α-Synuclein modulates neurite outgrowth by interacting with SPTBN1

Biochemical and Biophysical Research Communications

Volumn 424, Issue 3, 2012, Pages 497-502

  Lee, Hak Joo ^a   Lee, Kyunghee ^a   Im, Hana ^a  

^a Sejong University   (South Korea)

Author keywords

Synuclein; Neurite outgrowth; Protein interaction; SPTBN1

Indexed keywords

ALPHA SYNUCLEIN; COMPLEMENTARY DNA; PHAGE DISPLAY ASSAY; SPECTRIN; SPECTRIN BETA NON ERYTHROCYTE 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; ASSAY; CONTROLLED STUDY; DOPAMINERGIC ACTIVITY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNOPRECIPITATION; IN VITRO STUDY; MODULATION; MOUSE; NERVE CELL; NERVE FIBER GROWTH; NEURITE; NONHUMAN; PERIKARYON; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION;

ALPHA-SYNUCLEIN; BRAIN; CELL LINE; DOPAMINERGIC NEURONS; HUMANS; IMMUNOPRECIPITATION; NEURITES; PARKINSON DISEASE; SPECTRIN; TRANSFECTION;

EID: 84864746318     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.06.143     Document Type: Article

References (30)

1. Dawson T.M., Dawson V.L. Molecular pathways of neurodegeneration in Parkinson's disease. Science 2003, 302:819-822.
2. Polymeropoulos M.H., Lavedan C., Leroy E., Ide S.E., Dehejia A., Dutra A., Pike B., Root H., Rubenstein J., Boyer R., Stenroos E.S., Chandrasekharappa S., Athanassiadou A., Papapetropoulos T., Johnson W.G., Lazzarini A.M., Duvoisin R.C., Di Iorio G., Golbe L.I., Nussbaum R.L. Mutation in the α-synuclein gene identified in families with Parkinson's disease. Science 1997, 276:2045-2047.
3. Kruger R., Kuhn W., Muller T., Woitalla D., Graeber M., Kosel S., Przuntek H., Epplen J.T., Schols L., Riess O. Ala30Pro mutation in the gene encoding α-synuclein in Parkinson's disease. Nature Genetics 1998, 18:106-108.
4. Singleton A.B., Farrer M., Johnson J., Singleton A., Haque S., Lachergus J., Hulihan M., Perualinna T., Dutra A., Nussbaum R., Lincoln S., Crawley A., Hanson M., Miller D., Blancato J., Hardy J., Grinn-Hardy K. α-Synuclein locus triplication causes Parkinson's disease. Science 2003, 302:841.
5. Charitier-Harlin M.C., Kachergus J., Roumier C., Mouroux V., Douay X., Lincoln S., Levecque C., Larvor L., Andrieux J., Hulihan M., Waucquier N., Defebvre L., Amouyel P., Farrer M., Destee A. Alpha-synuclein locus duplication as a cause of familial Parkinson's disease. Lancet 2004, 364:1167-1169.
6. Cookson M.R., van der Brug M. Cell systems and the toxic mechanism(s) of alpha-synuclein. Experimental Neurology 2008, 209:5-11.
7. Abeliovich A., Schmitz Y., Farinas I., Choi-Lundberg D., Ho W.-H., Castillo P.E., Shinsky N., Verdugo J.M., Armanini M., Ryan A., Hynes M., Phillips H., Sulzer D., Rosenthal A. Mice lacking α-synuclein display functional deficits in the nigrostriatal dopamine system. Neuron 2000, 25:239-252.
8. Gitler A.D., Bevis B.J., Shorter J., Strathearn K.E., Hamamichi S., Su L.J., Caldwell K.A., Caldwell G.A., Rochet J.C., McCaffery J.M., Barlowe C., Lindquist S. The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis. Proceedings of the National Academy of Science of the United States of America 2008, 105:145-150.
9. Thayanidhi N., Helm J.R., Nycz D.C., Bentley M., Liang Y., Hay J.C. Alpha-synuclein delays endoplasmic reticulum (ER)-to-Golgi transport in mammalian cells by antagonizing ER/Golgi SNAREs. Molecular and Cellular Biology 2010, 21:1850-1863.
10. Cooper A.A., Gitler A.D., Cashikar A., Haynes C.M., Hill K.J., Bhullar B., Liu K., Xu K., Strathearn K.E., Liu F., Cao S., Caldwell K.A., Caldwell G.A., Marsischky G., Kolodner R.D., Labaer J., Rochet J.C., Bonini N.M., Lindquist S. α-Synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models. Science 2006, 313:324-328.
11. Saha A.R., Hill J., Utton M.A., Asuni A.A., Ackerley S., Grierson A.J., Miller C.C., Davies A.M., Buchman V.L., Anderton B.H., Hanger D.P. Parkinson's disease alpha-synuclein mutations exhibit defective axonal transport in cultured neurons. Journal of Cell Science 2004, 117:1017-1024.
12. Chung C.Y., Koprich J.B., Siddiqi H., Isacson O. Dynamic changes in presynaptic and axonal transport proteins combined with striatal neuroinflammation precede dopaminergic neuronal loss in a rat model of AAV alpha-synucleinopathy. Journal of Neuroscience 2009, 29:3365-3373.
13. Fulga T.A., Elson-Schwab I., Khurana V., Steinhilb M.L., Spires T.L., Hyman B.T., Feany M.B. Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo. Nature Cell Biology 2007, 9:139-148.
14. Gourlay C.W., Carpp L.N., Timpson P., Winder S.J., Ayscough K.R. A role for the actin cytoskeleton in cell death and aging in yeast. Journal of Cell Biology 2004, 164:803-809.
15. Bonaldo M.F., Lennon G., Soares M.B. Normalization and subtraction: two approaches to facilitate gene discovery. Genome Research 1996, 6:791-806.
16. Lee H.J., Kang S.J., Lee K., Im H. Human α-synuclein modulates vesicle trafficking through its interaction with prenylated Rab acceptor protein 1. Biochemical Biophysical Research Communications 2011, 412:526-531.
17. Gold S.J., Ni Y.G., Dohlman H.G., Nestler E.J. Regulators of G-protein signaling (RGS) proteins: region-specific expression of nine subtypes in rat brain. Journal of Neuroscience 1997, 17:8024-8037.
18. Seroogy K.B., Gall C.M., Kornblum H.I. Proliferative zones of postnatal rat brain express epidermal growth factor receptor mRNA. Brain Research 1995, 670:157-164.
19. Beck K.A., Buchanan J.A., Malhotra V., Nelson W.J. Golgi spectrin: identification of an erythroid beta-spectrin homolog associated with the Golgi complex. Journal of Cell Biology 1994, 127:707-723.
20. Goodman S.R., Zimmer W.E., Clark M.B., Zagon I.S., Barker J.E., Bloom M.L. Brain spectrin: of mice and men. Brain Research Bulletin 1995, 36:593-606.
21. Yan Y., Winograd E., Viel A., Cronin T., Harrison S.C., Branton D. Crystal structure of the repetitive segments of spectrin. Science 1993, 262:2027-2030.
22. An X., Guo X., Gratzer W., Mohandas N. Phospholipid binding by proteins of the spectrin family: a comparative study. Biochemical Biophysical Research Communications 2005, 327:794-800.
23. Leverenz J.B., Umar I., Wang Q., Montine T.J., McMillan P.J., Tsuang D.W., Jin J., Pan C., Shin J., Zhu D., Zhang J. Proteomic identification of novel proteins in cortical Lewy bodies. Brain Pathology 2007, 17:139-145.
24. McFarland M.A., Ellis C.E., Markey S.P., Nussbaum R.L. Proteomics analysis identifies phosphorylation-dependent alpha-synuclein protein interactions. Molecular and Cellular Proteomics 2008, 7:2123-2137.
25. Huber A.B., Kolodkin A.L., Ginty D.D., Cloutier J.F. Signaling at the growth cone: ligand-receptor complexes and the control of axon growth and guidance. Annual Review of Neuroscience 2003, 26:509-563.
26. Takenouchi T., Hashimoto M., Hsu L.J., Mackowski B., Rockenstein E., Mallory M., Masliah E. Reduced neuritic outgrowth and cell adhesion in neuronal cells transfected with human alpha-synuclein. Molecular and Cellular Neuroscience 2001, 17:141-150.
27. Pielage J., Fetter R.D., Davis G.W. Presynaptic spectrin is essential for synapse stabilization. Current Biology 2005, 15:918-928.
28. Sikorski A.F., Terlecki G., Zagon I.S., Goodman S.R. Synapsin I-mediated interaction of brain spectrin with synaptic vesicles. Journal of Cell Biology 1991, 114:313-318.
29. Sikorski A.F., Sangerman J., Goodman S.R., Critz S.D. Spectrin (betaSpIIsigma1) is an essential component of synaptic transmission. Brain Research 2000, 852:161-166.
30. Goodman S.T. Discovery of nonerythroid spectrin to the demonstration of its key role in synaptic transmission. Brain Research Bulletin 1999, 50:345-346.