Preparation and performance of hydroxypropyl methylcellulose esters of substituted succinates for in vitro supersaturation of a crystalline hydrophobic drug

Molecular Pharmaceutics

Volumn 11, Issue 1, 2014, Pages 175-185

  Yin, Ligeng ^a   Hillmyer, Marc A ^a  

^a University of Minnesota   (United States)

Author keywords

crystallization inhibition; HPMC esters of substituted succinates; HPMCAS; phenytoin; spray dried dispersions; supersaturated solutions

Indexed keywords

ESTER DERIVATIVE; HYDROXYPROPYLMETHYLCELLULOSE; PHENYTOIN; SUCCINIC ACID DERIVATIVE; SUCCINIC ANHYDRIDE; SULFIDE;

ARTICLE; CRYSTALLIZATION; DIFFERENTIAL SCANNING CALORIMETRY; DRUG SOLUBILITY; HYDROPHOBICITY; IN VITRO STUDY; LIGHT SCATTERING; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE PROPERTY RELATION; REFRACTION INDEX; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SCANNING ELECTRON MICROSCOPY; SPRAY DRYING; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; SYNTHESIS; THERMOSTABILITY; VISCOSITY; X RAY POWDER DIFFRACTION;

ANTICONVULSANTS; CALORIMETRY, DIFFERENTIAL SCANNING; ESTERS; EXCIPIENTS; FREEZE DRYING; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; METHYLCELLULOSE; MICROSCOPY, ELECTRON, SCANNING; PHENYTOIN; PHYSICOCHEMICAL PHENOMENA; SOLUBILITY; X-RAY DIFFRACTION;

EID: 84891764194     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp4003656     Document Type: Article

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