Fused piperidines as a novel class of potent and orally available transient receptor potential melastatin type 8 (TRPM8) antagonists

Journal of Medicinal Chemistry

Volumn 55, Issue 4, 2012, Pages 1593-1611

  Tamayo, Nuria A ^a   Bo, Yunxin ^a   Gore, Vijay ^a   Ma, Vu ^a   Nishimura, Nobuko ^a   Tang, Phi ^a   Deng, Hong ^a   Klionsky, Lana ^a   Lehto, Sonya G ^a   Wang, Weiya ^a   Youngblood, Brad ^a   Chen, Jiyun ^a   Correll, Tiffany L ^a   Bartberger, Michael D ^a   Gavva, Narender R ^a   Norman, Mark H ^a  

^a AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

N(4 CHLOROPHENYL) 4 PROPYL 6,7DIHYDROTHIENO[3,2 C]PYRIDINE 5(4H) CARBOXAMIDE; N(4 FLUOROPHENYL) 1 [4 (TRIFLUOROMETHYL)PHENYL] 3,4 DIHYDROISOQUINOLINE 2(1H) CARBOXAMIDE; PIPERIDINE DERIVATIVE; PROTEIN INHIBITOR; TETRAHYDROISOQUINOLINE; TRANSIENT RECEPTOR POTENTIAL CHANNEL M8; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM TRANSPORT; DOSE RESPONSE; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; WET DOG SHAKES;

ADMINISTRATION, ORAL; ANALGESICS; ANIMALS; CALCIUM; CHO CELLS; CRICETINAE; CRICETULUS; MALE; MICROSOMES, LIVER; PIPERIDINES; PYRIMIDINONES; RATS; RATS, SPRAGUE-DAWLEY; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TRPM CATION CHANNELS;

EID: 84863116635     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm2013634     Document Type: Article

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