De-regulation of gene expression and alternative splicing affects distinct cellular pathways in the aging hippocampus

Frontiers in Cellular Neuroscience

Volumn 8, Issue November, 2014, Pages

  Stilling, Roman M ^a,b,c   Benito, Eva ^b   Gertig, Michael ^b   Barth, Jonas ^b   Capece, Vincenzo ^b   Burkhardt, Susanne ^b   Bonn, Stefan ^b   Fischer, Andre ^a,b  

^a UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

^b GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^c UNIVERSITY COLLEGE CORK   (Ireland)

Author keywords

Gene environment interaction; Inflammaging; Innate immune system; Learning and memory; Neuroinflammation; RNA editing; RNA seq; Synaptic plasticity

Indexed keywords

COMPLEMENT COMPONENT C4A; COMPLEMENT COMPONENT C4B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON REGULATORY FACTOR 1; INTERFERON REGULATORY FACTOR 2; KRUPPEL LIKE FACTOR 4; MESSENGER RNA; POSITIVE REGULATORY DOMAIN ZINC FINGER PROTEIN 1; PROTEIN; SEROTONIN 2C RECEPTOR; SPECTRIN; STAT1 PROTEIN; STAT2 PROTEIN; STAT4 PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR ELF 5; TRANSCRIPTION FACTOR ERG; TRANSCRIPTION FACTOR ETS; TRANSCRIPTION FACTOR FRA 1; TRANSCRIPTION FACTOR GATA; TRANSCRIPTION FACTOR JUNB; TRANSCRIPTOME; UNCLASSIFIED DRUG;

AGING; ALTERNATIVE RNA SPLICING; ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING SITE; BIOINFORMATICS; COMPLEMENT ACTIVATION; CONTROLLED STUDY; DOWN REGULATION; EXON; GENE; GENE EXPRESSION REGULATION; GENOTYPE ENVIRONMENT INTERACTION; HIPPOCAMPUS; IMMUNE SYSTEM; IMMUNOHISTOCHEMISTRY; MALAT1 GENE; MICROARRAY ANALYSIS; MOUSE; NEAT1 GENE; NERVE CELL PLASTICITY; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; NOVEL OBJECT RECOGNITION TEST; PISD PS1 GENE; PROMOTER REGION; REAL TIME POLYMERASE CHAIN REACTION; RNA EDITING; RNA EXTRACTION; RNA SEQUENCE; SIGNAL TRANSDUCTION; SLC7A2 GENE; SPLEEN FOCUS FORMING VIRUS PROVIRAL INTEGRATION ONCOGENE; UPREGULATION; YOUNG ADULT;

EID: 84927539588     PISSN: 16625102     EISSN: None     Source Type: Journal    
DOI: 10.3389/fncel.2014.00373     Document Type: Article

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