Biodistribution and computed tomography blood-pool imaging properties of polyethylene glycol-coated iopromide-carrying liposomes

Investigative Radiology

Volumn 32, Issue 1, 1997, Pages 44-50

  Sachse, Andreas ^a   Leike, Jens U ^a   Schneider, Thomas ^a,b   Wagner, Susanne E ^c   Rößling, Georg L ^a   Krause, Werner ^a   Brandl, Martin ^b  

^a BAYER PHARMA AG   (Germany)

^b LS Pharmazeutische Technologie   (Germany)

^c Forschungs institut für Respiratorische Diagnostik   (Germany)

Author keywords

biodistribution; blood pool agent; computed tomography; iopromide; Liposomes; polyethylene glycol

Indexed keywords

CHOLESTEROL; IOPROMIDE; LIPOSOME; MACROGOL; PHOSPHOLIPID;

ANIMAL EXPERIMENT; ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DRUG COATING; DRUG DISTRIBUTION; DRUG FORMULATION; GATED IMAGING; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RABBIT; RAT;

EID: 0031021803     PISSN: 00209996     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004424-199701000-00007     Document Type: Article

References (20)

1. Seltzer SE. Liposomes in diagnostic imaging. In: Gregoriadis G, ed. Liposomes as drug carriers. Chichester, NY: John Wiley & Sons, 1988:509-525.
2. Tilcock C. Liposomal MR contrast agents. J Liposome Res 1994;4:811-834.
3. Senior JH. Fate and behaviour of liposomes in vivo: A review of controlling factors. CRC Critic Rev Therap Drug Carrier Sys 1987;3:123-193.
4. Allen TM. The use of glycolipids and hydrophilic polymers in avoiding rapid uptake of liposomes by the mononuclear phagocyte system. Adv Drug Deliv Rev 1994;13:285-309.
5. Tilcock C. Liposomal blood pool agents for nuclear medicine and magnetic resonance imaging. J Liposome Res 1994;4:909-936.
6. Torchilin VP, Trubetskoy VS. In vivo visualizing of organs and tissues with liposomes. J Liposome Res 1995;5:795-812.
7. Tilcock C, Yap M, Szucs M, Utkhede D. PEG-coated lipid vesicles with en-capsulated technetium-99m as blood pool agents for nuclear medicine. Nucl Med Biol 1994;21:165-170.
8. Seltzer SE, Jarvis MA, Adams DF, Shuehin PM, Landis WJ, Havron A. Liposomes carrying diatrizoate: Characterization of biophysical properties and imaging applications. Invest Radiol 1984;2:142-151.
9. Schneider T, Sachse A, Rößling G, Brandl M. Generation of contrast-carrying liposomes of defined size with a new continuous high pressure extrusion method. Int J Pharm 1995;117:1-12.
10. Schneider T, Sachse A, Rößling G, et al. Surface modification of continuously extruded contrast-carrying liposomes: Effect on their physical properties. Int J Pharm 1996;132:9-21.
11. Schuhmann-Giampieri G, Leike J, Sachse A, Krause W. Characterization of iopromide-carrying liposomes. J Liposome Res 1994;4:239-253.
12. Sachse A, Leike J, Rößling G, Wagner S, Krause W. Preparation and evaluation of lyophilized iopromide-carrying liposomes for liver tumor imaging. Invest Radiol 1993;28:838-844.
13. Viguera AR, Mencia M, Goni FM. Time-resolved and equilibrium measurements of the effects of poly(ethyleneglycol) on small unilamellar phospholipid vesicles. Biochemistry 1993;32:3708-3713.
14. Fonseca MJ, Alsina MA, Reig F. Coating liposomes with collagen (Mr 50000) increases uptake into liver. Biochim Biophys Acta 1996;1279:259-265.
15. Allen TM, Hansen C, Martin F, Redemann C, Yau-Young A. Liposomes containing lipid derivatives of poly(ethyleneglycol) show prolonged circulation half-lives in vivo. Biochim Biophys Acta 1991;1066:29-36.
16. Woodle MC, Lasic DD. Sterically stabilized liposomes. Biochim Biophys Acta 1992;1113:171-199.
17. Litzinger DC, Buiting AMJ, van Rooijen N, Huang L. Effect of liposome size on the circulation time and intraorgan distribution of amphiphatic poly(ethyleneglycol)-containing liposomes. Biochim Biophys Acta 1994;1190:99-107.
18. Bogdanov AA Jr, Weissleder R, Brady TJ. Long-circulating blood pool imaging agents. Adv Drug Delivery Rev 1995;16:335-348.
19. Revel D, Chambon C, Havard PH, et al. Iodinated polymer as blood-pool contrast agent: Computed tomography evaluation in rabbits. Invest Radiol 1991;26:S57-S59.
20. Gazelle GS, Wolf GL, McIntire GL, et al. Nanoparticulate computed tomography contrast agents for blood pool and liver-spleen imaging. Acad Radiol 1994;1:373-376.