dilution obscures detection of a biologically significant resistance mutation in EGFR-amplified lung cancer
    • Engelman JA, Mukohara T, Zejnullahu K, Lifshits E, Borras AM, Gale CM, et al. Allelic dilution obscures detection of a biologically significant resistance mutation in EGFR-amplified lung cancer. J Clin Invest. 2006;116:2695-706.
    • (2006) J Clin Invest , vol.116 , pp. 2695-2706
    • Engelman, J.A.1    Mukohara, T.2    Zejnullahu, K.3    Lifshits, E.4    Borras, A.M.5    Gale, C.M.6
  • 77
    • 77955277111 scopus 로고    scopus 로고
    • Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: A retrospective consortium analysis
    • De Roock W, Claes B, Bernasconi D, De Schutter J, Biesmans B, Fountzilas G, et al. Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis. Lancet Oncol. 2010;11:753-62.
    • (2010) Lancet Oncol , vol.11 , pp. 753-762
    • De Roock, W.1    Claes, B.2    Bernasconi, D.3    De Schutter, J.4    Biesmans, B.5    Fountzilas, G.6
  • 78
    • 84902551553 scopus 로고    scopus 로고
    • The dual PI3K/mTOR inhibitor PKI-587 enhances sensitivity to cetuximab in EGFR-resistant human head and neck cancer models
    • D'Amato V, Rosa R, D'Amato C, Formisano L, Marciano R, Nappi L, et al. The dual PI3K/mTOR inhibitor PKI-587 enhances sensitivity to cetuximab in EGFR-resistant human head and neck cancer models. Br J Cancer. 2014;110:2887-95.
    • (2014) Br J Cancer , vol.110 , pp. 2887-2895
    • D'Amato, V.1    Rosa, R.2    D'Amato, C.3    Formisano, L.4    Marciano, R.5    Nappi, L.6
  • 79
    • 78650842574 scopus 로고    scopus 로고
    • Mechanisms underlying resistance to cetuximab in the HNSCC cell line: Role of AKT inhibition in bypassing this resistance
    • Rebucci M, Peixoto P, Dewitte A, Wattez N, De Nuncques MA, Rezvoy N, et al. Mechanisms underlying resistance to cetuximab in the HNSCC cell line: role of AKT inhibition in bypassing this resistance. Int J Oncol. 2011;38:189-200.
    • (2011) Int J Oncol , vol.38 , pp. 189-200
    • Rebucci, M.1    Peixoto, P.2    Dewitte, A.3    Wattez, N.4    De Nuncques, M.A.5    Rezvoy, N.6
  • 80
    • 65949086609 scopus 로고    scopus 로고
    • PTEN loss contributes to erlotinib resistance in EGFR-mutant lung cancer by activation of Akt and EGFR
    • Sos ML, Koker M, Weir BA, Heynck S, Rabinovsky R, Zander T, et al. PTEN loss contributes to erlotinib resistance in EGFR-mutant lung cancer by activation of Akt and EGFR. Cancer Res. 2009;69:3256-61.
    • (2009) Cancer Res , vol.69 , pp. 3256-3261
    • Sos, M.L.1    Koker, M.2    Weir, B.A.3    Heynck, S.4    Rabinovsky, R.5    Zander, T.6
  • 81
    • 33846252977 scopus 로고    scopus 로고
    • PTEN and PIK3CA expression is associated with prolonged survival after gefitinib treatment in EGFR-mutated lung cancer patients
    • Endoh H, Yatabe Y, Kosaka T, Kuwano H, Mitsudomi T. PTEN and PIK3CA expression is associated with prolonged survival after gefitinib treatment in EGFR-mutated lung cancer patients. J Thorac Oncol. 2006;1:629-34.
    • (2006) J Thorac Oncol , vol.1 , pp. 629-634
    • Endoh, H.1    Yatabe, Y.2    Kosaka, T.3    Kuwano, H.4    Mitsudomi, T.5
  • 82
    • 77954217891 scopus 로고    scopus 로고
    • Acquired resistance to cetuximab is mediated by increased PTEN instability and leads cross-resistance to gefitinib in HCC827 NSCLC cells
    • Kim SM, Kim JS, Kim JH, Yun CO, Kim EM, Kim HK, et al. Acquired resistance to cetuximab is mediated by increased PTEN instability and leads cross-resistance to gefitinib in HCC827 NSCLC cells. Cancer Lett. 2010;296:150-9.
    • (2010) Cancer Lett , vol.296 , pp. 150-159
    • Kim, S.M.1    Kim, J.S.2    Kim, J.H.3    Yun, C.O.4    Kim, E.M.5    Kim, H.K.6
  • 83
    • 77649273768 scopus 로고    scopus 로고
    • Loss of PTEN expression predicts resistance to EGFR-targeted monoclonal antibodies in patients with metastatic colorectal cancer
    • Mao C, Liao RY, Chen Q. Loss of PTEN expression predicts resistance to EGFR-targeted monoclonal antibodies in patients with metastatic colorectal cancer. Br J Cancer. 2010;102:940.
    • (2010) Br J Cancer , vol.102 , pp. 940
    • Mao, C.1    Liao, R.Y.2    Chen, Q.3
  • 84
    • 73349094741 scopus 로고    scopus 로고
    • Analysis of PTEN, BRAF, and EGFR status in determining benefit from cetuximab therapy in wild-type KRAS metastatic colon cancer
    • Laurent-Puig P, Cayre A, Manceau G, Buc E, Bachet JB, Lecomte T, et al. Analysis of PTEN, BRAF, and EGFR status in determining benefit from cetuximab therapy in wild-type KRAS metastatic colon cancer. J Clin Oncol. 2009;27:5924-30.
    • (2009) J Clin Oncol , vol.27 , pp. 5924-5930
    • Laurent-Puig, P.1    Cayre, A.2    Manceau, G.3    Buc, E.4    Bachet, J.B.5    Lecomte, T.6
  • 85
    • 84875856180 scopus 로고    scopus 로고
    • Silenced expression of NFKBIA in lung adenocarcinoma patients with a never-smoking history
    • Furukawa M, Soh J, Yamamoto H, Ichimura K, Shien K, Maki Y, et al. Silenced expression of NFKBIA in lung adenocarcinoma patients with a never-smoking history. Acta Med Okayama. 2013;67:19-24.
    • (2013) Acta Med Okayama , vol.67 , pp. 19-24
    • Furukawa, M.1    Soh, J.2    Yamamoto, H.3    Ichimura, K.4    Shien, K.5    Maki, Y.6
  • 86
    • 0032217264 scopus 로고    scopus 로고
    • Structure of an IkappaBalpha/NF-kappaB complex
    • Jacobs MD, Harrison SC. Structure of an IkappaBalpha/NF-kappaB complex. Cell. 1998;95:749-58.
    • (1998) Cell , vol.95 , pp. 749-758
    • Jacobs, M.D.1    Harrison, S.C.2
  • 87
    • 79953046542 scopus 로고    scopus 로고
    • FAS and NF-kappaB signalling modulate dependence of lung cancers on mutant EGFR
    • Bivona TG, Hieronymus H, Parker J, Chang K, Taron M, Rosell R, et al. FAS and NF-kappaB signalling modulate dependence of lung cancers on mutant EGFR. Nature. 2011;471:523-6.
    • (2011) Nature , vol.471 , pp. 523-526
    • Bivona, T.G.1    Hieronymus, H.2    Parker, J.3    Chang, K.4    Taron, M.5    Rosell, R.6
  • 88
    • 34548536941 scopus 로고    scopus 로고
    • Nuclear factor-kappaB tumor expression predicts response and survival in irinotecan-refractory metastatic colorectal cancer treated with cetuximab-irinotecan therapy
    • Scartozzi M, Bearzi I, Pierantoni C, Mandolesi A, Loupakis F, Zaniboni A, et al. Nuclear factor-kappaB tumor expression predicts response and survival in irinotecan-refractory metastatic colorectal cancer treated with cetuximab-irinotecan therapy. J Clin Oncol. 2007;25:3930-5.
    • (2007) J Clin Oncol , vol.25 , pp. 3930-3935
    • Scartozzi, M.1    Bearzi, I.2    Pierantoni, C.3    Mandolesi, A.4    Loupakis, F.5    Zaniboni, A.6
  • 89
    • 0034693799 scopus 로고    scopus 로고
    • The protein tyrosine kinase family of the human genome
    • Robinson DR, Wu YM, Lin SF. The protein tyrosine kinase family of the human genome. Oncogene. 2000;19:5548-57.
    • (2000) Oncogene , vol.19 , pp. 5548-5557
    • Robinson, D.R.1    Wu, Y.M.2    Lin, S.F.3
  • 90
    • 78649420006 scopus 로고    scopus 로고
    • MET signalling: Principles and functions in development, organ regeneration and cancer
    • Trusolino L, Bertotti A, Comoglio PM. MET signalling: principles and functions in development, organ regeneration and cancer. Nat Rev Mol Cell Biol. 2010;11:834-48.
    • (2010) Nat Rev Mol Cell Biol , vol.11 , pp. 834-848
    • Trusolino, L.1    Bertotti, A.2    Comoglio, P.M.3
  • 91
    • 84875914687 scopus 로고    scopus 로고
    • MET as a possible target for non-small-cell lung cancer
    • Sadiq AA, Salgia R. MET as a possible target for non-small-cell lung cancer. J Clin Oncol. 2013;31:1089-96.
    • (2013) J Clin Oncol , vol.31 , pp. 1089-1096
    • Sadiq, A.A.1    Salgia, R.2
  • 92
    • 84863229341 scopus 로고    scopus 로고
    • High MET copy number and MET overexpression: Poor outcome in non-small cell lung cancer patients
    • Park S, Choi YL, Sung CO, An J, Seo J, Ahn MJ, et al. High MET copy number and MET overexpression: poor outcome in non-small cell lung cancer patients. Histol Histopathol. 2012;27:197-207.
    • (2012) Histol Histopathol , vol.27 , pp. 197-207
    • Park, S.1    Choi, Y.L.2    Sung, C.O.3    An, J.4    Seo, J.5    Ahn, M.J.6
  • 93
    • 33947207989 scopus 로고    scopus 로고
    • Lung cancer cell lines harboring MET gene amplification are dependent on Met for growth and survival
    • Lutterbach B, Zeng Q, Davis LJ, Hatch H, Hang G, Kohl NE, et al. Lung cancer cell lines harboring MET gene amplification are dependent on Met for growth and survival. Cancer Res. 2007;67:2081-8.
    • (2007) Cancer Res , vol.67 , pp. 2081-2088
    • Lutterbach, B.1    Zeng, Q.2    Davis, L.J.3    Hatch, H.4    Hang, G.5    Kohl, N.E.6
  • 94
    • 56449089812 scopus 로고    scopus 로고
    • Hepatocyte growth factor induces gefitinib resistance of lung adenocarcinoma with epidermal growth factor receptor-activating mutations
    • Yano S, Wang W, Li Q, Matsumoto K, Sakurama H, Nakamura T, et al. Hepatocyte growth factor induces gefitinib resistance of lung adenocarcinoma with epidermal growth factor receptor-activating mutations. Cancer Res. 2008;68:9479-87.
    • (2008) Cancer Res , vol.68 , pp. 9479-9487
    • Yano, S.1    Wang, W.2    Li, Q.3    Matsumoto, K.4    Sakurama, H.5    Nakamura, T.6
  • 95
    • 84873978591 scopus 로고    scopus 로고
    • The c-Met inhibitors: A new class of drugs in the battle against advanced non-small-cell lung cancer
    • Sgambato A, Casaluce F, Maione P, Rossi A, Rossi E, Napolitano A, et al. The c-Met inhibitors: a new class of drugs in the battle against advanced non-small-cell lung cancer. Curr Pharm Des. 2012;18:6155-68.
    • (2012) Curr Pharm Des , vol.18 , pp. 6155-6168
    • Sgambato, A.1    Casaluce, F.2    Maione, P.3    Rossi, A.4    Rossi, E.5    Napolitano, A.6
  • 96
    • 38049150665 scopus 로고    scopus 로고
    • MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib
    • Bean J, Brennan C, Shih JY, Riely G, Viale A, Wang L, et al. MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib. Proc Natl Acad Sci U S A. 2007;104:20932-7.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 20932-20937
    • Bean, J.1    Brennan, C.2    Shih, J.Y.3    Riely, G.4    Viale, A.5    Wang, L.6
  • 97
    • 34249075147 scopus 로고    scopus 로고
    • MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
    • Engelman JA, Zejnullahu K, Mitsudomi T, Song Y, Hyland C, Park JO, et al. MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science. 2007;316:1039-43.
    • (2007) Science , vol.316 , pp. 1039-1043
    • Engelman, J.A.1    Zejnullahu, K.2    Mitsudomi, T.3    Song, Y.4    Hyland, C.5    Park, J.O.6
  • 98
    • 84878862323 scopus 로고    scopus 로고
    • Amplification of the MET receptor drives resistance to anti-EGFR therapies in colorectal cancer
    • Bardelli A, Corso S, Bertotti A, Hobor S, Valtorta E, Siravegna G, et al. Amplification of the MET receptor drives resistance to anti-EGFR therapies in colorectal cancer. Cancer Discov. 2013;3:658-73.
    • (2013) Cancer Discov , vol.3 , pp. 658-673
    • Bardelli, A.1    Corso, S.2    Bertotti, A.3    Hobor, S.4    Valtorta, E.5    Siravegna, G.6
  • 99
    • 84898764896 scopus 로고    scopus 로고
    • Cetuximab-induced MET activation acts as a novel resistance mechanism in colon cancer cells
    • Song N, Liu S, Zhang J, Liu J, Xu L, Liu Y, et al. Cetuximab-induced MET activation acts as a novel resistance mechanism in colon cancer cells. Int J Mol Sci. 2014;15:5838-51.
    • (2014) Int J Mol Sci , vol.15 , pp. 5838-5851
    • Song, N.1    Liu, S.2    Zhang, J.3    Liu, J.4    Xu, L.5    Liu, Y.6
  • 100
    • 77950239573 scopus 로고    scopus 로고
    • HER kinase axis receptor dimer partner switching occurs in response to EGFR tyrosine kinase inhibition despite failure to block cellular proliferation
    • Jain A, Penuel E, Mink S, Schmidt J, Hodge A, Favero K, et al. HER kinase axis receptor dimer partner switching occurs in response to EGFR tyrosine kinase inhibition despite failure to block cellular proliferation. Cancer Res. 2010;70:1989-99.
    • (2010) Cancer Res , vol.70 , pp. 1989-1999
    • Jain, A.1    Penuel, E.2    Mink, S.3    Schmidt, J.4    Hodge, A.5    Favero, K.6
  • 102
    • 2142843806 scopus 로고    scopus 로고
    • Diversification of Neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactions
    • Pinkas-Kramarski R, Soussan L, Waterman H, Levkowitz G, Alroy I, Klapper L, et al. Diversification of Neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactions. EMBO J. 1996;15:2452-67.
    • (1996) EMBO J , vol.15 , pp. 2452-2467
    • Pinkas-Kramarski, R.1    Soussan, L.2    Waterman, H.3    Levkowitz, G.4    Alroy, I.5    Klapper, L.6
  • 103
    • 84902588138 scopus 로고    scopus 로고
    • HER2 driven non-small cell lung cancer (NSCLC): Potential therapeutic approaches
    • Garrido-Castro AC, Felip E. HER2 driven non-small cell lung cancer (NSCLC): potential therapeutic approaches. Transl Cancer Res. 2013;2:122-7.
    • (2013) Transl Cancer Res , vol.2 , pp. 122-127
    • Garrido-Castro, A.C.1    Felip, E.2
  • 104
    • 84875217382 scopus 로고    scopus 로고
    • HER2 gene copy number status may influence clinical efficacy to anti-EGFR monoclonal antibodies in metastatic colorectal cancer patients
    • Martin V, Landi L, Molinari F, Fountzilas G, Geva R, Riva A, et al. HER2 gene copy number status may influence clinical efficacy to anti-EGFR monoclonal antibodies in metastatic colorectal cancer patients. Br J Cancer. 2013;108:668-75.
    • (2013) Br J Cancer , vol.108 , pp. 668-675
    • Martin, V.1    Landi, L.2    Molinari, F.3    Fountzilas, G.4    Geva, R.5    Riva, A.6
  • 105
    • 80051676156 scopus 로고    scopus 로고
    • Increased VEGFR-2 gene copy is associated with chemoresistance and shorter survival in patients with non-small-cell lung carcinoma who receive adjuvant chemotherapy
    • Yang F, Tang X, Riquelme E, Behrens C, Nilsson MB, Giri U, et al. Increased VEGFR-2 gene copy is associated with chemoresistance and shorter survival in patients with non-small-cell lung carcinoma who receive adjuvant chemotherapy. Cancer Res. 2011;71:5512-21.
    • (2011) Cancer Res , vol.71 , pp. 5512-5521
    • Yang, F.1    Tang, X.2    Riquelme, E.3    Behrens, C.4    Nilsson, M.B.5    Giri, U.6
  • 106
    • 84892512436 scopus 로고    scopus 로고
    • Fibroblast growth factor receptor 1 amplification in non-small cell lung cancer by quantitative real-time PCR
    • Gadgeel SM, Chen W, Cote ML, Bollig-Fischer A, Land S, Schwartz AG, et al. Fibroblast growth factor receptor 1 amplification in non-small cell lung cancer by quantitative real-time PCR. PLoS One. 2013;8:e79820.
    • (2013) PLoS One , vol.8
    • Gadgeel, S.M.1    Chen, W.2    Cote, M.L.3    Bollig-Fischer, A.4    Land, S.5    Schwartz, A.G.6
  • 107
    • 58149106094 scopus 로고    scopus 로고
    • Prognostic impact of platelet-derived growth factors in non-small cell lung cancer tumor and stromal cells
    • Donnem T, Al-Saad S, Al-Shibli K, Andersen S, Busund LT, Bremnes RM. Prognostic impact of platelet-derived growth factors in non-small cell lung cancer tumor and stromal cells. J Thorac Oncol. 2008;3:963-70.
    • (2008) J Thorac Oncol , vol.3 , pp. 963-970
    • Donnem, T.1    Al-Saad, S.2    Al-Shibli, K.3    Andersen, S.4    Busund, L.T.5    Bremnes, R.M.6
  • 108
    • 84864402225 scopus 로고    scopus 로고
    • Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer
    • Zhang Z, Lee JC, Lin L, Olivas V, Au V, LaFramboise T, et al. Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer. Nat Genet. 2012;44:852-60.
    • (2012) Nat Genet , vol.44 , pp. 852-860
    • Zhang, Z.1    Lee, J.C.2    Lin, L.3    Olivas, V.4    Au, V.5    LaFramboise, T.6
  • 109
    • 84875841411 scopus 로고    scopus 로고
    • Concomitant high gene copy number and protein overexpression of IGF1R and EGFR negatively affect disease-free survival of surgically resected non-small-cell-lung cancer patients
    • Ludovini V, Flacco A, Bianconi F, Ragusa M, Vannucci J, Bellezza G, et al. Concomitant high gene copy number and protein overexpression of IGF1R and EGFR negatively affect disease-free survival of surgically resected non-small-cell-lung cancer patients. Cancer Chemother Pharm. 2013;71:671-80.
    • (2013) Cancer Chemother Pharm , vol.71 , pp. 671-680
    • Ludovini, V.1    Flacco, A.2    Bianconi, F.3    Ragusa, M.4    Vannucci, J.5    Bellezza, G.6
  • 110
    • 84856886733 scopus 로고    scopus 로고
    • Treatment of nonsmall cell lung cancer: Overcoming the resistance to epidermal growth factor receptor inhibitors
    • Carter CA, Giaccone G. Treatment of nonsmall cell lung cancer: overcoming the resistance to epidermal growth factor receptor inhibitors. Curr Opin Oncol. 2012;24:123-9.
    • (2012) Curr Opin Oncol , vol.24 , pp. 123-129
    • Carter, C.A.1    Giaccone, G.2
  • 111
    • 84865506979 scopus 로고    scopus 로고
    • Rationale and design of MARQUEE: A phase III, randomized, double-blind study of tivantinib plus erlotinib versus placebo plus erlotinib in previously treated patients with locally advanced or metastatic, nonsquamous, non-small-cell lung cancer
    • Scagliotti GV, Novello S, Schiller JH, Hirsh V, Sequist LV, Soria JC, et al. Rationale and design of MARQUEE: a phase III, randomized, double-blind study of tivantinib plus erlotinib versus placebo plus erlotinib in previously treated patients with locally advanced or metastatic, nonsquamous, non-small-cell lung cancer. Clin Lung Cancer. 2012;13:391-5.
    • (2012) Clin Lung Cancer , vol.13 , pp. 391-395
    • Scagliotti, G.V.1    Novello, S.2    Schiller, J.H.3    Hirsh, V.4    Sequist, L.V.5    Soria, J.C.6
  • 112
    • 84887497121 scopus 로고    scopus 로고
    • The quest to overcome resistance to EGFR-targeted therapies in cancer
    • Chong CR, Janne PA. The quest to overcome resistance to EGFR-targeted therapies in cancer. Nat Med. 2013;19:1389-400.
    • (2013) Nat Med , vol.19 , pp. 1389-1400
    • Chong, C.R.1    Janne, P.A.2
  • 113
    • 84904790548 scopus 로고    scopus 로고
    • Novel therapeutic strategies for patients with NSCLC that do not respond to treatment with EGFR inhibitors
    • Rolfo C, Giovannetti E, Hong DS, Bivona T, Raez LE, Bronte G, et al. Novel therapeutic strategies for patients with NSCLC that do not respond to treatment with EGFR inhibitors. Cancer Treat Rev. 2014;40:990-1004.
    • (2014) Cancer Treat Rev , vol.40 , pp. 990-1004
    • Rolfo, C.1    Giovannetti, E.2    Hong, D.S.3    Bivona, T.4    Raez, L.E.5    Bronte, G.6
  • 114
    • 59049089201 scopus 로고    scopus 로고
    • PI3KCA/PTEN deregulation contributes to impaired responses to cetuximab in metastatic colorectal cancer patients
    • Perrone F, Lampis A, Orsenigo M, Di Bartolomeo M, Gevorgyan A, Losa M, et al. PI3KCA/PTEN deregulation contributes to impaired responses to cetuximab in metastatic colorectal cancer patients. Ann Oncol. 2009;20:84-90.
    • (2009) Ann Oncol , vol.20 , pp. 84-90
    • Perrone, F.1    Lampis, A.2    Orsenigo, M.3    Di Bartolomeo, M.4    Gevorgyan, A.5    Losa, M.6
  • 115
    • 14844366111 scopus 로고    scopus 로고
    • ErbB-3 mediates phosphoinositide 3-kinase activity in gefitinib-sensitive non-small cell lung cancer cell lines
    • Engelman JA, Janne PA, Mermel C, Pearlberg J, Mukohara T, Fleet C, et al. ErbB-3 mediates phosphoinositide 3-kinase activity in gefitinib-sensitive non-small cell lung cancer cell lines. Proc Natl Acad Sci U S A. 2005;102:3788-93.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 3788-3793
    • Engelman, J.A.1    Janne, P.A.2    Mermel, C.3    Pearlberg, J.4    Mukohara, T.5    Fleet, C.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.