Serendipity in drug-discovery: A new series of 2-(benzyloxy)benzamides as TRPM8 antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 22, 2013, Pages 6118-6122

  Brown, Alan ^a   Ellis, David ^a   Favor, David A ^b   Kirkup, Tony ^c   Klute, Wolfgang ^d   MacKenny, Malcolm ^e   McMurray, Gordon ^a   Stennett, Adam ^f  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

^b Shanghai ChemPartner Co Ltd   (China)

^c St Anslem's RC Secondary School   (United Kingdom)

^d ASTRAZENECA R AND D   (Sweden)

^e CXR Biosciences Ltd   (United Kingdom)

^f King's School   (United Kingdom)

Author keywords

1,3 Diamino cyclohexane; Lead hopping; Library design; Multi dimensional scaling; TRPM8

Indexed keywords

2 (BENZYLOXY)BENZAMIDE; BENZAMIDE DERIVATIVE; DIAMINE; THIOPHENE; TRANSIENT RECEPTOR POTENTIAL CHANNEL M8; UNCLASSIFIED DRUG;

ARTICLE; ELECTRON; ENANTIOMER; LIPOPHILICITY; PRODUCTIVITY;

1,3-DIAMINO CYCLOHEXANE; LEAD HOPPING; LIBRARY DESIGN; MULTI-DIMENSIONAL SCALING; TRPM8;

ANIMALS; BENZAMIDES; DRUG DESIGN; DRUG DISCOVERY; HUMANS; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; TRPM CATION CHANNELS;

EID: 84885955218     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.09.016     Document Type: Article

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