A novel bottom-up process to produce drug nanocrystals: Controlled crystallization during freeze-drying

Journal of Controlled Release

Volumn 128, Issue 2, 2008, Pages 179-183

  de Waard, H ^a   Hinrichs, W L J ^a   Frijlink, H W ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

Crystallization; Dissolution; Fenofibrate; Nanocrystal; Poorly water soluble drug

Indexed keywords

CRYSTALLIZATION; DISPERSIONS; DRUG PRODUCTS; DRYING; FREEZING; MIXTURES;

FENOFIBRATE; INTERSTITIAL SPACES; PHYSICAL MIXTURES; POORLY WATER SOLUBLE DRUG;

NANOCRYSTALS;

FENOFIBRATE; MANNITOL; NANOCRYSTAL; TERT BUTYL ALCOHOL; WATER;

ARTICLE; CRYSTAL STRUCTURE; CRYSTALLIZATION; DIFFERENTIAL SCANNING CALORIMETRY; DISPERSION; DISSOLUTION; DRUG FORMULATION; DRUG RESEARCH; DRUG SOLUBILITY; FREEZE DRYING; INTERMETHOD COMPARISON; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; TABLET FORMULATION; X RAY POWDER DIFFRACTION;

ANTILIPEMIC AGENTS; CALORIMETRY, DIFFERENTIAL SCANNING; CRYSTALLIZATION; FREEZE DRYING; FREEZING; KINETICS; MANNITOL; MICROSCOPY, ELECTRON, SCANNING; NANOPARTICLES; PROCETOFEN; SOLVENTS; TABLETS; TERT-BUTYL ALCOHOL; WATER; X-RAY DIFFRACTION;

EID: 43449094630     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2008.03.002     Document Type: Article

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