Overcoming HERG affinity in the discovery of the CCR5 antagonist maraviroc

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 17, 2006, Pages 4633-4637

  Price, David A ^a   Armour, Duncan ^a   de Groot, Marcel ^a   Leishman, Derek ^a   Napier, Carolyn ^a   Perros, Manos ^a   Stammen, Blanda L ^a   Wood, Anthony ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

Herg; Ion channel; Maraviroc; Triazoles; Tropanes

Indexed keywords

CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CCR5 ANTAGONIST; MARAVIROC; POTASSIUM CHANNEL HERG;

ARTICLE; BINDING AFFINITY; CORRELATION ANALYSIS; DRUG EFFECT; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; EMBRYO; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL;

ANTIVIRAL AGENTS; CELL LINE; ETHER-A-GO-GO POTASSIUM CHANNELS; HIV; HUMANS; MACROPHAGE INFLAMMATORY PROTEIN-1; MODELS, MOLECULAR; MOLECULAR STRUCTURE; RECEPTORS, CCR5; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33746233345     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.06.012     Document Type: Article

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