-
1
-
-
84878888082
-
First-line management of EGFR-mutated advanced lung adenocarcinoma: Recent developments
-
1:CAS:528:DC%2BC3sXhvVWmtLrM 23479407 10.1007/s40265-013-0020-8
-
Liao B-C, Lin C-C, Yang JC-H. First-line management of EGFR-mutated advanced lung adenocarcinoma: recent developments. Drugs. 2013;73(4):357-69.
-
(2013)
Drugs
, vol.73
, Issue.4
, pp. 357-369
-
-
Liao, B.-C.1
Lin, C.-C.2
Yang, J.-H.3
-
2
-
-
81155123620
-
Role of genotyping in non-small cell lung cancer treatment: Current status
-
1:CAS:528:DC%2BC38Xit1ShtL4%3D 22085382 10.2165/11597700-000000000-00000
-
Bonanno L, Favaretto A, Rugge M. Role of genotyping in non-small cell lung cancer treatment: current status. Drugs. 2011;71(17):2231-46.
-
(2011)
Drugs
, vol.71
, Issue.17
, pp. 2231-2246
-
-
Bonanno, L.1
Favaretto, A.2
Rugge, M.3
-
4
-
-
79955853698
-
The LUX-Lung clinical trial program of afatinib for non-small-cell lung cancer
-
1:CAS:528:DC%2BC3MXlvFGju7k%3D 21554040 10.1586/era.11.34
-
Metro G, Crinò L. The LUX-Lung clinical trial program of afatinib for non-small-cell lung cancer. Expert Rev Anticancer Ther. 2011;11(5):673-82.
-
(2011)
Expert Rev Anticancer Ther
, vol.11
, Issue.5
, pp. 673-682
-
-
Metro, G.1
Crinò, L.2
-
5
-
-
79960110757
-
Afatinib (BIBW 2992) development in non-small-cell lung cancer
-
1:CAS:528:DC%2BC3MXos1SlurY%3D 21732753 10.2217/fon.11.62
-
Hirsh V. Afatinib (BIBW 2992) development in non-small-cell lung cancer. Future Oncol. 2011;7(7):817-25.
-
(2011)
Future Oncol
, vol.7
, Issue.7
, pp. 817-825
-
-
Hirsh, V.1
-
6
-
-
84875013524
-
Afatinib: Emerging next-generation tyrosine kinase inhibitor for NSCLC
-
1:CAS:528:DC%2BC3sXkt1Wlsbc%3D 3594037 23493883
-
Nelson V, Ziehr J, Agulnik M, et al. Afatinib: emerging next-generation tyrosine kinase inhibitor for NSCLC. Onco Targets Ther. 2013;6:135-43.
-
(2013)
Onco Targets Ther
, vol.6
, pp. 135-143
-
-
Nelson, V.1
Ziehr, J.2
Agulnik, M.3
-
7
-
-
78650945778
-
Afatinib (BIBW-2992): A novel dual EGFR/HER2neu inhibitor with promising activity in non-small-cell lung cancer
-
1:CAS:528:DC%2BC3cXhs1Sju7fO 10.2217/thy.10.86
-
Bordoni RE. Afatinib (BIBW-2992): a novel dual EGFR/HER2neu inhibitor with promising activity in non-small-cell lung cancer. Therapy. 2011;8(1):15-22.
-
(2011)
Therapy
, vol.8
, Issue.1
, pp. 15-22
-
-
Bordoni, R.E.1
-
8
-
-
84863410315
-
EGFR-TKI resistant non-small cell lung cancer (NSCLC): New developments and implications for future treatment
-
22281074 10.1016/j.lungcan.2011.12.014
-
Brugger W, Thomas M. EGFR-TKI resistant non-small cell lung cancer (NSCLC): new developments and implications for future treatment. Lung Cancer. 2012;77(1):2-8.
-
(2012)
Lung Cancer
, vol.77
, Issue.1
, pp. 2-8
-
-
Brugger, W.1
Thomas, M.2
-
9
-
-
84895728277
-
-
Boehringer Ingelheim Accessed 2 Dec 2013
-
®) in Asian and non-Asian lung cancer patients [media release]. 2013. http://www.boehringer- ingelheim.com/news/news-releases/press-releases/2013/27-october-2013-oncology. html. Accessed 2 Dec 2013.
-
(2013)
®) in Asian and Non-Asian Lung Cancer Patients [Media Release]
-
-
-
10
-
-
84895764889
-
-
European Medicines Agency Accessed 18 Oct 2013
-
European Medicines Agency. Giotrif (afatinib) film-coated tablets: EU summary of product characteristics. 2013. http://www.ema.europa.eu/docs/en-GB/ document-library/EPAR-Product-Information/human/002280/WC500152392.pdf. Accessed 18 Oct 2013.
-
(2013)
Giotrif (Afatinib) Film-coated Tablets: EU Summary of Product Characteristics
-
-
-
14
-
-
49149118719
-
BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models
-
1:CAS:528:DC%2BD1cXptlKnsbk%3D 2748240 18408761 10.1038/onc.2008.109
-
Li D, Ambrogio L, Shimamura T, et al. BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models. Oncogene. 2008;27(34):4702-11.
-
(2008)
Oncogene
, vol.27
, Issue.34
, pp. 4702-4711
-
-
Li, D.1
Ambrogio, L.2
Shimamura, T.3
-
15
-
-
84867621201
-
Target binding properties and cellular activity of afatinib (BIBW 2992), an irreversible ErbB family blocker
-
1:CAS:528:DC%2BC38XhsFKktbzE 22888144 10.1124/jpet.112.197756
-
Solca F, Dahl G, Zoephel A, et al. Target binding properties and cellular activity of afatinib (BIBW 2992), an irreversible ErbB family blocker. J Pharmacol Exp Ther. 2012;343(2):342-50.
-
(2012)
J Pharmacol Exp Ther
, vol.343
, Issue.2
, pp. 342-350
-
-
Solca, F.1
Dahl, G.2
Zoephel, A.3
-
16
-
-
84862791294
-
Targeting the epidermal growth factor receptor in non-small cell lung cancer cells: The effect of combining RNA interference with tyrosine kinase inhibitors or cetuximab
-
1:CAS:528:DC%2BC38Xos12mtbs%3D 3334713 22436374 10.1186/1741-7015-10-28
-
Chen G, Kronenberger P, Teugels E, et al. Targeting the epidermal growth factor receptor in non-small cell lung cancer cells: the effect of combining RNA interference with tyrosine kinase inhibitors or cetuximab. BMC Med. 2012;10:28.
-
(2012)
BMC Med
, vol.10
, pp. 28
-
-
Chen, G.1
Kronenberger, P.2
Teugels, E.3
-
17
-
-
77953394930
-
Enhanced anticancer effect of the combination of BIBW2992 and thymidylate synthase-targeted agents in non-small cell lung cancer with the T790M mutation of epidermal growth factor receptor
-
1:CAS:528:DC%2BC3cXntFGgtr0%3D 20530710 10.1158/1535-7163.MCT-09-1009
-
Takezawa K, Okamoto I, Tanizaki J, et al. Enhanced anticancer effect of the combination of BIBW2992 and thymidylate synthase-targeted agents in non-small cell lung cancer with the T790M mutation of epidermal growth factor receptor. Mol Cancer Ther. 2010;9(6):1647-56.
-
(2010)
Mol Cancer Ther
, vol.9
, Issue.6
, pp. 1647-1656
-
-
Takezawa, K.1
Okamoto, I.2
Tanizaki, J.3
-
18
-
-
84876416258
-
Sensitivity and kinase activity of epidermal growth factor receptor (EGFR) exon 19 and others to EGFR-tyrosine kinase inhibitors
-
1:CAS:528:DC%2BC3sXlvVCjs7s%3D 23387505 10.1111/cas.12125
-
Furuyama K, Harada T, Iwama E, et al. Sensitivity and kinase activity of epidermal growth factor receptor (EGFR) exon 19 and others to EGFR-tyrosine kinase inhibitors. Cancer Sci. 2013;104(5):584-9.
-
(2013)
Cancer Sci
, vol.104
, Issue.5
, pp. 584-589
-
-
Furuyama, K.1
Harada, T.2
Iwama, E.3
-
19
-
-
84877660788
-
Afatinib prolongs survival compared with gefitinib in an epidermal growth factor receptor-driven lung cancer model
-
1:CAS:528:DC%2BC3sXntlSisro%3D 23443806 10.1158/1535-7163.MCT-12-0885
-
Ninomiya T, Takigawa N, Ichihara E, et al. Afatinib prolongs survival compared with gefitinib in an epidermal growth factor receptor-driven lung cancer model. Mol Cancer Ther. 2013;12(5):589-97.
-
(2013)
Mol Cancer Ther
, vol.12
, Issue.5
, pp. 589-597
-
-
Ninomiya, T.1
Takigawa, N.2
Ichihara, E.3
-
20
-
-
84859418112
-
The EGFR T790M mutation in acquired resistance to an irreversible second-generation EGFR inhibitor
-
1:CAS:528:DC%2BC38XjtlKitr4%3D 22228822 10.1158/1535-7163.MCT-11-0750
-
Kim Y, Ko J, Cui Z-Y, et al. The EGFR T790M mutation in acquired resistance to an irreversible second-generation EGFR inhibitor. Mol Cancer Ther. 2012;11(3):784-91.
-
(2012)
Mol Cancer Ther
, vol.11
, Issue.3
, pp. 784-791
-
-
Kim, Y.1
Ko, J.2
Cui, Z.-Y.3
-
21
-
-
70349684791
-
Dual targeting of EGFR can overcome a major drug resistance mutation in mouse models of EGFR mutant lung cancer
-
1:CAS:528:DC%2BD1MXht1GjurzN 2752070 19759520
-
Regales L, Gong Y, Shen R, et al. Dual targeting of EGFR can overcome a major drug resistance mutation in mouse models of EGFR mutant lung cancer. J Clin Invest. 2009;119(10):3000-10.
-
(2009)
J Clin Invest
, vol.119
, Issue.10
, pp. 3000-3010
-
-
Regales, L.1
Gong, Y.2
Shen, R.3
-
22
-
-
84867405669
-
Activation of IL-6R/JAK1/STAT3 signaling induces de novo resistance to irreversible EGFR inhibitors in non-small cell lung cancer with T790M resistance mutation
-
1:CAS:528:DC%2BC38XhsVyksrvI 22891040 10.1158/1535-7163.MCT-12-0311
-
Kim SM, Kwon O-J, Hong YK, et al. Activation of IL-6R/JAK1/STAT3 signaling induces de novo resistance to irreversible EGFR inhibitors in non-small cell lung cancer with T790M resistance mutation. Mol Cancer Ther. 2012;11(10):2254-64.
-
(2012)
Mol Cancer Ther
, vol.11
, Issue.10
, pp. 2254-2264
-
-
Kim, S.M.1
Kwon, O.-J.2
Hong, Y.K.3
-
23
-
-
84875083480
-
Synergistic effect of afatinib with su11274 in non-small cell lung cancer cells resistant to gefitinib or erlotinib
-
1:CAS:528:DC%2BC3sXltFSnu7w%3D 3601073 23527257 10.1371/journal.pone. 0059708
-
Chen G, Noor A, Kronenberger P, et al. Synergistic effect of afatinib with su11274 in non-small cell lung cancer cells resistant to gefitinib or erlotinib. PLoS One. 2013;8(3):e59708.
-
(2013)
PLoS One
, vol.8
, Issue.3
, pp. 59708
-
-
Chen, G.1
Noor, A.2
Kronenberger, P.3
-
24
-
-
84890317176
-
Phase II, open-label trial to assess QTcF effects, pharmacokinetics and antitumor activity of afatinib in patients with relapsed or refractory solid tumors
-
1:CAS:528:DC%2BC3sXhsFCqtLvE 24085260 10.1007/s00280-013-2286-7
-
Molife LR, Rudman SM, Alam S, et al. Phase II, open-label trial to assess QTcF effects, pharmacokinetics and antitumor activity of afatinib in patients with relapsed or refractory solid tumors. Cancer Chemother Pharmacol. 2013;72(6):1213-22.
-
(2013)
Cancer Chemother Pharmacol
, vol.72
, Issue.6
, pp. 1213-1222
-
-
Molife, L.R.1
Rudman, S.M.2
Alam, S.3
-
25
-
-
38049038935
-
A phase i dose escalation study of BIBW 2992, an irreversible dual inhibitor of epidermal growth factor receptor 1 (EGFR) and 2 (HER2) tyrosine kinase in a 2-week on, 2-week off schedule in patients with advanced solid tumours
-
1:CAS:528:DC%2BD1cXisF2qtg%3D%3D 2359721 18026190 10.1038/sj.bjc.6604108
-
Eskens FALM, Mom CH, Planting AST, et al. A phase I dose escalation study of BIBW 2992, an irreversible dual inhibitor of epidermal growth factor receptor 1 (EGFR) and 2 (HER2) tyrosine kinase in a 2-week on, 2-week off schedule in patients with advanced solid tumours. Br J Cancer. 2008;98(1):80-5.
-
(2008)
Br J Cancer
, vol.98
, Issue.1
, pp. 80-85
-
-
Eskens, F.1
Mom, C.H.2
Planting, A.S.T.3
-
26
-
-
84879551143
-
A phase I, open-label, dose escalation study of afatinib, in a 3-week-on/1-week-off schedule in patients with advanced solid tumors
-
1:CAS:528:DC%2BC3sXjsleisLk%3D 3589659 23161335 10.1007/s10637-012-9890-y
-
Marshall J, Hwang J, Eskens FALM, et al. A phase I, open-label, dose escalation study of afatinib, in a 3-week-on/1-week-off schedule in patients with advanced solid tumors. Invest New Drugs. 2013;31(2):399-408.
-
(2013)
Invest New Drugs
, vol.31
, Issue.2
, pp. 399-408
-
-
Marshall, J.1
Hwang, J.2
Eskens, F.3
-
27
-
-
77957585027
-
Phase i trial of the irreversible EGFR and HER2 kinase inhibitor BIBW 2992 in patients with advanced solid tumors
-
1:CAS:528:DC%2BC3cXht1eqsbzF 20679611 10.1200/JCO.2009.26.7278
-
Yap TA, Vidal L, Adam J, et al. Phase I trial of the irreversible EGFR and HER2 kinase inhibitor BIBW 2992 in patients with advanced solid tumors. J Clin Oncol. 2010;28(25):3965-72.
-
(2010)
J Clin Oncol
, vol.28
, Issue.25
, pp. 3965-3972
-
-
Yap, T.A.1
Vidal, L.2
Adam, J.3
-
28
-
-
84879551355
-
A phase I, open-label, dose-escalation study of continuous once-daily oral treatment with afatinib in patients with advanced solid tumors
-
1:CAS:528:DC%2BC3sXjsleisL0%3D 3589633 23242861 10.1007/s10637-012-9904-9
-
Gordon MS, Mendelson DS, Gross M, et al. A phase I, open-label, dose-escalation study of continuous once-daily oral treatment with afatinib in patients with advanced solid tumors. Invest New Drugs. 2013;31(2):409-16.
-
(2013)
Invest New Drugs
, vol.31
, Issue.2
, pp. 409-416
-
-
Gordon, M.S.1
Mendelson, D.S.2
Gross, M.3
-
29
-
-
84890490464
-
Phase II, open-label trial to assess the effect of continuous oral afatinib (BIBW 2992) at a daily dose of 50 mg on QTc, pharmacokinetics, and efficacy in relapsed or refractory solid tumors including brain metastases and glioblastoma that is not amenable to other therapy [abstract no. 2613]
-
Kristeleit H, Puglisi M, Middleton GW, et al. Phase II, open-label trial to assess the effect of continuous oral afatinib (BIBW 2992) at a daily dose of 50 mg on QTc, pharmacokinetics, and efficacy in relapsed or refractory solid tumors including brain metastases and glioblastoma that is not amenable to other therapy [abstract no. 2613]. J Clin Oncol. 2011;29(15 Suppl 1).
-
(2011)
J Clin Oncol
, vol.29
, Issue.15 SUPPL. 1
-
-
Kristeleit, H.1
Puglisi, M.2
Middleton, G.W.3
-
30
-
-
84885994849
-
Pharmacokinetics of afatinib, a selective irreversible ErbB family blocker, in patients with advanced solid tumours
-
1:CAS:528:DC%2BC3sXhvVSmtr%2FO 23813493 10.1007/s40262-013-0091-4
-
Wind S, Schmid M, Erhardt J, et al. Pharmacokinetics of afatinib, a selective irreversible ErbB family blocker, in patients with advanced solid tumours. Clin Pharmacokinet. 2013;52(12):1101-9.
-
(2013)
Clin Pharmacokinet
, vol.52
, Issue.12
, pp. 1101-1109
-
-
Wind, S.1
Schmid, M.2
Erhardt, J.3
-
31
-
-
84884736973
-
Phase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations
-
1:CAS:528:DC%2BC3sXhs1KrsrzP 23816960 10.1200/JCO.2012.44.2806
-
Sequist LV, Yang JC-H, Yamamoto N, et al. Phase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations. J Clin Oncol. 2013;31(27):3327-34.
-
(2013)
J Clin Oncol
, vol.31
, Issue.27
, pp. 3327-3334
-
-
Sequist, L.V.1
Yang, J.-H.2
Yamamoto, N.3
-
32
-
-
84859793822
-
Afatinib pharmacokinetics and metabolism after oral administration to healthy male volunteers
-
1:CAS:528:DC%2BC38XkvVCrsL4%3D 22200729 10.1007/s00280-011-1803-9
-
Stopfer P, Marzin K, Narjes H, et al. Afatinib pharmacokinetics and metabolism after oral administration to healthy male volunteers. Cancer Chemother Pharmacol. 2012;69(4):1051-61.
-
(2012)
Cancer Chemother Pharmacol
, vol.69
, Issue.4
, pp. 1051-1061
-
-
Stopfer, P.1
Marzin, K.2
Narjes, H.3
-
33
-
-
33751421795
-
A phase i dose escalation study of BIBW 2992, and irreversible dual EGFR/HER2 receptor tyrosine kinase inhibitor, in a continuous schedule in patients with advanced solid tumours [abstract]
-
Agus DB, Terlizzi E, Stopfer P, et al. A phase I dose escalation study of BIBW 2992, and irreversible dual EGFR/HER2 receptor tyrosine kinase inhibitor, in a continuous schedule in patients with advanced solid tumours [abstract]. J Clin Oncol. 2006;24(18S):2074.
-
(2006)
J Clin Oncol
, vol.24
, Issue.18 S
, pp. 2074
-
-
Agus, D.B.1
Terlizzi, E.2
Stopfer, P.3
-
34
-
-
84862819699
-
Afatinib for patients with lung adenocarcinoma and epidermal growth factor receptor mutations (LUX-Lung 2): A phase 2 trial
-
1:CAS:528:DC%2BC38Xmslyhsbk%3D 22452895 10.1016/S1470-2045(12)70086-4
-
Yang JC-H, Shih J-Y, Su W-C, et al. Afatinib for patients with lung adenocarcinoma and epidermal growth factor receptor mutations (LUX-Lung 2): a phase 2 trial. Lancet Oncol. 2012;13(5):539-48.
-
(2012)
Lancet Oncol
, vol.13
, Issue.5
, pp. 539-548
-
-
Yang, J.-H.1
Shih, J.-Y.2
Su, W.-C.3
-
35
-
-
84895762711
-
LUX-Lung 6: A randomized, open-label, phase III study of afatinib (A) versus gemcitabine/cisplatin (GC) as first-line treatment for Asian patients (pts) with EGFR mutation-positive (EGFR M+) advanced adenocarcinoma of the lung [abstract no. 8016]
-
(plus poster presented at the 49th Annual Meeting of the American Society of Clinical Oncology; 31 May-4 Jun 2013; Chicago (IL))
-
Wu YL, Zhou C, Hu C-P, et al. LUX-Lung 6: a randomized, open-label, phase III study of afatinib (A) versus gemcitabine/cisplatin (GC) as first-line treatment for Asian patients (pts) with EGFR mutation-positive (EGFR M+) advanced adenocarcinoma of the lung [abstract no. 8016]. J Clin Oncol. 2013;31(15 Suppl) (plus poster presented at the 49th Annual Meeting of the American Society of Clinical Oncology; 31 May-4 Jun 2013; Chicago (IL)).
-
(2013)
J Clin Oncol.
, vol.31
, Issue.15 SUPPL
-
-
Wu, Y.L.1
Zhou, C.2
Hu, C.-P.3
-
36
-
-
84884605223
-
Symptom control and quality of life in LUX-Lung 3: A phase III study of afatinib or cisplatin/pemetrexed in patients with advanced lung adenocarcinoma with EGFR mutations
-
1:CAS:528:DC%2BC3sXhs1KrsrzF 23816967 10.1200/JCO.2012.46.1764
-
Yang JC-H, Hirsh V, Schuler M, et al. Symptom control and quality of life in LUX-Lung 3: a phase III study of afatinib or cisplatin/pemetrexed in patients with advanced lung adenocarcinoma with EGFR mutations. J Clin Oncol. 2013;31(27):3342-50.
-
(2013)
J Clin Oncol
, vol.31
, Issue.27
, pp. 3342-3350
-
-
Yang, J.-H.1
Hirsh, V.2
Schuler, M.3
-
37
-
-
84895755298
-
LUX-Lung 6: Patient-reported outcomes (PROs) from a randomized open-label, phase III study in first-line advanced NSCLC patients (pts) harboring epidermal growth factor receptor (EGFR) mutations [abstract no. 8061]
-
(plus poster presented at the 49th Annual Meeting of the American Society of Clinical Oncology; 31 May-4 Jun 2013; Chicago (IL))
-
Geater SL, Zhou C, Hu C-P, et al. LUX-Lung 6: patient-reported outcomes (PROs) from a randomized open-label, phase III study in first-line advanced NSCLC patients (pts) harboring epidermal growth factor receptor (EGFR) mutations [abstract no. 8061]. J Clin Oncol. 2013;31(15 Suppl) (plus poster presented at the 49th Annual Meeting of the American Society of Clinical Oncology; 31 May-4 Jun 2013; Chicago (IL)).
-
(2013)
J Clin Oncol.
, vol.31
, Issue.15 SUPPL
-
-
Geater, S.L.1
Zhou, C.2
Hu, C.-P.3
-
38
-
-
84895752756
-
Activity of afatinib in uncommon epidermal growth factor receptor (EGFR) mutations in LUX-Lung 3, a phase III trial of afatinib or cisplatin/pemetrexed in EGFR mutation-positive lung cancer [abstract no. 1252P]
-
Yang JC, Schuler M, Yamamoto N, et al. Activity of afatinib in uncommon epidermal growth factor receptor (EGFR) mutations in LUX-Lung 3, a phase III trial of afatinib or cisplatin/pemetrexed in EGFR mutation-positive lung cancer [abstract no. 1252P]. Ann Oncol. 2012;23(Suppl 9):ix410-1.
-
(2012)
Ann Oncol
, vol.23
, Issue.SUPPL. 9
-
-
Yang, J.C.1
Schuler, M.2
Yamamoto, N.3
-
39
-
-
84895732481
-
Activity of afatinib in uncommon epidermal growth factor receptor (EGFR) mutations: Findings from three trials of afatinib in EGFR mutation-positive lung cancer [abstract no. O03.05 plus slide presentation]
-
27-30 Oct; Sydney
-
Yang JC-H, Sequist LV, Geater SL, et al. Activity of afatinib in uncommon epidermal growth factor receptor (EGFR) mutations: findings from three trials of afatinib in EGFR mutation-positive lung cancer [abstract no. O03.05 plus slide presentation]. 15th World Conference on Lung Cancer; 27-30 Oct 2013; Sydney.
-
(2013)
15th World Conference on Lung Cancer
-
-
Jc-H, Y.1
Sequist, L.V.2
Geater, S.L.3
-
40
-
-
84895752790
-
LUX-Lung 3: Afatinib vs. Cisplatin and pemetrexed in Asian patients with adenocarcinoma of the lung harbouring an epidermal growth factor receptor mutation [abstract no. HO-003]
-
26-28 Nov; Fukuoka
-
Mok T, Schuler M, Yamamoto N, et al. LUX-Lung 3: afatinib vs. cisplatin and pemetrexed in Asian patients with adenocarcinoma of the lung harbouring an epidermal growth factor receptor mutation [abstract no. HO-003]. 5th Asia Pacific Lung Cancer Conference; 26-28 Nov 2012; Fukuoka.
-
(2012)
5th Asia Pacific Lung Cancer Conference
-
-
Mok, T.1
Schuler, M.2
Yamamoto, N.3
-
41
-
-
84895733874
-
LUX-Lung 3: Afatinib vs. Cisplatin and pemetrexed in Japanese patients with adenocarcinoma of the lung harbouring an EGFR mutation [abstract no. PLS-6]
-
Yamamoto N, Schuler M, O'Byrne K, et al. LUX-Lung 3: afatinib vs. cisplatin and pemetrexed in Japanese patients with adenocarcinoma of the lung harbouring an EGFR mutation [abstract no. PLS-6]. Ann Oncol. 2012;23(Suppl 11):xi8.
-
(2012)
Ann Oncol
, vol.23
, Issue.SUPPL. 11
, pp. 8
-
-
Yamamoto, N.1
Schuler, M.2
O'Byrne, K.3
-
42
-
-
84895740031
-
Efficacy of afatinib vs. Chemotherapy in treatment-naïve patients with non-small cell lung cancer (NSCLC) harbouring activating EGFR mutations with or without metastatic brain disease [abstract no. MO07.13 plus slide presentation]
-
27-30 Oct; Sydney
-
Schuler M, Yang JC-H, Sequist LV, et al. Efficacy of afatinib vs. chemotherapy in treatment-naïve patients with non-small cell lung cancer (NSCLC) harbouring activating EGFR mutations with or without metastatic brain disease [abstract no. MO07.13 plus slide presentation]. 15th World Conference on Lung Cancer; 27-30 Oct 2013; Sydney.
-
(2013)
15th World Conference on Lung Cancer
-
-
Schuler, M.1
Jc-H, Y.2
Sequist, L.V.3
-
43
-
-
84895731447
-
Epidermal growth factor receptor (EGFR)-mediated adverse events in patients with EGFR mutation-positive non-small cell lung cancer (NSCLC) treated with afatinib [abstract no. 895]
-
(plus poster presented at European Cancer Congress 2013; 27 Sep-1 Oct 2013; Amsterdam)
-
Yang JC-H, Sequist LV, O'Byrne KJ, et al. Epidermal growth factor receptor (EGFR)-mediated adverse events in patients with EGFR mutation-positive non-small cell lung cancer (NSCLC) treated with afatinib [abstract no. 895]. Eur J Cancer. 2013;49(Suppl 2):S190 (plus poster presented at European Cancer Congress 2013; 27 Sep-1 Oct 2013; Amsterdam).
-
(2013)
Eur J Cancer
, vol.49
, Issue.SUPPL. 2
-
-
Jc-H, Y.1
Sequist, L.V.2
O'Byrne, K.J.3
-
44
-
-
84879347777
-
Diarrhea associated with afatinib: An oral ErbB family blocker
-
1:CAS:528:DC%2BC3sXpsFKiur0%3D 23506556 10.1586/era.13.31
-
Yang JC-H, Reguart N, Barinoff J, et al. Diarrhea associated with afatinib: an oral ErbB family blocker. Expert Rev Anticancer Ther. 2013;13(6):729-36.
-
(2013)
Expert Rev Anticancer Ther
, vol.13
, Issue.6
, pp. 729-736
-
-
Yang, J.-H.1
Reguart, N.2
Barinoff, J.3
-
45
-
-
84879347673
-
Dermatologic adverse events associated with afatinib: An oral ErbB family blocker
-
1:CAS:528:DC%2BC3sXpsFKiurg%3D 23506519 10.1586/era.13.30
-
Lacouture ME, Schadendorf D, Chu C-YC, et al. Dermatologic adverse events associated with afatinib: an oral ErbB family blocker. Expert Rev Anticancer Ther. 2013;13(6):721-8.
-
(2013)
Expert Rev Anticancer Ther
, vol.13
, Issue.6
, pp. 721-728
-
-
Lacouture, M.E.1
Schadendorf, D.2
Chu, C.-Y.3
-
46
-
-
84895738790
-
LUX-Lung 8: A randomized, open-label, phase III trial of afatinib vs. Erlotinib in patients with advanced squamous cell carcinoma of the lung as second-line therapy following first-line platinum-based chemotherapy [abstract no. 509TiP]
-
Goss G, Lu S, Felip E, et al. LUX-Lung 8: a randomized, open-label, phase III trial of afatinib vs. erlotinib in patients with advanced squamous cell carcinoma of the lung as second-line therapy following first-line platinum-based chemotherapy [abstract no. 509TiP]. Ann Oncol. 2012;23(Suppl 9):ix174.
-
(2012)
Ann Oncol
, vol.23
, Issue.SUPPL. 9
, pp. 174
-
-
Goss, G.1
Lu, S.2
Felip, E.3
-
49
-
-
84879884454
-
Clinical perspective of afatinib in non-small cell lung cancer
-
23664448 10.1016/j.lungcan.2013.02.021
-
Chen X, Zhu Q, Zhu L, et al. Clinical perspective of afatinib in non-small cell lung cancer. Lung Cancer. 2013;81(2):155-61.
-
(2013)
Lung Cancer
, vol.81
, Issue.2
, pp. 155-161
-
-
Chen, X.1
Zhu, Q.2
Zhu, L.3
-
50
-
-
84873677937
-
Activity of afatinib/cetuximab in patients (pts) with EGFR mutant non-small cell lung cancer (NSCLC) and acquired resistance (AR) to EGFR inhibitors [abstract no. 12270]
-
Janjigian YY, Smit EF, Horn L, et al. Activity of afatinib/cetuximab in patients (pts) with EGFR mutant non-small cell lung cancer (NSCLC) and acquired resistance (AR) to EGFR inhibitors [abstract no. 12270]. Ann Oncol. 2012;23(Suppl 9):ix401.
-
(2012)
Ann Oncol
, vol.23
, Issue.SUPPL. 9
, pp. 401
-
-
Janjigian, Y.Y.1
Smit, E.F.2
Horn, L.3
-
52
-
-
84893080787
-
Epidermal growth factor receptor inhibition in mutation-positive non-small-cell lung cancer: Is afatinib better or simply newer?
-
1:CAS:528:DC%2BC3sXhs1Krsr%2FF 23980079 10.1200/JCO.2013.49.8782
-
Langer CJ. Epidermal growth factor receptor inhibition in mutation-positive non-small-cell lung cancer: is afatinib better or simply newer? J Clin Oncol. 2013;31(27):3303-6.
-
(2013)
J Clin Oncol
, vol.31
, Issue.27
, pp. 3303-3306
-
-
Langer, C.J.1
-
53
-
-
84858002759
-
Clinical activity of afatinib (BIBW 2992) in patients with lung adenocarcinoma with mutations in the kinase domain of HER2/neu
-
22325357 10.1016/j.lungcan.2012.01.008
-
De Grevè J, Teugels E, Geers C, et al. Clinical activity of afatinib (BIBW 2992) in patients with lung adenocarcinoma with mutations in the kinase domain of HER2/neu. Lung Cancer. 2012;76(1):123-7.
-
(2012)
Lung Cancer
, vol.76
, Issue.1
, pp. 123-127
-
-
De Grevè, J.1
Teugels, E.2
Geers, C.3
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