Identification of a fragment-like small molecule ligand for the methyl-lysine binding protein, 53BP1

ACS Chemical Biology

Volumn 10, Issue 4, 2015, Pages 1072-1081

  Perfetti, Michael T ^a   Baughman, Brandi M ^a   Dickson, Bradley M ^a   Mu, Yunxiang ^b   Cui, Gaofeng ^c   Mader, Pavel ^d   Dong, Aiping ^d   Norris, Jacqueline L ^a   Rothbart, Scott B ^e   Strahl, Brian D ^e   Brown, Peter J ^d   Janzen, William P ^a   Arrowsmith, Cheryl H ^d   Mer, Georges ^c   McBride, Kevin M ^b   James, Lindsey I ^a   Frye, Stephen V ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b UNIVERSITY OF TEXAS   (United States)

^c MAYO GRADUATE SCHOOL   (United States)

^d UNIVERSITY OF TORONTO   (Canada)

^e UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

53BP1 PROTEIN; AMINE; ANTINEOPLASTIC AGENT; BINDING PROTEIN; DNA; HISTONE H4; HYDROGEN; LIGAND; LYSINE DERIVATIVE; TRYPTOPHAN; UNC 2170; UNC 2892; UNCLASSIFIED DRUG; 3-BROMO-N-(3-(TERT-BUTYLAMINO)PROPYL)BENZAMIDE; BENZAMIDE DERIVATIVE; CHROMATIN; DIAMINE; HISTONE; LYSINE; MOLECULAR LIBRARY; SIGNAL PEPTIDE; TP53BP1 PROTEIN, HUMAN; TUMOR SUPPRESSOR P53 BINDING PROTEIN 1;

ANIMAL CELL; ARTICLE; BLEACHING; CARBON NUCLEAR MAGNETIC RESONANCE; CELL LYSATE; CELL MEMBRANE PERMEABILITY; CHROMATIN; CLASS SWITCH RECOMBINATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DNA DAMAGE; DNA RECOMBINATION; DOUBLE STRANDED DNA BREAK; DRUG BINDING; DRUG DESIGN; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG TARGETING; FLUORESCENCE ACTIVATED CELL SORTING; GENE SWITCHING; GENE TARGETING; GENETIC SCREENING; HETERONUCLEAR SINGLE QUANTUM COHERENCE; HISTONE METHYLATION; HYDROGEN BOND; IC50; IONIZING RADIATION; ISOTHERMAL TITRATION CALORIMETRY; LIGAND BINDING; MOLECULAR WEIGHT; MOUSE; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTON NUCLEAR MAGNETIC RESONANCE; SPLEEN CELL; STATIC ELECTRICITY; STRUCTURE ACTIVITY RELATION; U2OS CELL LINE; UBIQUITINATION; WESTERN BLOTTING; X RAY CRYSTALLOGRAPHY; ANIMAL; B LYMPHOCYTE; BINDING SITE; C57BL MOUSE; CHEMISTRY; DRUG EFFECTS; GENETICS; HEK293 CELL LINE; HUMAN; METABOLISM; MOLECULAR LIBRARY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN TERTIARY STRUCTURE;

ANIMALS; B-LYMPHOCYTES; BENZAMIDES; BINDING SITES; CHROMATIN; CRYSTALLOGRAPHY, X-RAY; DIAMINES; HEK293 CELLS; HISTONES; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIGANDS; LYSINE; MAGNETIC RESONANCE SPECTROSCOPY; MICE, INBRED C57BL; PROTEIN STRUCTURE, TERTIARY; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR SUPPRESSOR P53-BINDING PROTEIN 1;

EID: 84928144828     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb500956g     Document Type: Article

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