메뉴 건너뛰기




Volumn 6, Issue 8, 2011, Pages

Voluntary wheel running reverses age-induced changes in hippocampal gene expression

Author keywords

[No Author keywords available]

Indexed keywords

AGE DISTRIBUTION; AGED; AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN REGION; CELL GROWTH; CHROMATIN ASSEMBLY AND DISASSEMBLY; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GENE FUNCTION; HIPPOCAMPUS; IMMUNE RESPONSE; MALE; MOUSE; NONHUMAN; SYNAPTIC POTENTIAL; TISSUE MICROARRAY; TREADMILL EXERCISE; VOLUNTARY MOVEMENT; AGE; ANIMAL; BAGG ALBINO MOUSE; BODY WEIGHT; DNA MICROARRAY; GENE EXPRESSION PROFILING; METABOLISM; METHODOLOGY; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 79961193015     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0022654     Document Type: Article
Times cited : (59)

References (71)
  • 1
    • 77951004217 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor is associated with age-related decline in hippocampal volume
    • Erickson KI, Prakash RS, Voss MW, Chaddock L, Heo S, et al. (2010) Brain-derived neurotrophic factor is associated with age-related decline in hippocampal volume. J Neurosci 30: 5368-75.
    • (2010) J Neurosci , vol.30 , pp. 5368-5375
    • Erickson, K.I.1    Prakash, R.S.2    Voss, M.W.3    Chaddock, L.4    Heo, S.5
  • 2
    • 25444533023 scopus 로고    scopus 로고
    • Exercise enhances learning and hippocampal neurogenesis in aged mice
    • van Praag H, Shubert T, Zhao C, Gage FH, (2005) Exercise enhances learning and hippocampal neurogenesis in aged mice. J Neurosci 25: 8680-5.
    • (2005) J Neurosci , vol.25 , pp. 8680-8685
    • van Praag, H.1    Shubert, T.2    Zhao, C.3    Gage, F.H.4
  • 3
    • 0032524647 scopus 로고    scopus 로고
    • Dietary supplementation with vitamin E reverses the age-related deficit in long term potentiation in dentate gyrus
    • Murray CA, Lynch MA, (1998) Dietary supplementation with vitamin E reverses the age-related deficit in long term potentiation in dentate gyrus. J Biol Chem 273: 12161-8.
    • (1998) J Biol Chem , vol.273 , pp. 12161-12168
    • Murray, C.A.1    Lynch, M.A.2
  • 4
    • 34548801253 scopus 로고    scopus 로고
    • Aging, plasticity and environmental enrichment: structural changes and neurotransmitter dynamics in several areas of the brain
    • Mora F, Segovia G, del Arco A, (2007) Aging, plasticity and environmental enrichment: structural changes and neurotransmitter dynamics in several areas of the brain. Brain Res Rev 55: 78-88.
    • (2007) Brain Res Rev , vol.55 , pp. 78-88
    • Mora, F.1    Segovia, G.2    del Arco, A.3
  • 5
    • 13844257516 scopus 로고    scopus 로고
    • Neurogenesis in a rat model of age-related cognitive decline
    • Bizon JL, Lee HJ, Gallagher M, (2004) Neurogenesis in a rat model of age-related cognitive decline. Aging Cell 3: 227-34.
    • (2004) Aging Cell , vol.3 , pp. 227-234
    • Bizon, J.L.1    Lee, H.J.2    Gallagher, M.3
  • 6
    • 66649114067 scopus 로고    scopus 로고
    • Aerobic fitness is associated with hippocampal volume in elderly humans
    • Erickson KI, Prakash RS, Voss MW, Chaddock L, Hu L, et al. (2009) Aerobic fitness is associated with hippocampal volume in elderly humans. Hippocampus 19: 1030-9.
    • (2009) Hippocampus , vol.19 , pp. 1030-1039
    • Erickson, K.I.1    Prakash, R.S.2    Voss, M.W.3    Chaddock, L.4    Hu, L.5
  • 8
    • 78649332667 scopus 로고    scopus 로고
    • Age-dependent alterations in nerve growth factor (NGF)-related proteins, sortilin, and learning and memory in rats
    • Terry AV Jr, Kutiyanawalla A, Pillai A, (2011) Age-dependent alterations in nerve growth factor (NGF)-related proteins, sortilin, and learning and memory in rats. Physiol Behav 102: 149-57.
    • (2011) Physiol Behav , vol.102 , pp. 149-157
    • Terry Jr., A.V.1    Kutiyanawalla, A.2    Pillai, A.3
  • 9
    • 33745883312 scopus 로고    scopus 로고
    • Impaired trace and contextual fear conditioning in aged rats
    • Moyer JR, Jr, Brown TH, (2006) Impaired trace and contextual fear conditioning in aged rats. Behav Neurosci 120: 612-24.
    • (2006) Behav Neurosci , vol.120 , pp. 612-624
    • Moyer Jr., J.R.1    Brown, T.H.2
  • 10
    • 0025348842 scopus 로고
    • Reversal of age-related cognitive impairments by an M1 cholinergic agonist, AF102B
    • Brandeis R, Dachir S, Sapir M, Levy A, Fisher A, (1990) Reversal of age-related cognitive impairments by an M1 cholinergic agonist, AF102B. Pharmacol Biochem Behav 36: 89-95.
    • (1990) Pharmacol Biochem Behav , vol.36 , pp. 89-95
    • Brandeis, R.1    Dachir, S.2    Sapir, M.3    Levy, A.4    Fisher, A.5
  • 11
    • 65549125564 scopus 로고    scopus 로고
    • Neural stem and progenitor cells retain their potential for proliferation and differentiation into functional neurons despite lower number in aged brain
    • Ahlenius H, Visan V, Kokaia M, Lindvall O, Kokaia Z, (2009) Neural stem and progenitor cells retain their potential for proliferation and differentiation into functional neurons despite lower number in aged brain. J Neurosci 29: 4408-19.
    • (2009) J Neurosci , vol.29 , pp. 4408-4419
    • Ahlenius, H.1    Visan, V.2    Kokaia, M.3    Lindvall, O.4    Kokaia, Z.5
  • 12
    • 33644913116 scopus 로고    scopus 로고
    • Age-related alterations in hippocampal spines and deficiencies in spatial memory in mice
    • von Bohlen und Halbach O, Zacher C, Gass P, Unsicker K, (2006) Age-related alterations in hippocampal spines and deficiencies in spatial memory in mice. J Neurosci Res 83: 525-31.
    • (2006) J Neurosci Res , vol.83 , pp. 525-531
    • von Bohlen und Halbach, O.1    Zacher, C.2    Gass, P.3    Unsicker, K.4
  • 13
    • 0038206578 scopus 로고    scopus 로고
    • Gene microarrays in hippocampal aging: statistical profiling identifies novel processes correlated with cognitive impairment
    • Blalock EM, Chen KC, Sharrow K, Herman JP, Porter NM, et al. (2003) Gene microarrays in hippocampal aging: statistical profiling identifies novel processes correlated with cognitive impairment. J Neurosci 23: 3807-19.
    • (2003) J Neurosci , vol.23 , pp. 3807-3819
    • Blalock, E.M.1    Chen, K.C.2    Sharrow, K.3    Herman, J.P.4    Porter, N.M.5
  • 14
    • 2542637241 scopus 로고    scopus 로고
    • Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice
    • Verbitsky M, Yonan AL, Malleret G, Kandel ER, Gilliam TC, et al. (2004) Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice. Learn Mem 11: 253-60.
    • (2004) Learn Mem , vol.11 , pp. 253-260
    • Verbitsky, M.1    Yonan, A.L.2    Malleret, G.3    Kandel, E.R.4    Gilliam, T.C.5
  • 16
    • 42749087468 scopus 로고    scopus 로고
    • Caloric restriction and age affect synaptic proteins in hippocampal CA3 and spatial learning ability
    • Adams MM, Shi L, Linville MC, Forbes ME, Long AB, et al. (2008) Caloric restriction and age affect synaptic proteins in hippocampal CA3 and spatial learning ability. Exp Neurol 211: 141-9.
    • (2008) Exp Neurol , vol.211 , pp. 141-149
    • Adams, M.M.1    Shi, L.2    Linville, M.C.3    Forbes, M.E.4    Long, A.B.5
  • 17
    • 50249153471 scopus 로고    scopus 로고
    • Intact neurogenesis is required for benefits of exercise on spatial memory but not motor performance or contextual fear conditioning in C57BL/6J mice
    • Clark PJ, Brzezinska WJ, Thomas MW, Ryzhenko NA, Toshkov SA, et al. (2008) Intact neurogenesis is required for benefits of exercise on spatial memory but not motor performance or contextual fear conditioning in C57BL/6J mice. Neuroscience 155: 1048-58.
    • (2008) Neuroscience , vol.155 , pp. 1048-1058
    • Clark, P.J.1    Brzezinska, W.J.2    Thomas, M.W.3    Ryzhenko, N.A.4    Toshkov, S.A.5
  • 20
    • 34047213120 scopus 로고    scopus 로고
    • Physical activity in prevention and treatment of the metabolic syndrome
    • Lakka TA, Laaksonen DE, (2007) Physical activity in prevention and treatment of the metabolic syndrome. Appl Physiol Nutr Metab 32: 76-88.
    • (2007) Appl Physiol Nutr Metab , vol.32 , pp. 76-88
    • Lakka, T.A.1    Laaksonen, D.E.2
  • 21
    • 77955161623 scopus 로고    scopus 로고
    • Physical activities and future risk of Parkinson disease
    • Xu Q, Park Y, Huang X, Hollenbeck A, Blair A, et al. (2010) Physical activities and future risk of Parkinson disease. Neurology 75: 341-8.
    • (2010) Neurology , vol.75 , pp. 341-348
    • Xu, Q.1    Park, Y.2    Huang, X.3    Hollenbeck, A.4    Blair, A.5
  • 22
    • 77956363424 scopus 로고    scopus 로고
    • Exercise and Alzheimer's disease biomarkers in cognitively normal older adults
    • Liang KY, Mintun MA, Fagan AM, Goate AM, Bugg JM, et al. (2010) Exercise and Alzheimer's disease biomarkers in cognitively normal older adults. Ann Neurol 68: 311-8.
    • (2010) Ann Neurol , vol.68 , pp. 311-318
    • Liang, K.Y.1    Mintun, M.A.2    Fagan, A.M.3    Goate, A.M.4    Bugg, J.M.5
  • 24
    • 52049089429 scopus 로고    scopus 로고
    • Exercising our brains: how physical activity impacts synaptic plasticity in the dentate gyrus
    • Christie BR, Eadie BD, Kannangara TS, Robillard JM, Shin J, et al. (2008) Exercising our brains: how physical activity impacts synaptic plasticity in the dentate gyrus. Neuromolecular Med 10: 47-58.
    • (2008) Neuromolecular Med , vol.10 , pp. 47-58
    • Christie, B.R.1    Eadie, B.D.2    Kannangara, T.S.3    Robillard, J.M.4    Shin, J.5
  • 26
    • 34548499151 scopus 로고    scopus 로고
    • Exercise builds brain health: key roles of growth factor cascades and inflammation
    • Cotman CW, Berchtold NC, Christie LA, (2007) Exercise builds brain health: key roles of growth factor cascades and inflammation. Trends Neurosci 30: 464-72.
    • (2007) Trends Neurosci , vol.30 , pp. 464-472
    • Cotman, C.W.1    Berchtold, N.C.2    Christie, L.A.3
  • 27
    • 52049106816 scopus 로고    scopus 로고
    • Central mechanisms of HPA axis regulation by voluntary exercise
    • Stranahan AM, Lee K, Mattson MP, (2008) Central mechanisms of HPA axis regulation by voluntary exercise. Neuromolecular Med 10: 118-27.
    • (2008) Neuromolecular Med , vol.10 , pp. 118-127
    • Stranahan, A.M.1    Lee, K.2    Mattson, M.P.3
  • 28
    • 77956924897 scopus 로고    scopus 로고
    • Hippocampal gene expression patterns underlying the enhancement of memory by running in aged mice
    • Stranahan AM, Lee K, Becker KG, Zhang Y, Maudsley S, et al. (2008) Hippocampal gene expression patterns underlying the enhancement of memory by running in aged mice. Neurobiol Aging 31: 1937-49.
    • (2008) Neurobiol Aging , vol.31 , pp. 1937-1949
    • Stranahan, A.M.1    Lee, K.2    Becker, K.G.3    Zhang, Y.4    Maudsley, S.5
  • 29
    • 0035664114 scopus 로고    scopus 로고
    • Effects of exercise on gene-expression profile in the rat hippocampus
    • Tong L, Shen H, Perreau VM, Balazs R, Cotman CW, (2001) Effects of exercise on gene-expression profile in the rat hippocampus. Neurobiol Dis 8: 1046-56.
    • (2001) Neurobiol Dis , vol.8 , pp. 1046-1056
    • Tong, L.1    Shen, H.2    Perreau, V.M.3    Balazs, R.4    Cotman, C.W.5
  • 30
    • 1442316352 scopus 로고    scopus 로고
    • Differential effects of acute and chronic exercise on plasticity-related genes in the rat hippocampus revealed by microarray
    • Molteni R, Ying Z, Gomez-Pinilla F, (2002) Differential effects of acute and chronic exercise on plasticity-related genes in the rat hippocampus revealed by microarray. Eur J Neurosci 16: 1107-16.
    • (2002) Eur J Neurosci , vol.16 , pp. 1107-1116
    • Molteni, R.1    Ying, Z.2    Gomez-Pinilla, F.3
  • 31
    • 0141919620 scopus 로고    scopus 로고
    • Exercise increases hippocampal neurogenesis to high levels but does not improve spatial learning in mice bred for increased voluntary wheel running
    • Rhodes JS, van Praag H, Jeffrey S, Girard I, Mitchell GS, et al. (2003) Exercise increases hippocampal neurogenesis to high levels but does not improve spatial learning in mice bred for increased voluntary wheel running. Behav Neurosci 117: 1006-16.
    • (2003) Behav Neurosci , vol.117 , pp. 1006-1016
    • Rhodes, J.S.1    van Praag, H.2    Jeffrey, S.3    Girard, I.4    Mitchell, G.S.5
  • 32
    • 0033932604 scopus 로고    scopus 로고
    • Body temperatures of house mice artificially selected for high voluntary wheel-running behavior: repeatability and effect of genetic selection
    • Rhodes JS, Koteja P, Swallow JG, Carter PA, Garland T, (2000) Body temperatures of house mice artificially selected for high voluntary wheel-running behavior: repeatability and effect of genetic selection. J Therm Biol 25: 391-400.
    • (2000) J Therm Biol , vol.25 , pp. 391-400
    • Rhodes, J.S.1    Koteja, P.2    Swallow, J.G.3    Carter, P.A.4    Garland, T.5
  • 33
    • 0033403663 scopus 로고    scopus 로고
    • Behaviour of house mice artificially selected for high levels of voluntary wheel running
    • Koteja P, Garland T Jr, Sax JK, Swallow JG, Carter PA, (1999) Behaviour of house mice artificially selected for high levels of voluntary wheel running. Anim Behav 58: 1307-1318.
    • (1999) Anim Behav , vol.58 , pp. 1307-1318
    • Koteja, P.1    Garland Jr., T.2    Sax, J.K.3    Swallow, J.G.4    Carter, P.A.5
  • 34
    • 0242317675 scopus 로고    scopus 로고
    • Experimental validation of novel and conventional approaches to quantitative real-time PCR data analysis
    • Peirson SN, Butler JN, Foster RG, (2003) Experimental validation of novel and conventional approaches to quantitative real-time PCR data analysis. Nucleic Acids Res 31: e73.
    • (2003) Nucleic Acids Res , vol.31
    • Peirson, S.N.1    Butler, J.N.2    Foster, R.G.3
  • 35
    • 46249088370 scopus 로고    scopus 로고
    • lumi: a pipeline for processing Illumina microarray
    • Du P, Kibbe WA, Lin SM, (2008) lumi: a pipeline for processing Illumina microarray. Bioinformatics 24: 1547-8.
    • (2008) Bioinformatics , vol.24 , pp. 1547-1548
    • Du, P.1    Kibbe, W.A.2    Lin, S.M.3
  • 36
    • 39149111937 scopus 로고    scopus 로고
    • Model-based variance-stabilizing transformation for Illumina microarray data
    • Lin SM, Du P, Huber W, Kibbe WA, (2008) Model-based variance-stabilizing transformation for Illumina microarray data. Nucleic Acids Res 36: e11.
    • (2008) Nucleic Acids Res , vol.36
    • Lin, S.M.1    Du, P.2    Huber, W.3    Kibbe, W.A.4
  • 37
    • 0001677717 scopus 로고
    • Controlling the False Discovery Rate: a practical and powerful approach to multiple testing
    • Yoav B YH, (1995) Controlling the False Discovery Rate: a practical and powerful approach to multiple testing. Journal of the Royal Statistical Society 57: 289-300.
    • (1995) Journal of the Royal Statistical Society , vol.57 , pp. 289-300
    • Yoav, B.Y.H.1
  • 38
    • 61449172037 scopus 로고    scopus 로고
    • Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
    • Huang da W, Sherman BT, Lempicki RA, (2009) Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 4: 44-57.
    • (2009) Nat Protoc , vol.4 , pp. 44-57
    • da Huang, W.1    Sherman, B.T.2    Lempicki, R.A.3
  • 39
  • 40
    • 29544438645 scopus 로고    scopus 로고
    • Doublecortin-like kinase controls neurogenesis by regulating mitotic spindles and M phase progression
    • Shu T, Tseng HC, Sapir T, Stern P, Zhou Y, et al. (2006) Doublecortin-like kinase controls neurogenesis by regulating mitotic spindles and M phase progression. Neuron 49: 25-39.
    • (2006) Neuron , vol.49 , pp. 25-39
    • Shu, T.1    Tseng, H.C.2    Sapir, T.3    Stern, P.4    Zhou, Y.5
  • 42
    • 77957331010 scopus 로고    scopus 로고
    • Chromatin remodeling in development and disease: focus on CHD7
    • Martin DM, (2010) Chromatin remodeling in development and disease: focus on CHD7. PLoS Genet 6: e1001010.
    • (2010) PLoS Genet , vol.6
    • Martin, D.M.1
  • 43
    • 77956096768 scopus 로고    scopus 로고
    • CHD7 functions in the nucleolus as a positive regulator of ribosomal RNA biogenesis
    • Zentner GE, Hurd EA, Schnetz MP, Handoko L, Wang C, et al. (2010) CHD7 functions in the nucleolus as a positive regulator of ribosomal RNA biogenesis. Hum Mol Genet 19: 3491-501.
    • (2010) Hum Mol Genet , vol.19 , pp. 3491-3501
    • Zentner, G.E.1    Hurd, E.A.2    Schnetz, M.P.3    Handoko, L.4    Wang, C.5
  • 44
    • 79959836522 scopus 로고    scopus 로고
    • Chromatin structure as a mediator of aging
    • Feser J, Tyler J, (2011) Chromatin structure as a mediator of aging. FEBS Lett.
    • (2011) FEBS Lett
    • Feser, J.1    Tyler, J.2
  • 45
    • 77956520661 scopus 로고    scopus 로고
    • Elevated histone expression promotes life span extension
    • Feser J, Truong D, Das C, Carson JJ, Kieft J, et al. (2010) Elevated histone expression promotes life span extension. Mol Cell 39: 724-35.
    • (2010) Mol Cell , vol.39 , pp. 724-735
    • Feser, J.1    Truong, D.2    Das, C.3    Carson, J.J.4    Kieft, J.5
  • 46
    • 0027938872 scopus 로고
    • Characterization by cDNA cloning of two new human protein kinases. Evidence by sequence comparison of a new family of mammalian protein kinases
    • Hanes J, von der Kammer H, Klaudiny J, Scheit KH, (1994) Characterization by cDNA cloning of two new human protein kinases. Evidence by sequence comparison of a new family of mammalian protein kinases. J Mol Biol 244: 665-72.
    • (1994) J Mol Biol , vol.244 , pp. 665-672
    • Hanes, J.1    von der Kammer, H.2    Klaudiny, J.3    Scheit, K.H.4
  • 47
    • 0037718047 scopus 로고    scopus 로고
    • Pre-mRNA splicing modulations in senescence
    • Meshorer E, Soreq H, (2002) Pre-mRNA splicing modulations in senescence. Aging Cell 1: 10-6.
    • (2002) Aging Cell , vol.1 , pp. 10-16
    • Meshorer, E.1    Soreq, H.2
  • 48
    • 24144439091 scopus 로고    scopus 로고
    • TAF10 is required for the establishment of skin barrier function in foetal, but not in adult mouse epidermis
    • Indra AK, Mohan WS 2nd, Frontini M, Scheer E, Messaddeq N, et al. (2005) TAF10 is required for the establishment of skin barrier function in foetal, but not in adult mouse epidermis. Dev Biol 285: 28-37.
    • (2005) Dev Biol , vol.285 , pp. 28-37
    • Indra, A.K.1    Mohan II, W.S.2    Frontini, M.3    Scheer, E.4    Messaddeq, N.5
  • 49
    • 0036841289 scopus 로고    scopus 로고
    • Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits
    • Hu P, Wu S, Sun Y, Yuan CC, Kobayashi R, et al. (2002) Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits. Mol Cell Biol 22: 8044-55.
    • (2002) Mol Cell Biol , vol.22 , pp. 8044-8055
    • Hu, P.1    Wu, S.2    Sun, Y.3    Yuan, C.C.4    Kobayashi, R.5
  • 50
    • 54249124166 scopus 로고    scopus 로고
    • Aging, microglial cell priming, and the discordant central inflammatory response to signals from the peripheral immune system
    • Dilger RN, Johnson RW, (2008) Aging, microglial cell priming, and the discordant central inflammatory response to signals from the peripheral immune system. J Leukoc Biol 84: 932-9.
    • (2008) J Leukoc Biol , vol.84 , pp. 932-939
    • Dilger, R.N.1    Johnson, R.W.2
  • 51
    • 23444443814 scopus 로고    scopus 로고
    • Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system
    • Godbout JP, Chen J, Abraham J, Richwine AF, Berg BM, et al. (2005) Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system. Faseb J 19: 1329-31.
    • (2005) Faseb J , vol.19 , pp. 1329-1331
    • Godbout, J.P.1    Chen, J.2    Abraham, J.3    Richwine, A.F.4    Berg, B.M.5
  • 53
    • 0034495294 scopus 로고    scopus 로고
    • Spontaneous classical pathway activation and deficiency of membrane regulators render human neurons susceptible to complement lysis
    • Singhrao SK, Neal JW, Rushmere NK, Morgan BP, Gasque P, (2000) Spontaneous classical pathway activation and deficiency of membrane regulators render human neurons susceptible to complement lysis. Am J Pathol 157: 905-18.
    • (2000) Am J Pathol , vol.157 , pp. 905-918
    • Singhrao, S.K.1    Neal, J.W.2    Rushmere, N.K.3    Morgan, B.P.4    Gasque, P.5
  • 54
    • 33748780095 scopus 로고    scopus 로고
    • Role of complement in neurodegeneration and neuroinflammation
    • Bonifati DM, Kishore U, (2007) Role of complement in neurodegeneration and neuroinflammation. Mol Immunol 44: 999-1010.
    • (2007) Mol Immunol , vol.44 , pp. 999-1010
    • Bonifati, D.M.1    Kishore, U.2
  • 55
    • 42549169556 scopus 로고    scopus 로고
    • Exercise alters the immune profile in Tg2576 Alzheimer mice toward a response coincident with improved cognitive performance and decreased amyloid
    • Nichol KE, Poon WW, Parachikova AI, Cribbs DH, Glabe CG, et al. (2008) Exercise alters the immune profile in Tg2576 Alzheimer mice toward a response coincident with improved cognitive performance and decreased amyloid. J Neuroinflammation 5: 13.
    • (2008) J Neuroinflammation , vol.5 , pp. 13
    • Nichol, K.E.1    Poon, W.W.2    Parachikova, A.I.3    Cribbs, D.H.4    Glabe, C.G.5
  • 56
    • 0030568986 scopus 로고    scopus 로고
    • Complement gene expression in mouse microglia and astrocytes in culture: comparisons with mouse peritoneal macrophages
    • Haga S, Aizawa T, Ishii T, Ikeda K, (1996) Complement gene expression in mouse microglia and astrocytes in culture: comparisons with mouse peritoneal macrophages. Neurosci Lett 216: 191-4.
    • (1996) Neurosci Lett , vol.216 , pp. 191-194
    • Haga, S.1    Aizawa, T.2    Ishii, T.3    Ikeda, K.4
  • 57
    • 34548384916 scopus 로고    scopus 로고
    • The CNS glycoprotein Shadoo has PrP(C)-like protective properties and displays reduced levels in prion infections
    • Watts JC, Drisaldi B, Ng V, Yang J, Strome B, et al. (2007) The CNS glycoprotein Shadoo has PrP(C)-like protective properties and displays reduced levels in prion infections. Embo J 26: 4038-50.
    • (2007) Embo J , vol.26 , pp. 4038-4050
    • Watts, J.C.1    Drisaldi, B.2    Ng, V.3    Yang, J.4    Strome, B.5
  • 58
    • 4344564527 scopus 로고    scopus 로고
    • Region-specific alterations in insulin-like growth factor-I receptor in the central nervous system of nNOS knockout mice
    • Chung YH, Joo KM, Nam RH, Lee WB, Lee KH, et al. (2004) Region-specific alterations in insulin-like growth factor-I receptor in the central nervous system of nNOS knockout mice. Brain Res 1021: 132-9.
    • (2004) Brain Res , vol.1021 , pp. 132-139
    • Chung, Y.H.1    Joo, K.M.2    Nam, R.H.3    Lee, W.B.4    Lee, K.H.5
  • 59
    • 0027438693 scopus 로고
    • Comparison of protein synthesis in brain and peripheral tissue during aging. Relationship to insulin-like growth factor-1 and type 1 IGF receptors
    • D'Costa AP, Lenham JE, Ingram RL, Sonntag WE, (1993) Comparison of protein synthesis in brain and peripheral tissue during aging. Relationship to insulin-like growth factor-1 and type 1 IGF receptors. Ann N Y Acad Sci 692: 253-5.
    • (1993) Ann N Y Acad Sci , vol.692 , pp. 253-255
    • D'Costa, A.P.1    Lenham, J.E.2    Ingram, R.L.3    Sonntag, W.E.4
  • 60
    • 0842287527 scopus 로고    scopus 로고
    • From hormones to immunity: the physiology of immunology
    • Kelley KW, (2004) From hormones to immunity: the physiology of immunology. Brain Behav Immun 18: 95-113.
    • (2004) Brain Behav Immun , vol.18 , pp. 95-113
    • Kelley, K.W.1
  • 62
    • 77952419074 scopus 로고    scopus 로고
    • Regular voluntary exercise cures stress-induced impairment of cognitive function and cell proliferation accompanied by increases in cerebral IGF-1 and GST activity in mice
    • Nakajima S, Ohsawa I, Ohta S, Ohno M, Mikami T, (2002) Regular voluntary exercise cures stress-induced impairment of cognitive function and cell proliferation accompanied by increases in cerebral IGF-1 and GST activity in mice. Behav Brain Res 211: 178-84.
    • (2002) Behav Brain Res , vol.211 , pp. 178-184
    • Nakajima, S.1    Ohsawa, I.2    Ohta, S.3    Ohno, M.4    Mikami, T.5
  • 63
    • 73749087580 scopus 로고    scopus 로고
    • Mitochondrial function as a determinant of life span
    • Lanza IR, Nair KS, (2010) Mitochondrial function as a determinant of life span. Pflugers Arch 459: 277-89.
    • (2010) Pflugers Arch , vol.459 , pp. 277-289
    • Lanza, I.R.1    Nair, K.S.2
  • 64
    • 0032567490 scopus 로고    scopus 로고
    • Mammalian mitochondrial ribosomal proteins. N-terminal amino acid sequencing, characterization, and identification of corresponding gene sequences
    • Goldschmidt-Reisin S, Kitakawa M, Herfurth E, Wittmann-Liebold B, Grohmann L, et al. (1998) Mammalian mitochondrial ribosomal proteins. N-terminal amino acid sequencing, characterization, and identification of corresponding gene sequences. J Biol Chem 273: 34828-36.
    • (1998) J Biol Chem , vol.273 , pp. 34828-34836
    • Goldschmidt-Reisin, S.1    Kitakawa, M.2    Herfurth, E.3    Wittmann-Liebold, B.4    Grohmann, L.5
  • 65
    • 0035416644 scopus 로고    scopus 로고
    • The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders
    • Kenmochi N, Suzuki T, Uechi T, Magoori M, Kuniba M, et al. (2001) The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. Genomics 77: 65-70.
    • (2001) Genomics , vol.77 , pp. 65-70
    • Kenmochi, N.1    Suzuki, T.2    Uechi, T.3    Magoori, M.4    Kuniba, M.5
  • 66
    • 70349452132 scopus 로고    scopus 로고
    • Exercise enhances hippocampal-dependent learning in the rat: evidence for a BDNF-related mechanism
    • Griffin EW, Bechara RG, Birch AM, Kelly AM, (2009) Exercise enhances hippocampal-dependent learning in the rat: evidence for a BDNF-related mechanism. Hippocampus 19: 973-80.
    • (2009) Hippocampus , vol.19 , pp. 973-980
    • Griffin, E.W.1    Bechara, R.G.2    Birch, A.M.3    Kelly, A.M.4
  • 67
    • 74849094086 scopus 로고    scopus 로고
    • Regulation of hippocampal progenitor cell survival, proliferation and dendritic development by BDNF
    • Choi SH, Li Y, Parada LF, Sisodia SS, (2009) Regulation of hippocampal progenitor cell survival, proliferation and dendritic development by BDNF. Mol Neurodegener 4: 52.
    • (2009) Mol Neurodegener , vol.4 , pp. 52
    • Choi, S.H.1    Li, Y.2    Parada, L.F.3    Sisodia, S.S.4
  • 68
    • 66449130744 scopus 로고    scopus 로고
    • RVB1/RVB2: running rings around molecular biology
    • Jha S, Dutta A, (2009) RVB1/RVB2: running rings around molecular biology. Mol Cell 34: 521-33.
    • (2009) Mol Cell , vol.34 , pp. 521-533
    • Jha, S.1    Dutta, A.2
  • 69
    • 78649815064 scopus 로고    scopus 로고
    • Deletion of the nuclear isoform of poly(ADP-ribose) glycohydrolase (PARG) reveals its function in DNA repair, genomic stability and tumorigenesis
    • Min W, Cortes U, Herceg Z, Tong WM, Wang ZQ, (2010) Deletion of the nuclear isoform of poly(ADP-ribose) glycohydrolase (PARG) reveals its function in DNA repair, genomic stability and tumorigenesis. Carcinogenesis 31: 2058-65.
    • (2010) Carcinogenesis , vol.31 , pp. 2058-2065
    • Min, W.1    Cortes, U.2    Herceg, Z.3    Tong, W.M.4    Wang, Z.Q.5
  • 70
    • 68149108384 scopus 로고    scopus 로고
    • PUMA, a potent killer with or without p53
    • Yu J, Zhang L, (2008) PUMA, a potent killer with or without p53. Oncogene 27 (Suppl 1): S71-83.
    • (2008) Oncogene , vol.27 , Issue.SUPPL. 1
    • Yu, J.1    Zhang, L.2
  • 71
    • 0000847978 scopus 로고    scopus 로고
    • Gene-expression profile of the ageing brain in mice
    • Lee CK, Weindruch R, Prolla TA, (2000) Gene-expression profile of the ageing brain in mice. Nat Genet 25: 294-7.
    • (2000) Nat Genet , vol.25 , pp. 294-297
    • Lee, C.K.1    Weindruch, R.2    Prolla, T.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.