Protective effects of diallyl disulfide on carbon tetrachloride-induced hepatotoxicity through activation of Nrf2

Environmental Toxicology

Volumn 30, Issue 5, 2015, Pages 538-548

  Lee, In Chul ^a   Kim, Sung Hwan ^a   Baek, Hyung Seon ^a   Moon, Changjong ^a   Kim, Sung Ho ^a   Kim, Yun Bae ^b   Yun, Won Kee ^c   Kim, Hyoung Chin ^c   Kim, Jong Choon ^a  

^a Chonnam National University   (South Korea)

^b Chungbuk National University   (South Korea)

^c Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

Author keywords

Carbon tetrachloride; Cytochrome P450 2E1; Diallyl disulfide; Hepatotoxicity; Nuclear factor E2 related factor 2

Indexed keywords

AMINO ACIDS; ANTIOXIDANTS; CARBON; CARBON TETRACHLORIDE; CHEMICAL ACTIVATION; ENZYMES; PROTEINS; SULFUR COMPOUNDS;

ALANINE AMINOTRANSFERASE; ANTIOXIDANT ENZYME ACTIVITY; CYTOCHROME P450; DIALLYL DISULFIDE; HEPATOTOXICITY; HISTOPATHOLOGICAL EXAMINATIONS; NUCLEAR TRANSLOCATIONS; RELATED FACTORS;

CARBON DISULFIDE;

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CARBON TETRACHLORIDE; COPPER ZINC SUPEROXIDE DISMUTASE; CYTOCHROME P450 2E1; DIALLYL DISULFIDE; GLUTAMATE CYSTEINE LIGASE; GLUTAMATE CYSTEINE LIGASE CATALYTIC SUBUNIT; GLUTATHIONE; GLUTATHIONE TRANSFERASE; HEME OXYGENASE 1; MALONALDEHYDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE QUININE OXIDOREDUCTASE 1; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; ALLYL COMPOUND; ANTIOXIDANT; DISULFIDE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BODY WEIGHT; CELL INFILTRATION; CONTROLLED STUDY; CYTOSOL; DOWN REGULATION; ENZYME ACTIVITY; FATTY LIVER; HISTOPATHOLOGY; INFLAMMATORY CELL; LIVER INJURY; LIVER NECROSIS; LIVER PROTECTION; LIVER TOXICITY; LIVER WEIGHT; MALE; METABOLIC ACTIVATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SINGLE DRUG DOSE; UPREGULATION; WESTERN BLOTTING; ANIMAL; CARBON TETRACHLORIDE POISONING; DOSE RESPONSE; DRUG EFFECTS; GENETICS; LIPID PEROXIDATION; LIVER MICROSOME; METABOLISM; ORGAN SIZE; PATHOLOGY; SPRAGUE DAWLEY RAT; TOXIC HEPATITIS;

RATTUS;

ACTIVATION, METABOLIC; ALLYL COMPOUNDS; ANIMALS; ANTIOXIDANTS; BODY WEIGHT; CARBON TETRACHLORIDE POISONING; CYTOCHROME P-450 CYP2E1; CYTOSOL; DISULFIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG-INDUCED LIVER INJURY; LIPID PEROXIDATION; MALE; MICROSOMES, LIVER; NF-E2-RELATED FACTOR 2; ORGAN SIZE; RATS; RATS, SPRAGUE-DAWLEY; UP-REGULATION;

EID: 84928273604     PISSN: 15204081     EISSN: 15227278     Source Type: Journal    
DOI: 10.1002/tox.21930     Document Type: Article

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