Multi-slice computed tomography with N1177 identifies ruptured atherosclerotic plaques in rabbits

Basic Research in Cardiology

Volumn 105, Issue 1, 2010, Pages 51-59

  Van Herck, Jozef Leo ^a   De Meyer, Guido R Y ^b   Martinet, Wim ^b   Salgado, Rodrigo A ^a   Shivalkar, Bharati ^a   De Mondt, Roel ^b   Van De Ven, Helene ^b   Ludwig, Annick ^b   Van Der Veken, Pieter ^b   Van Vaeck, Luc ^b   Bult, Hidde ^b   Herman, Arnold G ^b   Vrints, Christiaan J ^a  

^a ANTWERP UNIVERSITY HOSPITAL   (Belgium)

^b UNIVERSITY OF ANTWERP   (Belgium)

Author keywords

Macrophage; Molecular imaging; Multi slice computed tomography; N1177

Indexed keywords

ACETYLSALICYLIC ACID; CONTRAST MEDIUM; HEPARIN; INTERLEUKIN 6; N 1177; NANOPARTICLE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATHEROSCLEROTIC PLAQUE; CELL FUNCTION; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXICITY; DIAGNOSTIC IMAGING; EXPERIMENTAL RABBIT; FLOW CYTOMETRY; IN VITRO STUDY; IN VIVO STUDY; MACROPHAGE; MOUSE; MULTIDETECTOR COMPUTED TOMOGRAPHY; NONHUMAN; TIME OF FLIGHT MASS SPECTROMETRY;

ANIMALS; ATHEROSCLEROSIS; CELL LINE; CELL SURVIVAL; CONTRAST MEDIA; IODINE; MACROPHAGES; MICE; NANOPARTICLES; RABBITS; RUPTURE, SPONTANEOUS; TOMOGRAPHY, X-RAY COMPUTED;

EID: 72449187033     PISSN: 03008428     EISSN: 14351803     Source Type: Journal    
DOI: 10.1007/s00395-009-0052-0     Document Type: Article

References (51)

1. AC Barger R Beeuwkes 3rd LL Lainey KJ Silverman 1984 Hypothesis: vasa vasorum and neovascularization of human coronary arteries. A possible role in the pathophysiology of atherosclerosis N Engl J Med 310 175 177 1:STN:280:DyaL2c%2FptlCntA%3D%3D 6197652
2. M Barreto P Schoenhagen A Nair S Amatangelo M Milite NA Obuchowski ML Lieber SS Halliburton 2008 Potential of dual-energy computed tomography to characterize atherosclerotic plaque: ex vivo assessment of human coronary arteries in comparison to histology J Cardiovasc Comput Tomogr 2 234 242 10.1016/j.jcct.2008.05.146 19083956
3. CR Becker K Nikolaou M Muders G Babaryka A Crispin UJ Schoepf U Loehrs MF Reiser 2003 Ex vivo coronary atherosclerotic plaque characterization with multi-detector-row CT Eur Radiol 13 2094 2098 10.1007/s00330-003-1889-5 12692681 (Pubitemid 37080742)
4. MJ Budoff S Achenbach RS Blumenthal JJ Carr JG Goldin P Greenland AD Guerci JA Lima DJ Rader GD Rubin LJ Shaw SE Wiegers 2006 Assessment of coronary artery disease by cardiac computed tomography: a scientific statement from the American Heart Association Committee on Cardiovascular Imaging and Intervention, Council on Cardiovascular Radiology and Intervention, and Committee on Cardiac Imaging, Council on Clinical Cardiology Circulation 114 1761 1791 10.1161/CIRCULATIONAHA.106.178458 17015792 (Pubitemid 44607126)
5. H Bult GRY De Meyer AG Herman 1995 Influence of chronic treatment with a nitric oxide donor on fatty streak development and reactivity of the rabbit aorta Br J Pharmacol 114 1371 1382 1:CAS:528:DyaK2MXkvFChtbg%3D 7606341
6. PM Carrascosa CM Capunay P Garcia-Merletti J Carrascosa MF Garcia 2006 Characterization of coronary atherosclerotic plaques by multidetector computed tomography Am J Cardiol 97 598 602 10.1016/j.amjcard.2005.09.096 16490420 (Pubitemid 43255022)
7. C Caussin A Ohanessian S Ghostine L Jacq B Lancelin G Dambrin A Sigal-Cinqualbre CY Angel JF Paul 2004 Characterization of vulnerable nonstenotic plaque with 16-slice computed tomography compared with intravascular ultrasound Am J Cardiol 94 99 104 10.1016/j.amjcard.2004.03.036 15219516 (Pubitemid 38813461)
8. GRY De Meyer MF Hoylaerts MM Kockx H Yamamoto AG Herman H Bult 1999 Intimal deposition of functional von Willebrand factor in atherogenesis Arterioscler Thromb Vasc Biol 19 2524 2534 10521383
9. TG Flohr BM Ohnesorge 2008 Imaging of the heart with computed tomography Basic Res Cardiol 103 161 173 10.1007/s00395-008-0699-y 18324372 (Pubitemid 351356758)
10. R Funada Y Oikawa J Yajima H Kirigaya K Nagashima K Ogasawara S Matsuno T Inaba Y Nakagawa M Nakamura M Kurabayashi T Aizawa 2009 The potential of RF backscattered IVUS data and multidetector-row computed tomography images for tissue characterization of human coronary atherosclerotic plaques Int J Cardiovasc Imaging 25 471 478 10.1007/s10554-009-9446-1 19263239
11. JA Goldstein MJ Gallagher WW O'Neill MA Ross BJ O'Neil GL Raff 2007 A randomized controlled trial of multi-slice coronary computed tomography for evaluation of acute chest pain J Am Coll Cardiol 49 863 871 10.1016/j.jacc.2006. 08.064 17320744 (Pubitemid 46275355)
12. K Graf M Grafe E Fleck 2008 Cardiovascular diseases as target for imaging Basic Res Cardiol 103 82 86 10.1007/s00395-008-0700-9 18324363 (Pubitemid 351356750)
13. U Hoffmann F Moselewski K Nieman IK Jang M Ferencik AM Rahman RC Cury S Abbara H Joneidi-Jafari S Achenbach TJ Brady 2006 Noninvasive assessment of plaque morphology and composition in culprit and stable lesions in acute coronary syndrome and stable lesions in stable angina by multidetector computed tomography J Am Coll Cardiol 47 1655 1662 10.1016/j.jacc.2006.01.041 16631006
14. L Husmann I Valenta O Gaemperli O Adda V Treyer CA Wyss P Veit-Haibach F Tatsugami GK von Schulthess PA Kaufmann 2008 Feasibility of low-dose coronary CT angiography: first experience with prospective ECG-gating Eur Heart J 29 191 197 10.1093/eurheartj/ehm613 18089704
15. F Hyafil J-C Cornily JE Feig R Gordon E Vucic V Amirbekian EA Fisher V Fuster LJ Feldman ZA Fayad 2007 Noninvasive detection of macrophages using a nanoparticulate contrast agent for computed tomography Nat Med 13 636 641 10.1038/nm1571 1:CAS:528:DC%2BD2sXkvVOhu7k%3D 17417649 (Pubitemid 46828482)
16. T Kitagawa H Yamamoto J Horiguchi N Ohhashi F Tadehara T Shokawa Y Dohi E Kunita H Utsunomiya N Kohno Y Kihara 2009 Characterization of noncalcified coronary plaques and identification of culprit lesions in patients with acute coronary syndrome by 64-slice computed tomography J Am Coll Cardiol Imaging 2 153 160
17. F Knollmann F Ducke L Krist T Kertesz R Meyer H Guski R Felix 2008 Quantification of atherosclerotic coronary plaque components by submillimeter computed tomography Int J Cardiovasc Imaging 24 301 310 10.1007/s10554-007-9262- 4 17849236
18. MM Kockx KM Cromheeke MWM Knaapen JM Bosmans GRY De Meyer AG Herman H Bult 2003 Phagocytosis and macrophage activation associated with hemorrhagic microvessels in human atherosclerosis Arterioscler Thromb Vasc Biol 23 440 446 10.1161/01.ATV.0000057807.28754.7F 1:CAS:528:DC%2BD3sXhslWhsLw%3D 12615689 (Pubitemid 36337220)
19. ME Kooi VC Cappendijk KBJM Cleutjens AGH Kessels PJEHM Kitslaar M Borgers PM Frederik MJAP Daemen JMA van Engelshoven 2003 Accumulation of ultrasmall superparamagnetic particles of iron oxide in human atherosclerotic plaques can be detected by in vivo magnetic resonance imaging Circulation 107 2453 2458 10.1161/01.CIR.0000068315.98705.CC 1:CAS:528:DC%2BD3sXjs1antb8%3D 12719280 (Pubitemid 36605228)
20. G Korosoglou RG Weiss DA Kedziorek P Walczak WD Gilson M Schar DE Sosnovik DL Kraitchman RC Boston JW Bulte R Weissleder M Stuber 2008 Noninvasive detection of macrophage-rich atherosclerotic plaque in hyperlipidemic rabbits using "positive contrast" magnetic resonance imaging J Am Coll Cardiol 52 483 491 10.1016/j.jacc.2008.03.063 1:CAS:528:DC%2BD1cXpt1GrsL0%3D 18672170 (Pubitemid 352043838)
21. AW Leber A Becker A Knez F von Ziegler M Sirol K Nikolaou B Ohnesorge ZA Fayad CR Becker M Reiser G Steinbeck P Boekstegers 2006 Accuracy of 64-slice computed tomography to classify and quantify plaque volumes in the proximal coronary system: a comparative study using intravascular ultrasound J Am Coll Cardiol 47 672 677 10.1016/j.jacc.2005.10.058 16458154 (Pubitemid 43170862)
22. AW Leber A Knez F von Ziegler A Becker K Nikolaou S Paul B Wintersperger M Reiser CR Becker G Steinbeck P Boekstegers 2005 Quantification of obstructive and nonobstructive coronary lesions by 64-slice computed tomography: a comparative study with quantitative coronary angiography and intravascular ultrasound J Am Coll Cardiol 46 147 154 10.1016/j.jacc.2005.03.071 15992649 (Pubitemid 40905143)
23. B Levkau 2008 Opportunities, challenges, and caveats of successful molecular imaging of cardiovascular diseases Basic Res Cardiol 103 79 81 10.1007/s00395-008-0705-4 18324362 (Pubitemid 351356749)
24. P Libby 2006 Atherosclerosis: disease biology affecting the coronary vasculature Am J Cardiol 98 3Q 9Q 10.1016/j.amjcard.2006.09.020 1:CAS:528:DC%2BD2sXhtVKqtL8%3D 17169627 (Pubitemid 44880276)
25. CW Lowik MJ Alblas M van de Ruit SE Papapoulos G van der Pluijm 1993 Quantification of adherent and nonadherent cells cultured in 96-well plates using the supravital stain neutral red Anal Biochem 213 426 433 10.1006/abio.1993.1442 1:CAS:528:DyaK3sXlvFyrtLk%3D 7694524
26. W Martinet DM Schrijvers JP Timmermans AG Herman GR De Meyer 2009 Phagocytosis of bacteria is enhanced in macrophages undergoing nutrient deprivation FEBS J 276 2227 2240 10.1111/j.1742-4658.2009.06951.x 1:CAS:528:DC%2BD1MXksVKnsbY%3D 19302214
27. WB Meijboom MFL Meijs JD Schuijf MJ Cramer NR Mollet CAG van Mieghem K Nieman JM van Werkhoven G Pundziute AC Weustink AM de Vos F Pugliese B Rensing JW Jukema JJ Bax M Prokop PA Doevendans MGM Hunink GP Krestin PJ de Feyter 2008 Diagnostic accuracy of 64-slice computed tomography coronary angiography: a prospective, multicenter, multivendor study J Am Coll Cardiol 52 2135 2144 10.1016/j.jacc.2008.08.058 19095130
28. GS Mintz JA Painter AD Pichard KM Kent LF Satler JJ Popma YC Chuang TA Bucher LE Sokolowicz MB Leon 1995 Atherosclerosis in angiographically "normal" coronary artery reference segments: an intravascular ultrasound study with clinical correlations J Am Coll Cardiol 25 1479 1485 10.1016/0735-1097(95)00088-L 1:STN:280:DyaK2M3nvFKjtg%3D%3D 7759694
29. PR Moreno E Falk IF Palacios JB Newell V Fuster JT Fallon 1994 Macrophage infiltration in acute coronary syndromes. Implications for plaque rupture Circulation 90 775 778 1:STN:280:DyaK2czitVamsA%3D%3D 8044947
30. S Motoyama T Kondo M Sarai A Sugiura H Harigaya T Sato K Inoue M Okumura J Ishii H Anno R Virmani Y Ozaki H Hishida J Narula 2007 Multislice computed tomographic characteristics of coronary lesions in acute coronary syndromes J Am Coll Cardiol 50 319 326 10.1016/j.jacc.2007.03.044 17659199 (Pubitemid 47058884)
31. M Nahrendorf DE Sosnovik R Weissleder 2008 MR-optical imaging of cardiovascular molecular targets Basic Res Cardiol 103 87 94 10.1007/s00395-008-0707-2 1:CAS:528:DC%2BD1cXksF2qtLw%3D 18324364 (Pubitemid 351356751)
32. M Petranovic A Soni H Bezzera R Loureiro A Sarwar C Raffel E Pomerantsev IK Jang TJ Brady S Achenbach RC Cury 2009 Assessment of nonstenotic coronary lesions by 64-slice multidetector computed tomography in comparison to intravascular ultrasound: evaluation of nonculprit coronary lesions J Cardiovasc Comput Tomogr 3 24 31 10.1016/j.jcct.2008.12.005 19201374
33. K Pohle S Achenbach B Macneill D Ropers M Ferencik F Moselewski U Hoffmann TJ Brady IK Jang WG Daniel 2007 Characterization of non-calcified coronary atherosclerotic plaque by multi-detector row CT: comparison to IVUS Atherosclerosis 190 174 180 10.1016/j.atherosclerosis.2006.01.013 1:CAS:528:DC%2BD28XhtlartLnN 16494883 (Pubitemid 44908312)
34. A-C Pouleur J-B de Waroux J Kefer A Pasquet J-L Vanoverschelde BL Gerber 2008 Direct comparison of whole-heart navigator-gated magnetic resonance coronary angiography and 40- and 64-slice multidetector row computed tomography to detect the coronary artery stenosis in patients scheduled for conventional coronary angiography Circ Cardiovasc Imaging 1 114 121 10.1161/CIRCIMAGING.107. 756304 19808528
35. S Saitoh T Saito T Ohwada A Ohtake F Onogi K Aikawa K Maehara Y Maruyama 1998 Morphological and functional changes in coronary vessel evoked by repeated endothelial injury in pigs Cardiovasc Res 38 772 781 10.1016/S0008-6363(98) 00053-4 1:CAS:528:DyaK1cXktFKlsrY%3D 9747446 (Pubitemid 28319887)
36. M Schafers 2008 The future of molecular imaging in the clinic needs a clear strategy and a multidisciplinary effort Basic Res Cardiol 103 200 202 10.1007/s00395-008-0708-1 1:STN:280:DC%2BD1cnltlyruw%3D%3D 18324376 (Pubitemid 351356762)
37. DM Schrijvers GR De Meyer AG Herman W Martinet 2007 Phagocytosis in atherosclerosis: molecular mechanisms and implications for plaque progression and stability Cardiovasc Res 73 470 480 10.1016/j.cardiores.2006.09.005 1:CAS:528:DC%2BD2sXltVSqsw%3D%3D 17084825 (Pubitemid 46073944)
38. JD Schuijf T Beck C Burgstahler JW Jukema MS Dirksen A de Roos EE van der Wall S Schroeder W Wijns JJ Bax 2007 Differences in plaque composition and distribution in stable coronary artery disease versus acute coronary syndromes: non-invasive evaluation with multi-slice computed tomography Acute Card Care 9 48 53 10.1080/17482940601052648 1:STN:280:DC%2BD2s3ksVejuw%3D%3D 17453539 (Pubitemid 46622770)
39. SM Schwartz MB Stemerman EP Benditt 1975 The aortic intima. II. Repair of the aortic lining after mechanical denudation Am J Pathol 81 15 42 1:STN:280:DyaE28%2FjslOnsg%3D%3D 1180329
40. PK Shah E Falk JJ Badimon A Fernandez-Ortiz A Mailhac G Villareal-Levy JT Fallon J Regnstrom V Fuster 1995 Human monocyte-derived macrophages induce collagen breakdown in fibrous caps of atherosclerotic plaques. Potential role of matrix-degrading metalloproteinases and implications for plaque rupture Circulation 92 1565 1569 1:CAS:528:DyaK2MXot1yit7g%3D 7664441
41. DE Sosnovik M Nahrendorf R Weissleder 2008 Magnetic nanoparticles for MR imaging: agents, techniques and cardiovascular applications Basic Res Cardiol 103 122 130 10.1007/s00395-008-0710-7 1:CAS:528:DC%2BD1cXksF2qtLc%3D 18324368 (Pubitemid 351356755)
42. J Sun Z Zhang B Lu W Yu Y Yang Y Zhou Y Wang Z Fan 2008 Identification and quantification of coronary atherosclerotic plaques: a comparison of 64-MDCT and intravascular ultrasound AJR Am J Roentgenol 190 748 754 10.2214/AJR.07.2763 18287448 (Pubitemid 351304521)
43. RA Trivedi J-M U-King-Im MJ Graves JJ Cross J Horsley MJ Goddard JN Skepper G Quartey E Warburton I Joubert L Wang PJ Kirkpatrick J Brown JH Gillard 2004 In vivo detection of macrophages in human carotid atheroma: temporal dependence of ultrasmall superparamagnetic particles of iron oxide-enhanced MRI Stroke 35 1631 1635 10.1161/01.STR.0000131268.50418.b7 15166394 (Pubitemid 38823638)
44. AC van der Wal AE Becker CM van der Loos PK Das 1994 Site of intimal rupture or erosion of thrombosed coronary atherosclerotic plaques is characterized by an inflammatory process irrespective of the dominant plaque morphology Circulation 89 36 44 8281670
45. L Van Vaeck A Adriaens R Gijbels 1999 Static secondary ion mass spectrometry (S-SIMS) Part 1: methodology and structural interpretation Mass Spectrom Rev 18 1 47 10.1002/(SICI)1098-2787(1999)18:1<1::AID-MAS1>3.0. CO;2-W (Pubitemid 129659001)
46. TJ Verbeuren FH Jordaens LL Zonnekeyn CE Van Hove MC Coene AG Herman 1986 Effect of hypercholesterolemia on vascular reactivity in the rabbit. I. Endothelium-dependent and endothelium-independent contractions and relaxations in isolated arteries of control and hypercholesterolemic rabbits Circ Res 58 552 564 1:CAS:528:DyaL28XhvVChtL0%3D 3486053
47. S Verheye W Martinet MM Kockx MWM Knaapen K Salu J-P Timmermans JT Ellis DL Kilpatrick GRY De Meyer 2007 Selective clearance of macrophages in atherosclerotic plaques by autophagy J Am Coll Cardiol 49 706 715 10.1016/j.jacc.2006.09.047 1:CAS:528:DC%2BD2sXhs1Slt7Y%3D 17291937 (Pubitemid 46205042)
48. R Virmani FD Kolodgie AP Burke A Farb SM Schwartz 2000 Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions Arterioscler Thromb Vasc Biol 20 1262 1275 1:STN:280:DC%2BD3c3ntVCntA%3D%3D 10807742
49. R Virmani J Narula A Farb 1998 When neoangiogenesis ricochets Am Heart J 136 937 939 10.1016/S0002-8703(98)70144-9 1:STN:280:DyaK1M%2FlvFKnuw%3D%3D 9842001 (Pubitemid 29080846)
50. WS Webster SP Bishop JC Geer 1974 Experimental aortic intimal thickening. II. Endothelialization and permeability Am J Pathol 76 265 284 1:STN:280:DyaE2c3nsl2jtQ%3D%3D 4843385
51. FF Weidinger JM McLenachan MI Cybulsky JB Gordon HG Rennke NK Hollenberg JT Fallon P Ganz JP Cooke 1990 Persistent dysfunction of regenerated endothelium after balloon angioplasty of rabbit iliac artery Circulation 81 1667 1679 1:STN:280:DyaK3c3jsFentw%3D%3D 2139594