Nanoscaled Iodized Oil Emulsion as a CT Contrast Agent for the Detection of Experimental Liver Tumors in a Rat Model

Academic Radiology

Volumn 17, Issue 8, 2010, Pages 985-991

  Lim, Soo Jeong ^a   Lim, Joon Seok ^b   Choi, Junjeong ^b   Choi, Jin Young ^b   Hyung, Woo Jin ^b   Kim, Hong Sik ^b   Suh, Jinsuk ^b   Kim, Ki Whang ^b  

^a Sejong University   (South Korea)

^b Yonsei University College of Medicine   (South Korea)

Author keywords

Contrast agent; CT; Emulsion; Hepatic metastasis; Iodized oil

Indexed keywords

IODINATED CONTRAST MEDIUM; IOPAMIDOL; LIPID EMULSION; NANOPARTICLE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; ECHOGRAPHY; FEMALE; HISTOPATHOLOGY; IMAGE ANALYSIS; IMAGE ENHANCEMENT; LIVER METASTASIS; LIVER TUMOR; NANOANALYSIS; NONHUMAN; PRIORITY JOURNAL; RAT; RETICULOENDOTHELIAL SYSTEM;

ANIMALS; CONTRAST MEDIA; FEMALE; IODIZED OIL; LIVER; LIVER NEOPLASMS, EXPERIMENTAL; RATS; RATS, SPRAGUE-DAWLEY; SPLEEN; TOMOGRAPHY, X-RAY COMPUTED; VENA CAVA, INFERIOR;

EID: 77954191631     PISSN: 10766332     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.acra.2010.03.021     Document Type: Article

References (22)

1. Hughes K.S., Simon R., Songhorabodi S., et al. Resection of the liver for colorectal carcinoma metastases: a multi-institutional study of patterns of recurrence. Surgery 1986, 100:278-284.
2. Kao C.Y., Hoffman E.A., Beck K.C., et al. Long-residence-time nano-scale liposomal iohexol for X-ray-based blood pool imaging. Acad Radiol 2003, 10:475-483.
3. Rubin D.L., Desser T.S., Qing F., et al. Nanoparticulate contrast media. Blood-pool and liver-spleen imaging. Invest Radiol 1994, 29(Suppl 2):S280-S283.
4. Mattrey R.F. Perfluorooctylbromide: a new contrast agent for CT, sonography, and MR imaging. AJR Am J Roentgenol 1989, 152:247-252.
5. Vermess M., Chatterji D.C., Doppman J.L., et al. Development and experimental evaluation of a contrast medium for computed tomographic examination of the liver and spleen. J Comput Assist Tomogr 1979, 3:25-31.
6. Seltzer S.E., Shulkin P.M., Adams D.F., et al. Usefulness of liposomes carrying losefamate for ct opacification of liver and spleen. Am J Roentgenol 1984, 143:575-579.
7. Chung Y.E., Hyung W.J., Kweon S., et al. Feasibility of interstitial CT lymphography using optimized iodized oil emulsion in rats. Invest Radiol 2010, 45:142-148.
8. Behan M., O'Connell D., Mattrey R.F., et al. Perfluorooctylbromide as a contrast agent for CT and sonography: preliminary clinical results. AJR Am J Roentgenol 1993, 160:399-405.
9. Sugarbaker P.H., Vermess M., Doppman J.L., et al. Improved detection of focal lesions with computerized tomographic examination of the liver using ethiodized oil emulsion (EOE-13) liver contrast. Cancer 1984, 54:1489-1495.
10. Blakeborough A., Ward J., Wilson D., et al. Hepatic lesion detection at MR imaging: a comparative study with four sequences. Radiology 1997, 203:759-765.
11. Strotzer M., Gmeinwieser J., Schmidt J., et al. Diagnosis of liver metastases from colorectal adenocarcinoma. Comparison of spiral-CTAP combined with intravenous contrast-enhanced spiral-CT and SPIO-enhanced MR combined with plain MR imaging. Acta Radiol 1997, 38:986-992.
12. Moss A.A., Schrumpf J., Schnyder P., et al. Computed tomography of focal hepatic lesions: a blind clinical evaluation of the effect of contrast enhancement. Radiology 1979, 131:427-430.
13. Tsang Y.M., Stark D.D., Chen M.C., et al. Hepatic micrometastases in the rat: ferrite-enhanced MR imaging. Radiology 1988, 167:21-24.
14. Miller D.L., Rosenbaum R.C., Sugarbaker P.H., et al. Detection of hepatic metastases: comparison of EOE-13 computed tomography and scintigraphy. AJR Am J Roentgenol 1983, 141:931-935.
15. Weichert J.P., Longino M.A., Spigarelli M.G., et al. Computed tomography scanning of Morris hepatomas with liver-specific polyiodinated triglycerides. Acad Radiol 1996, 3:412-417.
16. Weichert J.P., Lee F.T., Longino M.A., et al. Computed tomography scanning of hepatic tumors with polyiodinated triglycerides. Acad Radiol 1996, 3(Suppl 2):S229-S231.
17. Patronas N., Miller D.L., Girton M. Experimental comparison of EOE-13 and perfluoroctylbromide for the CT detection of hepatic metastases. Invest Radiol 1984, 19:570-573.
18. Illum L., Davis S.S. The organ uptake of intravenously administered colloidal particles can be altered using a non-ionic surfactant (Poloxamer 338). FEBS Lett 1984, 167:79-82.
19. Torchilin V.P. Polymeric contrast agents for medical imaging. Curr Pharm Biotechnol 2000, 1:183-215.
20. Ryan P.J., Davis M.A., DeGaeta L.R., et al. Liposomes loaded with contrast material for image enhancement in computed tomography. Work in progress. Radiology 1984, 152:759-762.
21. Weichert J.P., Lee F.T., Longino M.A., et al. Lipid-based blood-pool CT imaging of the liver. Acad Radiol 1998, 5(Suppl 1):S16-S19. discussion S28-S30.
22. Ivancev K., Lunderquist A., Isaksson A., et al. Clinical trials with a new iodinated lipid emulsion for computed tomography of the liver. Acta Radiol 1989, 30:449-457.