Design and optimization of benzimidazole-containing transient receptor potential melastatin 8 (TRPM8) antagonists

Journal of Medicinal Chemistry

Volumn 54, Issue 1, 2011, Pages 233-247

  Parks, Daniel J ^a   Parsons, William H ^a   Colburn, Raymond W ^a   Meegalla, Sanath K ^a   Ballentine, Shelley K ^a   Illig, Carl R ^a   Qin, Ning ^a   Liu, Yi ^a   Hutchinson, Tasha L ^a   Lubin, Mary Lou ^a   Stone, Dennis J ^a   Baker, Judith F ^a   Schneider, Craig R ^a   Ma, Jianya ^a   Damiano, Bruce P ^a   Flores, Christopher M ^a   Player, Mark R ^a  

^a JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

3 [7 TRIFLUOROMETHYL 5 (2 TRIFLUOROMETHYL PHENYL) 1H BENZIMID AZOL 2 YL]1 OXA 2 AZA SPIRO[4.5]DEC 2 ENE HYDROCHLORIDE; BENZIMIDAZOLE DERIVATIVE; MENTHOL; TRANSIENT RECEPTOR POTENTIAL CHANNEL M8; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ASSAY; COLD SENSITIVITY; CONTROLLED STUDY; HYPERALGESIA; IN VIVO STUDY; MALE; NEUROPATHIC PAIN; NONHUMAN; RAT; RECEPTOR POTENTIAL; SYNTHESIS; TEMPERATURE SENSITIVITY; WET DOG SHAKES;

ADMINISTRATION, ORAL; ANALGESICS; ANIMALS; BENZIMIDAZOLES; BIOLOGICAL AVAILABILITY; CONSTRICTION, PATHOLOGIC; DOGS; HEK293 CELLS; HUMANS; HYPERALGESIA; ISOXAZOLES; MACACA FASCICULARIS; MICROSOMES, LIVER; NEURALGIA; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; TRPM CATION CHANNELS;

EID: 78651093218     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm101075v     Document Type: Article

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