메뉴 건너뛰기




Volumn 6, Issue 3, 2015, Pages 339-352

Theory and practice of supersaturatable formulations for poorly soluble drugs

Author keywords

[No Author keywords available]

Indexed keywords

DRUG; NANOCRYSTAL; EMULSION; NANOPARTICLE;

EID: 84927664585     PISSN: 20415990     EISSN: 20416008     Source Type: Journal    
DOI: 10.4155/tde.14.116     Document Type: Review
Times cited : (33)

References (65)
  • 1
    • 84859734219 scopus 로고    scopus 로고
    • Modification of physicochemical characteristics of active pharmaceutical ingredients and application of supersaturatable dosage forms for improving bioavailability of poorly absorbed drugs
    • Kawakami K. Modification of physicochemical characteristics of active pharmaceutical ingredients and application of supersaturatable dosage forms for improving bioavailability of poorly absorbed drugs. Adv. Drug Deliv. Rev. 64(6), 480-495 (2012).
    • (2012) Adv. Drug Deliv. Rev. , vol.64 , Issue.6 , pp. 480-495
    • Kawakami, K.1
  • 2
    • 1242337285 scopus 로고    scopus 로고
    • Solubilizing excipients in oral and injectable formulations
    • Strickley RG. Solubilizing excipients in oral and injectable formulations. Pharm. Res. 21(2), 201-230 (2004).
    • (2004) Pharm. Res. , vol.21 , Issue.2 , pp. 201-230
    • Strickley, R.G.1
  • 3
    • 2642542630 scopus 로고    scopus 로고
    • Solubilization behavior of poorly soluble drugs with combined use of gelucire 44/14 and cosolvent
    • Kawakami K, Miyoshi K, Ida Y. Solubilization behavior of poorly soluble drugs with combined use of gelucire 44/14 and cosolvent. J. Pharm. Sci. 93(6), 1471-1479 (2004).
    • (2004) J. Pharm. Sci. , vol.93 , Issue.6 , pp. 1471-1479
    • Kawakami, K.1    Miyoshi, K.2    Ida, Y.3
  • 4
    • 33644892211 scopus 로고    scopus 로고
    • Solubilization behavior of a poorly soluble drug under combined use of surfactants and cosolvents
    • Kawakami K, Oda N, Miyoshi K, Funaki T, Ida Y. Solubilization behavior of a poorly soluble drug under combined use of surfactants and cosolvents. Eur. J. Pharm. Sci. 28(1-2), 7-14 (2006).
    • (2006) Eur. J. Pharm. Sci. , vol.28 , Issue.1-2 , pp. 7-14
    • Kawakami, K.1    Oda, N.2    Miyoshi, K.3    Funaki, T.4    Ida, Y.5
  • 5
    • 16344364096 scopus 로고    scopus 로고
    • Design and evaluation of cyclodextrin-based drug formulation
    • Uekama K. Design and evaluation of cyclodextrin-based drug formulation. Chem. Pharm. Bull. 52(8), 900-915 (2004).
    • (2004) Chem. Pharm. Bull. , vol.52 , Issue.8 , pp. 900-915
    • Uekama, K.1
  • 6
    • 34548134519 scopus 로고    scopus 로고
    • Cyclodextrins as pharmaceutical solubilizers
    • Brewster ME, Loftsson T. Cyclodextrins as pharmaceutical solubilizers. Adv. Drug Deliv. Rev. 59(7), 645-666 (2007).
    • (2007) Adv. Drug Deliv. Rev. , vol.59 , Issue.7 , pp. 645-666
    • Brewster, M.E.1    Loftsson, T.2
  • 7
    • 0347418153 scopus 로고    scopus 로고
    • Combined effect of SLS and (SBE)7M-beta-CD on the solubilization of NSC-639829
    • Yang G, Jain N, Yalkowsky SH. Combined effect of SLS and (SBE)7M-beta-CD on the solubilization of NSC-639829. Int. J. Pharm. 269(1), 141-148 (2004).
    • (2004) Int. J. Pharm. , vol.269 , Issue.1 , pp. 141-148
    • Yang, G.1    Jain, N.2    Yalkowsky, S.H.3
  • 8
    • 76649105411 scopus 로고    scopus 로고
    • Solubility advantage of amorphous pharmaceuticals: I. Thermodynamic analysis
    • Murdande SB, Pikal MJ, Shanker RM, Bogner RH. Solubility advantage of amorphous pharmaceuticals: I. Thermodynamic analysis. J. Pharm. Sci. 99(3), 1254-1264 (2010).
    • (2010) J. Pharm. Sci. , vol.99 , Issue.3 , pp. 1254-1264
    • Murdande, S.B.1    Pikal, M.J.2    Shanker, R.M.3    Bogner, R.H.4
  • 9
    • 68249128120 scopus 로고    scopus 로고
    • Supersaturating drug delivery systems: The answer to solubility-limited oral bioavailability?
    • Brouwers J, Brewster ME, Augustijns P. Supersaturating drug delivery systems: the answer to solubility-limited oral bioavailability? J. Pharm. Sci. 98(8), 2549-2572 (2009).
    • (2009) J. Pharm. Sci. , vol.98 , Issue.8 , pp. 2549-2572
    • Brouwers, J.1    Brewster, M.E.2    Augustijns, P.3
  • 10
    • 1942434656 scopus 로고    scopus 로고
    • The use of three different solid dispersion formulations - melt extrusion, filmcoated beads, and a glass thermoplastic system - To improve the bioavailability of a novel microsomal triglyceride transfer protein inhibitor
    • Verreck G, Vandecruys R, De Conde V et al. The use of three different solid dispersion formulations - melt extrusion, filmcoated beads, and a glass thermoplastic system - to improve the bioavailability of a novel microsomal triglyceride transfer protein inhibitor. J. Pharm. Sci. 93(5), 1217-1228 (2004).
    • (2004) J. Pharm. Sci. , vol.93 , Issue.5 , pp. 1217-1228
    • Verreck, G.1    Vandecruys, R.2    De Conde, V.3
  • 11
    • 79958254915 scopus 로고    scopus 로고
    • Coaxial electrospray formulations for improving oral absorption of a poorly water-soluble drug
    • Zhang S, Kawakami K, Yamamoto M et al. Coaxial electrospray formulations for improving oral absorption of a poorly water-soluble drug. Mol. Pharm. 8(3), 807-813 (2011).
    • (2011) Mol. Pharm. , vol.8 , Issue.3 , pp. 807-813
    • Zhang, S.1    Kawakami, K.2    Yamamoto, M.3
  • 12
    • 84891756937 scopus 로고    scopus 로고
    • Unravelling the relationship between degree of disorder and the dissolution behavior of milled glibenclamide
    • Mah PT, Laaksonen, T, Rades T et al. Unravelling the relationship between degree of disorder and the dissolution behavior of milled glibenclamide. Mol. Pharm. 11(1), 234-242 (2014).
    • (2014) Mol. Pharm. , vol.11 , Issue.1 , pp. 234-242
    • Mah, P.T.1    Laaksonen, T.2    Rades, T.3
  • 13
    • 79958812380 scopus 로고    scopus 로고
    • Dissolution and precipitation behavior of amorphous solid dispersions
    • Alonzo DE, Gao Y, Zhou D et al. Dissolution and precipitation behavior of amorphous solid dispersions. J. Pharm. Sci. 100(8), 3316-3331 (2011).
    • (2011) J. Pharm. Sci. , vol.100 , Issue.8 , pp. 3316-3331
    • Alonzo, D.E.1    Gao, Y.2    Zhou, D.3
  • 14
    • 84891757636 scopus 로고    scopus 로고
    • Insights into atomic-level interaction between mefenamic acid and eudragit EPO in a supersaturated solution by high-resolution magic-angle spinning NMR spectroscopy
    • Higashi K, Yamamoto K, Pandey MK et al. Insights into atomic-level interaction between mefenamic acid and Eudragit EPO in a supersaturated solution by high-resolution magic-angle spinning NMR spectroscopy. Mol. Pharm. 11(1), 351-357 (2014).
    • (2014) Mol. Pharm. , vol.11 , Issue.1 , pp. 351-357
    • Higashi, K.1    Yamamoto, K.2    Pandey, M.K.3
  • 15
    • 39549094916 scopus 로고    scopus 로고
    • Formation mechanism of colloidal nanoparticles obtained from probucol/PVP/SDS ternary ground mixture
    • Pongpeerapat A, Wanawongthai C, Tozuka Y, Moribe K, Yamamoto K. Formation mechanism of colloidal nanoparticles obtained from probucol/PVP/SDS ternary ground mixture. Int. J. Pharm. 352(1-2), 309-316 (2008).
    • (2008) Int. J. Pharm. , vol.352 , Issue.1-2 , pp. 309-316
    • Pongpeerapat, A.1    Wanawongthai, C.2    Tozuka, Y.3    Moribe, K.4    Yamamoto, K.5
  • 16
    • 84896696978 scopus 로고    scopus 로고
    • The effect of HPMCAS functional groups on drug crystallization from the supersaturated state and dissolution improvement
    • Ueda K, Higashi K, Yamamoto K, Moribe K. The effect of HPMCAS functional groups on drug crystallization from the supersaturated state and dissolution improvement. Int. J. Pharm. 464(1-2), 205-213 (2014).
    • (2014) Int. J. Pharm. , vol.464 , Issue.1-2 , pp. 205-213
    • Ueda, K.1    Higashi, K.2    Yamamoto, K.3    Moribe, K.4
  • 17
    • 84891764194 scopus 로고    scopus 로고
    • Preparation and performance of hydroxypropyl methylcellulose esters of substituted succinates for in vitro supersaturation of a crystalline hydrophobic drug
    • Yin L, Hillmyer MA. Preparation and performance of hydroxypropyl methylcellulose esters of substituted succinates for in vitro supersaturation of a crystalline hydrophobic drug. Mol. Pharm. 11(1), 175-185 (2014).
    • (2014) Mol. Pharm. , vol.11 , Issue.1 , pp. 175-185
    • Yin, L.1    Hillmyer, M.A.2
  • 18
    • 84901802573 scopus 로고    scopus 로고
    • Relationship between crystallization tendencies during cooling from melt and isothermal storage: Toward a general understanding of physical stability of pharmaceutical glasses
    • Kawakami K, Harada T, Miura K et al. Relationship between crystallization tendencies during cooling from melt and isothermal storage: toward a general understanding of physical stability of pharmaceutical glasses. Mol. Pharm. 11(6), 1835-1843 (2014).
    • (2014) Mol. Pharm. , vol.11 , Issue.6 , pp. 1835-1843
    • Kawakami, K.1    Harada, T.2    Miura, K.3
  • 19
    • 84919784893 scopus 로고    scopus 로고
    • Surface effects on the crystallization of ritonavir glass
    • Kawakami K. Surface effects on the crystallization of ritonavir glass. J. Pharm. Sci. 104(1), 276-279 (2015).
    • (2015) J. Pharm. Sci. , vol.104 , Issue.1 , pp. 276-279
    • Kawakami, K.1
  • 20
    • 84870704112 scopus 로고    scopus 로고
    • Crystallization of amorphous solid dispersions of resveratrol during preparation and storage - impact of different polymers
    • Wegiel LA, Mauer LJ, Edgar KJ, Taylor LS. Crystallization of amorphous solid dispersions of resveratrol during preparation and storage - impact of different polymers. J. Pharm. Sci. 102(1) 171-184 (2013).
    • (2013) J. Pharm. Sci. , vol.102 , Issue.1 , pp. 171-184
    • Wegiel, L.A.1    Mauer, L.J.2    Edgar, K.J.3    Taylor, L.S.4
  • 21
    • 77953290060 scopus 로고    scopus 로고
    • Influence of preparation methods on solid state supersaturation of amorphous solid dispersions: A case study with itraconazole and eudragit E100
    • Janssens S, De Zeure A, Paudel A et al. Influence of preparation methods on solid state supersaturation of amorphous solid dispersions: a case study with itraconazole and Eudragit E100. Pharm. Res. 27(5), 775-785 (2010).
    • (2010) Pharm. Res. , vol.27 , Issue.5 , pp. 775-785
    • Janssens, S.1    De Zeure, A.2    Paudel, A.3
  • 22
    • 79952486267 scopus 로고    scopus 로고
    • Comparison between hot-melt extrusion and spray-drying for manufacturing solid dispersions of the graft copolymer of ethylene glycol and vinylalcohol
    • Guns S, Dereymaker A, Kayaert P et al. Comparison between hot-melt extrusion and spray-drying for manufacturing solid dispersions of the graft copolymer of ethylene glycol and vinylalcohol. Pharm. Res. 28(3), 673-682 (2011).
    • (2011) Pharm. Res. , vol.28 , Issue.3 , pp. 673-682
    • Guns, S.1    Dereymaker, A.2    Kayaert, P.3
  • 23
    • 0002497312 scopus 로고
    • The influence of solvent upon the compatibility of polystyrene and poly(vinyl methyl ether)
    • Bank M, Leffingwell J, Thies C. The influence of solvent upon the compatibility of polystyrene and poly(vinyl methyl ether). Macromolecules 4(1), 43-46 (1971).
    • (1971) Macromolecules , vol.4 , Issue.1 , pp. 43-46
    • Bank, M.1    Leffingwell, J.2    Thies, C.3
  • 24
    • 84872500156 scopus 로고    scopus 로고
    • Competition of thermodynamic and dynamic factors during formation of multi-component particles via spray-drying
    • Kawakami K, Hasegawa Y, Deguchi K et al. Competition of thermodynamic and dynamic factors during formation of multi-component particles via spray-drying. J. Pharm. Sci. 102(2), 518-529 (2013).
    • (2013) J. Pharm. Sci. , vol.102 , Issue.2 , pp. 518-529
    • Kawakami, K.1    Hasegawa, Y.2    Deguchi, K.3
  • 25
    • 0037369754 scopus 로고    scopus 로고
    • Formation of physically stable amorphous drugs by milling with neusilin
    • Gupta MK, Vanwert A, Bogner RH. Formation of physically stable amorphous drugs by milling with Neusilin. J. Pharm. Sci. 92(3), 536-551 (2003).
    • (2003) J. Pharm. Sci. , vol.92 , Issue.3 , pp. 536-551
    • Gupta, M.K.1    Vanwert, A.2    Bogner, R.H.3
  • 26
    • 84884128381 scopus 로고    scopus 로고
    • Mesoporous systems for poorly soluble drugs
    • Xu W, Riikonen J, Lehto VP. Mesoporous systems for poorly soluble drugs. Int. J. Pharm. 453(1), 181-197 (2013).
    • (2013) Int. J. Pharm. , vol.453 , Issue.1 , pp. 181-197
    • Xu, W.1    Riikonen, J.2    Lehto, V.P.3
  • 27
    • 0036171845 scopus 로고    scopus 로고
    • Cryogenic grinding of indomethacin polymorphs and solvates: Assessment of amorphous phase formation and amorphous phase physical stability
    • Crowley KJ, Zografi G. Cryogenic grinding of indomethacin polymorphs and solvates: assessment of amorphous phase formation and amorphous phase physical stability. J. Pharm. Sci. 91(2), 492-507 (2002).
    • (2002) J. Pharm. Sci. , vol.91 , Issue.2 , pp. 492-507
    • Crowley, K.J.1    Zografi, G.2
  • 28
    • 0032885450 scopus 로고    scopus 로고
    • Solid dispersion of poorly water-soluble drugs: Early promises, subsequent problems, and recent breakthroughs
    • Serajuddin ATM. Solid dispersion of poorly water-soluble drugs: early promises, subsequent problems, and recent breakthroughs. J. Pharm. Sci. 88(10), 1058-1066 (1999).
    • (1999) J. Pharm. Sci. , vol.88 , Issue.10 , pp. 1058-1066
    • Serajuddin, A.T.M.1
  • 29
    • 74049124464 scopus 로고    scopus 로고
    • Spray drying technique: II. Current applications in pharmaceutical technology
    • Sollohub K, Cal K. Spray drying technique: II. Current applications in pharmaceutical technology. J. Pharm. Sci. 99(2), 587-597 (2010).
    • (2010) J. Pharm. Sci. , vol.99 , Issue.2 , pp. 587-597
    • Sollohub, K.1    Cal, K.2
  • 30
    • 1842865536 scopus 로고    scopus 로고
    • Melt extrusion: From process to drug delivery technology
    • Breitenbach J. Melt extrusion: from process to drug delivery technology. Eur. J. Pharm. Biopharm. 54(2), 107-117 (2002).
    • (2002) Eur. J. Pharm. Biopharm. , vol.54 , Issue.2 , pp. 107-117
    • Breitenbach, J.1
  • 31
    • 84255167308 scopus 로고    scopus 로고
    • Melt extrusion: Process to product
    • Repka MA, Shah S, Lu J et al. Melt extrusion: process to product. Exp. Opin. Drug Deliv. 9(1), 105-125 (2012).
    • (2012) Exp. Opin. Drug Deliv. , vol.9 , Issue.1 , pp. 105-125
    • Repka, M.A.1    Shah, S.2    Lu, J.3
  • 32
    • 0036181889 scopus 로고    scopus 로고
    • Practical aspects of lyophilization using non-aqueous co-solvent systems
    • Teagarden DL, Baker DS. Practical aspects of lyophilization using non-aqueous co-solvent systems. Eur. J. Pharm. Sci. 15(2), 115-133 (2002).
    • (2002) Eur. J. Pharm. Sci. , vol.15 , Issue.2 , pp. 115-133
    • Teagarden, D.L.1    Baker, D.S.2
  • 33
    • 39149138682 scopus 로고    scopus 로고
    • Particle design of poorly water-soluble substances using supercritical fluid technologies
    • Yasuji T, Takeuchi H, Kawashima Y. Particle design of poorly water-soluble substances using supercritical fluid technologies. Adv. Drug Deliv. Rev. 60(3), 388-398 (2008).
    • (2008) Adv. Drug Deliv. Rev. , vol.60 , Issue.3 , pp. 388-398
    • Yasuji, T.1    Takeuchi, H.2    Kawashima, Y.3
  • 34
    • 70350057599 scopus 로고    scopus 로고
    • Phase behavior of poly(vinylpyrrolidone) containing amorphous solid dispersions in the presence of moisture
    • Rumondor ACF, Marsac RJ, Stanford LA, Taylor LS. Phase behavior of poly(vinylpyrrolidone) containing amorphous solid dispersions in the presence of moisture. Mol. Pharm. 6(5), 1492-1505 (2009).
    • (2009) Mol. Pharm. , vol.6 , Issue.5 , pp. 1492-1505
    • Rumondor, A.C.F.1    Marsac, R.J.2    Stanford, L.A.3    Taylor, L.S.4
  • 35
    • 73949151261 scopus 로고    scopus 로고
    • Effect of temperature and moisture on the miscibility of amorphous dispersions of felodipine and poly(vinyl pyrrolidone)
    • Marsac RJ, Rumondor ACF, Nivens DE et al. Effect of temperature and moisture on the miscibility of amorphous dispersions of felodipine and poly(vinyl pyrrolidone). J. Pharm. Sci. 99(1), 169-185 (2010).
    • (2010) J. Pharm. Sci. , vol.99 , Issue.1 , pp. 169-185
    • Marsac, R.J.1    Rumondor, A.C.F.2    Nivens, D.E.3
  • 36
    • 0028268210 scopus 로고
    • The relationship between the glass transition temperature and the water content of amorphous pharmaceutical solids
    • Hancock BC, Zografi G. The relationship between the glass transition temperature and the water content of amorphous pharmaceutical solids. Pharm. Res. 11(4), 471-477 (1994).
    • (1994) Pharm. Res. , vol.11 , Issue.4 , pp. 471-477
    • Hancock, B.C.1    Zografi, G.2
  • 37
    • 41349100668 scopus 로고    scopus 로고
    • Evaluation of solid state properties of solid dispersions prepared by hot-melt extrusion and solvent co-precipitation
    • Dong Z, Chatterji A, Sandhu H et al. Evaluation of solid state properties of solid dispersions prepared by hot-melt extrusion and solvent co-precipitation. Int. J. Pharm. 355(1-2), 141-149 (2008).
    • (2008) Int. J. Pharm. , vol.355 , Issue.1-2 , pp. 141-149
    • Dong, Z.1    Chatterji, A.2    Sandhu, H.3
  • 38
    • 85008071016 scopus 로고
    • Studies on absorption of eutectic mixture. I. A comparison of the behavior of eutectic mixture of sulfathiazole and that of ordinary sulfathiazole in man
    • Sekiguchi K, Obi N. Studies on absorption of eutectic mixture. I. A comparison of the behavior of eutectic mixture of sulfathiazole and that of ordinary sulfathiazole in man. Chem. Pharm. Bull. 9(11), 866-872 (1961).
    • (1961) Chem. Pharm. Bull. , vol.9 , Issue.11 , pp. 866-872
    • Sekiguchi, K.1    Obi, N.2
  • 39
    • 0037312695 scopus 로고    scopus 로고
    • Nanosizing: A formulation approach for poorly-water-soluble compounds
    • Merisko-Liversidge E, Liversidge GG, Cooper ER. Nanosizing: a formulation approach for poorly-water-soluble compounds. Eur. J. Pharm. Sci. 18(2), 113-120 (2003).
    • (2003) Eur. J. Pharm. Sci. , vol.18 , Issue.2 , pp. 113-120
    • Merisko-Liversidge, E.1    Liversidge, G.G.2    Cooper, E.R.3
  • 40
    • 53949092998 scopus 로고    scopus 로고
    • Top-down production of drug nanocrystals: Nanosuspension stabilization, miniaturization and transformation into solid products
    • Van Eedenbrugh B, Van den Mooter G, Augustijins P. Top-down production of drug nanocrystals: nanosuspension stabilization, miniaturization and transformation into solid products. Int. J. Pharm. 364(1), 64-75 (2008).
    • (2008) Int. J. Pharm. , vol.364 , Issue.1 , pp. 64-75
    • Van Eedenbrugh, B.1    Van Den-Mooter, G.2    Augustijins, P.3
  • 41
    • 34548049483 scopus 로고    scopus 로고
    • Nanosizing - oral formulation development and biopharmaceutical evaluation
    • Kesisoglou F, Panmai S, Wu Y. Nanosizing - oral formulation development and biopharmaceutical evaluation. Adv. Drug Deliv. Rev. 59(7), 631-644 (2007).
    • (2007) Adv. Drug Deliv. Rev. , vol.59 , Issue.7 , pp. 631-644
    • Kesisoglou, F.1    Panmai, S.2    Wu, Y.3
  • 42
    • 33746868980 scopus 로고    scopus 로고
    • The effects of milling on the surface properties of form I paracetamol crystals
    • Heng JYY, Thielmann F, Williams DR. The effects of milling on the surface properties of form I paracetamol crystals. Pharm. Res. 23(8), 1918-1927 (2006).
    • (2006) Pharm. Res. , vol.23 , Issue.8 , pp. 1918-1927
    • Heng, J.Y.Y.1    Thielmann, F.2    Williams, D.R.3
  • 43
    • 0030471901 scopus 로고    scopus 로고
    • Gastrointestinal uptake of biodegradable microparticles: Effect of particle size
    • Desai MP, Labhasetwar V, Amidon GL, Levy RJ. Gastrointestinal uptake of biodegradable microparticles: effect of particle size. Pharm. Res. 13(12), 1838-1845 (1996).
    • (1996) Pharm. Res. , vol.13 , Issue.12 , pp. 1838-1845
    • Desai, M.P.1    Labhasetwar, V.2    Amidon, G.L.3    Levy, R.J.4
  • 44
    • 33846841057 scopus 로고    scopus 로고
    • Rapid transport of large polymeric nanoparticles in fresh undiluted human mucus
    • Lai SK, O'Hanlon DE, Harrold S et al. Rapid Transport of large polymeric nanoparticles in fresh undiluted human mucus. Proc. Natl. Acad. Sci. USA 104(5), 1482-1487 (2007).
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , Issue.5 , pp. 1482-1487
    • Lai, S.K.1    O'Hanlon, D.E.2    Harrold, S.3
  • 45
    • 67349210622 scopus 로고    scopus 로고
    • 2009. Nanoparticle formation from probucol/PVP/sodium alkyl sulfate co-ground mixture
    • Wanawongthai C, Pongpeerapat A, Higashi K et al. 2009. Nanoparticle formation from probucol/PVP/sodium alkyl sulfate co-ground mixture. Int. J. Pharm. 376(1-2), 169-175 (2009).
    • (2009) Int. J. Pharm. , vol.376 , Issue.1-2 , pp. 169-175
    • Wanawongthai, C.1    Pongpeerapat, A.2    Higashi, K.3
  • 46
    • 0037467170 scopus 로고    scopus 로고
    • Microcrystals for dissolution rate enhancement of poorly water-soluble drugs
    • Rasenack N, Hartenhauer H, Müller BW. Microcrystals for dissolution rate enhancement of poorly water-soluble drugs. Int. J. Pharm. 254(2), 137-145 (2003).
    • (2003) Int. J. Pharm. , vol.254 , Issue.2 , pp. 137-145
    • Rasenack, N.1    Hartenhauer, H.2    Müller, B.W.3
  • 47
    • 43449094630 scopus 로고    scopus 로고
    • A novel bottom-up process to produce drug nanocrystals: Controlled crystallization during freeze-drying
    • De Waard H, Hinrichs WLJ, Frijlink HW. A novel bottom-up process to produce drug nanocrystals: controlled crystallization during freeze-drying. J. Control. Release 128(2), 179-183 (2008).
    • (2008) J. Control. Release , vol.128 , Issue.2 , pp. 179-183
    • De Waard, H.1    Hinrichs, W.L.J.2    Frijlink, H.W.3
  • 48
    • 41349085155 scopus 로고    scopus 로고
    • Characteristics of polymers enabling nano-comminution of water-insoluble drugs
    • Lee J, Choi, JY, Park CH. Characteristics of polymers enabling nano-comminution of water-insoluble drugs. Int. J. Pharm. 355(1-2), 328-336 (2008).
    • (2008) Int. J. Pharm. , vol.355 , Issue.1-2 , pp. 328-336
    • Lee, J.1    Choi, J.Y.2    Park, C.H.3
  • 49
    • 84870219955 scopus 로고    scopus 로고
    • Identifying the correlation between drug/stabilizer properties and critical quality attributes (CQAs) of nanosuspension formulation prepared by wet media milling technology
    • George M, Ghosh I. Identifying the correlation between drug/stabilizer properties and critical quality attributes (CQAs) of nanosuspension formulation prepared by wet media milling technology. Eur. J. Pharm. Sci. 48(1-2), 142-152 (2013).
    • (2013) Eur. J. Pharm. Sci. , vol.48 , Issue.1-2 , pp. 142-152
    • George, M.1    Ghosh, I.2
  • 50
    • 34547800192 scopus 로고    scopus 로고
    • Freezedrying of nanoparticles: Formulation, process and storage considerations
    • Abdelwahed W, Degobert G, Stainmesse S, Fessi H. Freezedrying of nanoparticles: formulation, process and storage considerations. Adv. Drug Deliv. Rev. 58(15), 1688-1713 (2006).
    • (2006) Adv. Drug Deliv. Rev. , vol.58 , Issue.15 , pp. 1688-1713
    • Abdelwahed, W.1    Degobert, G.2    Stainmesse, S.3    Fessi, H.4
  • 51
    • 0035967341 scopus 로고    scopus 로고
    • Effect of hydrophilic polymers on physical stability of liposome dispersions
    • Kawakami K, Nishihara Y, Hirano K. Effect of hydrophilic polymers on physical stability of liposome dispersions. J. Phys. Chem. B 105(12), 2374-2385 (2001).
    • (2001) J. Phys. Chem. B , vol.105 , Issue.12 , pp. 2374-2385
    • Kawakami, K.1    Nishihara, Y.2    Hirano, K.3
  • 52
    • 20844446627 scopus 로고    scopus 로고
    • The role of biopharmaceutics in the development of a clinical nanoparticle formulation of MK-0869: A beagle dog model predicts improved bioavailability and diminished food effect on absorption in human
    • Wu Y, Loper A, Landis E et al. The role of biopharmaceutics in the development of a clinical nanoparticle formulation of MK-0869: a Beagle dog model predicts improved bioavailability and diminished food effect on absorption in human. Int. J. Pharm. 285(1-2), 135-146 (2004).
    • (2004) Int. J. Pharm. , vol.285 , Issue.1-2 , pp. 135-146
    • Wu, Y.1    Loper, A.2    Landis, E.3
  • 53
    • 84884167198 scopus 로고    scopus 로고
    • Amorphous solid dispersions and nano-crystal technologies for poorly water-soluble drug delivery
    • Brough C, Williams III, RO. Amorphous solid dispersions and nano-crystal technologies for poorly water-soluble drug delivery. Int. J. Pharm. 453(1), 157-166 (2013).
    • (2013) Int. J. Pharm. , vol.453 , Issue.1 , pp. 157-166
    • Brough, C.1    Williams, R.O.2
  • 54
    • 84888100588 scopus 로고    scopus 로고
    • Influence of drug physicochemical properties on absorption of water insoluble drug nanosuspensions
    • Li W, Quan P, Zhang Y et al. Influence of drug physicochemical properties on absorption of water insoluble drug nanosuspensions. Int. J. Pharm. 460(1-2), 13-23 (2014).
    • (2014) Int. J. Pharm. , vol.460 , Issue.1-2 , pp. 13-23
    • Li, W.1    Quan, P.2    Zhang, Y.3
  • 55
    • 0037123703 scopus 로고    scopus 로고
    • Microemulsion formulation for enhanced absorption of poorly soluble drugs. I. Prescription design
    • Kawakami K, Yoshikawa T, Moroto Y et al. Microemulsion formulation for enhanced absorption of poorly soluble drugs. I. Prescription design. J. Control. Release 81(1-2), 65-74 (2002).
    • (2002) J. Control. Release , vol.81 , Issue.1-2 , pp. 65-74
    • Kawakami, K.1    Yoshikawa, T.2    Moroto, Y.3
  • 56
    • 0034614208 scopus 로고    scopus 로고
    • Microemulsion-based media as novel drug delivery systems
    • Lawrence MJ, Rees GD. Microemulsion-based media as novel drug delivery systems. Adv. Drug Deliv. Rev. 45(1-2), 89-121 (2000).
    • (2000) Adv. Drug Deliv. Rev. , vol.45 , Issue.1-2 , pp. 89-121
    • Lawrence, M.J.1    Rees, G.D.2
  • 57
    • 39149097505 scopus 로고    scopus 로고
    • What determines drug solubility in lipid vehicles: Is it predictable?
    • Rane SS, Anderson BD. What determines drug solubility in lipid vehicles: is it predictable? Adv. Drug Deliv. Rev. 60(6), 638-656 (2008).
    • (2008) Adv. Drug Deliv. Rev. , vol.60 , Issue.6 , pp. 638-656
    • Rane, S.S.1    Anderson, B.D.2
  • 58
    • 0028335905 scopus 로고
    • Reduced inter- and intraindividual variability in cyclosporine pharmacokinetics from a microemulsion formulation
    • Kovarik JM, Mueller EA, van Bree JB, Tetzloff W, Kutz K. Reduced inter- and intraindividual variability in cyclosporine pharmacokinetics from a microemulsion formulation. J. Pharm. Sci. 83(3), 444-446 (1994).
    • (1994) J. Pharm. Sci. , vol.83 , Issue.3 , pp. 444-446
    • Kovarik, J.M.1    Mueller, E.A.2    Van Bree, J.B.3    Tetzloff, W.4    Kutz, K.5
  • 59
    • 39149092022 scopus 로고    scopus 로고
    • Enhancing intestinal drug solubilisation using lipid-based delivery systems
    • Porter CJH, Pouton CW, Cuine JF, Charman WN. Enhancing intestinal drug solubilisation using lipid-based delivery systems. Adv. Drug Deliv. Rev. 60(6), 673-691 (2008).
    • (2008) Adv. Drug Deliv. Rev. , vol.60 , Issue.6 , pp. 673-691
    • Porter, C.J.H.1    Pouton, C.W.2    Cuine, J.F.3    Charman, W.N.4
  • 60
    • 4344578729 scopus 로고    scopus 로고
    • Susceptibility to lipase-mediated digestion reduces the oral bioavailability of danazol after administration as a medium-chain lipid-based microemulsion formulation
    • Porter CJH, Kaukonen AM, Boyd BJ, Edwards GA, Charman WN. Susceptibility to lipase-mediated digestion reduces the oral bioavailability of danazol after administration as a medium-chain lipid-based microemulsion formulation. Pharm. Res. 21(8), 1405-1412 (2004).
    • (2004) Pharm. Res. , vol.21 , Issue.8 , pp. 1405-1412
    • Porter, C.J.H.1    Kaukonen, A.M.2    Boyd, B.J.3    Edwards, G.A.4    Charman, W.N.5
  • 61
    • 39149091886 scopus 로고    scopus 로고
    • Evaluation of the impact of surfactant digestion on the bioavailability of danazol after oral administration of lipidic self-emulsifying formulations to dogs
    • Cuine JF, McEvoy CL, Charman WN et al. Evaluation of the impact of surfactant digestion on the bioavailability of danazol after oral administration of lipidic self-emulsifying formulations to dogs. J. Pharm. Sci. 97(2), 995-1012 (2008).
    • (2008) J. Pharm. Sci. , vol.97 , Issue.2 , pp. 995-1012
    • Cuine, J.F.1    McEvoy, C.L.2    Charman, W.N.3
  • 62
    • 0037123701 scopus 로고    scopus 로고
    • Microemulsion formulation for enhanced absorption of poorly soluble drugs. II. in vivo study
    • Kawakami K, Yoshikawa T, Hayashi T, Nishihara Y, Masuda K. Microemulsion formulation for enhanced absorption of poorly soluble drugs. II. In vivo study. J. Control. Release 81(1-2), 75-82 (2002).
    • (2002) J. Control. Release , vol.81 , Issue.1-2 , pp. 75-82
    • Kawakami, K.1    Yoshikawa, T.2    Hayashi, T.3    Nishihara, Y.4    Masuda, K.5
  • 63
    • 1242337284 scopus 로고    scopus 로고
    • Enhanced oral absorption of paclitaxel in a novel self-microemulsifying drug delivery system with or without concomitant use of P-glycoprotein inhibitors
    • Yang S, Gursoy RN, Lambert G, Benita S. Enhanced oral absorption of paclitaxel in a novel self-microemulsifying drug delivery system with or without concomitant use of P-glycoprotein inhibitors. Pharm. Res. 21(2), 261-270 (2004).
    • (2004) Pharm. Res. , vol.21 , Issue.2 , pp. 261-270
    • Yang, S.1    Gursoy, R.N.2    Lambert, G.3    Benita, S.4
  • 64
    • 0344012523 scopus 로고    scopus 로고
    • Development of a supersaturatable SEDDS (S-SEDDS) formulation of paclitaxel with improved oral bioavailability
    • Gao P, Rush BD, Pfund WP et al. Development of a supersaturatable SEDDS (S-SEDDS) formulation of paclitaxel with improved oral bioavailability. J. Pharm. Sci. 92(12), 2386-2398 (2003).
    • (2003) J. Pharm. Sci. , vol.92 , Issue.12 , pp. 2386-2398
    • Gao, P.1    Rush, B.D.2    Pfund, W.P.3
  • 65
    • 68949105637 scopus 로고    scopus 로고
    • Current status of amorphous formulation and other supersaturatable dosage forms as formulations for early clinical phases
    • Kawakami K. Current status of amorphous formulation and other supersaturatable dosage forms as formulations for early clinical phases. J. Pharm. Sci. 98(9), 2875-2885 (2009).
    • (2009) J. Pharm. Sci. , vol.98 , Issue.9 , pp. 2875-2885
    • Kawakami, K.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.