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Volumn 2, Issue SPEC. ISS.2, 2010, Pages 81-88

Therapeutic potential of TRPM8 modulators

Author keywords

Cold; Menthol; Pain; TRP channel; TRPM8

Indexed keywords

1 (2 HYDROXYPHENYL) 4 (3 NITROPHENYL) 1,2,3,6 TETRAHYDROPYRIMIDIN 2 ONE; 1 [2 (4 METHOXYPHENYL) 2 [3 (4 METHOXYPHENYL)PROPOXY]ETHYL] 1H IMIDAZOLE; AG 3 5; ANALGESIC AGENT; CAPSAZEPINE; CINEOLE; COOLACT P; COOLING AGENT 10; COTRIMOXAZOLE; CPS 113; CPS 369; FRESCOLAT MGA; FRESCOLAT ML; GERANIOL; HYDROXYCITRONELLAL; LINALOOL; MENTHOL; N (3 AMINOPROPYL) 2 [[(3 METHYLPHENYL)METHYL]OXY]N (2 THIENYLMETHYL)BENZAMIDE; N (4 TERTBUTYLPHENYL) 4 (3 CHLOROPYRIDIN 2 YL)PIPERAZINE 1 CARBOXAMIDE; PMD 38; THIO N (4 TERTBUTYLPHENYL) 4 (3 CHLOROPYRIDIN 2 YL)PIPERAZINE 1 CARBOXAMIDE; TRANSIENT RECEPTOR POTENTIAL CHANNEL M8; UNCLASSIFIED DRUG; WS 12; WS 140; WS 148; WS 23; WS 3; WS 30;

EID: 84862804874     PISSN: None     EISSN: 18773818     Source Type: Journal    
DOI: 10.2174/1877381801002030081     Document Type: Review
Times cited : (24)

References (59)
  • 1
    • 34250795146 scopus 로고    scopus 로고
    • Temperature sensing across species
    • McKemy, D.D. Temperature sensing across species. Pflugers Arch. 2007, 454(5), 777-791.
    • (2007) Pflugers Arch , vol.454 , Issue.5 , pp. 777-791
    • McKemy, D.D.1
  • 2
    • 0041878279 scopus 로고    scopus 로고
    • Lessons from peppers and peppermint, the molecular logic of thermosensation
    • Jordt, S.E.; McKemy, D.D.; Julius, D. Lessons from peppers and peppermint, the molecular logic of thermosensation. Curr. Opin. Neurobiol., 2003, 13(4), 487-492.
    • (2003) Curr. Opin. Neurobiol , vol.13 , Issue.4 , pp. 487-492
    • Jordt, S.E.1    McKemy, D.D.2    Julius, D.3
  • 3
    • 0037034931 scopus 로고    scopus 로고
    • Identification of a cold receptor reveals a general role for TRP channels in thermosensation
    • McKemy, D.D.; Neuhausser, W.M.; Julius, D. Identification of a cold receptor reveals a general role for TRP channels in thermosensation. Nature, 2002, 416(6876), 52-58.
    • (2002) Nature , vol.416 , Issue.6876 , pp. 52-58
    • McKemy, D.D.1    Neuhausser, W.M.2    Julius, D.3
  • 7
    • 34748875979 scopus 로고    scopus 로고
    • Mice left out in the cold, commentary on the phenotype of TRPM8-nulls. Mol
    • Daniels, R.L.; McKemy, D.D. Mice left out in the cold, commentary on the phenotype of TRPM8-nulls. Mol. Pain, 2007, 3, 23.
    • (2007) Pain , vol.3 , pp. 23
    • Daniels, R.L.1    McKemy, D.D.2
  • 9
    • 0031884824 scopus 로고    scopus 로고
    • Temporal and qualitative properties of cold pain and heat pain, a psychophysical study
    • Morin, C.; Bushnell, M.C. Temporal and qualitative properties of cold pain and heat pain, a psychophysical study. Pain, 1998, 74(1), 67-73.
    • (1998) Pain , vol.74 , Issue.1 , pp. 67-73
    • Morin, C.1    Bushnell, M.C.2
  • 10
    • 0028024219 scopus 로고
    • Menthol and related cooling compounds
    • Eccles, R. Menthol and related cooling compounds. J. Pharm. Pharmacol., 1994, 46(8), 618-630.
    • (1994) J. Pharm. Pharmacol , vol.46 , Issue.8 , pp. 618-630
    • Eccles, R.1
  • 11
    • 0026658720 scopus 로고
    • The sensory effects of l-menthol on human skin
    • B.G. The sensory effects of l-menthol on human skin. Somatosens Mot. Res., 1992, 9(3), 235-244.
    • (1992) Somatosens Mot. Res , vol.9 , Issue.3 , pp. 235-244
  • 12
    • 0003041481 scopus 로고
    • The effect of menthol on the thermoreceptors
    • Hensel, H.; Zotterman, Y. The effect of menthol on the thermoreceptors. Acta Physiol. Scand., 1951, 24, 27-34.
    • (1951) Acta Physiol. Scand , vol.24 , pp. 27-34
    • Hensel, H.1    Zotterman, Y.2
  • 13
    • 2442616221 scopus 로고    scopus 로고
    • Topical menthol-a human model for cold pain by activation and sensitization of C nociceptors
    • Wasner, G.; Schattschneider, J.; Binder, A.; Baron, R. Topical menthol-a human model for cold pain by activation and sensitization of C nociceptors. Brain, 2004, 127(Pt 5), 1159-1171.
    • (2004) Brain , vol.127 , Issue.Pt 5 , pp. 1159-1171
    • Wasner, G.1    Schattschneider, J.2    Binder, A.3    Baron, R.4
  • 17
    • 33644875032 scopus 로고    scopus 로고
    • The TRP superfamily of cation channels
    • Montell, C. The TRP superfamily of cation channels. Sci. STKE, 2005, 2005(272), re3.
    • (2005) Sci. STKE , vol.2005 , Issue.272
    • Montell, C.1
  • 18
    • 0035328671 scopus 로고    scopus 로고
    • Trp-p8. a novel prostate-specific gene is up-regulated in prostate cancer and other malignancies and shares high homology with transient receptor potential calcium channel proteins
    • Tsavaler, L.; Shapero, M.H.; Morkowski, S.; Laus, R. Trp-p8. a novel prostate-specific gene is up-regulated in prostate cancer and other malignancies and shares high homology with transient receptor potential calcium channel proteins. Cancer Res., 2001, 61(9), 3760-3769.
    • (2001) Cancer Res , vol.61 , Issue.9 , pp. 3760-3769
    • Tsavaler, L.1    Shapero, M.H.2    Morkowski, S.3    Laus, R.4
  • 19
    • 38549180951 scopus 로고    scopus 로고
    • Visualizing cold spots, TRPM8-expressing sensory neurons and their projections
    • Dhaka, A.; Earley, T.J.; Watson, J.; Patapoutian, A. Visualizing cold spots, TRPM8-expressing sensory neurons and their projections. J. Neurosci., 2008, 28(3), 566-575.
    • (2008) J. Neurosci , vol.28 , Issue.3 , pp. 566-575
    • Dhaka, A.1    Earley, T.J.2    Watson, J.3    Patapoutian, A.4
  • 20
    • 38349101323 scopus 로고    scopus 로고
    • Diversity in the neural circuitry of cold sensing revealed by genetic axonal labeling of transient receptor potential melastatin 8 neurons
    • Takashima, Y.; Daniels, R.L.; Knowlton, W.; Teng, J.; Liman, E.R.; McKemy, D.D. Diversity in the neural circuitry of cold sensing revealed by genetic axonal labeling of transient receptor potential melastatin 8 neurons. J. Neurosci., 2007, 27(51), 14147-14157.
    • (2007) J. Neurosci , vol.27 , Issue.51 , pp. 14147-14157
    • Takashima, Y.1    Daniels, R.L.2    Knowlton, W.3    Teng, J.4    Liman, E.R.5    McKemy, D.D.6
  • 21
    • 0036183242 scopus 로고    scopus 로고
    • Specificity of cold thermotransduction is determined by differential ionic channel expression. Nat
    • Viana, F.; de la Pena, E.; Belmonte, C. Specificity of cold thermotransduction is determined by differential ionic channel expression. Nat. Neurosci., 2002, 5(3), 254-260.
    • (2002) Neurosci , vol.5 , Issue.3 , pp. 254-260
    • Viana, F.1    de la Pena, E.2    Belmonte, C.3
  • 22
    • 0023637275 scopus 로고
    • Cold stimulation of teeth, a comparison between the responses of cat intradental A delta and C fibres and human sensation
    • Jyvasjarvi, E.; Kniffki, K.D. Cold stimulation of teeth, a comparison between the responses of cat intradental A delta and C fibres and human sensation. J. Physiol., 1987, 391, 193-207.
    • (1987) J. Physiol , vol.391 , pp. 193-207
    • Jyvasjarvi, E.1    Kniffki, K.D.2
  • 23
    • 33845222371 scopus 로고    scopus 로고
    • How cold is it? TRPM8 and TRPA1 in the molecular logic of cold sensation. Mol
    • McKemy D.D. How cold is it? TRPM8 and TRPA1 in the molecular logic of cold sensation. Mol. Pain, 2005, 1(1), 16.
    • (2005) Pain , vol.1 , Issue.1 , pp. 16
    • McKemy, D.D.1
  • 24
    • 33845202099 scopus 로고    scopus 로고
    • Detection of cold pain, cold allodynia and cold hyperalgesia in freely behaving rats
    • Allchorne, A.J.; Broom, D.C.; Woolf, C.J. Detection of cold pain, cold allodynia and cold hyperalgesia in freely behaving rats. Mol. Pain, 2005, 1, 36.
    • (2005) Mol. Pain , vol.1 , pp. 36
    • Allchorne, A.J.1    Broom, D.C.2    Woolf, C.J.3
  • 25
    • 0031895862 scopus 로고    scopus 로고
    • The cold plate as a test of nociceptive behaviors, description and application to the study of chronic neuropathic and inflammatory pain models
    • Jasmin, L.; Kohan, L.; Franssen, M.; Janni, G.; Goff, J.R. The cold plate as a test of nociceptive behaviors, description and application to the study of chronic neuropathic and inflammatory pain models. Pain, 1998, 75(2-3), 367-382.
    • (1998) Pain , vol.75 , Issue.2-3 , pp. 367-382
    • Jasmin, L.1    Kohan, L.2    Franssen, M.3    Janni, G.4    Goff, J.R.5
  • 27
    • 13944255381 scopus 로고    scopus 로고
    • Altered thermal selection behavior in mice lacking transient receptor potential vanilloid 4
    • Lee, H.; Iida, T.; Mizuno, A.; Suzuki, M.; Caterina, M.J. Altered thermal selection behavior in mice lacking transient receptor potential vanilloid 4. J. Neurosci., 2005, 25(5), 1304-1310.
    • (2005) J. Neurosci , vol.25 , Issue.5 , pp. 1304-1310
    • Lee, H.1    Iida, T.2    Mizuno, A.3    Suzuki, M.4    Caterina, M.J.5
  • 29
    • 33646061333 scopus 로고    scopus 로고
    • TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for haircell transduction
    • Kwan, K.Y.; Allchorne, A.J.; Vollrath, M.A.; Christensen, A.P.; Zhang, D.S.; Woolf, C.J.; Corey, D.P. TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for haircell transduction. Neuron, 2006, 50(2), 277-289.
    • (2006) Neuron , vol.50 , Issue.2 , pp. 277-289
    • Kwan, K.Y.1    Allchorne, A.J.2    Vollrath, M.A.3    Christensen, A.P.4    Zhang, D.S.5    Woolf, C.J.6    Corey, D.P.7
  • 31
    • 64549120669 scopus 로고    scopus 로고
    • TRPA1 and cold transduction, an unresolved issue
    • Caspani, O.; Heppenstall, P.A. TRPA1 and cold transduction, an unresolved issue? J. Gen. Physiol., 2009, 133(3), 245-249.
    • (2009) J. Gen. Physiol , vol.133 , Issue.3 , pp. 245-249
    • Caspani, O.1    Heppenstall, P.A.2
  • 32
    • 70449670391 scopus 로고    scopus 로고
    • Analgesic efficacy oftramadol, pregabalin and ibuprofen in menthol-evoked cold hyperalgesia
    • Altis, K.; Schmidtko, A.; Angioni, C.; Kuczka, K.; Schmidt, H.; Geisslinger, G.; Lötsch, J.; Tegeder, I. Analgesic efficacy oftramadol, pregabalin and ibuprofen in menthol-evoked cold hyperalgesia. Pain, 2009, 147(1-3), 116-121.
    • (2009) Pain , vol.147 , Issue.1-3 , pp. 116-121
    • Altis, K.1    Schmidtko, A.2    Angioni, C.3    Kuczka, K.4    Schmidt, H.5    Geisslinger, G.6    Lötsch, J.7    Tegeder, I.8
  • 35
    • 67049154139 scopus 로고    scopus 로고
    • Intragastric administration of TRPV1, TRPV3, TRPM8, and TRPA1 agonists modulates autonomic thermoregulation in different manners in mice
    • Masamoto, Y.; Kawabata, F.; Fushiki, T. Intragastric administration of TRPV1, TRPV3, TRPM8, and TRPA1 agonists modulates autonomic thermoregulation in different manners in mice. Biosci. Biotechnol. Biochem., 2009, 73(5), 1021-1027.
    • (2009) Biosci. Biotechnol. Biochem , vol.73 , Issue.5 , pp. 1021-1027
    • Masamoto, Y.1    Kawabata, F.2    Fushiki, T.3
  • 36
    • 0020675813 scopus 로고
    • AG-3-5, a chemical producing sensations of cold
    • Wei, E.T.; Seid, D.A. AG-3-5, a chemical producing sensations of cold. J. Pharm. Pharmacol., 1983, 35(2), 110-112.
    • (1983) J. Pharm. Pharmacol , vol.35 , Issue.2 , pp. 110-112
    • Wei, E.T.1    Seid, D.A.2
  • 37
    • 14844309685 scopus 로고    scopus 로고
    • Attenuated fever response in mice lacking TRPV1. Neurosci
    • Iida, T.; Shimizu, I.; Nealen, M.L.; Campbell, A.; Caterina, M. Attenuated fever response in mice lacking TRPV1. Neurosci. Lett., 2005, 378(1), 28-33.
    • (2005) Lett , vol.378 , Issue.1 , pp. 28-33
    • Iida, T.1    Shimizu, I.2    Nealen, M.L.3    Campbell, A.4    Caterina, M.5
  • 38
    • 35348913801 scopus 로고    scopus 로고
    • Thermoregulation, channels that are cool to the core
    • Montell, C.; Caterina, M.J. Thermoregulation, channels that are cool to the core. Curr. Biol., 2007, 17(20), R885-887.
    • (2007) Curr. Biol , vol.17 , Issue.20
    • Montell, C.1    Caterina, M.J.2
  • 39
    • 54349127771 scopus 로고    scopus 로고
    • Body-temperature maintenance as the predominant function of the vanilloid receptor TRPV1
    • Gavva, N.R. Body-temperature maintenance as the predominant function of the vanilloid receptor TRPV1. Trends Pharmacol. Sci., 2008, 29(11), 550-557.
    • (2008) Trends Pharmacol. Sci , vol.29 , Issue.11 , pp. 550-557
    • Gavva, N.R.1
  • 41
    • 34748877218 scopus 로고    scopus 로고
    • Characterisation of TRPM8 as a pharmacophore receptor
    • Bodding, M.; Wissenbach, U.; Flockerzi, V. Characterisation of TRPM8 as a pharmacophore receptor. Cell Calcium, 2007, 42(6), 618-628.
    • (2007) Cell Calcium , vol.42 , Issue.6 , pp. 618-628
    • Bodding, M.1    Wissenbach, U.2    Flockerzi, V.3
  • 43
    • 4544368241 scopus 로고    scopus 로고
    • The super-cooling agent icilin reveals a mechanism of coincidence detection by a temperature-sensitive TRP channel
    • Chuang, H.H.; Neuhausser, W.M.; Julius, D. The super-cooling agent icilin reveals a mechanism of coincidence detection by a temperature-sensitive TRP channel. Neuron, 2004, 43(6), 859-869.
    • (2004) Neuron , vol.43 , Issue.6 , pp. 859-869
    • Chuang, H.H.1    Neuhausser, W.M.2    Julius, D.3
  • 44
    • 0036183319 scopus 로고    scopus 로고
    • Molecular basis for species-specific sensitivity to hot chili peppers
    • Jordt, S.E.; Julius, D. Molecular basis for species-specific sensitivity to hot chili peppers. Cell, 2002, 108(3), 421-430.
    • (2002) Cell , vol.108 , Issue.3 , pp. 421-430
    • Jordt, S.E.1    Julius, D.2
  • 45
    • 23044500197 scopus 로고    scopus 로고
    • Conservation of functional and pharmacological properties in the distantly related temperature sensors TRVP1 and TRPM8. Mol
    • Weil, A.; Moore, S.E.; Waite, N.J.; Randall, A.; Gunthorpe, M.J. Conservation of functional and pharmacological properties in the distantly related temperature sensors TRVP1 and TRPM8. Mol. Pharmacol., 2005, 68(2), 518-527.
    • (2005) Pharmacol , vol.68 , Issue.2 , pp. 518-527
    • Weil, A.1    Moore, S.E.2    Waite, N.J.3    Randall, A.4    Gunthorpe, M.J.5
  • 46
    • 1842453817 scopus 로고    scopus 로고
    • Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay
    • Behrendt, H.J.; Germann, T.; Gillen, C.; Hatt, H.; Jostock, R. Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay. Br. J. Pharmacol., 2004, 141(4), 737-745.
    • (2004) Br. J. Pharmacol , vol.141 , Issue.4 , pp. 737-745
    • Behrendt, H.J.1    Germann, T.2    Gillen, C.3    Hatt, H.4    Jostock, R.5
  • 48
    • 0030742250 scopus 로고    scopus 로고
    • Capsazepine block of voltage-activated calcium channels in adult rat dorsal root ganglion neurones in culture
    • Docherty, R.J.; Yeats, J.C.; Piper, A.S. Capsazepine block of voltage-activated calcium channels in adult rat dorsal root ganglion neurones in culture. Br. J. Pharmacol., 1997, 121(7), 1461-1467.
    • (1997) Br. J. Pharmacol , vol.121 , Issue.7 , pp. 1461-1467
    • Docherty, R.J.1    Yeats, J.C.2    Piper, A.S.3
  • 49
    • 0030792361 scopus 로고    scopus 로고
    • Capsazepine, a vanilloid receptor antagonist, inhibits nicotinic acetylcholine receptors in rat trigeminal ganglia. Neurosci
    • Liu, L.; Simon, S.A. Capsazepine, a vanilloid receptor antagonist, inhibits nicotinic acetylcholine receptors in rat trigeminal ganglia. Neurosci. Lett., 1997, 228(1), 29-32.
    • (1997) Lett , vol.228 , Issue.1 , pp. 29-32
    • Liu, L.1    Simon, S.A.2
  • 50
    • 8844256161 scopus 로고    scopus 로고
    • Current perspectives on the therapeutic utility of VR1 antagonists
    • Valenzano, K.J.; Sun, Q. Current perspectives on the therapeutic utility of VR1 antagonists. Curr. Med. Chem., 2004, 11(24), 3185-3202.
    • (2004) Curr. Med. Chem , vol.11 , Issue.24 , pp. 3185-3202
    • Valenzano, K.J.1    Sun, Q.2
  • 51
    • 33845261834 scopus 로고    scopus 로고
    • Viana, F. Contribution of TRPM8 channels to cold transduction in primary sensory neurons and peripheral nerve terminals
    • Madrid, R.; Donovan-Rodriguez, T.; Meseguer, V.; Acosta, M.C.; Belmonte, C.; Viana, F. Contribution of TRPM8 channels to cold transduction in primary sensory neurons and peripheral nerve terminals. J. Neurosci., 2006, 26(48), 12512-12525.
    • (2006) J. Neurosci , vol.26 , Issue.48 , pp. 12512-12525
    • Madrid, R.1    Donovan-Rodriguez, T.2    Meseguer, V.3    Acosta, M.C.4    Belmonte, C.5
  • 54
    • 59449084852 scopus 로고    scopus 로고
    • McKemy D.D. Activity of the neuronal cold sensor TRPM8 is regulated by phospholipase C via the phospholipid phosphoinositol 4, 5-bisphosphate
    • Daniels R.L.; Takashima Y.; McKemy D.D. Activity of the neuronal cold sensor TRPM8 is regulated by phospholipase C via the phospholipid phosphoinositol 4, 5-bisphosphate. J. Biol. Chem., 2009, 284(3), 1570-1582.
    • (2009) J. Biol. Chem , vol.284 , Issue.3 , pp. 1570-1582
    • Daniels, R.L.1    Takashima, Y.2
  • 55
    • 14044261739 scopus 로고    scopus 로고
    • Qin, F. Functional control of cold- and menthol-sensitive TRPM8 ion channels by phosphatidylinositol 4, 5-bisphosphate
    • Liu, B.; Qin, F. Functional control of cold- and menthol-sensitive TRPM8 ion channels by phosphatidylinositol 4, 5-bisphosphate. J. Neurosci., 2005, 25(7), 1674-1681.
    • (2005) J. Neurosci , vol.25 , Issue.7 , pp. 1674-1681
    • Liu, B.1
  • 56
    • 17844373771 scopus 로고    scopus 로고
    • (4, 5) P2 regulates the activation and desensitization of TRPM8 channels through the TRP domain. Nat
    • Rohacs, T.; Lopes, C.M.; Michailidis, I.; Logothetis, D.E. PI (4, 5) P2 regulates the activation and desensitization of TRPM8 channels through the TRP domain. Nat. Neurosci., 2005, 8(5), 626-634.
    • (2005) Neurosci , vol.8 , Issue.5 , pp. 626-634
    • Rohacs, T.1    Lopes, C.M.2    Michailidis, I.3    Logothetis, D.E.P.I.4
  • 57
    • 34548658196 scopus 로고    scopus 로고
    • Regulation of transient receptor potential (TRP) channels by phosphoinositides
    • Rohacs, T.; Nilius, B. Regulation of transient receptor potential (TRP) channels by phosphoinositides. Pflugers Arch., 2007, 455(1), 157-168.
    • (2007) Pflugers Arch , vol.455 , Issue.1 , pp. 157-168
    • Rohacs, T.1    Nilius, B.2
  • 58
    • 33644769222 scopus 로고    scopus 로고
    • Ca2+dependent PKC activation mediates menthol-induced desensitization of transient receptor potential M8. Neurosci
    • Abe, J.; Hosokawa, H.; Sawada, Y.; Matsumura, K.; Kobayashi, S. Ca2+dependent PKC activation mediates menthol-induced desensitization of transient receptor potential M8. Neurosci. Lett., 2006, 397(1-2), 140-144.
    • (2006) Lett , vol.397 , Issue.1-2 , pp. 140-144
    • Abe, J.1    Hosokawa, H.2    Sawada, Y.3    Matsumura, K.4    Kobayashi, S.5
  • 59
    • 2942536048 scopus 로고    scopus 로고
    • TRPM8 activation by menthol, icilin, and cold is differentially modulated by intracellular pH
    • Andersson, D.A.; Chase, H.W.; Bevan, S. TRPM8 activation by menthol, icilin, and cold is differentially modulated by intracellular pH. J. Neurosci., 2004, 24(23), 5364-5369.
    • (2004) J. Neurosci , vol.24 , Issue.23 , pp. 5364-5369
    • Andersson, D.A.1    Chase, H.W.2    Bevan, S.3


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