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Volumn 13, Issue 7, 2012, Pages 789-802

Pharmacogenetics of EGFR in lung cancer: Perspectives and clinical applications

Author keywords

Tyrosine kinase inhibitors

Indexed keywords

4 (3 BROMOANILINO) 6,7 DIMETHOXYQUINAZOLINE; AFATINIB; ANTINEOPLASTIC AGENT; BRCA1 PROTEIN; CARBOPLATIN; CISPLATIN; DOCETAXEL; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIDERMAL GROWTH FACTOR RECEPTOR 3; EPIDERMAL GROWTH FACTOR RECEPTOR 4; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; ERLOTINIB; GEFITINIB; GEMCITABINE; I KAPPA B KINASE; IMATINIB; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA; NERATINIB; PACLITAXEL; PHOSPHATIDYLINOSITOL 3 KINASE; PLATINUM COMPLEX; PROTEIN KINASE B; SCATTER FACTOR; SILIBININ; SOMATOMEDIN C RECEPTOR; UNINDEXED DRUG;

EID: 84861167686     PISSN: 14622416     EISSN: 17448042     Source Type: Journal    
DOI: 10.2217/pgs.12.54     Document Type: Review
Times cited : (36)

References (85)
  • 2
    • 69949126786 scopus 로고    scopus 로고
    • Personalized medicine and inhibition of EGFR signaling in lung cancer
    • Gazdar AF. Personalized medicine and inhibition of EGFR signaling in lung cancer. N. Engl. J. Med. 361(10), 1018-1020 (2009).
    • (2009) N. Engl. J. Med. , vol.361 , Issue.10 , pp. 1018-1020
    • Gazdar, A.F.1
  • 3
    • 79251490374 scopus 로고    scopus 로고
    • New driver mutations in non-small-cell lung cancer
    • Pao W, Girard N. New driver mutations in non-small-cell lung cancer. Lancet Oncol. 12(2), 175-180 (2011).
    • (2011) Lancet Oncol. , vol.12 , Issue.2 , pp. 175-180
    • Pao, W.1    Girard, N.2
  • 5
    • 34548484397 scopus 로고    scopus 로고
    • Pooled analysis of the prospective trials of gefitinib monotherapy for EGFR-mutant non-small cell lung cancers
    • DOI 10.1016/j.lungcan.2007.05.017, PII S0169500207003224
    • Costa DB, Kobayashi S, Tenen DG, Huberman MS. Pooled analysis of the prospective trials of gefitinib monotherapy for EGFR-mutant non-small cell lung cancers. Lung Cancer 58(1), 95-103 (2007). (Pubitemid 47379970)
    • (2007) Lung Cancer , vol.58 , Issue.1 , pp. 95-103
    • Costa, D.B.1    Kobayashi, S.2    Tenen, D.G.3    Huberman, M.S.4
  • 6
    • 69949186250 scopus 로고    scopus 로고
    • Screening for epidermal growth factor receptor mutations in lung cancer
    • Rosell R, Moran T, Queralt C et al. Screening for epidermal growth factor receptor mutations in lung cancer. N. Engl. J. Med. 361(10), 958-967 (2009).
    • (2009) N. Engl. J. Med. , vol.361 , Issue.10 , pp. 958-967
    • Rosell, R.1    Moran, T.2    Queralt, C.3
  • 7
    • 73349096261 scopus 로고    scopus 로고
    • Resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer
    • Hammerman PS, Janne PA, Johnson BE. Resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer. Clin. Cancer Res. 15(24), 7502-7509 (2009).
    • (2009) Clin. Cancer Res. , vol.15 , Issue.24 , pp. 7502-7509
    • Hammerman, P.S.1    Janne, P.A.2    Johnson, B.E.3
  • 8
    • 43749107912 scopus 로고    scopus 로고
    • Acquired resistance to tyrosine kinase inhibitors during cancer therapy
    • DOI 10.1016/j.gde.2008.01.004, PII S0959437X08000087
    • Engelman JA, Settleman J. Acquired resistance to tyrosine kinase inhibitors during cancer therapy. Curr. Opin. Genet. Dev. 18(1), 73-79 (2008). (Pubitemid 351694445)
    • (2008) Current Opinion in Genetics and Development , vol.18 , Issue.1 , pp. 73-79
    • Engelman, J.A.1    Settleman, J.2
  • 9
    • 79952264325 scopus 로고    scopus 로고
    • Pretreatment EGFR T790M mutation and BRCA1 mRNA expression in erlotinib-treated advanced non-small-cell lung cancer patients with EGFR mutations
    • Rosell R, Molina MA, Costa C et al. Pretreatment EGFR T790M mutation and BRCA1 mRNA expression in erlotinib-treated advanced non-small-cell lung cancer patients with EGFR mutations. Clin. Cancer Res. 17(5), 1160-1168 (2011).
    • (2011) Clin. Cancer Res. , vol.17 , Issue.5 , pp. 1160-1168
    • Rosell, R.1    Molina, M.A.2    Costa, C.3
  • 10
    • 79953046542 scopus 로고    scopus 로고
    • FAS and NF-kappaB signalling modulate dependence of lung cancers on mutant EGFR
    • Bivona TG, Hieronymus H, Parker J et al. FAS and NF-kappaB signalling modulate dependence of lung cancers on mutant EGFR. Nature 471(7339), 523-526 (2011).
    • (2011) Nature , vol.471 , Issue.7339 , pp. 523-526
    • Bivona, T.G.1    Hieronymus, H.2    Parker, J.3
  • 11
    • 59449097300 scopus 로고    scopus 로고
    • BRCA1: A new genomic marker for non-small-cell lung cancer
    • Reguart N, Cardona AF, Carrasco E et al. BRCA1: a new genomic marker for non-small-cell lung cancer. Clin. Lung Cancer 9(6), 331-339 (2008).
    • (2008) Clin. Lung Cancer , vol.9 , Issue.6 , pp. 331-339
    • Reguart, N.1    Cardona, A.F.2    Carrasco, E.3
  • 12
    • 36149000984 scopus 로고    scopus 로고
    • Epidermal growth factor (EGF) activates nuclear factor-κB through IκBα kinase-independent but EGF receptor-kinase dependent tyrosine 42 phosphorylation of IκBα
    • DOI 10.1038/sj.onc.1210544, PII 1210544
    • Sethi G, Ahn KS, Chaturvedi MM, Aggarwal BB. Epidermal growth factor (EGF) activates nuclear factor-kappaB through IkappaBalpha kinase-independent but EGF receptor-kinase dependent tyrosine 42 phosphorylation of IkappaBalpha. Oncogene 26(52), 7324-7332 (2007). (Pubitemid 350115978)
    • (2007) Oncogene , vol.26 , Issue.52 , pp. 7324-7332
    • Sethi, G.1    Ahn, K.S.2    Chaturvedi, M.M.3    Aggarwal, B.B.4
  • 13
    • 68949201629 scopus 로고    scopus 로고
    • Activating and resistance mutations of EGFR in non-small-cell lung cancer: Role in clinical response to EGFR tyrosine kinase inhibitors
    • Gazdar AF. Activating and resistance mutations of EGFR in non-small-cell lung cancer: role in clinical response to EGFR tyrosine kinase inhibitors. Oncogene 28(suppl. 1), S24-S31 (2009).
    • (2009) Oncogene , vol.28 , Issue.SUPPL. 1
    • Gazdar, A.F.1
  • 14
    • 43249096031 scopus 로고    scopus 로고
    • Structure and clinical relevance of the epidermal growth factor receptor in human cancer
    • Kumar A, Petri ET, Halmos B, Boggon TJ. Structure and clinical relevance of the epidermal growth factor receptor in human cancer. J. Clin. Oncol. 26(10), 1742-1751 (2008).
    • (2008) J. Clin. Oncol. , vol.26 , Issue.10 , pp. 1742-1751
    • Kumar, A.1    Petri, E.T.2    Halmos, B.3    Boggon, T.J.4
  • 15
    • 78650034175 scopus 로고    scopus 로고
    • Genetically informed lung cancer medicine
    • Pao W, Iafrate AJ, Su Z. Genetically informed lung cancer medicine. J. Pathol. 223(2), 230-240 (2010).
    • (2010) J. Pathol. , vol.223 , Issue.2 , pp. 230-240
    • Pao, W.1    Iafrate, A.J.2    Su, Z.3
  • 16
    • 40849147041 scopus 로고    scopus 로고
    • EGFR antagonists in cancer treatment
    • Ciardiello F, Tortora G. EGFR antagonists in cancer treatment. N. Engl. J. Med. 358(11), 1160-1174 (2008).
    • (2008) N. Engl. J. Med. , vol.358 , Issue.11 , pp. 1160-1174
    • Ciardiello, F.1    Tortora, G.2
  • 17
    • 77954718424 scopus 로고    scopus 로고
    • Predictive biomarkers to tyrosine kinase inhibitors for the epidermal growth factor receptor in non-small-cell lung cancer
    • De Luca A, Normanno N. Predictive biomarkers to tyrosine kinase inhibitors for the epidermal growth factor receptor in non-small-cell lung cancer. Curr. Drug Targets 11(7), 851-864 (2010).
    • (2010) Curr. Drug Targets , vol.11 , Issue.7 , pp. 851-864
    • De Luca, A.1    Normanno, N.2
  • 18
    • 61749090015 scopus 로고    scopus 로고
    • Deregulated EGFR signaling during lung cancer progression: Mutations, amplicons, and autocrine loops
    • Gazdar AF, Minna JD. Deregulated EGFR signaling during lung cancer progression: mutations, amplicons, and autocrine loops. Cancer Prev. Res. (Phila.) 1(3), 156-160 (2008).
    • (2008) Cancer Prev. Res. (Phila.) , vol.1 , Issue.3 , pp. 156-160
    • Gazdar, A.F.1    Minna, J.D.2
  • 19
    • 0026521394 scopus 로고
    • Amplified and rearranged epidermal growth factor receptor genes in human glioblastomas reveal deletions of sequences encoding portions of the N-and/or C-terminal tails
    • Ekstrand AJ, Sugawa N, James CD, Collins VP. Amplified and rearranged epidermal growth factor receptor genes in human glioblastomas reveal deletions of sequences encoding portions of the N-and/or C-terminal tails. Proc. Natl Acad. Sci. USA 89(10), 4309-4313 (1992).
    • (1992) Proc. Natl Acad. Sci. USA , vol.89 , Issue.10 , pp. 4309-4313
    • Ekstrand, A.J.1    Sugawa, N.2    James, C.D.3    Collins, V.P.4
  • 22
    • 33746133158 scopus 로고    scopus 로고
    • Biological and clinical implications of EGFR mutations in lung cancer
    • DOI 10.1007/s10147-006-0583-4
    • Mitsudomi T, Kosaka T, Yatabe Y. Biological and clinical implications of EGFR mutations in lung cancer. Int J. Clin. Oncol. 11(3), 190-198 (2006). (Pubitemid 44087117)
    • (2006) International Journal of Clinical Oncology , vol.11 , Issue.3 , pp. 190-198
    • Mitsudomi, T.1    Kosaka, T.2    Yatabe, Y.3
  • 24
    • 80155171655 scopus 로고    scopus 로고
    • Antiangiogenic and antimetastatic activity of JAK inhibitor AZD1480
    • Xin H, Herrmann A, Reckamp K et al. Antiangiogenic and antimetastatic activity of JAK inhibitor AZD1480. Cancer Res. 71(21), 6601-6610 (2011).
    • (2011) Cancer Res. , vol.71 , Issue.21 , pp. 6601-6610
    • Xin, H.1    Herrmann, A.2    Reckamp, K.3
  • 25
    • 76749137179 scopus 로고    scopus 로고
    • Epidermal growth factor receptor tyrosine kinase inhibitors as first-line treatment in advanced nonsmall-cell lung cancer
    • Rosell R, Viteri S, Molina MA, Benlloch S, Taron M. Epidermal growth factor receptor tyrosine kinase inhibitors as first-line treatment in advanced nonsmall-cell lung cancer. Curr. Opin. Oncol. 22(2), 112-120 (2010).
    • (2010) Curr. Opin. Oncol. , vol.22 , Issue.2 , pp. 112-120
    • Rosell, R.1    Viteri, S.2    Molina, M.A.3    Benlloch, S.4    Taron, M.5
  • 26
    • 69949162760 scopus 로고    scopus 로고
    • Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma
    • Mok TS, Wu YL, Thongprasert S et al. Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N. Engl. J. Med. 361(10), 947-957 (2009).
    • (2009) N. Engl. J. Med. , vol.361 , Issue.10 , pp. 947-957
    • Mok, T.S.1    Wu, Y.L.2    Thongprasert, S.3
  • 27
    • 75249087060 scopus 로고    scopus 로고
    • Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): An open label, randomised phase 3 trial
    • Mitsudomi T, Morita S, Yatabe Y et al. Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial. Lancet Oncol. 11(2), 121-128 (2010).
    • (2010) Lancet Oncol. , vol.11 , Issue.2 , pp. 121-128
    • Mitsudomi, T.1    Morita, S.2    Yatabe, Y.3
  • 28
    • 77953930730 scopus 로고    scopus 로고
    • Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR
    • Maemondo M, Inoue A, Kobayashi K et al. Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR. N. Engl. J. Med. 362(25), 2380-2388 (2010).
    • (2010) N. Engl. J. Med. , vol.362 , Issue.25 , pp. 2380-2388
    • Maemondo, M.1    Inoue, A.2    Kobayashi, K.3
  • 29
    • 79960889662 scopus 로고    scopus 로고
    • Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): A multicentre, open-label, randomised, phase 3 study
    • Zhou C, Wu Y-L, Chen G et al. Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study. Lancet Oncol. 12, 735-742 (2011).
    • (2011) Lancet Oncol. , vol.12 , pp. 735-742
    • Zhou, C.1    Wu, Y.-L.2    Chen, G.3
  • 30
    • 57149089886 scopus 로고    scopus 로고
    • EGFR mutations predict survival benefit from gefitinib in patients with advanced lung adenocarcinoma: A historical comparison of patients treated before and after gefitinib approval in Japan
    • Takano T, Fukui T, Ohe Y et al. EGFR mutations predict survival benefit from gefitinib in patients with advanced lung adenocarcinoma: a historical comparison of patients treated before and after gefitinib approval in Japan. J. Clin. Oncol. 26(34), 5589-5595 (2008).
    • (2008) J. Clin. Oncol. , vol.26 , Issue.34 , pp. 5589-5595
    • Takano, T.1    Fukui, T.2    Ohe, Y.3
  • 31
    • 45149084723 scopus 로고    scopus 로고
    • First-line gefitinib in patients with advanced non-small-cell lung cancer harboring somatic EGFR mutations
    • Sequist LV, Martins RG, Spigel D et al. First-line gefitinib in patients with advanced non-small-cell lung cancer harboring somatic EGFR mutations. J. Clin. Oncol. 26(15), 2442-2449 (2008).
    • (2008) J. Clin. Oncol. , vol.26 , Issue.15 , pp. 2442-2449
    • Sequist, L.V.1    Martins, R.G.2    Spigel, D.3
  • 32
    • 84857502654 scopus 로고    scopus 로고
    • Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): A multicentre, open-label, randomised phase 3 trial
    • Rosell R, Carcereny E, Gervais R et al. Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial. Lancet Oncol. 13(3), 239-246 (2012).
    • (2012) Lancet Oncol. , vol.13 , Issue.3 , pp. 239-246
    • Rosell, R.1    Carcereny, E.2    Gervais, R.3
  • 33
    • 84863221857 scopus 로고    scopus 로고
    • Epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) therapy is effective as first-line treatment of advanced non-small-cell lung cancer with mutated EGFR: A meta-analysis from 6 phase III randomized controlled trials
    • doi:10.1002/ijc.27396 Epub ahead of print
    • Gao G, Ren S, Li A et al. Epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) therapy is effective as first-line treatment of advanced non-small-cell lung cancer with mutated EGFR: a meta-analysis from 6 phase III randomized controlled trials. Int. J. Cancer doi:10.1002/ijc.27396 (2011) (Epub ahead of print).
    • (2011) Int. J. Cancer
    • Gao, G.1    Ren, S.2    Li, A.3
  • 37
    • 77649222572 scopus 로고    scopus 로고
    • Molecular predictors of outcome with gefitinib and docetaxel in previously treated non-small-cell lung cancer: Data from the randomized Phase III INTEREST trial
    • Douillard JY, Shepherd FA, Hirsh V et al. Molecular predictors of outcome with gefitinib and docetaxel in previously treated non-small-cell lung cancer: data from the randomized Phase III INTEREST trial. J. Clin. Oncol. 28(5), 744-752 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , Issue.5 , pp. 744-752
    • Douillard, J.Y.1    Shepherd, F.A.2    Hirsh, V.3
  • 38
    • 52049096854 scopus 로고    scopus 로고
    • Gefitinib versus vinorelbine in chemotherapy-naive elderly patients with advanced non-small-cell lung cancer (INVITE): A randomized
    • Crino L, Cappuzzo F, Zatloukal P et al. Gefitinib versus vinorelbine in chemotherapy-naive elderly patients with advanced non-small-cell lung cancer (INVITE): a randomized, Phase II study. J. Clin. Oncol. 26(26), 4253-4260 (2008).
    • (2008) Phase II Study. J. Clin. Oncol. , vol.26 , Issue.26 , pp. 4253-4260
    • Crino, L.1    Cappuzzo, F.2    Zatloukal, P.3
  • 39
    • 80755181069 scopus 로고    scopus 로고
    • Prospective molecular marker analyses of EGFR and KRAS from a randomized, placebo-controlled study of erlotinib maintenance therapy in advanced non-small-cell lung cancer
    • Brugger W, Triller N, Blasinska-Morawiec M et al. Prospective molecular marker analyses of EGFR and KRAS from a randomized, placebo-controlled study of erlotinib maintenance therapy in advanced non-small-cell lung cancer. J. Clin. Oncol. 29(31), 4113-4120 (2011).
    • (2011) J. Clin. Oncol. , vol.29 , Issue.31 , pp. 4113-4120
    • Brugger, W.1    Triller, N.2    Blasinska-Morawiec, M.3
  • 40
    • 42049094628 scopus 로고    scopus 로고
    • Epidermal growth factor receptor gene amplification is acquired in association with tumor progression of EGFR-mutated lung cancer
    • DOI 10.1158/0008-5472.CAN-07-5211
    • Yatabe Y, Takahashi T, Mitsudomi T. Epidermal growth factor receptor gene amplification is acquired in association with tumor progression of EGFR-mutated lung cancer. Cancer Res. 68(7), 2106-2111 (2008). (Pubitemid 351521782)
    • (2008) Cancer Research , vol.68 , Issue.7 , pp. 2106-2111
    • Yatabe, Y.1    Takahashi, T.2    Mitsudomi, T.3
  • 41
    • 58149151261 scopus 로고    scopus 로고
    • Fluorescence in situ hybridization subgroup analysis of TRIBUTE a Phase III trial of erlotinib plus carboplatin and paclitaxel in non-small cell lung cancer
    • Hirsch FR, Varella-Garcia M, Dziadziuszko R et al. Fluorescence in situ hybridization subgroup analysis of TRIBUTE, a Phase III trial of erlotinib plus carboplatin and paclitaxel in non-small cell lung cancer. Clin. Cancer Res. 14(19), 6317-6323 (2008).
    • (2008) Clin. Cancer Res. , vol.14 , Issue.19 , pp. 6317-6323
    • Hirsch, F.R.1    Varella-Garcia, M.2    Dziadziuszko, R.3
  • 42
    • 79960702788 scopus 로고    scopus 로고
    • Biomarker analyses and final overall survival results from a Phase III, randomized, open-label, first-line study of gefitinib versus carboplatin/paclitaxel in clinically selected patients with advanced non-small-cell lung cancer in Asia (IPASS)
    • Fukuoka M, Wu YL, Thongprasert S et al. Biomarker analyses and final overall survival results from a Phase III, randomized, open-label, first-line study of gefitinib versus carboplatin/paclitaxel in clinically selected patients with advanced non-small-cell lung cancer in Asia (IPASS). J. Clin. Oncol. 29(21), 2866-2874 (2011).
    • (2011) J. Clin. Oncol. , vol.29 , Issue.21 , pp. 2866-2874
    • Fukuoka, M.1    Wu, Y.L.2    Thongprasert, S.3
  • 43
    • 18244371651 scopus 로고    scopus 로고
    • Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain
    • Pao W, Miller VA, Politi KA et al. Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. PLoS Med. 2(3), e73 (2005).
    • (2005) PLoS Med. , vol.2 , Issue.3
    • Pao, W.1    Miller, V.A.2    Politi, K.A.3
  • 46
    • 0037674323 scopus 로고    scopus 로고
    • Mutation of threonine 766 in the epidermal growth factor receptor reveals a hotspot for resistance formation against selective tyrosine kinase inhibitors
    • DOI 10.1074/jbc.M211158200
    • Blencke S, Ullrich A, Daub H. Mutation of threonine 766 in the epidermal growth factor receptor reveals a hotspot for resistance formation against selective tyrosine kinase inhibitors. J. Biol. Chem. 278(17), 15435-15440 (2003). (Pubitemid 36799884)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.17 , pp. 15435-15440
    • Blencke, S.1    Ullrich, A.2    Daub, H.3
  • 48
    • 65249127504 scopus 로고    scopus 로고
    • Noninvasive detection of EGFR T790M in gefitinib or erlotinib resistant non-small cell lung cancer
    • Kuang Y, Rogers A, Yeap BY et al. Noninvasive detection of EGFR T790M in gefitinib or erlotinib resistant non-small cell lung cancer. Clin. Cancer Res. 15(8), 2630-2636 (2009).
    • (2009) Clin. Cancer Res. , vol.15 , Issue.8 , pp. 2630-2636
    • Kuang, Y.1    Rogers, A.2    Yeap, B.Y.3
  • 49
    • 79952259564 scopus 로고    scopus 로고
    • Rebiopsy of lung cancer patients with acquired resistance to EGFR inhibitors and enhanced detection of the T790M mutation using a locked nucleic acid-based assay
    • Arcila ME, Oxnard GR, Nafa K et al. Rebiopsy of lung cancer patients with acquired resistance to EGFR inhibitors and enhanced detection of the T790M mutation using a locked nucleic acid-based assay. Clin. Cancer Res. 17(5), 1169-1180 (2011).
    • (2011) Clin. Cancer Res. , vol.17 , Issue.5 , pp. 1169-1180
    • Arcila, M.E.1    Oxnard, G.R.2    Nafa, K.3
  • 50
    • 76149086520 scopus 로고    scopus 로고
    • Endobronchial ultrasound-guided transbronchial needle aspiration for identifying EGFR mutations
    • Garcia-Olive I, Monso E, Andreo F et al. Endobronchial ultrasound-guided transbronchial needle aspiration for identifying EGFR mutations. Eur. Respir. J. 35(2), 391-395 (2010).
    • (2010) Eur. Respir. J. , vol.35 , Issue.2 , pp. 391-395
    • Garcia-Olive, I.1    Monso, E.2    Andreo, F.3
  • 51
    • 84863011443 scopus 로고    scopus 로고
    • Pretreatment epidermal growth factor receptor (EGFR) T790M mutation predicts shorter EGFR tyrosine kinase inhibitor response duration in patients with non-small-cell lung cancer
    • Su KY, Chen HY, Li KC et al. Pretreatment epidermal growth factor receptor (EGFR) T790M mutation predicts shorter EGFR tyrosine kinase inhibitor response duration in patients with non-small-cell lung cancer. J. Clin. Oncol. 30(4), 433-440 (2012).
    • (2012) J. Clin. Oncol. , vol.30 , Issue.4 , pp. 433-440
    • Su, K.Y.1    Chen, H.Y.2    Li, K.C.3
  • 53
    • 56449089812 scopus 로고    scopus 로고
    • Hepatocyte growth factor induces gefitinib resistance of lung adenocarcinoma with epidermal growth factor receptor-activating mutations
    • Yano S, Wang W, Li Q et al. Hepatocyte growth factor induces gefitinib resistance of lung adenocarcinoma with epidermal growth factor receptor-activating mutations. Cancer Res. 68(22), 9479-9487 (2008).
    • (2008) Cancer Res. , vol.68 , Issue.22 , pp. 9479-9487
    • Yano, S.1    Wang, W.2    Li, Q.3
  • 54
    • 79953118839 scopus 로고    scopus 로고
    • Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors
    • Sequist LV, Waltman BA, Dias-Santagata D et al. Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors. Sci. Transl. Med. 3(75), 75ra26 (2011).
    • (2011) Sci. Transl. Med. , vol.3 , Issue.75
    • Sequist, L.V.1    Waltman, B.A.2    Dias-Santagata, D.3
  • 56
    • 79959872399 scopus 로고    scopus 로고
    • Epithelial to mesenchymal transition in an epidermal growth factor receptor-mutant lung cancer cell line with acquired resistance to erlotinib
    • Suda K, Tomizawa K, Fujii M et al. Epithelial to mesenchymal transition in an epidermal growth factor receptor-mutant lung cancer cell line with acquired resistance to erlotinib. J. Thorac. Oncol. 6(7), 1152-1161 (2011).
    • (2011) J. Thorac. Oncol. , vol.6 , Issue.7 , pp. 1152-1161
    • Suda, K.1    Tomizawa, K.2    Fujii, M.3
  • 57
    • 77957273623 scopus 로고    scopus 로고
    • TGF-beta IL-6 axis mediates selective and adaptive mechanisms of resistance to molecular targeted therapy in lung cancer
    • Yao Z, Fenoglio S, Gao DC et al. TGF-beta IL-6 axis mediates selective and adaptive mechanisms of resistance to molecular targeted therapy in lung cancer. Proc. Natl Acad. Sci. USA 107(35), 15535-15540 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.1107 , Issue.35 , pp. 15535-15540
    • Yao, Z.1    Fenoglio, S.2    Gao, D.C.3
  • 60
    • 79960085862 scopus 로고    scopus 로고
    • Optimization of dosing for EGFR-mutant non-small cell lung cancer with evolutionary cancer modeling
    • Chmielecki J, Foo J, Oxnard GR et al. Optimization of dosing for EGFR-mutant non-small cell lung cancer with evolutionary cancer modeling. Sci. Transl. Med. 3(90), 90ra59 (2011).
    • (2011) Sci. Transl. Med. , vol.3 , Issue.90
    • Chmielecki, J.1    Foo, J.2    Oxnard, G.R.3
  • 61
    • 80053531654 scopus 로고    scopus 로고
    • Disease flare after tyrosine kinase inhibitor discontinuation in patients with EGFR-mutant lung cancer and acquired resistance to erlotinib or gefitinib
    • Chaft JE, Oxnard GR, Sima CS et al. Disease flare after tyrosine kinase inhibitor discontinuation in patients with EGFR-mutant lung cancer and acquired resistance to erlotinib or gefitinib. Clin. Cancer Res. 17(19), 6298-6303 (2011).
    • (2011) Clin. Cancer Res. , vol.17 , Issue.19 , pp. 6298-6303
    • Chaft, J.E.1    Oxnard, G.R.2    Sima, C.S.3
  • 62
    • 72949092456 scopus 로고    scopus 로고
    • Novel mutant-selective EGFR kinase inhibitors against EGFR T790M
    • Zhou W, Ercan D, Chen L et al. Novel mutant-selective EGFR kinase inhibitors against EGFR T790M. Nature 462(7276), 1070-1074 (2009).
    • (2009) Nature , vol.462 , Issue.7276 , pp. 1070-1074
    • Zhou, W.1    Ercan, D.2    Chen, L.3
  • 63
    • 33847323129 scopus 로고    scopus 로고
    • Epidermal growth factor receptor mutations in lung cancer
    • Sharma SV, Bell DW, Settleman J, Haber DA. Epidermal growth factor receptor mutations in lung cancer. Nat. Rev. Cancer 7(3), 169-181 (2007).
    • (2007) Nat. Rev. Cancer , vol.7 , Issue.3 , pp. 169-181
    • Sharma, S.V.1    Bell, D.W.2    Settleman, J.3    Haber, D.A.4
  • 64
    • 77957585027 scopus 로고    scopus 로고
    • Phase i trial of the irreversible EGFR and HER2 kinase inhibitor BIBW 2992 in patients with advanced solid tumors
    • Yap TA, Vidal L, Adam J et al. Phase I trial of the irreversible EGFR and HER2 kinase inhibitor BIBW 2992 in patients with advanced solid tumors. J. Clin. Oncol. 28(25), 3965-3972 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , Issue.25 , pp. 3965-3972
    • Yap, T.A.1    Vidal, L.2    Adam, J.3
  • 65
    • 77954584507 scopus 로고    scopus 로고
    • Neratinib, an irreversible pan-ErbB receptor tyrosine kinase inhibitor: Results of a Phase II trial in patients with advanced non-small-cell lung cancer
    • Sequist LV, Besse B, Lynch TJ et al. Neratinib, an irreversible pan-ErbB receptor tyrosine kinase inhibitor: results of a Phase II trial in patients with advanced non-small-cell lung cancer. J. Clin. Oncol. 28(18), 3076-3083 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , Issue.18 , pp. 3076-3083
    • Sequist, L.V.1    Besse, B.2    Lynch, T.J.3
  • 66
    • 78650442303 scopus 로고    scopus 로고
    • Combined treatment with silibinin and epidermal growth factor receptor tyrosine kinase inhibitors overcomes drug resistance caused by T790M mutation
    • Rho JK, Choi YJ, Jeon BS et al. Combined treatment with silibinin and epidermal growth factor receptor tyrosine kinase inhibitors overcomes drug resistance caused by T790M mutation. Mol. Cancer Ther. 9(12), 3233-3243 (2010).
    • (2010) Mol. Cancer Ther. , vol.9 , Issue.12 , pp. 3233-3243
    • Rho, J.K.1    Choi, Y.J.2    Jeon, B.S.3
  • 67
    • 47949114668 scopus 로고    scopus 로고
    • Detection of mutations in EGFR in circulating lung-cancer cells
    • Maheswaran S, Sequist LV, Nagrath S et al. Detection of mutations in EGFR in circulating lung-cancer cells. N. Engl. J. Med. 359(4), 366-377 (2008).
    • (2008) N. Engl. J. Med. , vol.359 , Issue.4 , pp. 366-377
    • Maheswaran, S.1    Sequist, L.V.2    Nagrath, S.3
  • 68
    • 61549124759 scopus 로고    scopus 로고
    • Germ-line and somatic presentations of the EGFR T790M mutation in lung cancer
    • Prudkin L, Tang X, Wistuba II. Germ-line and somatic presentations of the EGFR T790M mutation in lung cancer. J. Thorac. Oncol. 4(1), 139-141 (2009).
    • (2009) J. Thorac. Oncol. , vol.4 , Issue.1 , pp. 139-141
    • Prudkin, L.1    Tang, X.2    Wistuba, I.I.3
  • 70
    • 80052252181 scopus 로고    scopus 로고
    • Novel therapeutic targets in non-small cell lung cancer
    • Janku F, Garrido-Laguna I, Petruzelka LB et al. Novel therapeutic targets in non-small cell lung cancer. J. Thorac. Oncol. 6(9), 1601-1612 (2011).
    • (2011) J. Thorac. Oncol. , vol.6 , Issue.9 , pp. 1601-1612
    • Janku, F.1    Garrido-Laguna, I.2    Petruzelka, L.B.3
  • 71
    • 67749122122 scopus 로고    scopus 로고
    • Targeting PI3K signalling in cancer: Opportunities, challenges and limitations
    • Engelman JA. Targeting PI3K signalling in cancer: opportunities, challenges and limitations. Nat. Rev. Cancer 9(8), 550-562 (2009).
    • (2009) Nat. Rev. Cancer , vol.9 , Issue.8 , pp. 550-562
    • Engelman, J.A.1
  • 72
    • 84856438988 scopus 로고    scopus 로고
    • Mutations of the catalytic subunit alpha of PI3K (PIK3CA)in erlotinib-treated non-small-cell lung cancer (NSCLC) patients (p) with epidermal growth factor receptor (EGFR) mutations
    • abstract 7588
    • Carcereny E, Molina MA, Sanchez JJ et al. Mutations of the catalytic subunit alpha of PI3K (PIK3CA) in erlotinib-treated non-small-cell lung cancer (NSCLC) patients (p) with epidermal growth factor receptor (EGFR) mutations J. Clin. Oncol. (Suppl. abstract 7588), 29 (2011).
    • (2011) J. Clin. Oncol. , Issue.SUPPL. , pp. 29
    • Carcereny, E.1    Molina, M.A.2    Sanchez, J.J.3
  • 73
    • 84856823963 scopus 로고    scopus 로고
    • Coexistence of PIK3CA and other oncogene mutations in lung adenocarcinoma-rationale for comprehensive mutation profiling
    • Chaft JE, Arcila ME, Paik PK et al. Coexistence of PIK3CA and other oncogene mutations in lung adenocarcinoma-rationale for comprehensive mutation profiling. Mol. Cancer Ther. 11(2), 485-491 (2011).
    • (2011) Mol. Cancer Ther. , vol.11 , Issue.2 , pp. 485-491
    • Chaft, J.E.1    Arcila, M.E.2    Paik, P.K.3
  • 74
    • 15744372810 scopus 로고    scopus 로고
    • KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib
    • Pao W, Wang TY, Riely GJ et al. KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib. PLoS Med. 2(1), e17 (2005).
    • (2005) PLoS Med. , vol.2 , Issue.1
    • Pao, W.1    Wang, T.Y.2    Riely, G.J.3
  • 76
    • 68049088934 scopus 로고    scopus 로고
    • EGFR/KRAS/BRAF mutations in primary lung adenocarcinomas and corresponding locoregional lymph node metastases
    • Schmid K, Oehl N, Wrba F et al. EGFR/KRAS/BRAF mutations in primary lung adenocarcinomas and corresponding locoregional lymph node metastases. Clin. Cancer Res. 15(14), 4554-4560 (2009).
    • (2009) Clin. Cancer Res. , vol.15 , Issue.14 , pp. 4554-4560
    • Schmid, K.1    Oehl, N.2    Wrba, F.3
  • 77
    • 38049155945 scopus 로고    scopus 로고
    • Regulation of DNA double-strand break repair pathway choice
    • Shrivastav M, De Haro LP, Nickoloff JA. Regulation of DNA double-strand break repair pathway choice. Cell Res. 18(1), 134-147 (2008).
    • (2008) Cell Res. , vol.18 , Issue.1 , pp. 134-147
    • Shrivastav, M.1    De Haro, L.P.2    Nickoloff, J.A.3
  • 79
    • 67649431893 scopus 로고    scopus 로고
    • Customized treatment in non-small-cell lung cancer based on EGFR mutations and BRCA1 mRNA expression
    • Rosell R, Perez-Roca L, Sanchez JJ et al. Customized treatment in non-small-cell lung cancer based on EGFR mutations and BRCA1 mRNA expression. PLoS ONE 4(5), e5133 (2009).
    • (2009) PLoS ONE , vol.4 , Issue.5
    • Rosell, R.1    Perez-Roca, L.2    Sanchez, J.J.3
  • 80
    • 76649094290 scopus 로고    scopus 로고
    • Inhibition of poly(ADP-ribose) polymerase down-regulates BRCA1 and RAD51 in a pathway mediated by E2F4 and p130
    • Hegan DC, Lu Y, Stachelek GC et al. Inhibition of poly(ADP-ribose) polymerase down-regulates BRCA1 and RAD51 in a pathway mediated by E2F4 and p130. Proc. Natl Acad. Sci. USA 107(5), 2201-2206 (2010).
    • (2010) Proc. Natl Acad. Sci. USA 107( , vol.5 , pp. 2201-2206
    • Hegan, D.C.1    Lu, Y.2    Stachelek, G.C.3
  • 81
    • 39149100913 scopus 로고    scopus 로고
    • Astrocyte elevated gene-1 activates cell survival pathways through PI3K-Akt signaling
    • DOI 10.1038/sj.onc.1210713, PII 1210713
    • Lee SG, Su ZZ, Emdad L, Sarkar D, Franke TF, Fisher PB. Astrocyte elevated gene-1 activates cell survival pathways through PI3K-Akt signaling. Oncogene 27(8), 1114-1121 (2008). (Pubitemid 351253177)
    • (2008) Oncogene , vol.27 , Issue.8 , pp. 1114-1121
    • Lee, S.-G.1    Su, Z.-Z.2    Emdad, L.3    Sarkar, D.4    Franke, T.F.5    Fisher, P.B.6
  • 82
    • 80053365354 scopus 로고    scopus 로고
    • MRNA expression levels and genetic status of genes involved in the EGFR and NF-kappaB pathways in metastatic non-small-cell lung cancer patients
    • Santarpia M, Magri I, Sanchez-Ronco M et al. mRNA expression levels and genetic status of genes involved in the EGFR and NF-kappaB pathways in metastatic non-small-cell lung cancer patients. J. Transl. Med. 9, 163 (2011).
    • (2011) J. Transl. Med. , vol.9 , pp. 163
    • Santarpia, M.1    Magri, I.2    Sanchez-Ronco, M.3
  • 83
    • 77955039099 scopus 로고    scopus 로고
    • Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: A proof-of-concept trial
    • Audeh MW, Carmichael J, Penson RT et al. Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial. Lancet 376(9737), 245-251 (2010).
    • (2010) Lancet , vol.376 , Issue.9737 , pp. 245-251
    • Audeh, M.W.1    Carmichael, J.2    Penson, R.T.3
  • 84
    • 77955019276 scopus 로고    scopus 로고
    • Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: A proof-of-concept trial
    • Tutt A, Robson M, Garber JE et al. Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial. Lancet 376(9737), 235-244.
    • Lancet , vol.376 , Issue.9737 , pp. 235-244
    • Tutt, A.1    Robson, M.2    Garber, J.E.3
  • 85
    • 66149163097 scopus 로고    scopus 로고
    • Combined vascular endothelial growth factor receptor and epidermal growth factor receptor (EGFR) blockade inhibits tumor growth in xenograft models of EGFR inhibitor resistance
    • Naumov GN, Nilsson MB, Cascone T et al. Combined vascular endothelial growth factor receptor and epidermal growth factor receptor (EGFR) blockade inhibits tumor growth in xenograft models of EGFR inhibitor resistance. Clin. Cancer Res. 15(10), 3484-3494 (2009).
    • (2009) Clin. Cancer Res. , vol.15 , Issue.10 , pp. 3484-3494
    • Naumov, G.N.1    Nilsson, M.B.2    Cascone, T.3


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