Parallel declines in cognition, motivation, and locomotion in aging mice: Association with immune gene upregulation in the medial prefrontal cortex

Experimental Gerontology

Volumn 46, Issue 8, 2011, Pages 643-659

  Bordner, Kelly A ^a   Kitchen, Robert R ^a,c   Carlyle, Becky ^a   George, Elizabeth D ^a   Mahajan, Milind C ^b   Mane, Shrikant M ^b   Taylor, Jane R ^a   Simen, Arthur A ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b YALE UNIVERSITY   (United States)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Aging; Cognition; Gene expression; Locomotion; Microarray analysis; Microglia; Motivation; Prefrontal cortex; RNA sequencing

Indexed keywords

ALPHA3 INTEGRIN; CD11B ANTIGEN; CD59 ANTIGEN; CD63 ANTIGEN; CD74 ANTIGEN; CD81 ANTIGEN; CD9 ANTIGEN; COMPLEMENT COMPONENT C1Q; COMPLEMENT COMPONENT C1QA; COMPLEMENT COMPONENT C1QB; COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C4B; CXCL1 CHEMOKINE; CXCL13 CHEMOKINE; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERFERON REGULATORY FACTOR 3; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 6; NERVE CELL ADHESION MOLECULE; NERVE CELL ADHESION MOLECULE 1; PROTEIN TYROSINE PHOSPHATASE SHP 2; RNA; STAT2 PROTEIN; STAT3 PROTEIN; TOLL LIKE RECEPTOR 2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADULT ANIMAL; AGE DISTRIBUTION; AGED; AGING; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; BRAIN TISSUE; CENTRAL NERVOUS SYSTEM; CHOICE SERIAL REACTION TIME TASK; COGNITIVE DEFECT; CONTROLLED STUDY; EXPERIMENTAL TEST; EXPLORATORY BEHAVIOR; GENE EXPRESSION REGULATION; GENETIC ASSOCIATION; IMMUNE RESPONSE GENE; MALE; MEDIAL PREFRONTAL CORTEX; MICROARRAY ANALYSIS; MICROGLIA; MOTIVATION; MOTOR DYSFUNCTION; MOUSE; NONHUMAN; OPEN FIELD TEST; PREFRONTAL CORTEX; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; RNA SEQUENCE; UPREGULATION; VISUAL PLACING TEST;

AGING; ANIMALS; COGNITION; GENE EXPRESSION REGULATION; LOCOMOTION; MALE; MICE; MICE, INBRED C57BL; MOTIVATION; PREFRONTAL CORTEX; PSYCHOMOTOR PERFORMANCE; UP-REGULATION;

MUS;

EID: 79960042515     PISSN: 05315565     EISSN: 18736815     Source Type: Journal    
DOI: 10.1016/j.exger.2011.03.003     Document Type: Article

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