Comparison between hot-melt extrusion and spray-drying for manufacturing solid dispersions of the graft copolymer of ethylene glycol and vinylalcohol

Pharmaceutical Research

Volumn 28, Issue 3, 2011, Pages 673-682

  Guns, Sandra ^a   Dereymaker, Aswin ^a   Kayaert, Pieterjan ^a   Mathot, Vincent ^b,c   Martens, Johan A ^c   Van Den Mooter, Guy ^a  

^a DEPARTMENT OF PHARMACEUTICAL AND PHARMACOLOGICAL SCIENCES   (Belgium)

^b SciTe BV   (Netherlands)

^c UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

hot melt extrusion; Kollicoat IR; poly(ethylene g vinylalcohol); solid dispersions; spray drying

Indexed keywords

COPOLYMER; MICONAZOLE; POLY(ETHYLENE GLYCOL G VINYLALCOHOL); UNCLASSIFIED DRUG;

ARTICLE; BIOAVAILABILITY; CHEMICAL ANALYSIS; CHEMICAL PROCEDURES; CHEMICAL STRUCTURE; COMPARATIVE STUDY; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DISPERSION; ENTHALPY; ENVIRONMENTAL TEMPERATURE; HOT MELT EXTRUSION; KINETICS; MISCIBILITY; PRIORITY JOURNAL; SPRAY DRYING; TEMPERATURE; TORQUE; X RAY POWDER DIFFRACTION;

CHEMISTRY, PHARMACEUTICAL; HOT TEMPERATURE; POLYETHYLENE GLYCOLS; POLYMERS; POLYVINYLS; SOLUTIONS; VINYL COMPOUNDS; X-RAY DIFFRACTION;

EID: 79952486267     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-010-0324-2     Document Type: Article

References (11)

1. Janssens S, Van den Mooter G. Review: physical chemistry of solid dispersions. J Pharm Pharmacol. 2009;61:1571-86.
2. Leuner C, Dressman J. Improving drug solubility for oral delivery using solid dispersions. Eur J Pharm Biopharm. 2000;50:47-60. (Pubitemid 30326688)
3. Vasconcelos T, Sarmento B, Costa P. Solid dispersions as strategy to improve oral bioavailability of poor water soluble drugs. Drug Discov Today. 2007;12:1068-75. (Pubitemid 350186132)
4. Janssens S, Denivelle S, Rombaut P, Van den Mooter G. Influence of polyethylene glycol chain length on compatibility and release characteristics of ternary solid dispersions of itraconazole in polyethylene glycol/ hydroxypropylmethylcellulose 2910 E5 blends. Eur J Pharm Sci. 2008;35(3):203-2010.
5. Janssens S, de Armas HN, Roberts CJ, Van den Mooter G. Characterization of ternary solid dispersions of itraconazole, PEG 6000 and HPMC 2910 E5. J Pharm Sci. 2008;97(6):2110-20.
6. Six K, Verreck G, Peeters J, Brewster M, Van den Mooter G. Increased physical stability and improved dissolution properties of itraconazole, a class II drug, by solid dispersions that combine fast-and slow dissolving polymers. J Pharm Sci. 2004;93(1):124-31. (Pubitemid 38081820)
7. Janssens S, Novoa de Armas H, Remon JP, Van den Mooter G. The use of a new hydrophilic polymer, Kollicoat IR®, in the formulation of solid dispersions of itraconazole. Eur J Pharm Sci. 2007;30:288-94. (Pubitemid 46282446)
8. Janssens S, Anné M, Rombaut P, Van den Mooter G. Spray-drying from complex solvent systems broadens the applicability of Kollicoat IR as a carrier in the formulation of solid dispersions. Eur J Pharm Sci. 2009;37:241-8.
9. Guns S, Kayaert P, Martens JA, VanHumbeeck J, Mathot V, Pijpers T, et al. Characterization of the copolymer poly(ethyleneglycol-gvinylalcohol) as a potential carrier in the formulation of solid dispersions. Eur J Pharm Biopharm. 2010;74(2):239-47.
10. Six K, Verreck G, Peeters J, Augustijns P, Kinget R, Van den Mooter G. Characterization of glassy itraconazole: a comparative study of its molecular mobility below T(g) with that of structural analogues using MTDSC. Int J Pharm. 2001;213:163-73. (Pubitemid 32119472)
11. Yu L. Inferring thermodynamic stability relationship of polymorphs from melting data. J Pharm Sci. 1995;84:966-74.