Imaging Characteristics of DHOG, a Hepatobiliary Contrast Agent for Preclinical MicroCT in Mice

Academic Radiology

Volumn 15, Issue 3, 2008, Pages 342-349

  Henning, Tobias ^a   Weber, Axel W ^b   Bauer, Jan S ^a   Meier, Reinhard ^a   Carlsen, Janette M ^b   Sutton, Elizabeth J ^a   Prevrhal, Sven ^a   Ziegler, Sibylle I ^b   Feussner, Hubertus ^b   Daldrup Link, Heike E ^a   Rummeny, Ernst J ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Department of Nuclear Medicine ^*  (Germany)

Author keywords

contrast agents; imaging; MicroCT

Indexed keywords

1,3 BIS[7 (3 AMINO 2,4,6 TRIIODOPHENYL)HEPTANOYL] 2 OLEOYLGLYCEROL; CONTRAST MEDIUM; FENESTRA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AORTA; ARTICLE; COMPUTED TOMOGRAPHY SCANNER; EXCRETION; FEMALE; IMAGING; KIDNEY; KIDNEY PARENCHYMA; LIVER; LIVER PARENCHYMA; MICRO-COMPUTED TOMOGRAPHY; MOUSE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RADIATION DOSE; REPRODUCIBILITY; SPLEEN;

ANIMALS; AORTOGRAPHY; CHOLANGIOGRAPHY; CONTRAST MEDIA; FEMALE; IMAGING, THREE-DIMENSIONAL; INJECTIONS, INTRAVENOUS; IODINE ISOTOPES; KIDNEY; LIVER; LIVER DISEASES; MICE; MICE, INBRED C3H; PHANTOMS, IMAGING; RADIATION DOSAGE; RADIOGRAPHIC IMAGE ENHANCEMENT; REPRODUCIBILITY OF RESULTS; SPLEEN; TIME FACTORS; TOMOGRAPHY SCANNERS, X-RAY COMPUTED; TOMOGRAPHY, X-RAY COMPUTED; TRIGLYCERIDES;

EID: 38949134535     PISSN: 10766332     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.acra.2007.10.007     Document Type: Article

References (20)

1. Weichert J.P., Longino M.A., Bakan D.A., et al. Polyiodinated triglyceride analogs as potential computed tomography imaging agents for the liver. J Med Chem 38 (1995) 636-646
2. Cooper A.D. Hepatic uptake of chylomicron remnants. J Lipid Res 38 (1997) 2173-2192
3. Masuno H., Shiosaka T., Itoh Y., et al. Hepatic triglyceride lipase and lipoprotein lipase activities in post-heparin plasma of patients with various cancers. Jpn J Cancer Res 76 (1985) 202-207
4. Weichert J.P., Longino M.A., Spigarelli M.G., et al. Computed tomography scanning of Morris hepatomas with liver-specific polyiodinated triglycerides. Acad Radiol 3 (1996) 412-417
5. Weichert J.P., Lee Jr. F.T., Longino M.A., et al. Lipid-based blood-pool CT imaging of the liver. Acad Radiol 5 Suppl 1 (1998) S16S9; discussion S28-S30
6. Bakan D.A., Longino M.A., Weichert J.P., et al. Physicochemical characterization of a synthetic lipid emulsion for hepatocyte-selective delivery of lipophilic compounds: application to polyiodinated triglycerides as contrast agents for computed tomography. J Pharm Sci 85 (1996) 908-914
7. Longino M.A., Bakan D.A., Weichert J.P., et al. Formulation of polyiodinated triglyceride analogues in a chylomicron remnant-like liver-selective delivery vehicle. Pharm Res 13 (1996) 875-879
8. Lee Jr. F.T., Chosy S.G., Naidu S.G., et al. CT depiction of experimental liver tumors: contrast enhancement with hepatocyte-selective iodinated triglyceride versus conventional techniques. Radiology 203 (1997) 465-470
9. Ford N.L., Thornton M.M., and Holdsworth D.W. Fundamental image quality limits for microcomputed tomography in small animals. Med Phys 30 (2003) 2869-2877
10. Desser T.S., Rubin D.L., Muller H.H., et al. Dynamics of tumor imaging with Gd-DTPA-polyethylene glycol polymers: dependence on molecular weight. J Magn Reson Imaging 4 (1994) 467-472
11. Simon G.H., Fu Y., Berejnoi K., et al. Initial computed tomography imaging experience using a new macromolecular iodinated contrast medium in experimental breast cancer. Invest Radiol 40 (2005) 614-620
12. Roberts T.P. Physiologic measurements by contrast-enhanced MR imaging: expectations and limitations. J Magn Reson Imaging 7 (1997) 82-90
13. Bakan D.A., Lee Jr. F.T., Weichert J.P., et al. Hepatobiliary imaging using a novel hepatocyte-selective CT contrast agent. Acad Radiol 9 Suppl 1 (2002) S194-S1949
14. Violante M.R., Dean P.B., Fischer H.W., et al. Particulate contrast media for computed tomographic scanning of the liver. Invest Radiol 15 (1980) S171-S175
15. Cassel D.M., Young S.W., Brody W.R., et al. Radiographic blood pool contrast agents for vascular and tumor imaging with projection radiography and computed tomography. J Comput Assist Tomogr 6 (1982) 141-146
16. Mattrey R.F., Long D.M., Peck W.W., et al. Perfluoroctylbromide as a blood pool contrast agent for liver, spleen, and vascular imaging in computed tomography. J Comput Assist Tomogr 8 (1984) 739-744
17. Rummeny E.J., Berning W., Fuest M., et al. New RES-specific contrast agents for CT. Acad Radiol 9 Suppl 1 (2002) S185-S190
18. Mukundan Jr. S., Ghaghada K.B., Badea C.T., et al. A liposomal nanoscale contrast agent for preclinical CT in mice. AJR Am J Roentgenol 186 (2006) 300-307
19. Vera D.R., and Mattrey R.F. A molecular CT blood pool contrast agent. Acad Radiol 9 (2002) 784-792
20. Torchilin V.P., Frank-Kamenetsky M.D., and Wolf G.L. CT visualization of blood pool in rats by using long-circulating, iodine-containing micelles. Acad Radiol 6 (1999) 61-65