Synthesis and pharmacological evaluation of novel N-aryl-3,4-dihydro- 1′H-spiro[chromene-2,4′-piperidine]-1′-carboxamides as TRPM8 antagonists

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 21, 2013, Pages 6542-6553

  Chaudhari, Sachin S ^a   Kadam, Ashok B ^a   Khairatkar Joshi, Neelima ^a   Mukhopadhyay, Indranil ^a   Karnik, Pallavi V ^a   Raghuram, Anupindi ^a   Rao, Shobha S ^a   Vaiyapuri, Thamil Selvan ^a   Wale, Dinesh P ^a   Bhosale, Vikram M ^a   Gudi, Girish S ^a   Sangana, Ramchandra R ^a   Thomas, Abraham ^a  

^a Glenmark Pharmaceuticals Limited   (India)

Author keywords

Cold allodynia; Neuropathic pain; Optical resolution of alcohols; Spiro chromene 2,4 piperidines ; Wet dog shake

Indexed keywords

8 CHLORO 4 HYDROXY N [4 (TRIFLUOROMETHOXY)PHENYL] 3,4 DIHYDRO 1'H SPIRO(CHROMENE 2,4' PIPERIDINE) 1' CARBOXAMIDE; N ARYL 3,4 DIHYDRO 1'H SPIRO(CHROMENE 2,4' PIPERIDINE) 1' CARBOXAMIDE DERIVATIVE; NEW DRUG; PREGABALIN; TRANSIENT RECEPTOR POTENTIAL CHANNEL AFFECTING AGENT; TRANSIENT RECEPTOR POTENTIAL CHANNEL M8; TRANSIENT RECEPTOR POTENTIAL CHANNEL M8 ANTAGONIST; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG DESIGN; DRUG EFFICACY; DRUG MEGADOSE; DRUG METABOLISM; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; EXPERIMENTAL RAT; IC 50; IN VITRO STUDY; ISOMERISM; MALE; MAXIMUM PLASMA CONCENTRATION; NEUROPATHIC PAIN; NONHUMAN; RAT; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; TIME TO MAXIMUM PLASMA CONCENTRATION;

CANIS FAMILIARIS; RATTUS; RODENTIA;

COLD ALLODYNIA; NEUROPATHIC PAIN; OPTICAL RESOLUTION OF ALCOHOLS; SPIRO[CHROMENE-2,4′-PIPERIDINES]; WET-DOG SHAKE;

ADMINISTRATION, ORAL; AMIDES; ANALGESICS; ANIMALS; DISEASE MODELS, ANIMAL; HALF-LIFE; MALE; MICE; MICE, INBRED C57BL; NEURALGIA; PIPERIDINES; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; SPIRO COMPOUNDS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TRPM CATION CHANNELS;

EID: 84885181839     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.08.031     Document Type: Article

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