Relationship between crystallization tendencies during cooling from melt and isothermal storage: Toward a general understanding of physical stability of pharmaceutical glasses

Molecular Pharmaceutics

Volumn 11, Issue 6, 2014, Pages 1835-1843

  Kawakami, Kohsaku ^a   Harada, Takuji ^a,b   Miura, Keiko ^c   Yoshihashi, Yasuo ^b   Yonemochi, Etsuo ^b,d   Terada, Katsuhide ^b   Moriyama, Hiroshi ^b  

^a NATIONAL INSTITUTE FOR MATERIALS SCIENCE   (Japan)

^b TOHO UNIVERSITY   (Japan)

^c JAPAN SYNCHROTRON RADIATION RESEARCH INSTITUTE   (Japan)

^d HOSHI UNIVERSITY   (Japan)

Author keywords

activation energy; amorphous; crystallization; glass transition temperature; nucleation; stability prediction

Indexed keywords

CHLORPROPAMIDE; HALOPERIDOL; LORATADINE; NIFEDIPINE; PARACETAMOL; RITONAVIR; TOLBUTAMIDE; GLASS;

ARTICLE; CHEMICAL STRUCTURE; COOLING; CRYSTALLIZATION; DISPERSION; ENERGY; GLASS TRANSITION TEMPERATURE; HEAT; MELTING POINT; MOISTURE; PHYSICAL CHEMISTRY; PRESSURE; PRIORITY JOURNAL; REPRODUCIBILITY; STANDARD; STORAGE; STORAGE TEMPERATURE; SURFACE PROPERTY; TEMPERATURE DEPENDENCE; THERMAL ANALYSIS; THERMODYNAMICS; THERMOSTABILITY; X RAY DIFFRACTION; CHEMISTRY; COLD; DRUG STABILITY; DRUG STORAGE; MEDICINAL CHEMISTRY; PROCEDURES; TRANSITION TEMPERATURE;

CHEMISTRY, PHARMACEUTICAL; COLD TEMPERATURE; CRYSTALLIZATION; DRUG STABILITY; DRUG STORAGE; GLASS; HOT TEMPERATURE; TRANSITION TEMPERATURE;

EID: 84901802573     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp400679m     Document Type: Article

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