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Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 23, 2014, Pages 5364-5368

Identification of a novel 2-pyridyl-benzensulfonamide derivative, RQ-00203078, as a selective and orally active TRPM8 antagonist

(8) Ohmi, Masashi a Shishido, Yuji a Inoue, Tadashi a Ando, Kazuo a Fujiuchi, Akiyoshi a Yamada, Akiko a Watanabe, Shuzo a Kawamura, Kiyoshi a

a RaQualia Pharma Inc (Japan)

Author keywords

Cold allodynia; RQ 00203078; Sulfonamide; TRPM8 antagonist; Wet dog shakes

Indexed keywords

ANTICONVULSIVE AGENT; BENZENESULFONAMIDE DERIVATIVE; RQ 00203078; TRANSIENT RECEPTOR POTENTIAL CHANNEL M8; UNCLASSIFIED DRUG; TRANSIENT RECEPTOR POTENTIAL CHANNEL M;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DRUG BIOAVAILABILITY; DRUG MECHANISM; DRUG STRUCTURE; HIGH THROUGHPUT SCREENING; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; WET DOG SHAKES; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; GENETICS; METABOLISM;

ANIMALS; MOLECULAR STRUCTURE; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; TRPM CATION CHANNELS;

EID: 84910107342 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2014.10.074 Document Type: Article

Times cited : (29)

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