메뉴 건너뛰기




Volumn 4, Issue 1, 2012, Pages 19-29

Erlotinib in the treatment of advanced non-small cell lung cancer: An update for clinicians

Author keywords

clinical trials; erlotinib; first line; non small cell lung cancer; treatment

Indexed keywords

CARBOPLATIN; CISPLATIN; ERLOTINIB; GEFITINIB; GEMCITABINE; PACLITAXEL; VASCULOTROPIN;

EID: 84863062587     PISSN: 17588340     EISSN: 17588359     Source Type: Journal    
DOI: 10.1177/1758834011427927     Document Type: Review
Times cited : (91)

References (44)
  • 1
    • 0036842170 scopus 로고    scopus 로고
    • Phase I safety, pharmacokinetic, and pharmacodynamic trial of ZD1839, a selective oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with five selected solid tumor types
    • Baselga J. Rischin D. Ranson M. Calvert H. Raymond E. Kieback D.G. et al. (2002) Phase I safety, pharmacokinetic, and pharmacodynamic trial of ZD1839, a selective oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with five selected solid tumor types. J Clin Oncol 20: 4292–4302.
    • (2002) J Clin Oncol , vol.20 , pp. 4292-4302
    • Baselga, J.1    Rischin, D.2    Ranson, M.3    Calvert, H.4    Raymond, E.5    Kieback, D.G.6
  • 2
    • 77953541527 scopus 로고    scopus 로고
    • Erlotinib as maintenance treatment in advanced non-small-cell lung cancer: a multicentre, randomised, placebo-controlled phase 3 study
    • Cappuzzo F. Ciuleanu T. Stelmakh L. Cicenas S. Szczesna A. Juhasz E. et al. (2010) Erlotinib as maintenance treatment in advanced non-small-cell lung cancer: a multicentre, randomised, placebo-controlled phase 3 study. Lancet Oncology, 11: 521–529.
    • (2010) Lancet Oncology , vol.11 , pp. 521-529
    • Cappuzzo, F.1    Ciuleanu, T.2    Stelmakh, L.3    Cicenas, S.4    Szczesna, A.5    Juhasz, E.6
  • 3
    • 84863011008 scopus 로고    scopus 로고
    • Survival benefit with erlotinib maintenance therapy in patients with advanced non-small-cell lung cancer (NSCLC) according to response to first-line chemotherapy
    • in press
    • Coudert B. Ciuleanu T. Park K. Wu Y.L. Giaccone G. Brugger W. et al. (2011) Survival benefit with erlotinib maintenance therapy in patients with advanced non-small-cell lung cancer (NSCLC) according to response to first-line chemotherapy. Ann Oncol, in press.
    • (2011) Ann Oncol
    • Coudert, B.1    Ciuleanu, T.2    Park, K.3    Wu, Y.L.4    Giaccone, G.5    Brugger, W.6
  • 4
    • 52049096854 scopus 로고    scopus 로고
    • Gefitinib versus vinorelbine in chemotherapy-naive elderly patients with advanced non-small-cell lung cancer (INVITE): a randomized, phase II study
    • Crino L. Cappuzzo F. Zatloukal P. Reck M. Pesek M. Thompson J.C. et al. (2008) Gefitinib versus vinorelbine in chemotherapy-naive elderly patients with advanced non-small-cell lung cancer (INVITE): a randomized, phase II study. J Clin Oncol 26: 4253–4260.
    • (2008) J Clin Oncol , vol.26 , pp. 4253-4260
    • Crino, L.1    Cappuzzo, F.2    Zatloukal, P.3    Reck, M.4    Pesek, M.5    Thompson, J.C.6
  • 5
    • 24944578615 scopus 로고    scopus 로고
    • Epidermal growth factor receptor tyrosine kinase inhibitors plus chemotherapy: case closed or is the jury still out?
    • Gandara D.R. Gumerlock P.H. (2005) Epidermal growth factor receptor tyrosine kinase inhibitors plus chemotherapy: case closed or is the jury still out? J Clin Oncol 23: 5856–5858.
    • (2005) J Clin Oncol , vol.23 , pp. 5856-5858
    • Gandara, D.R.1    Gumerlock, P.H.2
  • 6
    • 34248140107 scopus 로고    scopus 로고
    • Phase III study of erlotinib in combination with cisplatin and gemcitabine in advanced non-small-cell lung cancer: the Tarceva Lung Cancer Investigation Trial. J Clin Oncol
    • Gatzemerier U. Pluzanska A. Szczesna A. Kaukel E. Roubec J. de Rosa F. et al. (2007) Phase III study of erlotinib in combination with cisplatin and gemcitabine in advanced non-small-cell lung cancer: the Tarceva Lung Cancer Investigation Trial. J Clin Oncol, 25: 1545–1552.
    • (2007) , vol.25 , pp. 1545-1552
    • Gatzemerier, U.1    Pluzanska, A.2    Szczesna, A.3    Kaukel, E.4    Roubec, J.5    de Rosa, F.6
  • 7
    • 1542503746 scopus 로고    scopus 로고
    • Gefitinib in combination with gemcitabine and cisplatin in advanced non-small-cell lung cancer: a phase III trial–INTACT 1
    • Giaccone G. Herbst R.S. Manegold C. Scagliotti G. Rosell R. Miller V. et al. (2004) Gefitinib in combination with gemcitabine and cisplatin in advanced non-small-cell lung cancer: a phase III trial–INTACT 1. J Clin Oncol, 22: 777–784.
    • (2004) J Clin Oncol , vol.22 , pp. 777-784
    • Giaccone, G.1    Herbst, R.S.2    Manegold, C.3    Scagliotti, G.4    Rosell, R.5    Miller, V.6
  • 9
    • 65549154268 scopus 로고    scopus 로고
    • Randomized phase II study of gefitinib compared with placebo in chemotherapy-naive patients with advanced non-small-cell lung cancer and poor performance status
    • Goss G. Ferry D. Wierzbicki R. Laurie S.A. Thompson J. Biesma B. et al. (2009) Randomized phase II study of gefitinib compared with placebo in chemotherapy-naive patients with advanced non-small-cell lung cancer and poor performance status. J Clin Oncol 27: 2253–2260.
    • (2009) J Clin Oncol , vol.27 , pp. 2253-2260
    • Goss, G.1    Ferry, D.2    Wierzbicki, R.3    Laurie, S.A.4    Thompson, J.5    Biesma, B.6
  • 10
    • 63849290363 scopus 로고    scopus 로고
    • Potential treatment options after first-line chemotherapy for advanced NSCLC: maintenance treatment or early second-line?
    • Gridelli C. Maione P. Rossi A. Ferrara M.L. Bareschino M.A. Schettino C. et al. 2009. Potential treatment options after first-line chemotherapy for advanced NSCLC: maintenance treatment or early second-line? Oncologist 14: 137–147.
    • (2009) Oncologist , vol.14 , pp. 137-147
    • Gridelli, C.1    Maione, P.2    Rossi, A.3    Ferrara, M.L.4    Bareschino, M.A.5    Schettino, C.6
  • 11
    • 11444253115 scopus 로고    scopus 로고
    • Factors associated with the likelihood of receiving second line therapy for advanced non-small cell lung cancer
    • Hensing T.A. Schell M.J. Lee J.H. Socinski M.A. (2005) Factors associated with the likelihood of receiving second line therapy for advanced non-small cell lung cancer. Lung Cancer 47: 253–259.
    • (2005) Lung Cancer , vol.47 , pp. 253-259
    • Hensing, T.A.1    Schell, M.J.2    Lee, J.H.3    Socinski, M.A.4
  • 12
    • 0037106377 scopus 로고    scopus 로고
    • Selective oral epidermal growth factor receptor tyrosine kinase inhibitor ZD 1839 is generally well-tolerated and has activity in non-small-cell lung cancer and other solid tumors: results of a phase I trial
    • Herbst R.S. Maddox A.M. Rothenberg M.L. Small E.J. Rubin E.H. Baselga J. et al. (2002) Selective oral epidermal growth factor receptor tyrosine kinase inhibitor ZD 1839 is generally well-tolerated and has activity in non-small-cell lung cancer and other solid tumors: results of a phase I trial. J Clin Oncol 20: 3815–3825.
    • (2002) J Clin Oncol , vol.20 , pp. 3815-3825
    • Herbst, R.S.1    Maddox, A.M.2    Rothenberg, M.L.3    Small, E.J.4    Rubin, E.H.5    Baselga, J.6
  • 13
    • 1542713370 scopus 로고    scopus 로고
    • Gefitinib in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: a phase III trial–INTACT 2
    • Herbst R.S. Giaccone G. Schiller J.H. Natale R.B. Miller V. Manegold C. et al. (2004) Gefitinib in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: a phase III trial–INTACT 2. J Clin Oncol, 22: 785–794.
    • (2004) J Clin Oncol , vol.22 , pp. 785-794
    • Herbst, R.S.1    Giaccone, G.2    Schiller, J.H.3    Natale, R.B.4    Miller, V.5    Manegold, C.6
  • 14
    • 24944440830 scopus 로고    scopus 로고
    • TRIBUTE: a phase III trial of erlotinib hydrochloride (OSI-774) combined with carboplatin and paclitaxel chemotherapy in advanced non-small-cell lung cancer
    • Herbst R.S. Prager D. Hermann R. Fehrenbacher L. Johnson B.E. Sandler A. et al. (2005) TRIBUTE: a phase III trial of erlotinib hydrochloride (OSI-774) combined with carboplatin and paclitaxel chemotherapy in advanced non-small-cell lung cancer. J Clin Oncol 23: 5892–5899.
    • (2005) J Clin Oncol , vol.23 , pp. 5892-5899
    • Herbst, R.S.1    Prager, D.2    Hermann, R.3    Fehrenbacher, L.4    Johnson, B.E.5    Sandler, A.6
  • 15
    • 58149132477 scopus 로고    scopus 로고
    • Southwest Oncology Group phase II trial (S0341) of erlotinib (OSI-774) in patients with advanced non-small cell lung cancer and a performance status of 2
    • Hesketh P.J. Chansky K. Wozniak A.J. Hirsch F.R. Spreafico A. Moon J. et al. (2008) Southwest Oncology Group phase II trial (S0341) of erlotinib (OSI-774) in patients with advanced non-small cell lung cancer and a performance status of 2. J Thorac Oncol 3: 1026–1031.
    • (2008) J Thorac Oncol , vol.3 , pp. 1026-1031
    • Hesketh, P.J.1    Chansky, K.2    Wozniak, A.J.3    Hirsch, F.R.4    Spreafico, A.5    Moon, J.6
  • 16
    • 0035398631 scopus 로고    scopus 로고
    • Phase I and pharmacologic study of OSI-774, an epidermal growth factor receptor tyrosine kinase inhibitor, in patients with advanced solid malignancies
    • Hidalgo M. Siu L.L. Nemunaitis J. Rizzo J. Hammond L.A. Takimoto C. et al. (2001) Phase I and pharmacologic study of OSI-774, an epidermal growth factor receptor tyrosine kinase inhibitor, in patients with advanced solid malignancies. J Clin Oncol 19: 3267–3279.
    • (2001) J Clin Oncol , vol.19 , pp. 3267-3279
    • Hidalgo, M.1    Siu, L.L.2    Nemunaitis, J.3    Rizzo, J.4    Hammond, L.A.5    Takimoto, C.6
  • 17
    • 2942511506 scopus 로고    scopus 로고
    • Antitumor activity of erlotinib (OSI-774, Tarceva) alone or in combination in human non-small cell lung cancer tumor xenograft models
    • Higgins B. Kolinsky K. Smith M. Beck G. Rashed M. Adames V. et al. (2004) Antitumor activity of erlotinib (OSI-774, Tarceva) alone or in combination in human non-small cell lung cancer tumor xenograft models. Anticancer Drugs 15: 503–512.
    • (2004) Anticancer Drugs , vol.15 , pp. 503-512
    • Higgins, B.1    Kolinsky, K.2    Smith, M.3    Beck, G.4    Rashed, M.5    Adames, V.6
  • 18
    • 80052972204 scopus 로고    scopus 로고
    • A randomized, phase II, biomarker-selected study comparing erlotinib to erlotinib intercalated with chemotherapy in first-line therapy for advanced non-small-cell lung cancer
    • Hirsch F.R. Kabbinavar F. Eisen T. Martins R. Schnell F.M. Dziadziuszko R. et al. (2011) A randomized, phase II, biomarker-selected study comparing erlotinib to erlotinib intercalated with chemotherapy in first-line therapy for advanced non-small-cell lung cancer. J Clin Oncol 29: 3567–3573.
    • (2011) J Clin Oncol , vol.29 , pp. 3567-3573
    • Hirsch, F.R.1    Kabbinavar, F.2    Eisen, T.3    Martins, R.4    Schnell, F.M.5    Dziadziuszko, R.6
  • 20
    • 78449274913 scopus 로고    scopus 로고
    • Overall survival (OS) in ATLAS, a phase IIIb trial comparing bevacizumab (B) therapy with or without erlotinib (E) after completion of chemotherapy (chemo) with B for first-line treatment of locally advanced, recurrent, or metastatic non-small cell lung cancer (NSCLC)
    • suppl; abstr 7526
    • Kabbinavar F. Miller V. Johnson B. O'Connor P. Soh C. (2010) Overall survival (OS) in ATLAS, a phase IIIb trial comparing bevacizumab (B) therapy with or without erlotinib (E) after completion of chemotherapy (chemo) with B for first-line treatment of locally advanced, recurrent, or metastatic non-small cell lung cancer (NSCLC). J Clin Oncol 28: 15s (suppl; abstr 7526).
    • (2010) J Clin Oncol , vol.28 , pp. 15s
    • Kabbinavar, F.1    Miller, V.2    Johnson, B.3    O'Connor, P.4    Soh, C.5
  • 21
    • 84993826907 scopus 로고    scopus 로고
    • A randomized phase III study of gefitinib (IRESSA) versus standard chemotherapy (gemcitabine plus cisplatin) as a first-line treatment for never smokers with advanced or metastatic adenocarcinoma of the lung
    • 13th Biennial World Conference on Lung Cancer of the International Association of the Study of Lung Cancer (IASLC) San Francisco
    • Lee J. Park K. Kim S. Lee D. (2009) A randomized phase III study of gefitinib (IRESSA) versus standard chemotherapy (gemcitabine plus cisplatin) as a first-line treatment for never smokers with advanced or metastatic adenocarcinoma of the lung. 13th Biennial World Conference on Lung Cancer of the International Association of the Study of Lung Cancer (IASLC); San Francisco 2009.
    • (2009)
    • Lee, J.1    Park, K.2    Kim, S.3    Lee, D.4
  • 22
    • 78651108994 scopus 로고    scopus 로고
    • Phase II study of erlotinib for chemotherapy-naive patients with advanced or metastatic non-small cell lung cancer who are ineligible for platinum doublets
    • Lee D.H. Kim S.W. Suh C. Han Y.H. Lee J.S. (2011) Phase II study of erlotinib for chemotherapy-naive patients with advanced or metastatic non-small cell lung cancer who are ineligible for platinum doublets. Cancer Chemother Pharmacol 67: 35–39.
    • (2011) Cancer Chemother Pharmacol , vol.67 , pp. 35-39
    • Lee, D.H.1    Kim, S.W.2    Suh, C.3    Han, Y.H.4    Lee, J.S.5
  • 23
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
    • Lynch T.J. Bell D.W. Sordella R. Gurubhagavatula S. Okimoto R.A. Brannigan B.W. et al. (2004) Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 350: 2129–2139.
    • (2004) N Engl J Med , vol.350 , pp. 2129-2139
    • Lynch, T.J.1    Bell, D.W.2    Sordella, R.3    Gurubhagavatula, S.4    Okimoto, R.A.5    Brannigan, B.W.6
  • 24
    • 77953930730 scopus 로고    scopus 로고
    • Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR
    • Maemondo M. Inoue A. Kobayashi K. Sugawara S. Oizumi S. Isobe H. et al. (2010) Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR. N Engl J Med 362: 2380–2388.
    • (2010) N Engl J Med , vol.362 , pp. 2380-2388
    • Maemondo, M.1    Inoue, A.2    Kobayashi, K.3    Sugawara, S.4    Oizumi, S.5    Isobe, H.6
  • 25
    • 70349477817 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled, phase IIIb trial (ATLAS) comparing bevacizumab (B) therapy with or without erlotinib (E) after completion of chemotherapy with B for first-line treatment of locally advanced, recurrent, or metastatic non-small cell lung cancer (NSCLC)
    • suppl; abstr LBA8002
    • Miller V. O'Connor P. Soh C. Kabbinavar F. (2009) A randomized, double-blind, placebo-controlled, phase IIIb trial (ATLAS) comparing bevacizumab (B) therapy with or without erlotinib (E) after completion of chemotherapy with B for first-line treatment of locally advanced, recurrent, or metastatic non-small cell lung cancer (NSCLC). J Clin Oncol 27: 18s (suppl; abstr LBA8002).
    • (2009) J Clin Oncol , vol.27 , pp. 18s
    • Miller, V.1    O'Connor, P.2    Soh, C.3    Kabbinavar, F.4
  • 26
    • 75249087060 scopus 로고    scopus 로고
    • Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial
    • Mitsudomi T. Morita S. Yatabe Y. Negoro S. Okamoto I. Tsurutani J. et al. (2010) Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial. Lancet Oncol 11: 121–128.
    • (2010) Lancet Oncol , vol.11 , pp. 121-128
    • Mitsudomi, T.1    Morita, S.2    Yatabe, Y.3    Negoro, S.4    Okamoto, I.5    Tsurutani, J.6
  • 28
    • 75249084998 scopus 로고    scopus 로고
    • Randomized, placebo-controlled, phase II study of sequential erlotinib and chemotherapy as first-line treatment for advanced non-small-cell lung cancer
    • Mok T.S. Wu Y.L. Yu C.J. Zhou C. Chen Y.M. Zhang L. et al. (2009 b) Randomized, placebo-controlled, phase II study of sequential erlotinib and chemotherapy as first-line treatment for advanced non-small-cell lung cancer. J Clin Oncol 27: 5080–5087.
    • (2009) J Clin Oncol , vol.27 , pp. 5080-5087
    • Mok, T.S.1    Wu, Y.L.2    Yu, C.J.3    Zhou, C.4    Chen, Y.M.5    Zhang, L.6
  • 29
    • 33644845421 scopus 로고    scopus 로고
    • First-line single agent treatment with gefitinib in patients with advanced non-small-cell lung cancer: a phase II study
    • Niho S. Kubota K. Goto K. Yoh K. Ohmatsu H. Kakinuma R. et al. (2006) First-line single agent treatment with gefitinib in patients with advanced non-small-cell lung cancer: a phase II study. J Clin Oncol 24: 64–69.
    • (2006) J Clin Oncol , vol.24 , pp. 64-69
    • Niho, S.1    Kubota, K.2    Goto, K.3    Yoh, K.4    Ohmatsu, H.5    Kakinuma, R.6
  • 30
    • 1642421130 scopus 로고    scopus 로고
    • Target-based agents against ErbB receptors and their ligands: a novel approach to cancer treatment
    • Normanno N. Bianco C. de Luca A. Maiello M.R. Salomon D.S. (2003) Target-based agents against ErbB receptors and their ligands: a novel approach to cancer treatment. Endocr Relat Cancer 10: 1–21.
    • (2003) Endocr Relat Cancer , vol.10 , pp. 1-21
    • Normanno, N.1    Bianco, C.2    de Luca, A.3    Maiello, M.R.4    Salomon, D.S.5
  • 31
    • 2342624080 scopus 로고    scopus 로고
    • EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy
    • Paez J.G. Janne P.A. Lee J.C. Tracy S. Greulich H. Gabriel S. et al. (2004) EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 304: 1497–1500.
    • (2004) Science , vol.304 , pp. 1497-1500
    • Paez, J.G.1    Janne, P.A.2    Lee, J.C.3    Tracy, S.4    Greulich, H.5    Gabriel, S.6
  • 32
    • 0032695910 scopus 로고    scopus 로고
    • Inhibition of epidermal growth factor receptor-associated tyrosine phosphorylation in human carcinomas with CP-358,774: dynamics of receptor inhibition in situ and antitumor effects in athymic mice
    • Pollack V.A. Savage D.M. Baker D.A. Tsaparikos K.E. Sloan D.E. Moyer J.D. et al. (1999) Inhibition of epidermal growth factor receptor-associated tyrosine phosphorylation in human carcinomas with CP-358,774: dynamics of receptor inhibition in situ and antitumor effects in athymic mice. J Pharmacol Exp Ther 291: 739–748.
    • (1999) J Pharmacol Exp Ther , vol.291 , pp. 739-748
    • Pollack, V.A.1    Savage, D.M.2    Baker, D.A.3    Tsaparikos, K.E.4    Sloan, D.E.5    Moyer, J.D.6
  • 33
    • 33745616124 scopus 로고    scopus 로고
    • First line chemotherapy in advanced or metastatic NSCLC
    • Rinaldi M. Cauchi C. Gridelli C. (2006) First line chemotherapy in advanced or metastatic NSCLC. Ann Oncol 17(Suppl. 5): v64-v67.
    • (2006) Ann Oncol , vol.17 , pp. v64-v67
    • Rinaldi, M.1    Cauchi, C.2    Gridelli, C.3
  • 34
    • 80053561215 scopus 로고    scopus 로고
    • Erlotinib versus chemotherapy (CT) in advanced non-small cell lung cancer (NSCLC) patients (p) with epidermal growth factor receptor (EGFR) mutations: Interim results of the European Erlotinib Versus Chemotherapy (EURTAC) phase III randomized trial
    • abstract 7503
    • Rosell R. Gervais R. Vergnenegre A. Massuti B. Felip E. Cardenal F. et al. (2011) Erlotinib versus chemotherapy (CT) in advanced non-small cell lung cancer (NSCLC) patients (p) with epidermal growth factor receptor (EGFR) mutations: Interim results of the European Erlotinib Versus Chemotherapy (EURTAC) phase III randomized trial. J Clin Oncol 29(Suppl.): abstract 7503.
    • (2011) J Clin Oncol , vol.29
    • Rosell, R.1    Gervais, R.2    Vergnenegre, A.3    Massuti, B.4    Felip, E.5    Cardenal, F.6
  • 36
    • 5644303684 scopus 로고    scopus 로고
    • A randomized placebo-controlled trial of erlotinib in patients with advanced non-small cell lung cancer (NSCLC) following failure of 1(st) line or 2(nd) line chemotherapy. A National Cancer Institute of Canada Clinical Trials Group (NCIC CTG) trial
    • Shepherd F.A. Pereira J. Ciuleanu T.E. Tan E.H. Hirsh V. Thongprasert S. et al. (2004) A randomized placebo-controlled trial of erlotinib in patients with advanced non-small cell lung cancer (NSCLC) following failure of 1(st) line or 2(nd) line chemotherapy. A National Cancer Institute of Canada Clinical Trials Group (NCIC CTG) trial. J Clin Oncol 22: 622s–622s.
    • (2004) J Clin Oncol , vol.22 , pp. 622s-622s
    • Shepherd, F.A.1    Pereira, J.2    Ciuleanu, T.E.3    Tan, E.H.4    Hirsh, V.5    Thongprasert, S.6
  • 38
    • 0032733015 scopus 로고    scopus 로고
    • Comparative genomic hybridization analysis of natural killer cell lymphoma/leukemia. Recognition of consistent patterns of genetic alterations
    • Siu L.L. Wong K.F. Chan J.K. Kwong Y.L. (1999) Comparative genomic hybridization analysis of natural killer cell lymphoma/leukemia. Recognition of consistent patterns of genetic alterations. Am J Pathol 155: 1419–1425.
    • (1999) Am J Pathol , vol.155 , pp. 1419-1425
    • Siu, L.L.1    Wong, K.F.2    Chan, J.K.3    Kwong, Y.L.4
  • 39
    • 27544503230 scopus 로고    scopus 로고
    • Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer)
    • Thatcher N. Chang A. Parikh P. Rodrigues Pereira J. Ciuleanu T. et al. (2005) Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer). Lancet, 366: 1527–1537.
    • (2005) Lancet , vol.366 , pp. 1527-1537
    • Thatcher, N.1    Chang, A.2    Parikh, P.3    Rodrigues Pereira, J.4    Ciuleanu, T.5
  • 40
    • 77649184990 scopus 로고    scopus 로고
    • Pooled analysis of the reports of erlotinib after failure of gefitinib for non-small cell lung cancer
    • Yamamoto N. Kaira K. Naito T. Takahashi T. Ayabe E. Shimoyama R. et al. (2010) Pooled analysis of the reports of erlotinib after failure of gefitinib for non-small cell lung cancer. Lung Cancer 68: 99–104.
    • (2010) Lung Cancer , vol.68 , pp. 99-104
    • Yamamoto, N.1    Kaira, K.2    Naito, T.3    Takahashi, T.4    Ayabe, E.5    Shimoyama, R.6
  • 41
    • 45749120442 scopus 로고    scopus 로고
    • Specific EGFR mutations predict treatment outcome of stage IIIB / IV patients with chemotherapy-naive non-small-cell lung cancer receiving first-line gefitinib monotherapy
    • Yang C.H. Yu C.J. Shih J.Y. Chang Y.C. Hu F.C. Tsai M.C. et al. (2008) Specific EGFR mutations predict treatment outcome of stage IIIB / IV patients with chemotherapy-naive non-small-cell lung cancer receiving first-line gefitinib monotherapy. J Clin Oncol 26: 2745–2753.
    • (2008) J Clin Oncol , vol.26 , pp. 2745-2753
    • Yang, C.H.1    Yu, C.J.2    Shih, J.Y.3    Chang, Y.C.4    Hu, F.C.5    Tsai, M.C.6
  • 42
    • 22244480031 scopus 로고    scopus 로고
    • Clinical features of 5,628 primary lung cancer patients: experience at Mayo Clinic from 1997 to 2003
    • Yang P. Allen M.S. Aubry M.C. Wampfler J.A. Marks R.S. Edell E.S. et al. (2005) Clinical features of 5,628 primary lung cancer patients: experience at Mayo Clinic from 1997 to 2003. Chest 128: 452–462.
    • (2005) Chest , vol.128 , pp. 452-462
    • Yang, P.1    Allen, M.S.2    Aubry, M.C.3    Wampfler, J.A.4    Marks, R.S.5    Edell, E.S.6
  • 43
    • 80054731248 scopus 로고    scopus 로고
    • Efficacy, tolerability, and biomarker analyses from a phase III, randomized, placebo-controlled, parallel group study of gefitinib as maintenance therapy in patients with locally advanced or metastatic non-small cell lung cancer (NSCLC; INFORM; C-TONG 0804)
    • abstract LBA7511
    • Zhang L. Shenglin M. Song X. Han B. Cheng Y. Huang C. et al. (2011) Efficacy, tolerability, and biomarker analyses from a phase III, randomized, placebo-controlled, parallel group study of gefitinib as maintenance therapy in patients with locally advanced or metastatic non-small cell lung cancer (NSCLC; INFORM; C-TONG 0804). J Clin Oncol 29(Suppl.): abstract LBA7511.
    • (2011) J Clin Oncol , vol.29
    • Zhang, L.1    Shenglin, M.2    Song, X.3    Han, B.4    Cheng, Y.5    Huang, C.6
  • 44
    • 79960889662 scopus 로고    scopus 로고
    • Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study
    • Zhou C. Wu Y.L. Chen G. Feng J. Liu X.Q. Wang C. et al. (2011) Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study. Lancet Oncol 12: 735–742.
    • (2011) Lancet Oncol , vol.12 , pp. 735-742
    • Zhou, C.1    Wu, Y.L.2    Chen, G.3    Feng, J.4    Liu, X.Q.5    Wang, C.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.