Fibroblast growth factor receptor 1 amplification in non-small cell lung cancer by quantitative real-time PCR

PLoS ONE

Volumn 8, Issue 11, 2013, Pages

  Gadgeel, Shirish M ^a   Chen, Wei ^a   Cote, Michele L ^a   Bollig Fischer, Aliccia ^a   Land, Susan ^a   Schwartz, Ann G ^a   Bepler, Gerold ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FIBROBLAST GROWTH FACTOR RECEPTOR 1;

ADULT; AGED; ARTICLE; CANCER SURVIVAL; CELL LEVEL; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; COPY NUMBER VARIATION; DISEASE ASSOCIATION; EXON; FEMALE; FIBROBLAST GROWTH FACTOR REECEPTOR GENE; GENE; GENE AMPLIFICATION; GENE FREQUENCY; GENE FUNCTION; GENE IDENTIFICATION; GENE LOCATION; HUMAN; HUMAN CELL; LUNG ADENOCARCINOMA; LUNG NON SMALL CELL CANCER; LUNG SQUAMOUS CELL CARCINOMA; MALE; MOLECULAR DYNAMICS; OUTCOME ASSESSMENT; PROCESS OPTIMIZATION; PROTEIN DETERMINATION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; RELIABILITY; SURVIVAL RATE; TUMOR DIFFERENTIATION; VALIDATION PROCESS; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, NON-SMALL-CELL LUNG; COHORT STUDIES; DNA COPY NUMBER VARIATIONS; EXONS; FEMALE; GENE AMPLIFICATION; HUMANS; LUNG NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM STAGING; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 1;

EID: 84892512436     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0079820     Document Type: Article

References (23)

1. Larsen JE, Cascone T, Gerber DE, Heymach JV, Minna JD (2011) Targeted therapies for lung cancer: clinical experience and novel agents. Cancer J 17(6): 512-527. doi:10.1097/PPO. 0b013e31823e701a. PubMed: 22157296.
2. Oxnard GR, Binder A, Jänne PA (2013) New targetable oncogenes in non-small-cell lung cancer. J Clin Oncol 31(8): 1097-1104. doi:10.1200/JCO.2012. 42.9829. PubMed: 23401445.
3. Weiss J, Sos ML, Seidel D, Peifer M, Zander T et al. (2010) Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer. Sci Transl Med 2(62):62ra93. PubMed: 21160078.
4. Dutt A, Ramos AH, Hammerman PS, Mermel C, Cho J et al. (2011) Inhibitor-sensitive FGFR1 amplification in human non-small cell lung cancer. PLOS ONE 6(6): e20351. doi:10.1371/journal.pone.0020351. PubMed: 21666749.
5. Ahmad I, Iwata T, Leung HY (2012) Mechanisms of FGFR-mediated carcinogenesis. Biochim Biophys Acta 1823(4): 850-860. doi:10.1016/j.bbamcr. 2012.01.004. PubMed: 22273505.
6. Wolf J, LoRusso PM, Camidge RD, Perez JM, Tabernero J et al. (2012) Abstract LB-122: A phase I dose escalation study of NVP-BGJ398, a selective pan FGFR inhibitor in genetically preselected advanced solid tumors. Cancer Res 72(8 Supplement):LB-122
7. Kim HR, Kim DJ, Kang DR, Lee JG, Lim SM et al. (2013) Fibroblast growth factor receptor 1 gene amplification is associated with poor survival and cigarette smoking dosage in patients with resected squamous cell lung cancer. J Clin Oncol 31(6): 731-737. doi:10.1200/JCO.2012.43.8622. PubMed: 23182986.
8. Heist RS, Mino-Kenudson M, Sequist LV, Tammireddy S, Morrissey L et al. (2012) FGFR1 amplification in squamous cell carcinoma of the lung. J Thorac Oncol 7(12): 1775-1780. doi:10.1097/JTO. 0b013e31826aed28. PubMed: 23154548.
9. Zhang J, Zhang L, Su X, Li M, Xie L et al. (2012) Translating the therapeutic potential of AZD4547 in FGFR1-amplified non-small cell lung cancer through the use of patient-derived tumor xenograft models. Clin Cancer Res 18(24): 6658-6667. doi:10.1158/1078-0432.CCR-12-2694. PubMed: 23082000.
10. Pros E, Lantuejoul S, Sanchez-Verde L, Castillo SD, Bonastre E et al. (2013) Determining the profiles and parameters for gene amplification testing of growth factor receptors in lung cancer. Int J Cancer 133(4): 898-907. doi:10.1002/ijc.28090. PubMed: 23400671.
11. Schildhaus HU, Heukamp LC, Merkelbach-Bruse S, Riesner K, Schmitz K et al. (2012) Definition of a fluorescence in-situ hybridization score identifies high- and low-level FGFR1 amplification types in squamous cell lung cancer. Mod Pathol 25(11): 1473-1480. doi:10.1038/modpathol.2012.102. PubMed: 22684217.
12. Bepler G, Gautam A, McIntyre LM, Beck AF, Chervinsky DS et al. (2002) Prognostic significance of molecular genetic aberrations on chromosome segment 11p15.5 in non-small-cell lung cancer. J Clin Oncol 20(5): 1353-1360. doi:10.1200/JCO.20.5.1353. PubMed: 11870179.
13. Heid CA, Stevens J, Livak KJ, Williams PM (1996) Real time quantitative PCR. Genome Res 6 (10): 986-994. doi:10.1101/gr.6.10.986. PubMed: 8908518.
14. Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25(4): 402-408. doi:10.1006/meth.2001.1262. PubMed: 11846609.
15. Rubin DB (1977) Formalizing subjective notion about the effect of nonrespondents in sample surveys. J Am Stat Assoc 72: 538-543. doi:10.1080/01621459.1977.10480610.
16. Rubin DB (1987) Multiple imputation for nonreponse in surveys. New York: John Wiley & Sons.
17. R Development Core Team (2011) R: A language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing.
18. di ME, Tomlinson DC, Knowles MA (2012) A Decade of FGF Receptor Research in Bladder Cancer: Past, Present, and Future Challenges. Adv Urol 429213.
19. Gru AA, Allred DC (2012) FGFR1 amplification and the progression of non-invasive to invasive breast cancer. Breast Cancer Res 14(6): 116. doi:10.1186/bcr3340. PubMed: 23151501.
20. Mayr D, Kanitz V, Anderegg B, Luthardt B, Engel J et al. (2006) Analysis of gene amplification and prognostic markers in ovarian cancer using comparative genomic hybridization for microarrays and immunohistochemical analysis for tissue microarrays. Am J Clin Pathol 126(1): 101-109. doi:10.1309/ N6X5MB24BP42KP20. PubMed: 16753589.
21. Reis-Filho JS, Simpson PT, Turner NC, Lambros MB, Jones C et al. (2006) FGFR1 emerges as a potential therapeutic target for lobular breast carcinomas. Clin Cancer Res 12(22): 6652-6662. doi:10.1158/1078-0432.CCR-06-1164. PubMed: 17121884.
22. Young RJ, Lim AM, Angel C, Collins M, Deb S et al. (2013) Frequency of Fibroblast Growth Factor Receptor 1 gene amplification in oral tongue squamous cell carcinomas and associations with clinical features and patient outcome. Oral Oncol 49: 576-581. doi:10.1016/j.oraloncology.2013.01.006. PubMed: 23434054.
23. Cancer Genome Atlas Research Network (2012) Comprehensive genomic characterization of sqaumous cell lung cancer. Nature 489(7417): 519-525. doi:10.1038/nature11404. PubMed: 22960745.