Discovery of a selective TRPM8 antagonist with clinical efficacy in cold-related pain

ACS Medicinal Chemistry Letters

Volumn 6, Issue 4, 2015, Pages 419-424

  Andrews, Mark D ^a   Af Forselles, Kerry ^a   Beaumont, Kevin ^b   Galan, Sébastien R G ^a   Glossop, Paul A ^a   Grenie, Mathilde ^a   Jessiman, Alan ^a   Kenyon, Amy S ^a   Lunn, Graham ^a   Maw, Graham ^a   Owen, Robert M ^a   Pryde, David C ^a   Roberts, Dannielle ^a   Tran, Thien Duc ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

^b PFIZER INC   (United States)

Author keywords

clinical tool; hypothermia; ion channel; pain; PF 05105679; thermoregulation; TRP channel; TRPM8

Indexed keywords

ANTINOCICEPTIVE AGENT; PF 05105679; TRANSIENT RECEPTOR POTENTIAL CHANNEL AFFECTING AGENT; TRANSIENT RECEPTOR POTENTIAL CHANNEL M8; UNCLASSIFIED DRUG;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COLD INDUCED ALLODYNIA; DRUG ABSORPTION; DRUG CLEARANCE; DRUG DESIGN; DRUG EFFICACY; DRUG HALF LIFE; DRUG IDENTIFICATION; DRUG STRUCTURE; GUINEA PIG; HYPERALGESIA; IC50; IN VITRO STUDY; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; THERMOREGULATION;

MAMMALIA;

EID: 84927641413     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml500479v     Document Type: Article

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