메뉴 건너뛰기




Volumn 74, Issue 2, 2014, Pages 207-221

Afatinib: A review of its use in the treatment of advanced non-small cell lung cancer

(1)  Keating, Gillian M a  

a NONE   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

AFATINIB; ALANINE AMINOTRANSFERASE; CISPLATIN; EPIDERMAL GROWTH FACTOR RECEPTOR; GEMCITABINE; PEMETREXED; PROTEIN KINASE INHIBITOR; QUINAZOLINE DERIVATIVE;

EID: 84895766506     PISSN: 00126667     EISSN: 11791950     Source Type: Journal    
DOI: 10.1007/s40265-013-0170-8     Document Type: Article
Times cited : (74)

References (58)
  • 1
    • 84878888082 scopus 로고    scopus 로고
    • First-line management of EGFR-mutated advanced lung adenocarcinoma: Recent developments
    • 1:CAS:528:DC%2BC3sXhvVWmtLrM 23479407 10.1007/s40265-013-0020-8
    • Liao B-C, Lin C-C, Yang JC-H. First-line management of EGFR-mutated advanced lung adenocarcinoma: recent developments. Drugs. 2013;73(4):357-69.
    • (2013) Drugs , vol.73 , Issue.4 , pp. 357-369
    • Liao, B.-C.1    Lin, C.-C.2    Yang, J.-H.3
  • 2
    • 81155123620 scopus 로고    scopus 로고
    • Role of genotyping in non-small cell lung cancer treatment: Current status
    • 1:CAS:528:DC%2BC38Xit1ShtL4%3D 22085382 10.2165/11597700-000000000-00000
    • Bonanno L, Favaretto A, Rugge M. Role of genotyping in non-small cell lung cancer treatment: current status. Drugs. 2011;71(17):2231-46.
    • (2011) Drugs , vol.71 , Issue.17 , pp. 2231-2246
    • Bonanno, L.1    Favaretto, A.2    Rugge, M.3
  • 4
    • 79955853698 scopus 로고    scopus 로고
    • The LUX-Lung clinical trial program of afatinib for non-small-cell lung cancer
    • 1:CAS:528:DC%2BC3MXlvFGju7k%3D 21554040 10.1586/era.11.34
    • Metro G, Crinò L. The LUX-Lung clinical trial program of afatinib for non-small-cell lung cancer. Expert Rev Anticancer Ther. 2011;11(5):673-82.
    • (2011) Expert Rev Anticancer Ther , vol.11 , Issue.5 , pp. 673-682
    • Metro, G.1    Crinò, L.2
  • 5
    • 79960110757 scopus 로고    scopus 로고
    • Afatinib (BIBW 2992) development in non-small-cell lung cancer
    • 1:CAS:528:DC%2BC3MXos1SlurY%3D 21732753 10.2217/fon.11.62
    • Hirsh V. Afatinib (BIBW 2992) development in non-small-cell lung cancer. Future Oncol. 2011;7(7):817-25.
    • (2011) Future Oncol , vol.7 , Issue.7 , pp. 817-825
    • Hirsh, V.1
  • 6
    • 84875013524 scopus 로고    scopus 로고
    • Afatinib: Emerging next-generation tyrosine kinase inhibitor for NSCLC
    • 1:CAS:528:DC%2BC3sXkt1Wlsbc%3D 3594037 23493883
    • Nelson V, Ziehr J, Agulnik M, et al. Afatinib: emerging next-generation tyrosine kinase inhibitor for NSCLC. Onco Targets Ther. 2013;6:135-43.
    • (2013) Onco Targets Ther , vol.6 , pp. 135-143
    • Nelson, V.1    Ziehr, J.2    Agulnik, M.3
  • 7
    • 78650945778 scopus 로고    scopus 로고
    • Afatinib (BIBW-2992): A novel dual EGFR/HER2neu inhibitor with promising activity in non-small-cell lung cancer
    • 1:CAS:528:DC%2BC3cXhs1Sju7fO 10.2217/thy.10.86
    • Bordoni RE. Afatinib (BIBW-2992): a novel dual EGFR/HER2neu inhibitor with promising activity in non-small-cell lung cancer. Therapy. 2011;8(1):15-22.
    • (2011) Therapy , vol.8 , Issue.1 , pp. 15-22
    • Bordoni, R.E.1
  • 8
    • 84863410315 scopus 로고    scopus 로고
    • EGFR-TKI resistant non-small cell lung cancer (NSCLC): New developments and implications for future treatment
    • 22281074 10.1016/j.lungcan.2011.12.014
    • Brugger W, Thomas M. EGFR-TKI resistant non-small cell lung cancer (NSCLC): new developments and implications for future treatment. Lung Cancer. 2012;77(1):2-8.
    • (2012) Lung Cancer , vol.77 , Issue.1 , pp. 2-8
    • Brugger, W.1    Thomas, M.2
  • 9
    • 84895728277 scopus 로고    scopus 로고
    • Boehringer Ingelheim Accessed 2 Dec 2013
    • ®) in Asian and non-Asian lung cancer patients [media release]. 2013. http://www.boehringer- ingelheim.com/news/news-releases/press-releases/2013/27-october-2013-oncology. html. Accessed 2 Dec 2013.
    • (2013) ®) in Asian and Non-Asian Lung Cancer Patients [Media Release]
  • 10
  • 14
    • 49149118719 scopus 로고    scopus 로고
    • BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models
    • 1:CAS:528:DC%2BD1cXptlKnsbk%3D 2748240 18408761 10.1038/onc.2008.109
    • Li D, Ambrogio L, Shimamura T, et al. BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models. Oncogene. 2008;27(34):4702-11.
    • (2008) Oncogene , vol.27 , Issue.34 , pp. 4702-4711
    • Li, D.1    Ambrogio, L.2    Shimamura, T.3
  • 15
    • 84867621201 scopus 로고    scopus 로고
    • Target binding properties and cellular activity of afatinib (BIBW 2992), an irreversible ErbB family blocker
    • 1:CAS:528:DC%2BC38XhsFKktbzE 22888144 10.1124/jpet.112.197756
    • Solca F, Dahl G, Zoephel A, et al. Target binding properties and cellular activity of afatinib (BIBW 2992), an irreversible ErbB family blocker. J Pharmacol Exp Ther. 2012;343(2):342-50.
    • (2012) J Pharmacol Exp Ther , vol.343 , Issue.2 , pp. 342-350
    • Solca, F.1    Dahl, G.2    Zoephel, A.3
  • 16
    • 84862791294 scopus 로고    scopus 로고
    • Targeting the epidermal growth factor receptor in non-small cell lung cancer cells: The effect of combining RNA interference with tyrosine kinase inhibitors or cetuximab
    • 1:CAS:528:DC%2BC38Xos12mtbs%3D 3334713 22436374 10.1186/1741-7015-10-28
    • Chen G, Kronenberger P, Teugels E, et al. Targeting the epidermal growth factor receptor in non-small cell lung cancer cells: the effect of combining RNA interference with tyrosine kinase inhibitors or cetuximab. BMC Med. 2012;10:28.
    • (2012) BMC Med , vol.10 , pp. 28
    • Chen, G.1    Kronenberger, P.2    Teugels, E.3
  • 17
    • 77953394930 scopus 로고    scopus 로고
    • Enhanced anticancer effect of the combination of BIBW2992 and thymidylate synthase-targeted agents in non-small cell lung cancer with the T790M mutation of epidermal growth factor receptor
    • 1:CAS:528:DC%2BC3cXntFGgtr0%3D 20530710 10.1158/1535-7163.MCT-09-1009
    • Takezawa K, Okamoto I, Tanizaki J, et al. Enhanced anticancer effect of the combination of BIBW2992 and thymidylate synthase-targeted agents in non-small cell lung cancer with the T790M mutation of epidermal growth factor receptor. Mol Cancer Ther. 2010;9(6):1647-56.
    • (2010) Mol Cancer Ther , vol.9 , Issue.6 , pp. 1647-1656
    • Takezawa, K.1    Okamoto, I.2    Tanizaki, J.3
  • 18
    • 84876416258 scopus 로고    scopus 로고
    • Sensitivity and kinase activity of epidermal growth factor receptor (EGFR) exon 19 and others to EGFR-tyrosine kinase inhibitors
    • 1:CAS:528:DC%2BC3sXlvVCjs7s%3D 23387505 10.1111/cas.12125
    • Furuyama K, Harada T, Iwama E, et al. Sensitivity and kinase activity of epidermal growth factor receptor (EGFR) exon 19 and others to EGFR-tyrosine kinase inhibitors. Cancer Sci. 2013;104(5):584-9.
    • (2013) Cancer Sci , vol.104 , Issue.5 , pp. 584-589
    • Furuyama, K.1    Harada, T.2    Iwama, E.3
  • 19
    • 84877660788 scopus 로고    scopus 로고
    • Afatinib prolongs survival compared with gefitinib in an epidermal growth factor receptor-driven lung cancer model
    • 1:CAS:528:DC%2BC3sXntlSisro%3D 23443806 10.1158/1535-7163.MCT-12-0885
    • Ninomiya T, Takigawa N, Ichihara E, et al. Afatinib prolongs survival compared with gefitinib in an epidermal growth factor receptor-driven lung cancer model. Mol Cancer Ther. 2013;12(5):589-97.
    • (2013) Mol Cancer Ther , vol.12 , Issue.5 , pp. 589-597
    • Ninomiya, T.1    Takigawa, N.2    Ichihara, E.3
  • 20
    • 84859418112 scopus 로고    scopus 로고
    • The EGFR T790M mutation in acquired resistance to an irreversible second-generation EGFR inhibitor
    • 1:CAS:528:DC%2BC38XjtlKitr4%3D 22228822 10.1158/1535-7163.MCT-11-0750
    • Kim Y, Ko J, Cui Z-Y, et al. The EGFR T790M mutation in acquired resistance to an irreversible second-generation EGFR inhibitor. Mol Cancer Ther. 2012;11(3):784-91.
    • (2012) Mol Cancer Ther , vol.11 , Issue.3 , pp. 784-791
    • Kim, Y.1    Ko, J.2    Cui, Z.-Y.3
  • 21
    • 70349684791 scopus 로고    scopus 로고
    • Dual targeting of EGFR can overcome a major drug resistance mutation in mouse models of EGFR mutant lung cancer
    • 1:CAS:528:DC%2BD1MXht1GjurzN 2752070 19759520
    • Regales L, Gong Y, Shen R, et al. Dual targeting of EGFR can overcome a major drug resistance mutation in mouse models of EGFR mutant lung cancer. J Clin Invest. 2009;119(10):3000-10.
    • (2009) J Clin Invest , vol.119 , Issue.10 , pp. 3000-3010
    • Regales, L.1    Gong, Y.2    Shen, R.3
  • 22
    • 84867405669 scopus 로고    scopus 로고
    • Activation of IL-6R/JAK1/STAT3 signaling induces de novo resistance to irreversible EGFR inhibitors in non-small cell lung cancer with T790M resistance mutation
    • 1:CAS:528:DC%2BC38XhsVyksrvI 22891040 10.1158/1535-7163.MCT-12-0311
    • Kim SM, Kwon O-J, Hong YK, et al. Activation of IL-6R/JAK1/STAT3 signaling induces de novo resistance to irreversible EGFR inhibitors in non-small cell lung cancer with T790M resistance mutation. Mol Cancer Ther. 2012;11(10):2254-64.
    • (2012) Mol Cancer Ther , vol.11 , Issue.10 , pp. 2254-2264
    • Kim, S.M.1    Kwon, O.-J.2    Hong, Y.K.3
  • 23
    • 84875083480 scopus 로고    scopus 로고
    • Synergistic effect of afatinib with su11274 in non-small cell lung cancer cells resistant to gefitinib or erlotinib
    • 1:CAS:528:DC%2BC3sXltFSnu7w%3D 3601073 23527257 10.1371/journal.pone. 0059708
    • Chen G, Noor A, Kronenberger P, et al. Synergistic effect of afatinib with su11274 in non-small cell lung cancer cells resistant to gefitinib or erlotinib. PLoS One. 2013;8(3):e59708.
    • (2013) PLoS One , vol.8 , Issue.3 , pp. 59708
    • Chen, G.1    Noor, A.2    Kronenberger, P.3
  • 24
    • 84890317176 scopus 로고    scopus 로고
    • Phase II, open-label trial to assess QTcF effects, pharmacokinetics and antitumor activity of afatinib in patients with relapsed or refractory solid tumors
    • 1:CAS:528:DC%2BC3sXhsFCqtLvE 24085260 10.1007/s00280-013-2286-7
    • Molife LR, Rudman SM, Alam S, et al. Phase II, open-label trial to assess QTcF effects, pharmacokinetics and antitumor activity of afatinib in patients with relapsed or refractory solid tumors. Cancer Chemother Pharmacol. 2013;72(6):1213-22.
    • (2013) Cancer Chemother Pharmacol , vol.72 , Issue.6 , pp. 1213-1222
    • Molife, L.R.1    Rudman, S.M.2    Alam, S.3
  • 25
    • 38049038935 scopus 로고    scopus 로고
    • A phase i dose escalation study of BIBW 2992, an irreversible dual inhibitor of epidermal growth factor receptor 1 (EGFR) and 2 (HER2) tyrosine kinase in a 2-week on, 2-week off schedule in patients with advanced solid tumours
    • 1:CAS:528:DC%2BD1cXisF2qtg%3D%3D 2359721 18026190 10.1038/sj.bjc.6604108
    • Eskens FALM, Mom CH, Planting AST, et al. A phase I dose escalation study of BIBW 2992, an irreversible dual inhibitor of epidermal growth factor receptor 1 (EGFR) and 2 (HER2) tyrosine kinase in a 2-week on, 2-week off schedule in patients with advanced solid tumours. Br J Cancer. 2008;98(1):80-5.
    • (2008) Br J Cancer , vol.98 , Issue.1 , pp. 80-85
    • Eskens, F.1    Mom, C.H.2    Planting, A.S.T.3
  • 26
    • 84879551143 scopus 로고    scopus 로고
    • A phase I, open-label, dose escalation study of afatinib, in a 3-week-on/1-week-off schedule in patients with advanced solid tumors
    • 1:CAS:528:DC%2BC3sXjsleisLk%3D 3589659 23161335 10.1007/s10637-012-9890-y
    • Marshall J, Hwang J, Eskens FALM, et al. A phase I, open-label, dose escalation study of afatinib, in a 3-week-on/1-week-off schedule in patients with advanced solid tumors. Invest New Drugs. 2013;31(2):399-408.
    • (2013) Invest New Drugs , vol.31 , Issue.2 , pp. 399-408
    • Marshall, J.1    Hwang, J.2    Eskens, F.3
  • 27
    • 77957585027 scopus 로고    scopus 로고
    • Phase i trial of the irreversible EGFR and HER2 kinase inhibitor BIBW 2992 in patients with advanced solid tumors
    • 1:CAS:528:DC%2BC3cXht1eqsbzF 20679611 10.1200/JCO.2009.26.7278
    • Yap TA, Vidal L, Adam J, et al. Phase I trial of the irreversible EGFR and HER2 kinase inhibitor BIBW 2992 in patients with advanced solid tumors. J Clin Oncol. 2010;28(25):3965-72.
    • (2010) J Clin Oncol , vol.28 , Issue.25 , pp. 3965-3972
    • Yap, T.A.1    Vidal, L.2    Adam, J.3
  • 28
    • 84879551355 scopus 로고    scopus 로고
    • A phase I, open-label, dose-escalation study of continuous once-daily oral treatment with afatinib in patients with advanced solid tumors
    • 1:CAS:528:DC%2BC3sXjsleisL0%3D 3589633 23242861 10.1007/s10637-012-9904-9
    • Gordon MS, Mendelson DS, Gross M, et al. A phase I, open-label, dose-escalation study of continuous once-daily oral treatment with afatinib in patients with advanced solid tumors. Invest New Drugs. 2013;31(2):409-16.
    • (2013) Invest New Drugs , vol.31 , Issue.2 , pp. 409-416
    • Gordon, M.S.1    Mendelson, D.S.2    Gross, M.3
  • 29
    • 84890490464 scopus 로고    scopus 로고
    • Phase II, open-label trial to assess the effect of continuous oral afatinib (BIBW 2992) at a daily dose of 50 mg on QTc, pharmacokinetics, and efficacy in relapsed or refractory solid tumors including brain metastases and glioblastoma that is not amenable to other therapy [abstract no. 2613]
    • Kristeleit H, Puglisi M, Middleton GW, et al. Phase II, open-label trial to assess the effect of continuous oral afatinib (BIBW 2992) at a daily dose of 50 mg on QTc, pharmacokinetics, and efficacy in relapsed or refractory solid tumors including brain metastases and glioblastoma that is not amenable to other therapy [abstract no. 2613]. J Clin Oncol. 2011;29(15 Suppl 1).
    • (2011) J Clin Oncol , vol.29 , Issue.15 SUPPL. 1
    • Kristeleit, H.1    Puglisi, M.2    Middleton, G.W.3
  • 30
    • 84885994849 scopus 로고    scopus 로고
    • Pharmacokinetics of afatinib, a selective irreversible ErbB family blocker, in patients with advanced solid tumours
    • 1:CAS:528:DC%2BC3sXhvVSmtr%2FO 23813493 10.1007/s40262-013-0091-4
    • Wind S, Schmid M, Erhardt J, et al. Pharmacokinetics of afatinib, a selective irreversible ErbB family blocker, in patients with advanced solid tumours. Clin Pharmacokinet. 2013;52(12):1101-9.
    • (2013) Clin Pharmacokinet , vol.52 , Issue.12 , pp. 1101-1109
    • Wind, S.1    Schmid, M.2    Erhardt, J.3
  • 31
    • 84884736973 scopus 로고    scopus 로고
    • Phase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations
    • 1:CAS:528:DC%2BC3sXhs1KrsrzP 23816960 10.1200/JCO.2012.44.2806
    • Sequist LV, Yang JC-H, Yamamoto N, et al. Phase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations. J Clin Oncol. 2013;31(27):3327-34.
    • (2013) J Clin Oncol , vol.31 , Issue.27 , pp. 3327-3334
    • Sequist, L.V.1    Yang, J.-H.2    Yamamoto, N.3
  • 32
    • 84859793822 scopus 로고    scopus 로고
    • Afatinib pharmacokinetics and metabolism after oral administration to healthy male volunteers
    • 1:CAS:528:DC%2BC38XkvVCrsL4%3D 22200729 10.1007/s00280-011-1803-9
    • Stopfer P, Marzin K, Narjes H, et al. Afatinib pharmacokinetics and metabolism after oral administration to healthy male volunteers. Cancer Chemother Pharmacol. 2012;69(4):1051-61.
    • (2012) Cancer Chemother Pharmacol , vol.69 , Issue.4 , pp. 1051-1061
    • Stopfer, P.1    Marzin, K.2    Narjes, H.3
  • 33
    • 33751421795 scopus 로고    scopus 로고
    • A phase i dose escalation study of BIBW 2992, and irreversible dual EGFR/HER2 receptor tyrosine kinase inhibitor, in a continuous schedule in patients with advanced solid tumours [abstract]
    • Agus DB, Terlizzi E, Stopfer P, et al. A phase I dose escalation study of BIBW 2992, and irreversible dual EGFR/HER2 receptor tyrosine kinase inhibitor, in a continuous schedule in patients with advanced solid tumours [abstract]. J Clin Oncol. 2006;24(18S):2074.
    • (2006) J Clin Oncol , vol.24 , Issue.18 S , pp. 2074
    • Agus, D.B.1    Terlizzi, E.2    Stopfer, P.3
  • 34
    • 84862819699 scopus 로고    scopus 로고
    • Afatinib for patients with lung adenocarcinoma and epidermal growth factor receptor mutations (LUX-Lung 2): A phase 2 trial
    • 1:CAS:528:DC%2BC38Xmslyhsbk%3D 22452895 10.1016/S1470-2045(12)70086-4
    • Yang JC-H, Shih J-Y, Su W-C, et al. Afatinib for patients with lung adenocarcinoma and epidermal growth factor receptor mutations (LUX-Lung 2): a phase 2 trial. Lancet Oncol. 2012;13(5):539-48.
    • (2012) Lancet Oncol , vol.13 , Issue.5 , pp. 539-548
    • Yang, J.-H.1    Shih, J.-Y.2    Su, W.-C.3
  • 35
    • 84895762711 scopus 로고    scopus 로고
    • LUX-Lung 6: A randomized, open-label, phase III study of afatinib (A) versus gemcitabine/cisplatin (GC) as first-line treatment for Asian patients (pts) with EGFR mutation-positive (EGFR M+) advanced adenocarcinoma of the lung [abstract no. 8016]
    • (plus poster presented at the 49th Annual Meeting of the American Society of Clinical Oncology; 31 May-4 Jun 2013; Chicago (IL))
    • Wu YL, Zhou C, Hu C-P, et al. LUX-Lung 6: a randomized, open-label, phase III study of afatinib (A) versus gemcitabine/cisplatin (GC) as first-line treatment for Asian patients (pts) with EGFR mutation-positive (EGFR M+) advanced adenocarcinoma of the lung [abstract no. 8016]. J Clin Oncol. 2013;31(15 Suppl) (plus poster presented at the 49th Annual Meeting of the American Society of Clinical Oncology; 31 May-4 Jun 2013; Chicago (IL)).
    • (2013) J Clin Oncol. , vol.31 , Issue.15 SUPPL
    • Wu, Y.L.1    Zhou, C.2    Hu, C.-P.3
  • 36
    • 84884605223 scopus 로고    scopus 로고
    • Symptom control and quality of life in LUX-Lung 3: A phase III study of afatinib or cisplatin/pemetrexed in patients with advanced lung adenocarcinoma with EGFR mutations
    • 1:CAS:528:DC%2BC3sXhs1KrsrzF 23816967 10.1200/JCO.2012.46.1764
    • Yang JC-H, Hirsh V, Schuler M, et al. Symptom control and quality of life in LUX-Lung 3: a phase III study of afatinib or cisplatin/pemetrexed in patients with advanced lung adenocarcinoma with EGFR mutations. J Clin Oncol. 2013;31(27):3342-50.
    • (2013) J Clin Oncol , vol.31 , Issue.27 , pp. 3342-3350
    • Yang, J.-H.1    Hirsh, V.2    Schuler, M.3
  • 37
    • 84895755298 scopus 로고    scopus 로고
    • LUX-Lung 6: Patient-reported outcomes (PROs) from a randomized open-label, phase III study in first-line advanced NSCLC patients (pts) harboring epidermal growth factor receptor (EGFR) mutations [abstract no. 8061]
    • (plus poster presented at the 49th Annual Meeting of the American Society of Clinical Oncology; 31 May-4 Jun 2013; Chicago (IL))
    • Geater SL, Zhou C, Hu C-P, et al. LUX-Lung 6: patient-reported outcomes (PROs) from a randomized open-label, phase III study in first-line advanced NSCLC patients (pts) harboring epidermal growth factor receptor (EGFR) mutations [abstract no. 8061]. J Clin Oncol. 2013;31(15 Suppl) (plus poster presented at the 49th Annual Meeting of the American Society of Clinical Oncology; 31 May-4 Jun 2013; Chicago (IL)).
    • (2013) J Clin Oncol. , vol.31 , Issue.15 SUPPL
    • Geater, S.L.1    Zhou, C.2    Hu, C.-P.3
  • 38
    • 84895752756 scopus 로고    scopus 로고
    • Activity of afatinib in uncommon epidermal growth factor receptor (EGFR) mutations in LUX-Lung 3, a phase III trial of afatinib or cisplatin/pemetrexed in EGFR mutation-positive lung cancer [abstract no. 1252P]
    • Yang JC, Schuler M, Yamamoto N, et al. Activity of afatinib in uncommon epidermal growth factor receptor (EGFR) mutations in LUX-Lung 3, a phase III trial of afatinib or cisplatin/pemetrexed in EGFR mutation-positive lung cancer [abstract no. 1252P]. Ann Oncol. 2012;23(Suppl 9):ix410-1.
    • (2012) Ann Oncol , vol.23 , Issue.SUPPL. 9
    • Yang, J.C.1    Schuler, M.2    Yamamoto, N.3
  • 39
    • 84895732481 scopus 로고    scopus 로고
    • Activity of afatinib in uncommon epidermal growth factor receptor (EGFR) mutations: Findings from three trials of afatinib in EGFR mutation-positive lung cancer [abstract no. O03.05 plus slide presentation]
    • 27-30 Oct; Sydney
    • Yang JC-H, Sequist LV, Geater SL, et al. Activity of afatinib in uncommon epidermal growth factor receptor (EGFR) mutations: findings from three trials of afatinib in EGFR mutation-positive lung cancer [abstract no. O03.05 plus slide presentation]. 15th World Conference on Lung Cancer; 27-30 Oct 2013; Sydney.
    • (2013) 15th World Conference on Lung Cancer
    • Jc-H, Y.1    Sequist, L.V.2    Geater, S.L.3
  • 40
    • 84895752790 scopus 로고    scopus 로고
    • LUX-Lung 3: Afatinib vs. Cisplatin and pemetrexed in Asian patients with adenocarcinoma of the lung harbouring an epidermal growth factor receptor mutation [abstract no. HO-003]
    • 26-28 Nov; Fukuoka
    • Mok T, Schuler M, Yamamoto N, et al. LUX-Lung 3: afatinib vs. cisplatin and pemetrexed in Asian patients with adenocarcinoma of the lung harbouring an epidermal growth factor receptor mutation [abstract no. HO-003]. 5th Asia Pacific Lung Cancer Conference; 26-28 Nov 2012; Fukuoka.
    • (2012) 5th Asia Pacific Lung Cancer Conference
    • Mok, T.1    Schuler, M.2    Yamamoto, N.3
  • 41
    • 84895733874 scopus 로고    scopus 로고
    • LUX-Lung 3: Afatinib vs. Cisplatin and pemetrexed in Japanese patients with adenocarcinoma of the lung harbouring an EGFR mutation [abstract no. PLS-6]
    • Yamamoto N, Schuler M, O'Byrne K, et al. LUX-Lung 3: afatinib vs. cisplatin and pemetrexed in Japanese patients with adenocarcinoma of the lung harbouring an EGFR mutation [abstract no. PLS-6]. Ann Oncol. 2012;23(Suppl 11):xi8.
    • (2012) Ann Oncol , vol.23 , Issue.SUPPL. 11 , pp. 8
    • Yamamoto, N.1    Schuler, M.2    O'Byrne, K.3
  • 42
    • 84895740031 scopus 로고    scopus 로고
    • Efficacy of afatinib vs. Chemotherapy in treatment-naïve patients with non-small cell lung cancer (NSCLC) harbouring activating EGFR mutations with or without metastatic brain disease [abstract no. MO07.13 plus slide presentation]
    • 27-30 Oct; Sydney
    • Schuler M, Yang JC-H, Sequist LV, et al. Efficacy of afatinib vs. chemotherapy in treatment-naïve patients with non-small cell lung cancer (NSCLC) harbouring activating EGFR mutations with or without metastatic brain disease [abstract no. MO07.13 plus slide presentation]. 15th World Conference on Lung Cancer; 27-30 Oct 2013; Sydney.
    • (2013) 15th World Conference on Lung Cancer
    • Schuler, M.1    Jc-H, Y.2    Sequist, L.V.3
  • 43
    • 84895731447 scopus 로고    scopus 로고
    • Epidermal growth factor receptor (EGFR)-mediated adverse events in patients with EGFR mutation-positive non-small cell lung cancer (NSCLC) treated with afatinib [abstract no. 895]
    • (plus poster presented at European Cancer Congress 2013; 27 Sep-1 Oct 2013; Amsterdam)
    • Yang JC-H, Sequist LV, O'Byrne KJ, et al. Epidermal growth factor receptor (EGFR)-mediated adverse events in patients with EGFR mutation-positive non-small cell lung cancer (NSCLC) treated with afatinib [abstract no. 895]. Eur J Cancer. 2013;49(Suppl 2):S190 (plus poster presented at European Cancer Congress 2013; 27 Sep-1 Oct 2013; Amsterdam).
    • (2013) Eur J Cancer , vol.49 , Issue.SUPPL. 2
    • Jc-H, Y.1    Sequist, L.V.2    O'Byrne, K.J.3
  • 44
    • 84879347777 scopus 로고    scopus 로고
    • Diarrhea associated with afatinib: An oral ErbB family blocker
    • 1:CAS:528:DC%2BC3sXpsFKiur0%3D 23506556 10.1586/era.13.31
    • Yang JC-H, Reguart N, Barinoff J, et al. Diarrhea associated with afatinib: an oral ErbB family blocker. Expert Rev Anticancer Ther. 2013;13(6):729-36.
    • (2013) Expert Rev Anticancer Ther , vol.13 , Issue.6 , pp. 729-736
    • Yang, J.-H.1    Reguart, N.2    Barinoff, J.3
  • 45
    • 84879347673 scopus 로고    scopus 로고
    • Dermatologic adverse events associated with afatinib: An oral ErbB family blocker
    • 1:CAS:528:DC%2BC3sXpsFKiurg%3D 23506519 10.1586/era.13.30
    • Lacouture ME, Schadendorf D, Chu C-YC, et al. Dermatologic adverse events associated with afatinib: an oral ErbB family blocker. Expert Rev Anticancer Ther. 2013;13(6):721-8.
    • (2013) Expert Rev Anticancer Ther , vol.13 , Issue.6 , pp. 721-728
    • Lacouture, M.E.1    Schadendorf, D.2    Chu, C.-Y.3
  • 46
    • 84895738790 scopus 로고    scopus 로고
    • LUX-Lung 8: A randomized, open-label, phase III trial of afatinib vs. Erlotinib in patients with advanced squamous cell carcinoma of the lung as second-line therapy following first-line platinum-based chemotherapy [abstract no. 509TiP]
    • Goss G, Lu S, Felip E, et al. LUX-Lung 8: a randomized, open-label, phase III trial of afatinib vs. erlotinib in patients with advanced squamous cell carcinoma of the lung as second-line therapy following first-line platinum-based chemotherapy [abstract no. 509TiP]. Ann Oncol. 2012;23(Suppl 9):ix174.
    • (2012) Ann Oncol , vol.23 , Issue.SUPPL. 9 , pp. 174
    • Goss, G.1    Lu, S.2    Felip, E.3
  • 49
    • 84879884454 scopus 로고    scopus 로고
    • Clinical perspective of afatinib in non-small cell lung cancer
    • 23664448 10.1016/j.lungcan.2013.02.021
    • Chen X, Zhu Q, Zhu L, et al. Clinical perspective of afatinib in non-small cell lung cancer. Lung Cancer. 2013;81(2):155-61.
    • (2013) Lung Cancer , vol.81 , Issue.2 , pp. 155-161
    • Chen, X.1    Zhu, Q.2    Zhu, L.3
  • 50
    • 84873677937 scopus 로고    scopus 로고
    • Activity of afatinib/cetuximab in patients (pts) with EGFR mutant non-small cell lung cancer (NSCLC) and acquired resistance (AR) to EGFR inhibitors [abstract no. 12270]
    • Janjigian YY, Smit EF, Horn L, et al. Activity of afatinib/cetuximab in patients (pts) with EGFR mutant non-small cell lung cancer (NSCLC) and acquired resistance (AR) to EGFR inhibitors [abstract no. 12270]. Ann Oncol. 2012;23(Suppl 9):ix401.
    • (2012) Ann Oncol , vol.23 , Issue.SUPPL. 9 , pp. 401
    • Janjigian, Y.Y.1    Smit, E.F.2    Horn, L.3
  • 52
    • 84893080787 scopus 로고    scopus 로고
    • Epidermal growth factor receptor inhibition in mutation-positive non-small-cell lung cancer: Is afatinib better or simply newer?
    • 1:CAS:528:DC%2BC3sXhs1Krsr%2FF 23980079 10.1200/JCO.2013.49.8782
    • Langer CJ. Epidermal growth factor receptor inhibition in mutation-positive non-small-cell lung cancer: is afatinib better or simply newer? J Clin Oncol. 2013;31(27):3303-6.
    • (2013) J Clin Oncol , vol.31 , Issue.27 , pp. 3303-3306
    • Langer, C.J.1
  • 53
    • 84858002759 scopus 로고    scopus 로고
    • Clinical activity of afatinib (BIBW 2992) in patients with lung adenocarcinoma with mutations in the kinase domain of HER2/neu
    • 22325357 10.1016/j.lungcan.2012.01.008
    • De Grevè J, Teugels E, Geers C, et al. Clinical activity of afatinib (BIBW 2992) in patients with lung adenocarcinoma with mutations in the kinase domain of HER2/neu. Lung Cancer. 2012;76(1):123-7.
    • (2012) Lung Cancer , vol.76 , Issue.1 , pp. 123-127
    • De Grevè, J.1    Teugels, E.2    Geers, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.