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This overview of several RCTs demonstrated that EGFR-TKIs demonstrated encouraging efficacy, safety and survival when delivered as maintenance therapy for patients with advanced NSCLC after first-line chemotherapy, especially for the patients who had adenocarcinomas, were female, non-smokers and patients with EGFR gene mutations
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.•• Alimujiang S, Zhang T, Han ZG, Yuan SF, Wang Q, Yu TT, et al. Epidermal growth factor receptor tyrosine kinase inhibitor versus placebo as maintenance therapy for advanced non- small-cell lung cancer: a meta-analysis of randomized controlled trials. Asian Pacific journal of cancer prevention : APJCP. 2013;14(4):2413-9. This overview of several RCTs demonstrated that EGFR-TKIs demonstrated encouraging efficacy, safety and survival when delivered as maintenance therapy for patients with advanced NSCLC after first-line chemotherapy, especially for the patients who had adenocarcinomas, were female, non-smokers and patients with EGFR gene mutations.
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doi:10.1371/journal.pone.0059314. This overview of several RCTs demonstrated that maintenance therapy with erlotinib or gefitinib produces a significant PFS and OS benefit for unselected patients with advanced NSCLC compared with placebo or observation. Given the less toxicity of TKIs than chemotherapy and simple oral administration, this treatment strategy seems to be of important clinical value
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.•• Chen X, Liu Y, Roe OD, Qian Y, Guo R, Zhu L, et al. Gefitinib or erlotinib as maintenance therapy in patients with advanced stage non-small cell lung cancer: a systematic review. PLoS One. 2013;8(3):e59314. doi:10.1371/journal.pone.0059314. This overview of several RCTs demonstrated that maintenance therapy with erlotinib or gefitinib produces a significant PFS and OS benefit for unselected patients with advanced NSCLC compared with placebo or observation. Given the less toxicity of TKIs than chemotherapy and simple oral administration, this treatment strategy seems to be of important clinical value.
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.•• Qi W-X, Shen Z, Lin F, Sun Y-J, Min D-L, Tang L-N, et al. Comparison of the Efficacy and Safety of EFGR Tyrosine Kinase Inhibitor Monotherapy with Standard Second-line Chemotherapy in Previously Treated Advanced Non-small-cell Lung Cancer: a Systematic Review and Meta-analysis. Asian Pacific Journal of Cancer Prevention. 2012;13(10):5177- 82. doi:10.7314/apjcp.2012.13.10.5177. This overview of several RCTs demonstrated that EGFR-TKI monotherapy tended to be more effective in East Asian patients in terms of PFS and ORR compared with standard second-line chemotherapy.
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doi:10.1093/jnci/djt072. This overview of a large number of RCTs demonstrated that EGFRTKIs therapy statistically significantly delays disease progression in EGFRmut + patients but has no demonstrable impact on OS. EGFR mutation is a predictive biomarker of PFS benefit with EGFR-TKIs treatment in all settings. This study and our study have certain similarities, so we refer to some of its methods and data
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.•• Lee CK, Brown C, Gralla RJ, Hirsh V, Thongprasert S, Tsai CM, et al. Impact of EGFR inhibitor in non-small cell lung cancer on progression-free and overall survival: a meta-analysis. J Natl Cancer Inst. 2013;105(9):595-605. doi:10.1093/jnci/djt072. This overview of a large number of RCTs demonstrated that EGFRTKIs therapy statistically significantly delays disease progression in EGFRmut + patients but has no demonstrable impact on OS. EGFR mutation is a predictive biomarker of PFS benefit with EGFR-TKIs treatment in all settings. This study and our study have certain similarities, so we refer to some of its methods and data.
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