Inhibition of TRPM8 channels reduces pain in the cold pressor test in humans

Journal of Pharmacology and Experimental Therapeutics

Volumn 351, Issue 2, 2014, Pages 259-269

  Winchester, Wendy J ^a,b,g   Gore, Katrina ^a,c   Glatt, Sophie ^a   Petit, Wendy ^f   Gardiner, Jennifer C ^b   Conlon, Kelly ^b   Postlethwaite, Michael ^b   Saintot, Pierre Philippe ^b   Roberts, Sonia ^d   Gosset, James R ^e   Matsuura, Tomomi ^e   Andrews, Mark D ^a   Glossop, Paul A ^a   Palmer, Michael J ^a   Clear, Nicola ^a   Collins, Susie ^c   Beaumont, Kevin ^e   Reynolds, David S ^a,b  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

^b Genito Urinary Research Unit   (United Kingdom)

^c Clinical Research and Development Statistics   (United Kingdom)

^d Sandwich Laboratories   (United Kingdom)

^e Pharmacokinetics Dynamics and Metabolism   (United Kingdom)

^f PFIZER INC   (United States)

^g Neusentis Pfizer Ltd   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ION TRANSPORT AFFECTING AGENT; MENTHOL; OXYCODONE; PLACEBO; TRANSIENT RECEPTOR POTENTIAL CHANNEL M8; TRANSIENT RECEPTOR POTENTIAL CHANNEL M8 ANTAGONIST; UNCLASSIFIED DRUG; [3 [[1 (4-FLUOROPHENYL)ETHYL](QUINOLIN 3 YLCARBONYL)AMINO]METHYLBENZOIC ACID]; AGENTS AFFECTING WATER, MOLECULE OR ION TRANSPORT; TRANSIENT RECEPTOR POTENTIAL CHANNEL M; TRPM8 PROTEIN, HUMAN;

ACUTE DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; COHORT ANALYSIS; COLD PAIN; COLD PRESSOR TEST; CONTINUOUS INFUSION; CONTROLLED STUDY; CORE TEMPERATURE; CYSTOMETRY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG EFFICACY; DRUG METABOLISM; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SAFETY; DRUG SCREENING; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG TOLERABILITY; DYSGEUSIA; DYSPNEA; ELECTROPHYSIOLOGY; FACIAL HYPOESTHESIA; FATIGUE; GASTROINTESTINAL DISEASE; GUINEA PIG; HEADACHE; HEAT SENSATION; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERHIDROSIS; HYPESTHESIA; HYPOTHERMIA; IC50; IN VITRO STUDY; IN VIVO STUDY; MALE; MAXIMUM PLASMA CONCENTRATION; MEDIASTINUM DISEASE; NEUROLOGIC DISEASE; NONHUMAN; NUCLEOTIDE SEQUENCE; ORAL HYPOESTHESIA; PAIN; PARESTHESIA; PHARMACODYNAMICS; POSITIONAL DIZZINESS; RAT; RESPIRATORY TRACT DISEASE; SAMPLE SIZE; SIDE EFFECT; SKIN DISEASE; SOMNOLENCE; THORAX DISEASE; TIME TO MAXIMUM PLASMA CONCENTRATION; UPPER ABDOMINAL PAIN; WHOLE CELL PATCH CLAMP; ANIMAL; BODY TEMPERATURE; COLD; CONTROLLED CLINICAL TRIAL; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG ANTAGONISM; DRUG EFFECT; HEK293 CELL LINE; METABOLISM; RANDOMIZED CONTROLLED TRIAL; WISTAR RAT;

ANIMALS; BODY TEMPERATURE; COLD TEMPERATURE; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; GUINEA PIGS; HEK293 CELLS; HUMANS; MALE; MEMBRANE TRANSPORT MODULATORS; OXYCODONE; PAIN; RATS; RATS, WISTAR; TRPM CATION CHANNELS;

EID: 84907210884     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.114.216010     Document Type: Article

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