Arylglycine derivatives as potent transient receptor potential melastatin 8 (TRPM8) antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 7, 2013, Pages 2234-2237

  Zhu, Bin ^a   Xia, Mingde ^a   Xu, Xiaoqing ^a   Ludovici, Donald W ^a   Tennakoon, Manomi ^a   Youngman, Mark A ^a   Matthews, Jay M ^a   Dax, Scott L ^a   Colburn, Raymond W ^a   Qin, Ning ^a   Hutchinson, Tasha L ^a   Lubin, Mary Lou ^a   Brandt, Michael R ^a   Stone, Dennis J ^a   Flores, Christopher M ^a   MacIelag, Mark J ^a  

^a JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

Author keywords

Arylglycine; Cold allodynia; Pain; Transient receptor potential melastatin 8; TRPM8 antagonist

Indexed keywords

ANALGESIC AGENT; ARYLGLYCINE DERIVATIVE; CALCIUM ION; GLYCINE DERIVATIVE; TRANSIENT RECEPTOR POTENTIAL CHANNEL M8; UNCLASSIFIED DRUG;

ARTICLE; CALCIUM CELL LEVEL; COLD SENSITIVITY; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG POTENCY; DRUG TOLERABILITY; IC 50; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PAIN; PHARMACODYNAMICS; PROTEIN EXPRESSION; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; WET DOG SHAKES;

ANIMALS; BEHAVIOR, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; GLYCINE; HEK293 CELLS; HUMANS; MOLECULAR STRUCTURE; PYRIMIDINONES; RATS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TRPM CATION CHANNELS;

CANIS FAMILIARIS;

EID: 84875226380     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.01.062     Document Type: Article

References (21)

1. D.D. McKemy, W.M. Neuhausser, and D. Julius Nature 416 2002 52
2. A.M. Peier, A. Moqrich, A.C. Hergarden, A.J. Reeve, D.A. Andersson, G.M. Story, T.J. Earley, I. Dragoni, P. McIntyre, S. Bevan, and A. Patapoutian Cell 108 2002 705
3. M.L. Nealen, M.S. Godl, P.D. Thut, and M.J. Caterina J. Neurophysiol. 90 2003 515
4. K. Kobayashi, T. Fukuoka, K. Obata, H. Yamanaka, Y. Dai, A. Tokunaga, and K. Noguchi J. Comb. Neurol. 493 2005 596
5. D.M. Bautista, J. Simens, J.M. Glazer, P.R. Tsuruda, A.I. Basbaum, C.L. Stucky, S.E. Jordt, and D. Julius Nature 448 2007 204
6. R.W. Colburn, M.L. Lubin, D.J. Stone Jr., Y. Wang, D. Lawrence, M.R. D'Dndrea, M.R. Brandt, Y. Liu, C.M. Flores, and N. Qin Neuron 54 2007 379
7. A. Dhaka, A.N. Murray, J. Mathur, T.J. Earley, M.J. Petrus, and A. Patapoutian Neuron 54 2007 371
8. L.M. Broad, A.J. Mogg, R.E. Beattie, A.-M. Ogden, M.-J. Blanco, and D. Bleakman Expert Opin. Ther. Targets 13 2009 69
9. C.L. Stucky, A.E. Dubin, N.A. Jeske, S.A. Malin, D.D. McKemy, and G.M. Story Brain Res. Rev. 60 2009 2
10. D.N. Cortright, and A. Szallasi Curr. Pharm. Des. 15 2009 1736
11. G. Ortar, L.D. Petrocellis, L. Morera, A.S. Moriello, P. Orlando, E. Morera, M. Nalli, and V. Di Marzo Bioorg. Med. Chem. Lett. 20 2010 2729
12. J. DeFalco, D. Steiger, M. Dourado, D. Emerling, and M.A. Duncton Bioorg. Med. Chem. Lett. 20 2010 7076
13. D.J. Parks, W.H. Parsons, R.W. Colburn, S.K. Meegalla, S.K. Ballentine, C.R. Illig, N. Qin, Y. Liu, T.L. Hutchinson, M.L. Lubin, D.J. Stone, J.F. Baker, C.R. Shneider, J. Ma, B.P. Damiano, C.M. Flores, and M.R. Player J. Med. Chem. 54 2011 233
14. Matthews, J. M.; Qin, N.; Colburn, R. W.; Dax, S. L.; Hawkins, M.; McNally, J.; Reany, L.; Youngman, M.; Baker, J.; Hutchinson, T.; Liu, Y.; Lubin, M. L.; Neeper, M.; Brandt, M. R.; Stone, D. J.; Flores, C. M. Bioorg. Med. Chem. Lett., 2012, 22, 2922.
15. N.A. Tamayo, Y. Bo, V. Gore, V. Ma, N. Nishimura, P. Tang, H. Deng, L. Klionsky, S.G. Lehto, W. Wang, B. Youngblood, J. Chen, T.L. Correll, M.D. Bartberger, N.R. Gavva, and M.H. Norman J. Med. Chem. 55 2012 1593
16. R.R. Calvo, S.K. Meegalla, D.J. Parks, W.H. Parsons, S.K. Ballentine, M.L. Lubin, C. Schneider, R.W. Colburn, C.M. Flores, and M.R. Player Bioorg. Med. Chem. Lett. 22 2012 1903
17. N.S. Petasis, A. Goodman, and I.A. Zavialov Tetrahedron 53 1997 16463
18. Y. Liu, M.L. Lubin, T. Reitz, Y. Wang, R.W. Colburn, C.M. Flores, and N. Qin Eur. J. Pharmacol. 530 2006 23
19. H.J. Behrendt, T. Germann, C. Gillen, H. Hatt, and R. Jostock Br. J. Pharmacol. 141 2004 737
20. J.L. Werkheiser, S.M. Rawls, and A. Cowan Eur. J. Pharmacol. 547 2006 101
21. J.L. Werkheiser, S.M. Rawls, and A. Cowan Amino Acids 30 2006 307