Contrast agents for preclinical targeted X-ray imaging

Advanced Drug Delivery Reviews

Volumn 76, Issue 1, 2014, Pages 116-133

  Li, Xiang ^a,b   Anton, Nicolas ^a,b   Zuber, Guy ^a,b   Vandamme, Thierry ^a,b  

^a UNIVERSITÉ DE STRASBOURG   (France)

^b Faculté de Pharmacie   (France)

Author keywords

Computed tomography; Contrast agent; EPR; Micro CT; Targeting; X ray imaging

Indexed keywords

BIOCOMPATIBILITY; BIOLOGICAL ORGANS; BLOOD VESSELS; COST EFFECTIVENESS; ENZYME INHIBITION; NANOPARTICLES; PARAMAGNETIC RESONANCE; TUMORS; X RAY ANALYSIS;

CONTRAST AGENT; ENHANCED PERMEATION AND RETENTIONS; MICRO COMPUTED TOMOGRAPHY (MICRO-CT); MICRO CT; NANOPARTICLE PROPERTIES; PHYSICOCHEMICAL PROPERTY; TARGETING; XRAY IMAGING;

COMPUTERIZED TOMOGRAPHY;

CONTRAST MEDIUM; DENDRIMER; GADOTERIDOL; IOHEXOL; LIPOSOME; NANOPARTICLE; POLYMER;

ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; CRITICAL MICELLE CONCENTRATION; HUMAN; LIVER CELL; MICELLE; MICRO-COMPUTED TOMOGRAPHY; MOLECULAR IMAGING; NANOEMULSION; NANOENCAPSULATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; POLYMERIZATION; PRIORITY JOURNAL; RETICULOENDOTHELIAL SYSTEM; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; ANIMAL; DIAGNOSTIC USE;

ANIMALS; CONTRAST MEDIA; MOLECULAR IMAGING; X-RAY MICROTOMOGRAPHY;

EID: 84928205830     PISSN: 0169409X     EISSN: 18728294     Source Type: Journal    
DOI: 10.1016/j.addr.2014.07.013     Document Type: Review

References (160)

1. Desnoyers L.R., Pai R., Ferrando R.E., Hötzel K., Le T., Ross J., Carano R., D'Souza A., Qing J., Mohtashemi I., Ashkenazi A., French D.M. Targeting FGF19 inhibits tumor growth in colon cancer xenograft and FGF19 transgenic hepatocellular carcinoma models. Oncogene 2008, 27(1):85-97.
2. Badea C.T., Drangova M., Holdsworth D.W., Johnson G.A. In vivo small-animal imaging using micro-CT and digital subtraction angiography. Phys. Med. Biol. 2008, 53:R319-R350.
3. Schambach S.J., Bag S., Groden C., Schilling L., Brockmann M.A. Vascular imaging in small rodents using micro-CT. Methods 2010, 50:26-35.
4. Zagorchev L., Oses P., Zhuang Z.W., Moodie K., Mulligan-Kehoe M., Simons M., Couffinhal T. Micro computed tomography for vascular exploration. J. Angiogenesis Res. 2010, 2:7-17.
5. de Kemp R.A., Epstein F.H., Catana C., Tsui B.M.W., Ritman E.L. Small-animal molecular imaging methods. J. Nucl. Med. 2010, 51:18-32.
6. French J., Gingles N., Stewart J., Woodhouse N. Use of magnetic resonance imaging (MRI) and micro-computed tomography (micro-CT) in the morphological examination of rat and rabbit fetuses from embryo-fetal development studies. Reprod. Toxicol. 2010, 30:292-300.
7. Patterson B.M., Hamilton C.E. Dimensional standard for micro X-ray computed tomography. Anal. Chem. 2010, 82:8537-8543.
8. Ritman E.L. Small-animal CT: its difference from, and impact on, clinical CT. Nucl. Inst. Methods Phys. Res. A 2007, 580:968-970.
9. Williams J.C., McAteer J.A., Evan A.P., Lingeman J.E. Micro-computed tomography for analysis of urinary calculi. Urol. Res. 2010, 38:477-484.
10. Tsui B.M.W., Kraitchman D.L. Recent advances in small-animal cardiovascular imaging. J. Nucl. Med. 2009, 50:667-670.
11. Burghardt A.J., Link T.M., Majumdar S. High-resolution computed tomography for clinical imaging of bone microarchitecture. Clin. Orthop. Relat. Res. 2011, 469:2179-2193.
12. Weber E., Fernandez M., Wapner P., Hoffman W. Comparison of X-ray micro-tomography measurements of densities and porosity principally to values measured by mercury porosimetry for carbon-carbon composites. Carbon 2010, 48:2151-2158.
13. Li J., Chaudhary A., Chmura S.J., Pelizzari C., Rajh T., Wietholt C., Kurtoglu M., Aydogan B. A novel functional CT contrast agent for molecular imaging of cancer. Phys. Med. Biol. 2010, 55:4389-4397.
14. Graham K.C., Wirtzfeld L.A., MacKenzie L.T., Postenka C.O., Groom A.C., MacDonald I.C., Fenster A., Lacefield J.C., Chambers A.F. Three-dimensional high-frequency ultrasound imaging for longitudinal evaluation of liver metastases in preclinical models. Cancer Res. 2005, 65:5231-5237.
15. Bae K.H., Chung H.J., Park T.G. Nanomaterials for cancer therapy and imaging. Mol. Cells 2011, 31:295-302.
16. Maeda H. Tumor-selective delivery of macromolecular drugs via the EPR effect: background and future prospects. Bioconjug. Chem. 2010, 21:797-802.
17. Peer D., Karp J.M., Hong S., Farokhzad O.C., Margalit R., Langer R. Nanocarriers as an emerging platform for cancer therapy. Nat. Nanotechnol. 2007, 2:751-760.
18. Almajdub M., Nejjari M., Poncet G., Magnier L., Chereul E., Roche C., Janier M. In-vivo high-resolution X-ray microtomography for liver and spleen tumor assessment in mice. Contrast Media Mol. Imaging 2007, 2:88-93.
19. Kim H.W., Cai Q.-Y., Jun H.Y., Chon K.S., Park S.H., Byun S.J., Lee M.S., Oh J.M., Kim H.S., Yoon K.-H. Micro-CT imaging with a hepatocyte-selective contrast agent for detecting liver metastasis in living mice. Acad. Radiol. 2008, 15:1282-1290.
20. Ohta S., Lai E.W., Morris J.C., Bakan D.A., Klaunberg B., Cleary S., Powers J.F., Tischler A.S., Abu-Asab M., Schimel D., Pacak K. MicroCT for high-resolution imaging of ectopic pheochromocytoma tumors in the liver of nude mice. Int. J. Cancer 2006, 119:2236-2241.
21. Ghaghada K.B., Badea C.T., Karumbaiah L., Fettig N., Bellamkonda R.V., Johnson G.A., Annapragada A. Evaluation of tumor microenvironment in an animal model using a nanoparticle contrast agent in computed tomography imaging. Acad. Radiol. 2011, 18:20-30.
22. Kao C.-Y., Hoffman E.A., Beck K.C., Bellamkonda R.V., Annapragada A.V. Long-residence-time nano-scale liposomal iohexol for X-ray-based blood pool imaging. Acad. Radiol. 2003, 10:475-483.
23. Martiniova L., Schimel D., Lai E.W., Limpuangthip A., Kvetnansky R., Pacak K. In vivo micro-CT imaging of liver lesions in small animal models. Methods 2010, 50:20-25.
24. Rabin O., Manuel Perez J., Grimm J., Wojtkiewicz G., Weissleder R. An X-ray computed tomography imaging agent based on long-circulating bismuth sulphide nanoparticles. Nat. Mater. 2006, 5:118-122.
25. Torchilin V.P., Frank-Kamenetsky M.D., Wolf G.L. Ct visualization of blood pool in rats by using long-circulating, iodine-containing micelles. Acad. Radiol. 1999, 6:61-65.
26. van Tellingen O., Beijnen J., Verweij J., Scherrenburg E., Nooijen W., Sparreboom A. Rapid esterase-sensitive breakdown of polysorbate 80 and its impact on the plasma pharmacokinetics of docetaxel and metabolites in mice. Clin. Cancer Res. 1999, 5:2918-2924.
27. Storm G., Belliot S.O., Daemen T., Lasic D.D. Surface modification of nanoparticles to oppose uptake by the mononuclear phagocyte system. Adv. Drug Deliv. Rev. 1995, 17:31-48.
28. Brigger I., Dubernet C., Couvreur P. Nanoparticles in cancer therapy and diagnosis. Adv. Drug Deliv. Rev. 2002, 54:631-651.
29. Haley B., Frenkel E. Nanoparticles for drug delivery in cancer treatment. Urol. Oncol. 2008, 26:57-64.
30. Singh R., Lillard J.W. Nanoparticle-based targeted drug delivery. Exp. Mol. Pathol. 2009, 86:215-223.
31. Torchilin V.P., Trubetskoy V.S. Which polymers can make nanoparticulate drug carriers long-circulating?. Adv. Drug Deliv. Rev. 1995, 16:141-155.
32. Anton N., Benoit J.-P., Saulnier P. Design and production of nanoparticles formulated from nano-emulsion templates - a review. J. Control. Release 2008, 128:185-199.
33. Anton N., Vandamme T.F. The universality of low-energy nano-emulsification. Int. J. Pharm. 2009, 377:142-147.
34. Anton N., Mojzisova H., Porcher E., Benoit J.-P., Saulnier P. Reverse micelle-loaded lipid nano-emulsions: new technology for nano-encapsulation of hydrophilic materials. Int. J. Pharm. 2010, 398:204-209.
35. Anton N., Vandamme T. Nano-emulsions and micro-emulsions: clarifications of the critical differences. Pharm. Res. 2011, 28:978-995.
36. Fryd M., Mason T. Advanced nanoemulsions. Annu. Rev. Phys. Chem. 2012, 63:493-518.
37. McClements D. Nanoemulsions versus microemulsions: terminology, differences, and similarities. Soft Matter 2012, 8:1719-1729.
38. Hallouard F., Anton N., Choquet P., Constantinesco A., Vandamme T. Iodinated blood pool contrast media for preclinical X-ray imaging applications. Biomaterials 2010, 31:6249-6268.
39. Hallouard F., Anton N., Zuber G., Choquet P., Li X., Arntz Y., Aubertin G., Constantinesco A., Vandamme T. Radiopaque iodinated nano-emulsions for preclinical X-ray imaging. RSC Adv. 2011, 1:792-801.
40. Hallouard F., Briançon S., Anton N., Li X., Vandamme T., Fessi H. Iodinated nano-emulsions as contrast agents for preclinical X-ray imaging, impact of the free surfactants on the pharmacokinetics. Eur. J. Pharm. Biopharm. 2013, 83:54-62.
41. Li X., Anton N., Zuber G., Zhao M., Hallouard F., Fessi H., Messaddeq N., Bour G., Soler L., Vandamme T. Iodinated alpha-tocopherol nano-emulsions as non-toxic contrast agents for preclinical X-ray imaging. Biomaterials 2013, 34:481-491.
42. Weichert J.P., Lee F.T., Chosy S.G., Longino M.A., Kuhlman J.E., Heisey D.M., Leverson G.E. Combined hepatocyte-selective and blood-pool contrast agents for the CT detection of experimental liver tumors in rabbits. Radiology 2000, 216:865-871.
43. Badea C.T., Hedlund L.W., de Lin M., Boslego Mackel J.F., Johnson G.A. Tumor imaging in small animals with a combined micro-CT/micro-DSA system using iodinated conventional and blood pool contrast agents. Contrast Media Mol. Imaging 2006, 1:153-164.
44. Bakan D.A., Longino M.A., Weichert J.P., Counsell R.E. Physicochemical characterization of a synthetic lipid emulsion for hepatocyte-selective delivery of lipophilic compounds: application to polyiodinated triglycerides as contrast agents for computed tomography. J. Pharm. Sci. 1996, 85:908-914.
45. Weber S.M., Peterson K.A., Durkee B., Qi C., Longino M., Warner T., Lee F.T., Weichert J.P. Imaging of murine liver tumor using microct with a hepatocyte-selective contrast agent: accuracy is dependent on adequate contrast enhancement. J. Surg. Res. 2004, 119:41-45.
46. Weichert J.P., Groziak M.P., Longino M.A., Schwendner S.W., Counsell R.E. Potential tumor- or organ-imaging agents. 27. Polyiodinated 1,3-disubstituted and 1,2,3-trisubstituted triacylglycerols. J. Med. Chem. 1986, 29:2457-2465.
47. Weichert J.P., Longino M.A., Bakan D.A., Spigarelli M.G., Chou T., Schwendner S.W., Counsell R.E. Polyiodinated triglyceride analogs as potential computed tomography imaging agents for the liver. J. Med. Chem. 1995, 38:636-646.
48. Weichert J.P., Longino M.A., Schwendner S.W., Counsell R.E. Potential tumor- or organ-imaging agents. 26. Polyiodinated 2-substituted triacylglycerols as hepatographic agents. J. Med. Chem. 1986, 29:1674-1682.
49. Bakan D.A. Imaging efficacy of a hepatocyte-selective polyiodinated triglyceride for contrast-enhanced computed tomography. Am. J. Ther. 2001, 8:359-365.
50. de Vries A., Custers E., Lub J., van den Bosch S., Nicolay K., Grffill H. Block-copolymer-stabilized iodinated emulsions for use as CT contrast agents. Biomaterials 2010, 31:6537-6544.
51. Jiang D.Y., Scott Gazelle G., Wolf G.L. A model of focal cancer in rabbit lymph nodes. Acad. Radiol. 1996, 3:159-162.
52. McIntire G.L., Bacon E.R., Toner J.L., Cornacoff J.B., Losco P.E., Illig K.J., Nikula K.J., Muggenburg B.A., Ketai L. Pulmonary delivery of nanoparticles of insoluble, iodinated CT X-ray contrast agents to lung draining lymph nodes in dogs. J. Pharm. Sci. 1998, 87:1466-1470.
53. Wisner E.R., Katzberg R.W., Griffey S.M., Drake C.M., Haley P.J., Vessey A.R. Indirect computed tomography lymphography using iodinated nanoparticles: time and dose response in normal canine lymph nodes. Acad. Radiol. 1995, 2:985-993.
54. Wisner E.R., Weichert J.P., Longino M.A., Counsell R.E., Weisbrode S.E. Percutaneous CT lymphography using a new polyiodinated biomimetic microemulsion. Acad. Radiol. 2002, 9:S191-S193.
55. Oh M.H., Lee N., Kim H., Park S.P., Piao Y., Lee J., Jun S.W., Moon W.K., Choi S.H., Hyeon T. Large-scale synthesis of bioinert tantalum oxide nanoparticles for X-ray computed tomography imaging and bimodal image-guided sentinel lymph node mapping. J. Am. Chem. Soc. 2011, 133:5508-5515.
56. Desser T.S., Rubin D.L., Muller H., McIntire G.L., Bacon E.R., Toner J.L. Blood pool and liver enhancement in ct with liposomal iodixanol: comparison with iohexol. Acad. Radiol. 1999, 6:176-183.
57. Sachse A., Leike J.U., Schneider T., Wagner S.E., Rling G.L., Krause W., Brandl M. Biodistribution and computed tomography blood-pool imaging properties of polyethylene glycol-coated iopromide-carrying liposomes. Invest. Radiol. 1997, 32:44-50.
58. Schmiedl U.P., Krause W., Leike J., Sachse A. CT blood pool enhancement in primates with lopromide-carrying liposomes containing soy phosphatidyl glycerol. Acad. Radiol. 1999, 6:164-169.
59. Leander P., Hffiglund P., Borseth A., Kloster Y., Berg A. A new liposomal liver-specific contrast agent for CT: first human phase-I clinical trial assessing efficacy and safety. Eur. Radiol. 2001, 11:698-704.
60. Spinazzi A., Ceriati S., Pianezzola P., Lorusso V., Luzzani F., Fouillet X., Alvino S., Rummeny E.J. Safety and pharmacokinetics of a new liposomal liver-specific contrast agent for CT: results of clinical testing in nonpatient volunteers. Invest. Radiol. 2000, 35:1-7.
61. Mukundan S., Ghaghada K.B., Badea C.T., Kao C.-Y., Hedlund L.W., Provenzale J.M., Johnson G.A., Chen E., Bellamkonda R.V., Annapragada A. A liposomal nanoscale contrast agent for preclinical CT in mice. Am. J. Roentgenol. 2006, 186:300-307.
62. Burke S.J., Annapragada A., Hoffman E.A., Chen E., Ghaghada K.B., Sieren J., van Beek E.J.R. Imaging of pulmonary embolism and t-PA therapy effects using MDCT and liposomal iohexol blood pool agent. Preliminary results in a rabbit model. Acad. Radiol. 2007, 14:355-362.
63. Zheng J., Jaffray D., Allen C. Quantitative CT imaging of the spatial and temporal distribution of liposomes in a rabbit tumor model. Mol. Pharm. 2009, 6:571-580.
64. Elrod D.B., Partha R., Danila D., Casscells S.W., Conyers J.L. An iodinated liposomal computed tomographic contrast agent prepared from a diiodophosphatidylcholine lipid. Nanomed. Nanotechnol. Biol. Med. 2009, 5:42-45.
65. Fu Y., Nitecki D.E., Maltby D., Simon G.H., Berejnoi K., Raatschen H.-J., Yeh B.M., Shames D.M., Brasch R.C. Dendritic iodinated contrast agents with PEG-cores for CT imaging: synthesis and preliminary characterization. Bioconjug. Chem. 2006, 17:1043-1056.
66. Yordanov A., Mollov N., Lodder A., Woller E., Cloninger M., Walbridge S., Milenic D., Brechbiel M. A water-soluble triiodo amino acid and its dendrimer conjugate for computerized tomography (CT) imaging. J. Serb. Chem. Soc. 2005, 70:163-170.
67. Ho Kong W., Jae Lee W., Yun Cui Z., Hyun Bae K., Gwan Park T., Hoon Kim J., Park K., Won Seo S. Nanoparticulate carrier containing water-insoluble iodinated oil as a multifunctional contrast agent for computed tomography imaging. Biomaterials 2007, 28:5555-5561.
68. Ashcroft J.M., Hartman K.B., Kissell K.R., Mackeyev Y., Pheasant S., Young S., Van der Heide P.A.W., Mikos A.G., Wilson L.J. Single-molecule i2@US-tube nanocapsules: a new X-ray contrast-agent design. Adv. Mater. 2007, 19:573-576.
69. Boote E., Fent G., Kattumuri V., Casteel S., Katti K., Chanda N., Kannan R., Katti K., Churchill R. Gold nanoparticle contrast in a phantom and juvenile swine: models for molecular imaging of human organs using X-ray computed tomography. Acad. Radiol. 2010, 17:410-417.
70. Kattumuri V., Katti K., Bhaskaran S., Boote E.J., Casteel S.W., Fent G.M., Robertson D.J., Chandrasekhar M., Kannan R., Katti K.V. Gum arabic as a phytochemical construct for the stabilization of gold nanoparticles: in vivo pharmacokinetics and X-ray-contrast-imaging studies. Small 2007, 3:333-341.
71. de Krafft K.E., Xie Z., Cao G., Tran S., Ma L., Zhou O.Z., Lin W. Iodinated nanoscale coordination polymers as potential contrast agents for computed tomography. Angew. Chem. Int. Ed. 2009, 48:9901-9904.
72. Bosman A.W., Janssen H.M., Meijer E.W. About dendrimers: structure, physical properties, and applications. Chem. Rev. 1999, 99:1665-1688.
73. Koo O.M., Rubinstein I., Onyuksel H. Role of nanotechnology in targeted drug delivery and imaging: a concise review. Nanomed. Nanotechnol. Biol. Med. 2005, 1:193-212.
74. Guo R., Wang H., Peng C., Shen M., Pan M., Cao X., Zhang G., Shi X. X-ray attenuation property of dendrimer-entrapped gold nanoparticles. J. Phys. Chem. C 2009, 114:50-56.
75. Kojima C., Umeda Y., Ogawa M., Harada A., Magata Y., Kono K. X-ray computed tomography contrast agents prepared by seeded growth of gold nanoparticles in PEGylated dendrimer. Nanotechnology 2010, 21:245104.
76. Peng C., Wang H., Guo R., Shen M., Cao X., Zhu M., Zhang G., Shi X. Acetylation of dendrimer-entrapped gold nanoparticles: synthesis, stability, and x-ray attenuation properties. J. Appl. Polym. Sci. 2011, 119:1673-1682.
77. Guo R., Wang H., Peng C., Shen M., Zheng L., Zhang G., Shi X. Enhanced X-ray attenuation property of dendrimer-entrapped gold nanoparticles complexed with diatrizoic acid. J. Mater. Chem. 2011, 21:5120-5127.
78. Peng C., Zheng L., Chen Q., Shen M., Guo R., Wang H., Cao X., Zhang G., Shi X. Pegylated dendrimer-entrapped gold nanoparticles for in vivo blood pool and tumor imaging by computed tomography. Biomaterials 2012, 33:1107-1119.
79. Wang H., Zheng L., Peng C., Guo R., Shen M., Shi X., Zhang G. Computed tomography imaging of cancer cells using acetylated dendrimer-entrapped gold nanoparticles. Biomaterials 2011, 32:2979-2988.
80. Jakhmola A., Anton N., Vandamme T. Inorganic nanoparticles based contrast agents for X-ray computed tomography. Adv. Healthcare Mater. 2012, 1:413-431.
81. Boll H., Nittka S., Doyon F., Neumaier M., Marx A., Kramer M., Groden C., Brockmann M.A. Micro-CT based experimental liver imaging using a nanoparticulate contrast agent: a longitudinal study in mice. PLoS ONE 2011, 6:e25692-e25697.
82. Liu Y., Ai K., Liu J., Yuan Q., He Y., Lu L. A high-performance ytterbium-based nanoparticulate contrast agent for in vivo X-ray computed tomography imaging. Angew. Chem. Int. Edit. 2012, 51:1437-1442.
83. Connor E.E., Mwamuka J., Gole A., Murphy C.J., Wyatt M.D. Gold nanoparticles are taken up by human cells but do not cause acute cytotoxicity. Small 2005, 1:325-327.
84. Dalsin J.L., Hu B.-H., Lee B.P., Messersmith P.B. Mussel adhesive protein mimetic polymers for the preparation of nonfouling surfaces. J. Am. Chem. Soc. 2003, 125:4253-4258.
85. Hainfeld J.F., Slatkin D.N., Focella T.M., Smilowitz H.M. Gold nanoparticles: a new x-ray contrast agents. Br. J. Radiol. 2006, 79:248-253.
86. Hiebert L. The uptake of heparin by liver sinusoidal cells in normal and atherosclerotic rabbits. Thromb. Res. 1981, 21:383-390.
87. Kim D., Park S., Lee J.H., Jeong Y.Y., Jon S. Antibiofouling polymer-coated gold nanoparticles as a contrast agent for in vivo X-ray computed tomography imaging. J. Am. Chem. Soc. 2007, 129:7661-7665.
88. Park K., Kim K., Kwon I.C., Kim S.K., Lee S., Lee D.Y., Byun Y. Preparation and characterization of self-assembled nanoparticles of heparin-deoxycholic acid conjugates. Langmuir 2004, 20:11726-11731.
89. Shukla R., Bansal V., Chaudhary M., Basu A., Bhonde R.R., Sastry M. Biocompatibility of gold nanoparticles and their endocytotic fate inside the cellular compartment: a microscopic overview. Langmuir 2005, 21:10644-10654.
90. Sun I., Eun D., Na J.H., Lee S., Kim I., Youn I., Ko C., Kim H., Lim D., Choi K., Messersmith P.B., Park T.G., Kim S.Y., Kwon I.C., Kim K., Ahn C. Heparin-coated gold nanoparticles for liver-specific CT imaging. Chem. Eur. J. 2009, 15:13341-13347.
91. Eck W., Nicholson A.I., Zentgraf H., Semmler W., Bartling S. Anti-CD4-targeted gold nanoparticles induce specific contrast enhancement of peripheral lymph nodes in X-ray computed tomography of live mice. Nano Lett. 2010, 10:2318-2322.
92. Chanda N., Kattumuri V., Shukla R., Zambre A., Katti K., Upendran A., Kulkarni R.R., Kan P., Fent G.M., Casteel S.W., Smith C.J., Boote E., Robertson J.D., Cutler C., Lever J.R., Katti K.V., Kannan R. Bombesin functionalized gold nanoparticles show in vitro and in vivo cancer receptor specificity. Proc. Natl. Acad. Sci. U. S. A. 2010, 107:8760-8765.
93. Zhang Z., Ross R.D., Roeder R.K. Preparation of functionalized gold nanoparticles as a targeted X-ray contrast agent for damaged bone tissue. Nanoscale 2010, 2:582-586.
94. Torchilin V.P. Structure and design of polymeric surfactant-based drug delivery systems. J. Control. Release 2001, 73:137-172.
95. Torchilin V.P. Polymeric micelles in diagnostic imaging. Colloids Surf. B-Biointerfaces 1999, 16:305-319.
96. Lukyanov A.N., Torchilin V.P. Micelles from lipid derivatives of water-soluble polymers as delivery systems for poorly soluble drugs. Adv. Drug Deliv. Rev. 2004, 56:1273-1289.
97. Trubetskoy V.S., Gazelle G.S., Wolf G.L., Torchilin V.P. Block-copolymer of polyethylene glycol and polylysine as a carrier of organic iodine: design of long-circulating particulate contrast medium for X-ray computed tomography. J. Drug Target. 1997, 4:381-388.
98. Al Zaki A., Joh D., Cheng Z., De Barros A.L.B., Kao G., Dorsey J., Tsourkas A. Gold-loaded polymeric micelles for computed tomography-guided radiation therapy treatment and radiosensitization. ACS Nano 2014, 8:104-112.
99. Herck J.L., Meyer G.R.Y., Martinet W., Salgado R.A., Shivalkar B., Mondt R., Ven H., Ludwig A., Veken P., Vaeck L., Bult H., Herman A.G., Vrints C.J. Multi-slice computed tomography with n1177 identifies ruptured atherosclerotic plaques in rabbits. Basic Res. Cardiol. 2009, 105:51-59.
100. Hyafil F., Cornily J.-C., Feig J.E., Gordon R., Vucic E., Amirbekian V., Fisher E.A., Fuster V., Feldman L.J., Fayad Z.A. Noninvasive detection of macrophages using a nanoparticulate contrast agent for computed tomography. Nat. Med. 2007, 13:636-641.
101. Liu Y., Matsui O. Changes of intratumoral microvessels and blood perfusion during establishment of hepatic metastases in mice. Radiology 2007, 243:386-395.
102. Scott Gazelle G., Wolf G.L., McIntire G.L., Bacon E.R., George N., Halpern E.F., Toner J.L. Hepatic imaging with iodinated nanoparticles: a comparison with iohexol in rabbits. Acad. Radiol. 1995, 2:700-704.
103. Weichert J.P., Longino M.A., Spigarelli M.G., Lee F.T., Schwendner S.W., Counsell R.E. Computed tomography scanning of Morris hepatomas with liver-specific polyiodinated triglycerides. Acad. Radiol. 1996, 3:412-417.
104. Bergman A., Sundin A., Magnusson A. An iodinated lipid emulsion for CT of the liver: comparison with iohexol in the detection of experimental hepatic metastases. Acta Radiol. 1997, 38:55-60.
105. Krause W., Handreke K., Schuhmann-Giampieri G., Rupp K. Efficacy of the iodine-free computed tomography liver contrast agent, Dy-EOB-DTPA, in comparison with a conventional iodinated agent in normal and in tumor-bearing rabbits. Invest. Radiol. 2002, 37:241-247.
106. Lim S.-J., Lim J.S., Choi J., Choi J.-Y., Hyung W.J., Kim H.S., Suh J., Kim K.W. Nanoscaled iodized oil emulsion as a CT contrast agent for the detection of experimental liver tumors in a rat model. Acad. Radiol. 2010, 17:985-991.
107. Rummeny E.J., Berning W., Fuest M., Bick U., Niggemann B., Tournier P., Fouillet X. New RES-specific contrast agents for CT. Acad. Radiol. 2002, 9:S185-S190.
108. Kweon S., Lee H.-J., Hyung W.J., Suh J., Lim J.S., Lim S.-J. Liposomes coloaded with iopamidol/lipiodol as a RES-targeted contrast agent for computed tomography imaging. Pharm. Res. 2010, 27:1408-1415.
109. Aviv H., Bartling S., Kieslling F., Margel S. Radiopaque iodinated copolymeric nanoparticles for X-ray imaging applications. Biomaterials 2009, 30:5610-5616.
110. Galperin A., Margel D., Baniel J., Dank G., Biton H., Margel S. Radiopaque iodinated polymeric nanoparticles for X-ray imaging applications. Biomaterials 2007, 28:4461-4468.
111. Cooper A.D. Hepatic uptake of chylomicron remnants. J. Lipid Res. 1997, 38:2173-2192.
112. Bakan D.A., Lee F.T., Weichert J.P., Longino M.A., Counsell R.E. Hepatobiliary imaging using a novel hepatocyte-selective CT contrast agent. Acad. Radiol. 2002, 9:S194-S199.
113. Henning T., Weber A.W., Bauer J.S., Meier R., Carlsen J.M., Sutton E.J., Prevrhal S., Ziegler S.I., Feussner H., Daldrup-Link H.E., Rummeny E.J. Imaging characteristics of DHOG, a hepatobiliary contrast agent for preclinical microCT in mice. Acad. Radiol. 2008, 15:342-349.
114. Suckow C.E., Stout D.B. Microct liver contrast agent enhancement over time, dose, and mouse strain. Mol. Imaging Biol. 2008, 10:114-120.
115. Aprahamian M., Bour G., Akladios C.Y., Fylaktakidou K., Greferath R., Soler L., Marescaux J., Egly J.M., Lehn J.M., Nicolau C. Myo-inositoltrispyrophosphate treatment leads to HIF-1α suppression and eradication of early hepatoma tumors in rats. ChemBioChem 2011, 12:777-783.
116. Carmeliet P., Jain R.K. Angiogenesis in cancer and other diseases. Nature 2000, 407:249-257.
117. Hiroshi M. SMANCS and polymer-conjugated macromolecular drugs: advantages in cancer chemotherapy. Adv. Drug Deliv. Rev. 2001, 46:169-185.
118. Maeda H., Matsumoto T., Konno T., Iwai K., Ueda M. Tailor-making of protein drugs by polymer conjugation for tumor targeting: a brief review on SMANCS. J. Protein Chem. 1984, 3:181-193.
119. Maeda H., Wu J., Sawa T., Matsumura Y., Hori K. Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review. J. Control. Release 2000, 65:271-284.
120. Noguchi Y., Wu J., Duncan R., Strohalm J., Ulbrich K., Akaike T., Maeda H. Early phase tumor accumulation of macromolecules: a great difference in clearance rate between tumor and normal tissues. Cancer Sci. 1998, 89:307-314.
121. Schneider B.P., Miller K.D. Angiogenesis of breast cancer. J. Clin. Oncol. 2005, 23:1782-1790.
122. Karathanasis E., Suryanarayanan S., Balusu S.R., McNeeley K., Sechopoulos I., Karellas A., Annapragada A.V., Bellamkonda R.V. Imaging nanoprobe for prediction of outcome of nanoparticle chemotherapy by using mammography. Radiology 2009, 250:398-406.
123. Samei E., Saunders R.S., Badea C.T., Ghaghada K.B., Hedlund L.W., Qi Y., Yuan H., Bentley R.C., Mukundan S. Micro-CT imaging of breast tumors in rodents using a liposomal, nanoparticle contrast agents. Int. J. Nanomed. 2009, 4:277-282.
124. Anayama T., Nakajima T., Dunne M., Zheng J., Allen C., Driscoll B., Vines D., Keshavjee S., Jaffray D., Yasufuku K. A novel minimally invasive technique to create a rabbit VX2 lung tumor model for nano-sized image contrast and interventional studies. PLoS ONE 2013, 8:e67355.
125. Helmberger T., Semelka R.C. New contrast agents for imaging the liver. Magn. Reson. Imaging Clin. N. Am. 2001, 9:745-766.
126. Sun C., Lee J.S.H., Zhang M. Magnetic nanoparticles in MR imaging and drug delivery. Adv. Drug Deliv. Rev. 2008, 60:1252-1265.
127. Bulte J.W.M., Hoekstra Y., Kamman R.L., Magin R.L., Webb A.G., Briggs R.W., Gwan Go K., Hulstaert C.E., Miltenyi S., Hauw The T., De Leij L. Specific MR imaging of human lymphocytes by monoclonal antibody-guided dextran-magnetite particles. Magn. Reson. Med. 1992, 25:148-157.
128. Cerdan S., Lffitscher H.R., Kffinnecke B., Seelig J. Monoclonal antibody-coated magnetite particles as contrast agents in magnetic resonance imaging of tumors. Magn. Reson. Med. 1989, 12:151-163.
129. Wunderbaldinger P., Josephson L., Weissleder R. Tat peptide directs enhanced clearance and hepatic permeability of magnetic nanoparticles. Bioconjug. Chem. 2002, 13:264-268.
130. Lyons S.A., O'Neal J., Sontheimer H. Chlorotoxin, a scorpion-derived peptide, specifically binds to gliomas and tumors of neuroectodermal origin. Glia 2002, 39:162-173.
131. Sun C., Sze R., Zhang M. Folic acid-PEG conjugated superparamagnetic nanoparticles for targeted cellular uptake and detection by mri. J. Biomed. Mater. Res. A 2006, 78A:550-557.
132. Zhang Y., Sun C., Kohler N., Zhang M. Self-assembled coatings on individual monodisperse magnetite nanoparticles for efficient intracellular uptake. Biomed. Microdevices 2004, 6:33-40.
133. Hong H., Zhang Y., Sun J., Cai W. Molecular imaging and therapy of cancer with radiolabeled nanoparticles. Nano Today 2009, 4:399-413.
134. Weissleder R. Molecular imaging: exploring the next frontier. Radiology 1999, 212:609-614.
135. Chanda N., Shukla R., Zambre A., Mekapothula S., Kulkarni R.R., Katti K., Bhattacharyya K., Fent G.M., Casteel S.W., Boote E.J., Viator J.A., Upendran A., Kannan R., Katti K.V. An effective strategy for the synthesis of biocompatible gold nanoparticles using cinnamon phytochemicals for phantom CT imaging and photoacoustic detection of cancerous cells. Pharm. Res. 2010, 28:279-291.
136. Danila D., Partha R., Elrod D.B., Lackey M., Casscells S.W., Conyers J.L. Antibody-labeled liposomes for CT imaging of atherosclerotic plaques. Tex. Heart Inst. J. 2009, 36:393-403.
137. 3 integrin-targeted PLGA-PEG nanoparticles for enhanced anti-tumor efficacy of a PT(IV) prodrug. ACS Nano 2012, 6:4530-4539.
138. Austrup F., Vestweber D., Borges E., Lohning M., Brauer R., Herz U., Renz H., Hallmann R., Scheffold A., Radbruch A., Hamann A. P- and E-selectin mediate recruitment of T-helper-1 but not T-helper-2 cells into inflamed tissues. Nature 1997, 385:81-83.
139. Graves B.J., Crowther R.L., Chandran C., Rumberger J.M., Li S., Huang K.-S., Presky D.H., Familletti P.C., Wolitzky B.A., Burns D.K. Insight into E-selectin/ligand interaction from the crystal structure and mutagenesis of the lec/EGF domains. Nature 1994, 367:532-538.
140. Wyss C., Schaefer S.C., Juillerat-Jeanneret L., Lagopoulos L., Lehr H.-A., Becker C.D., Montet X. Molecular imaging by micro-CT: specific E-selectin imaging. Eur. Radiol. 2009, 19:2487-2494.
141. Sun I., Na J., Jeong S.Y., Kim D., Kwon I.C., Choi K., Ahn C., Kim K. Biocompatible glycol chitosan-coated gold nanoparticles for tumor-targeting CT imaging. Pharm. Res. 2014, 31:1418-1425.
142. Hainfeld J.F., O'Connor M.J., Dilmanian F.A., Slatkin D.N., Adams D.J., Smilowitz H.M. Micro-CT enables microlocalisation and quantification of Her2-targeted gold nanoparticles within tumour regions. Br. J. Radiol. 2011, 84:526-533.
143. Huang P., Bao L., Zhang C., Lin J., Luo T., Yang D., He M., Li Z., Gao G., Gao B., Fu S., Cui D. Folic acid-conjugated silica-modified gold nanorods for X-ray/CT imaging-guided dual-mode radiation and photo-thermal therapy. Biomaterials 2011, 32:9796-9809.
144. Kelkar S.S., Reineke T.M. Theranostics: combining imaging and therapy. Bioconjug. Chem. 2011, 22:1879-1903.
145. Hill M.L., Corbin I.R., Levitin R.B., Cao W., Mainprize J.G., Yaffe M.J., Zheng G. In vitro assessment of poly-iodinated triglyceride reconstituted low-density lipoprotein: initial steps toward ct molecular imaging. Acad. Radiol. 2010, 17:1359-1365.
146. Graziani S.R., Igreja F.A.F., Hegg R., Meneghetti C., Brandizzi L.I., Barboza R., Amancio R.F., Pinotti J.A., Maranhao R.C. Uptake of a cholesterol-rich emulsion by breast cancer. Gynecol. Oncol. 2002, 85:493-497.
147. Niendorf A., Nffigele H., Gerding D., Meyer-Pannwitt U., Gebhardt A. Increased LDL receptor mRNA expression in colon cancer is correlated with a rise in plasma cholesterol levels after curative surgery. Int. J. Cancer 1995, 61:461-464.
148. Stranzl A., Schmidt H., Winkler R., Kostner G.M. Low-density lipoprotein receptor mRNA in human breast cancer cells: Influence by PKC modulators. Breast Cancer Res. Treat. 1997, 42:195-205.
149. Tatidis L., Masquelier M., Vitols S. Elevated uptake of low density lipoprotein by drug resistant human leukemic cell lines. Biochem. Pharmacol. 2002, 63:2169-2180.
150. Lu Z.R. Theranostics: fusion of therapeutics and diagnostics. Pharm. Res. 2014, 31:1355-1357.
151. Krasia-Christoforou T., Georgiou T.K. Polymeric theranostics: using polymer-based systems for simultaneous imaging and therapy. J. Mater. Chem. B 2013, 1:3002-3025.
152. Choi K.Y., Liu G., Lee S., Chen X. Theranostic nanoplatforms for simultaneous cancer imaging and therapy: current approaches and future perspectives. Nanoscale 2012, 4:330-342.
153. Wang Z., Niu G., Chen X. Polymeric materials for theranostic applications. Pharm. Res. 2014, 31:1358-1376.
154. Mussi S.V., Torchilin V.P. Recent trends in the use of lipidic nanoparticles as pharmaceutical carriers for cancer therapy and diagnostics. J. Mater. Chem. B 2013, 1:5201-5209.
155. Bea K.H., Lee J.Y., Lee S.H., Park T.G., Nam Y.S. Optically traceable solid lipid nanoparticles loaded with siRNA and paclitaxel for synergistic chemotherapy with in situ imaging. Adv. Healthcare Mater. 2013, 2:576-584.
156. Nasongkla N., Bey E., Ren J., Ai H., Khemtong C., Guthi J.S., Chin S.F., Sherry A.D., Boothman D.A., Gao J. Multifunctional polymeric micelles as cancer-targeted, MRI-ultrasensitive drug delivery systems. Nano Lett. 2006, 6:2427-2430.
157. Yu M.K., Jeong Y.Y., Park J., Park S., Kim J.W., Min J.J., Kim K., Jon S. Drug-loaded superparamagnetic iron oxide nanoparticles for combined cancer imaging and therapy in vivo. Angew. Chem. Int. Ed. 2008, 47:5362-5365.
158. Wang D., Lin B., Ai H. Theranostic nanoparticles for cancer and cardiovascular applications. Pharm. Res. 2014, 31:1390-1406.
159. Kim D., Jeong Y.Y., Jon S. A drug-loaded aptamer-gold nanoparticle bioconjugate for combined CT imaging and therapy of prostate cancer. ACS Nano 2010, 4:3689-3696.
160. Tian G., Yin W.Y., Jin J., Zhang X., Xing G., Li S., Gu Z., Zhao Y. Engineered design of theranostic upconversion nanoparticles for tri-modal upconversion luminescence/magnetic resonance/X-ray computed tomography imaging and targeted delivery of combined anticancer drugs. J. Mater. Chem. B 2014, 2:1379-1389.