Micro-CT based experimental liver imaging using a nanoparticulate contrast agent: A longitudinal study in mice

PLoS ONE

Volumn 6, Issue 9, 2011, Pages

  Boll, Hanne ^a   Nittka, Stefanie ^a   Doyon, Fabian ^a   Neumaier, Michael ^a   Marx, Alexander ^a   Kramer, Martin ^b   Groden, Christoph ^a   Brockmann, Marc A ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CONTRAST MEDIUM; EXITRON NANO 12000; EXITRON NANO 6000; NANOPARTICLE; UNCLASSIFIED DRUG; DIAGNOSTIC AGENT;

ADRENAL GLAND; ANGIOGRAPHY; ANIMAL EXPERIMENT; ARTICLE; CONTRAST ENHANCEMENT; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG FORMULATION; DRUG TOLERABILITY; HEPATOGRAPHY; LIVER METASTASIS; LONGITUDINAL STUDY; LYMPH NODE; MEDIASTINUM LYMPH NODE; MICRO-COMPUTED TOMOGRAPHY; MOUSE; NONHUMAN; SINGLE DRUG DOSE; SPLEEN; ANIMAL; CHEMISTRY; COLON TUMOR; LIVER; LIVER TUMOR; METABOLISM; METASTASIS; METHODOLOGY; PATHOLOGY;

ANIMALIA; MUS;

ANIMALS; COLONIC NEOPLASMS; CONTRAST MEDIA; LIVER; LIVER NEOPLASMS; MICE; NANOPARTICLES; X-RAY MICROTOMOGRAPHY;

EID: 80053579564     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0025692     Document Type: Article

References (26)

1. Schambach SJ, Bag S, Schilling L, Groden C, Brockmann MA, (2010) Application of micro-CT in small animal imaging. Methods 50: 2-13.
2. Willekens I, Lahoutte T, Buls N, Vanhove C, Deklerck R, et al. (2009) Time-course of contrast enhancement in spleen and liver with Exia 160, Fenestra LC, and VC. Mol Imaging Biol 11: 128-135.
3. Suckow CE, Stout DB, (2008) MicroCT liver contrast agent enhancement over time, dose, and mouse strain. Mol Imaging Biol 10: 114-120.
4. Graham KC, Detombe SA, MacKenzie LT, Holdsworth DW, MacDonald IC, et al. (2008) Contrast-enhanced microcomputed tomography using intraperitoneal contrast injection for the assessment of tumor-burden in liver metastasis models. Invest Radiol 43: 488-495.
5. Montet X, Pastor CM, Vallee JP, Becker CD, Geissbuhler A, et al. (2007) Improved visualization of vessels and hepatic tumors by micro-computed tomography (CT) using iodinated liposomes. Invest Radiol 42: 652-658.
6. Almajdub M, Nejjari M, Poncet G, Magnier L, Chereul E, et al. (2007) In-vivo high-resolution X-ray microtomography for liver and spleen tumor assessment in mice. Contrast Media Mol Imaging 2: 88-93.
7. Ohta S, Lai EW, Morris JC, Bakan DA, Klaunberg B, et al. (2006) MicroCT for high-resolution imaging of ectopic pheochromocytoma tumors in the liver of nude mice. Int J Cancer 119: 2236-2241.
8. Weber SM, Peterson KA, Durkee B, Qi C, Longino M, et al. (2004) Imaging of murine liver tumor using microCT with a hepatocyte-selective contrast agent: accuracy is dependent on adequate contrast enhancement. J Surg Res 119: 41-45.
9. Bakan DA, Doerr-Stevens JK, Weichert JP, Longino MA, Lee FT Jr, et al. (2001) Imaging efficacy of a hepatocyte-selective polyiodinated triglyceride for contrast-enhanced computed tomography. Am J Ther 8: 359-365.
10. Bakan DA, Weichert JP, Longino MA, Counsell RE, (2000) Polyiodinated triglyceride lipid emulsions for use as hepatoselective contrast agents in CT: effects of physicochemical properties on biodistribution and imaging profiles. Invest Radiol 35: 158-169.
11. Bakan DA, Longino MA, Weichert JP, Counsell RE, (1996) Physicochemical characterization of a synthetic lipid emulsion for hepatocyte-selective delivery of lipophilic compounds: application to polyiodinated triglycerides as contrast agents for computed tomography. J Pharm Sci 85: 908-914.
12. Weichert JP, Longino MA, Bakan DA, Spigarelli MG, Chou TS, et al. (1995) Polyiodinated triglyceride analogs as potential computed tomography imaging agents for the liver. J Med Chem 38: 636-646.
13. Martiniova L, Kotys MS, Thomasson D, Schimel D, Lai EW, et al. (2009) Noninvasive monitoring of a murine model of metastatic pheochromocytoma: a comparison of contrast-enhanced microCT and nonenhanced MRI. J Magn Reson Imaging 29: 685-691.
14. Martiniova L, Schimel D, Lai EW, Limpuangthip A, Kvetnansky R, et al. (2010) In vivo micro-CT imaging of liver lesions in small animal models. Methods 50: 20-25.
15. Chouker A, Lizak M, Schimel D, Helmberger T, Ward JM, et al. (2008) Comparison of Fenestra VC Contrast-enhanced computed tomography imaging with gadopentetate dimeglumine and ferucarbotran magnetic resonance imaging for the in vivo evaluation of murine liver damage after ischemia and reperfusion. Invest Radiol 43: 77-91.
16. Schambach SJ, Bag S, Groden C, Schilling L, Brockmann MA, (2010) Vascular imaging in small rodents using micro-CT. Methods 50: 26-35.
17. Boll H, Bag S, Schambach SJ, Doyon F, Nittka S, et al. (2010) High-speed single-breath-hold micro-computed tomography of thoracic and abdominal structures in mice using a simplified method for intubation. J Comput Assist Tomogr 34: 783-790.
18. Boll H, Bag S, Nolte IS, Wilhelm T, Kramer M, et al. (2011) Double-contrast micro-CT colonoscopy in live mice. Int J Colorectal Dis 26: 721-727.
19. MacDonald KD, Chang HY, Mitzner W, (2009) An improved simple method of mouse lung intubation. J Appl Physiol 106: 984-987.
20. Kerl HU, Isaza CT, Boll H, Schambach SJ, Nolte IS, et al. (2011) Evaluation of a continuous-rotation, high-speed scanning protocol for micro-computed tomography. J Comput Assist Tomogr 35: 517-523.
21. Krause W, Handreke K, Schuhmann-Giampieri G, Rupp K, (2002) Efficacy of the iodine-free computed tomography liver contrast agent, Dy-EOB-DTPA, in comparison with a conventional iodinated agent in normal and in tumor-bearing rabbits. Invest Radiol 37: 241-247.
22. Weinmann HJ, Ebert W, Misselwitz B, Schmitt-Willich H, (2003) Tissue-specific MR contrast agents. Eur J Radiol 46: 33-44.
23. Ford NL, Graham KC, Groom AC, Macdonald IC, Chambers AF, et al. (2006) Time-course characterization of the computed tomography contrast enhancement of an iodinated blood-pool contrast agent in mice using a volumetric flat-panel equipped computed tomography scanner. Invest Radiol 41: 384-390.
24. Kiessling F, Greschus S, Lichy MP, Bock M, Fink C, et al. (2004) Volumetric computed tomography (VCT): a new technology for noninvasive, high-resolution monitoring of tumor angiogenesis. Nat Med 10: 1133-1138.
25. Mukundan S Jr, Ghaghada KB, Badea CT, Kao CY, Hedlund LW, et al. (2006) A liposomal nanoscale contrast agent for preclinical CT in mice. AJR Am J Roentgenol 186: 300-307.
26. Weichert JP, Lee FT Jr, Chosy SG, Longino MA, Kuhlman JE, et al. (2000) Combined hepatocyte-selective and blood-pool contrast agents for the CT detection of experimental liver tumors in rabbits. Radiology 216: 865-871.