Diallyl sulfide enhances antioxidants and inhibits inflammation through the activation of Nrf2 against gentamicin-induced nephrotoxicity in Wistar rats

European Journal of Pharmacology

Volumn 606, Issue 1-3, 2009, Pages 162-171

  Kalayarasan, Srinivasan ^a   Prabhu, Ponnuraj Nagendra ^a   Sriram, Narayanan ^a   Manikandan, Ramar ^a   Arumugam, Munusamy ^a   Sudhandiran, Ganapasam ^a  

^a UNIVERSITY OF MADRAS   (India)

Author keywords

Diallyl sulfide; Gentamicin; Nephrotoxicity; Nuclear factor E2 related factor 2 (Nrf2); Oxidative stress; Reactive oxygen species (ROS)

Indexed keywords

ALLYL SULFIDE; ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; CATALASE; DIRITHROMYCIN; GENTAMICIN; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; MYELOPEROXIDASE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); THIOBARBITURIC ACID REACTIVE SUBSTANCE; TRANSCRIPTION FACTOR NRF2; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; HISTOPATHOLOGY; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; INFLAMMATION; KIDNEY FUNCTION TEST; LIPID PEROXIDATION; MALE; NEPHROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RENAL PROTECTION; TREATMENT DURATION; WESTERN BLOTTING; WISTAR RAT;

ALLYL COMPOUNDS; ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; ASCORBIC ACID; BIOLOGICAL MARKERS; ENZYME INDUCTION; GENTAMICINS; GLUTATHIONE; INFLAMMATION; KIDNEY; KIDNEY GLOMERULUS; KIDNEY TUBULES; LIPID PEROXIDATION; MALE; NF-E2-RELATED FACTOR 2; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE II; OXIDATIVE STRESS; PEROXIDASE; RATS; RATS, WISTAR; SULFIDES; TUMOR NECROSIS FACTOR-ALPHA; VITAMIN E;

EID: 61449134946     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2008.12.055     Document Type: Article

References (76)

1. Ali B.H. Gentamicin nephrotoxicity in humans and animals: some recent research. Gen. Pharmacol. 26 (1995) 1477-1487
2. Ali B.H. Agents ameliorating or augmenting experimental gentamicin nephrotoxicity: some recent research. Food Chem. Toxicol. 41 (2003) 1447-1452
3. Appel G.B. Aminoglycoside nephrotoxicity. Am. J. Med. 88 (1990) 16S-20S
4. Baud L., and Ardaillou R. Tumor necrosis factor alpha in glomerular injury. Kidney Inter., Suppl. 45 (1994) S32-36
5. Benson A.M., Hunkeler M.J., and Talalay P. Increase of NAD(P)H:quinone reductase by dietary antioxidants: possible role in protection against carcinogenesis and toxicity. Proc. Natl. Acad. Sci. U. S. A. 77 (1980) 5216-5220
6. Buettner G.R. The pecking order of free radicals and antioxidants; lipid peroxidation, alpha-tocopherol and ascorbate. Arch. Biochem. Biophys. 300 (1993) 535-543
7. Caraway W.T. Uric acid. In: Seligson D. (Ed). Standard Methods of Clinical Chemistry (1963), Academic press, New York 239-247
8. Chan J.Y., and Kwong M. Impaired expression of glutathione synthetic enzyme genes in mice with targeted deletion of the Nrf2 basic-leucine zipper protein. Biochim. Biophys. Acta 1517 (2000) 19-26
9. Copple I.M., Goldring C.E., Kitteringham N.R., and Park B.K. The Nrf2-Keap1 defence pathway: role in protection against drug-induced toxicity. Toxicology 246 (2007) 24-33
10. Cuzzocrea S., Mazzon E., Dugo L., Serraino I., Di Paola R., Britti D., De Sarro A., Pierpaoli S., Caputi A., Masini E., and Salvemini D. A role for superoxide in gentamicin-mediated nephropathy in rats. Eur. J. Pharmacol. 16 (2002) 67-76
11. Dausch J.G., and Nixon D.W. Garlic: a review of its relationship to malignant disease. Prev. Med. 19 (1990) 346-361
12. Desai I.D. Vitamin E analysis methods for animal tissues. Methods Enzymol. 105 (1984) 138-147
13. Elbling L., Weiss R.M., Teufelhofer O., Uhl M., Knasmueller S., Schulte-Hermann R., Berger W., and Micksche M. Green tea extract and (-)-epigallocatechin-3-gallate, the major tea catechin, exert oxidant but lack antioxidant activities. FASEB J. 19 (2005) 807-809
14. Ellman G.L. Tissue sulfhydryl groups. Arch. Biochem. Biophys. 82 (1959) 70-77
15. Enomoto A., Itoh K., Nagayoshi E., Haruta J., Kimura T., O'Connor T., Harada T., and Yamamoto M. High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes. Toxicol. Sci. 59 (2001) 169-177
16. Erdem A., Gundogan N.U., Usubutun A., Kilinc K., Erdem S.R., Kara A., and Bozkurt A. The protective effect of taurine against gentamicin-induced acute tubular necrosis in rats. Nephrol. Dial. Transplant. 15 (2000) 1175-1182
17. Farombi E.O., and Ekor M. Curcumin attenuates gentamicin-induced renal oxidative damage in rats. Food Chem. Toxicol. 44 (2006) 1443-1448
18. Fridovich I. Super oxide dismutases. Ann. Rev. Biochem. 44 (1975) 147-159
19. Ghaznavi R., and Kadokhodaee M. Comparative effects of selective and non-selective nitric oxide synthase inhibition in gentamicin-induced rat nephrotoxicity. Arch. Toxicol. 81 (2007) 453-457
20. Ghaznavi R., Faghihi M., Kadokhodaee M., Shams S., and Khastar H. Effects of nitric oxide on gentamicin toxicity in isolated perfused rat kidneys. J. Nephrol. 18 (2005) 548-552
21. Grudzinski I.P., Frankiewicz-Jozko A., and Bany J. Diallyl sulfide - a flavour component from garlic (Allium sativum) attenuates lipid peroxidation in mice infected with Trichinella spiralis. Phytomedicine 8 (2001) 174-177
22. Guijarro C., and Egido J. Transcription factor-κB and renal disease. Kidney Int. 59 (2001) 415-424
23. Gutteridge J.M. Lipid peroxidation and antioxidants as biomarkers of tissue damage. Clin. Chem. 41 (1995) 1819-1828
24. Habig W.H., Pabst M.J., and Jarkoby W.B. Glutathione S transferases. The first enzymatic step in mercapturic acid formation. J. Biol. Chem. 249 (1974) 7130-7139
25. Hayashi T., Watanabe Y., Kumano K., Kitayama R., Yasuda R.T., Saikawa I., Katahira J., Kumada T., and Shimazu K. Protective effect of piperacillin against nephrotoxicity of cephaloridine and gentamicin in animals. Antimicrob. Agents Chemother. 32 (1988) 912-918
26. Hughes A.K., Stricklett K., Padilla E., and Kohan D.E. Effect of reactive oxygen species on endothelin-1 production by human mesangial cells. Kidney Int. 49 (1996) 181-189
27. Itoh K., Wakabayashi N., Katoh Y., Ishii T., O'Connor T., and Yamamoto M. Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles. Genes Cells 8 (2003) 379-391
28. Jaiswal A.K. Nrf2 signaling in coordinated activation of antioxidant gene expression. Free Radic. Biol. Med. 36 (2004) 1199-1207
29. Kalayarasan S., Sriram N., and Sudhandiran G. Diallyl sulfide attenuates bleomycin induced pulmonary fibrosis: critical role of iNOS, NFkB, TNFα and IL-1β. Life Sci. 82 (2008) 1142-1153
30. Kalayarasan S., Sriram N., Sureshkumar A., and Sudhandiran G. Chromium (VI)-induced oxidative stress and apoptosis through activation of Nrf2 in the hepatocytes of Wistar rats. J. Appl. Toxicol. 28 (2008) 908-919
31. Karahan I., Atessahin A., Yilmaz S., Ceribaşi A.O., and Sakin F. Protective effect of lycopene on gentamicin-induced oxidative stress and nephrotoxicity in rats. Toxicology 215 (2005) 198-204
32. Kawai Y., and Anno K. Mucopolysaccharide-degrading enzymes from the liver of the squid, Ommastrephes sloani pacificus, I. Hyaluronidase. Biochim. Biophys. Acta 242 (1971) 428-436
33. Kettle A.J., and Winterbourn C.C. Myeloperoxidase: a key regulator of neutrophil oxidant production. Redox Rep. 3 (1997) 3-15
34. Kuzniar J., Marchewka Z., Krasnowski R., Boratynska M., Dlugosz A., and Klinger M. Enzymuria and low molecular weight protein excretion as the differentiating marker of complications in the early post kidney transplantation period. Int. Urol. Nephrol. 38 (2006) 753-758
35. Lafayette R.A., Perrone R.D., and Levey A.S. Laboratory evaluation of renal function. In: Schrier R.W. (Ed). Diseases of the Kidney and Urinary Tract vol. 1 (2001), Lippincott Williams & Wilkins, Philadelphia 333-369
36. Laight D.W., Lad N., Woodward B., and Waterfall J.F. Assessment of myeloperoxidase activity in renal tissue after ischemia/reperfusion. Eur. J. Pharmacol. 292 (1994) 81-88
37. Lee J.M., and Johnson J.A. An important role of Nrf2-ARE pathway in the cellular defense mechanism. J. Biochem. Mol. Biol. 37 (2004) 139-143
38. Lee J.M., Li J., Johnson D.A., Stein T.D., Kraft A.D., Calkins M.J., Jakel R.J., and Johnson J.A. Nrf2, a multiorgan protector?. FASEB J. 19 (2005) 1061-1066
39. Li N., and Karin M. Is NF-κB the sensor of oxidative stress?. FASEB J. 13 (1999) 1137-1143
40. Lowry O.H., Rosebrough N.J., Farr A.L., and Randall R.J. Protein measurement with Folin-phenol reagent. J. Biol. Chem. 193 (1951) 265-275
41. Maldonado P.D., Barrera D., Medina-Campos O.N., Hernández-Pando R., Ibarra-Rubio M.E., and Pedraza-Chaverri J. Aged garlic extract attenuates gentamicin induced renal damage and oxidative stress in rats. Life Sci. 73 (2003) 2543-2556
42. Martindale J.L., and Holbrook N.J. Cellular response to oxidative stress: signaling for suicide and survival. J. Cell. Physiol. 192 (2002) 1-15
43. Maruhn D. Rapid colorimetric assay of beta-galactosidase and N-acetylbeta-glucosaminidase in human urine. Clin. Chim. Acta 73 (1976) 453-461
44. Misra H.P., and Fridovich I. The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. J. Biol. Chem. 247 (1972) 3170-3175
45. Natelson S., Scott M.L., and Beffa C. A rapid method for the estimation of urea in biologic fluids. Am. J. Clin. Pathol. 21 (1951) 275-281
46. Nguyen T., Sherratt P.J., and Pickett C.B. Regulatory mechanisms controlling gene expression mediated by the antioxidant response element. Annu. Rev. Pharmacol. Toxicol. 4 (2003) 233-260
47. Ohkawa H., Ohishi N., and Yagi K. Assay of lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 95 (1979) 351-358
48. Omaye S.T., Tumbull J.D., and Sauberlich H.E. Selected methods for the determination of ascorbic acid in animal cells, tissues and fluids. Methods Enzymol. 62 (1979) 3-11
49. Orlowski M., and Meister A. Isolation of gamma glutamyl transpeptidase from hog kidney. J. Biol. Chem. 240 (1965) 338-347
50. Ortiz A., and Egido J. Is there a role for specific anti-TNF strategies in glomerular diseases?. Nephrol. Dial. Transplant. 10 (1995) 309-311
51. Owen J.A., Iggo B., Scandrett F.J., and Stewart C.P. The determination of creatinine in plasma or serum, and in urine; a critical examination. Biochem. J. 58 (1954) 426-437
52. Parlakpinar H., Tasdemir S., Polat A., Bay-Karabulut A., Vardi N., Ucar M., and Acet A. Protective role of caffeic acid phenethyl ester (cape) on gentamicin-induced acute renal toxicity in rats. Toxicology 207 (2005) 169-177
53. Patel R.P., McAndrew J., Sellak H., White C.R., Jo H., Freeman B.A., and Darley-Usmar V.M. Biological aspects of reactive nitrogen species. Biochim. Biophys. Acta 1411 (1999) 385-400
54. Pedraza-Chaverri J., Maldonado P.D., Medina-Campos O.N., Olivares-Corichi I.M., Granados-Solvestre M.A., Hernandez-Pando R., and Ibarra-Rubio M.E. Garlic ameliorates gentamicin nephrotoxicity: relation to antioxidant enzymes. Free Radic. Biol. Med. 29 (2000) 602-611
55. Pedraza-Chaverri J., Maldonado P.D., Barrera D., Ceron A., Medina-Campos O.N., and Hernandez-Pando R. Protective effect of diallyl sulfide on oxidative stress and nephrotoxicity induced by gentamicin in rats. Mol. Cell. Biochem. 254 (2003) 125-130
56. Pick E., and Keisari Y. Superoxide anion and hydrogen peroxide production by chemically elicited peritoneal macrophages induction by multiple nonphagocytic stimuli. Cell. Immunol. 59 (1981) 301-318
57. Puntarulo S., and Cederbaum A.I. Effect of oxygen concentration on microsomal oxidation of ethanol and generation of oxygen radicals. Biochem. J. 251 (1988) 787-794
58. Rao A.V., and Shaha C. Multiple glutathione S-transferase isoforms are present on male germ cell plasma membrane. FEBS Lett. 507 (2001) 174-180
59. Ross D., Kepa J.K., Winski S.L., Beall H.D., Anwar A., and Siegel D. NAD(P)H:quinone oxidoreductase 1 (NQO1): chemoprotection, bioactivation, gene regulation and genetic polymorphisms. Chem. Biol. Interact. 129 (2000) 77-97
60. Rotruck J.T., Pope A.L., Ganther H.E., Swanson A.B., Hafeman D.G., and Hoekstra W.G. Selenium: biochemical role as a component of glutathione peroxidase. Science 179 (1973) 588-590
61. Shifow A.A., Kumar K.V., Naidu M.U., and Ratnakar K.S. Melatonin, a pineal hormone with antioxidant property, protects against gentamicin-induced nephrotoxicity in rats. Nephron 85 (2000) 167-174
62. Shimeda Y., Hirotan Y., Akimoto Y., Shindou K., Ijiri Y., Nishihori T., and Tanaka K. Protective effects of capsaicin against cisplatin-induced nephrotoxicity. Biol. Pharm. Bull. 28 (2005) 1635-1638
63. Siegel D., Gustafson D.L., Dehn D.L., Han J.Y., Boonchoong P., Berliner L.J., and Ross D. NAD(P)H:quinone oxidoreductase 1: role as a superoxide scavenger. Mol. Pharmacol. 65 (2004) 1238-1247
64. Sriram N., Kalayarasan S., Ashok kumar P., Suresh kumar A., and Sudhandiran G. Diallyl sulfide induces apoptosis in Colo 320 DM human colon cancer cells: involvement of Caspase-3, NF-κB and ERK-2. Mol. Cell. Biochem. 311 (2008) 157-165
65. Staal G.E., Hellman P.W., De wael J., and Veeger C. Purification and properties of an abnormal glutathione reductase of human erythrocytes. Biochim. Biophys. Acta 185 (1969) 63-69
66. Talalay P. Chemoprotection against cancer by induction of phase 2 enzymes. Biofactors 12 (2000) 5-11
67. Takahara S., Hamilton H.B., Neel J.V., Kobara T.Y., Ogura Y., and Nishimura E.T. Hypocatalasemia: a new genetic carrier state. J. Clin. Invest. 39 (1960) 610-619
68. Teixeira R.B., Kelly J., Alpert H., Pardo V., and Vaamonde C.A. Complete protection from gentamicin-induced acute renal failure in the diabetes mellitus rat. Kidney Int. 21 (1982) 600-612
69. Terquankar V. NFkappa B pathway: a good signaling paradigm and therapeutic target. Int. J. Biochem. Cell Biol. 38 (2006) 1647-1653
70. Wardle E.N. Nuclear factor-kB for the nephrologist. Nephrol. Dial. Transplant. 16 (2001) 1764-1768
71. Wefers H., and Sies H. The protection by ascorbate and glutathione against microsomal lipid peroxidation is dependent on vitamin E. Eur. J. Biochem. 174 (1988) 353-357
72. Wei H., and Frenkel K. Relationship of oxidative events and DNA oxidation in SENCAR mice to in vivo promoting activity of phorbol ester-type tumor promoters. Carcinogenesis 14 (1993) 1195-1201
73. Yanagida C., Ito K., Komiya I., and Horie T. Protective effect of fosfomycin on gentamicin-induced lipid peroxidation of rat renal tissue. Chem. Biol. Interact. 148 (2004) 139-147
74. Yin M.C., Hwang S.W., and Chan K.C. Non enzymatic antioxidant activity of four organo sulfur compounds derived from garlic. J. Agric. Food Chem. 50 (2002) 6143-6147
75. Zhang D.D. Mechanistic studies of the Nrf2-Keap1 signaling pathway. Drug Metab. Rev. 38 (2006) 769-789
76. Zhang Y., and Gordon G.B. A strategy for cancer prevention: stimulation of the Nrf2-ARE signaling pathway. Mol. Cancer Ther. 3 (2004) 885-893