-
1
-
-
35648980477
-
Ras nanoclusters: molecular structure and assembly
-
Abankwa, D., Gorfe, A. A. & Hancock, J. F. (2007). Ras nanoclusters: molecular structure and assembly. Seminars in Cell & Developmental Biology 18, 599-607.
-
(2007)
Seminars in Cell & Developmental Biology
, vol.18
, pp. 599-607
-
-
Abankwa, D.1
Gorfe, A.A.2
Hancock, J.F.3
-
2
-
-
75749150934
-
Ras membrane orientation and nanodomain localization generate isoform diversity
-
Abankwa, D., Gorfe, A. A., Inder, K. & Hancock, J. F. (2010). Ras membrane orientation and nanodomain localization generate isoform diversity. Proceedings of the National Academy of Sciences of the United States of America 107, 1130-1135.
-
(2010)
Proceedings of the National Academy of Sciences of the United States of America
, vol.107
, pp. 1130-1135
-
-
Abankwa, D.1
Gorfe, A.A.2
Inder, K.3
Hancock, J.F.4
-
3
-
-
40949130399
-
A novel switch region regulates H-ras membrane orientation and signal output
-
Abankwa, D., Hanzal-Bayer, M., Ariotti, N., Plowman, S. J., Gorfe, A. A., Parton, R. G., McCammon, J. A. & Hancock, J. F. (2008). A novel switch region regulates H-ras membrane orientation and signal output. The EMBO Journal 27, 727-735.
-
(2008)
The EMBO Journal
, vol.27
, pp. 727-735
-
-
Abankwa, D.1
Hanzal-Bayer, M.2
Ariotti, N.3
Plowman, S.J.4
Gorfe, A.A.5
Parton, R.G.6
McCammon, J.A.7
Hancock, J.F.8
-
4
-
-
33846419488
-
Lipid raft microdomains and neurotransmitter signalling
-
Allen, J. A., Halverson-Tamboli, R. A. & Rasenick, M. M. (2007). Lipid raft microdomains and neurotransmitter signalling. Nature Reviews Neuroscience 8, 128-140.
-
(2007)
Nature Reviews Neuroscience
, vol.8
, pp. 128-140
-
-
Allen, J.A.1
Halverson-Tamboli, R.A.2
Rasenick, M.M.3
-
5
-
-
78349254619
-
The LAT story: a tale of cooperativity, coordination, and choreography
-
Balagopalan, L., Coussens, N. P., Sherman, E., Samelson, L. E. & Sommers, C. L. (2010). The LAT story: a tale of cooperativity, coordination, and choreography. Cold Spring Harbor Perspectives in Biology 2, a005512.
-
(2010)
Cold Spring Harbor Perspectives in Biology
, vol.2
, pp. a005512
-
-
Balagopalan, L.1
Coussens, N.P.2
Sherman, E.3
Samelson, L.E.4
Sommers, C.L.5
-
6
-
-
44949124597
-
Galectin-1 is a novel structural component and a major regulator of h-ras nanoclusters
-
Belanis, L., Plowman, S. J., Rotblat, B., Hancock, J. F. & Kloog, Y. (2008). Galectin-1 is a novel structural component and a major regulator of h-ras nanoclusters. Molecular Biology of the Cell 19, 1404-1414.
-
(2008)
Molecular Biology of the Cell
, vol.19
, pp. 1404-1414
-
-
Belanis, L.1
Plowman, S.J.2
Rotblat, B.3
Hancock, J.F.4
Kloog, Y.5
-
7
-
-
77955825161
-
Spatial organization of transmembrane receptor signalling
-
Bethani, I., Skanland, S. S., Dikic, I. & Acker-Palmer, A. (2010). Spatial organization of transmembrane receptor signalling. The EMBO Journal 29, 2677-2688.
-
(2010)
The EMBO Journal
, vol.29
, pp. 2677-2688
-
-
Bethani, I.1
Skanland, S.S.2
Dikic, I.3
Acker-Palmer, A.4
-
8
-
-
84874040939
-
TCR nanoclusters as the framework for transmission of conformational changes and cooperativity
-
Blanco, R. & Alarcon, B. (2012). TCR nanoclusters as the framework for transmission of conformational changes and cooperativity. Frontiers in Immunology 3, 115(7).
-
(2012)
Frontiers in Immunology
, vol.3
, Issue.7
, pp. 115
-
-
Blanco, R.1
Alarcon, B.2
-
9
-
-
70349774556
-
Structural plasticity of eph receptor A4 facilitates cross-class ephrin signaling
-
Bowden, T. A., Aricescu, A. R., Nettleship, J. E., Siebold, C., Rahman-Huq, N., Owens, R. J., Stuart, D. I. & Jones, E. Y. (2009). Structural plasticity of eph receptor A4 facilitates cross-class ephrin signaling. Structure 17, 1386-1397.
-
(2009)
Structure
, vol.17
, pp. 1386-1397
-
-
Bowden, T.A.1
Aricescu, A.R.2
Nettleship, J.E.3
Siebold, C.4
Rahman-Huq, N.5
Owens, R.J.6
Stuart, D.I.7
Jones, E.Y.8
-
10
-
-
0031804503
-
Signaling complexes: biophysical constraints on intracellular communication
-
Bray, D. (1998). Signaling complexes: biophysical constraints on intracellular communication. Annual Review of Biophysics and Biomolecular Structure 27, 59-75.
-
(1998)
Annual Review of Biophysics and Biomolecular Structure
, vol.27
, pp. 59-75
-
-
Bray, D.1
-
11
-
-
0032492852
-
Receptor clustering as a cellular mechanism to control sensitivity
-
Bray, D., Levin, M. D. & Morton-Firth, C. J. (1998). Receptor clustering as a cellular mechanism to control sensitivity. Nature 393, 85-88.
-
(1998)
Nature
, vol.393
, pp. 85-88
-
-
Bray, D.1
Levin, M.D.2
Morton-Firth, C.J.3
-
12
-
-
76649135799
-
Signalling complexes and clusters: functional advantages and methodological hurdles
-
Cebecauer, M., Spitaler, M., Serge, A. & Magee, A. I. (2010). Signalling complexes and clusters: functional advantages and methodological hurdles. Journal of Cell Science 123, 309-320.
-
(2010)
Journal of Cell Science
, vol.123
, pp. 309-320
-
-
Cebecauer, M.1
Spitaler, M.2
Serge, A.3
Magee, A.I.4
-
13
-
-
84883743072
-
Defining the structural relationship between kainate-receptor deactivation and desensitization
-
Dawe, G. B., Musgaard, M., Andrews, E. D., Daniels, B. A., Aurousseau, M. R., Biggin, P. C. & Bowie, D. (2013). Defining the structural relationship between kainate-receptor deactivation and desensitization. Nature Structural & Molecular Biology 20, 1054-1061.
-
(2013)
Nature Structural & Molecular Biology
, vol.20
, pp. 1054-1061
-
-
Dawe, G.B.1
Musgaard, M.2
Andrews, E.D.3
Daniels, B.A.4
Aurousseau, M.R.5
Biggin, P.C.6
Bowie, D.7
-
14
-
-
79251589403
-
Galectin multimerization and lattice formation are regulated by linker region structure
-
Earl, L. A., Bi, S. & Baum, L. G. (2011). Galectin multimerization and lattice formation are regulated by linker region structure. Glycobiology 21, 6-12.
-
(2011)
Glycobiology
, vol.21
, pp. 6-12
-
-
Earl, L.A.1
Bi, S.2
Baum, L.G.3
-
15
-
-
0034097043
-
Regulation of B lymphocyte responses to foreign and self-antigens by the CD19/CD21 complex
-
Fearon, D. T. & Carroll, M. C. (2000). Regulation of B lymphocyte responses to foreign and self-antigens by the CD19/CD21 complex. Annual Review of Immunology 18, 393-422.
-
(2000)
Annual Review of Immunology
, vol.18
, pp. 393-422
-
-
Fearon, D.T.1
Carroll, M.C.2
-
16
-
-
84861732291
-
Structural insights into the assembly of large oligomeric signalosomes in the Toll-like receptor-interleukin-1 receptor superfamily
-
Ferrao, R., Li, J., Bergamin, E. & Wu, H. (2012). Structural insights into the assembly of large oligomeric signalosomes in the Toll-like receptor-interleukin-1 receptor superfamily. Science Signaling 5, re3.
-
(2012)
Science Signaling
, vol.5
, pp. re3
-
-
Ferrao, R.1
Li, J.2
Bergamin, E.3
Wu, H.4
-
17
-
-
84873088843
-
Lck, membrane microdomains, and TCR triggering machinery: defining the new rules of engagement
-
Filipp, D., Ballek, O. & Manning, J. (2012). Lck, membrane microdomains, and TCR triggering machinery: defining the new rules of engagement. Frontiers in Immunology 3, 155(14).
-
(2012)
Frontiers in Immunology
, vol.3
, Issue.14
, pp. 155
-
-
Filipp, D.1
Ballek, O.2
Manning, J.3
-
18
-
-
0026320866
-
The energy landscapes and motions of proteins
-
Frauenfelder, H., Sligar, S. G. & Wolynes, P. G. (1991). The energy landscapes and motions of proteins. Science 254, 1598-1603.
-
(1991)
Science
, vol.254
, pp. 1598-1603
-
-
Frauenfelder, H.1
Sligar, S.G.2
Wolynes, P.G.3
-
19
-
-
0029935339
-
Raf-1 kinase possesses distinct binding domains for phosphatidylserine and phosphatidic acid. Phosphatidic acid regulates the translocation of Raf-1 in 12-O-tetradecanoylphorbol-13-acetate-stimulated Madin-Darby canine kidney cells
-
Ghosh, S., Strum, J. C., Sciorra, V. A., Daniel, L. & Bell, R. M. (1996). Raf-1 kinase possesses distinct binding domains for phosphatidylserine and phosphatidic acid. Phosphatidic acid regulates the translocation of Raf-1 in 12-O-tetradecanoylphorbol-13-acetate-stimulated Madin-Darby canine kidney cells. The Journal of Biological Chemistry 271, 8472-8480.
-
(1996)
The Journal of Biological Chemistry
, vol.271
, pp. 8472-8480
-
-
Ghosh, S.1
Strum, J.C.2
Sciorra, V.A.3
Daniel, L.4
Bell, R.M.5
-
20
-
-
0028083893
-
The cysteine-rich region of raf-1 kinase contains zinc, translocates to liposomes, and is adjacent to a segment that binds GTP-ras
-
Ghosh, S., Xie, W. Q., Quest, A. F., Mabrouk, G. M., Strum, J. C. & Bell, R. M. (1994). The cysteine-rich region of raf-1 kinase contains zinc, translocates to liposomes, and is adjacent to a segment that binds GTP-ras. The Journal of Biological Chemistry 269, 10000-10007.
-
(1994)
The Journal of Biological Chemistry
, vol.269
, pp. 10000-10007
-
-
Ghosh, S.1
Xie, W.Q.2
Quest, A.F.3
Mabrouk, G.M.4
Strum, J.C.5
Bell, R.M.6
-
21
-
-
33847413103
-
Structure and dynamics of the full-length lipid-modified H-Ras protein in a 1,2-dimyristoylglycero-3-phosphocholine bilayer
-
Gorfe, A. A., Hanzal-Bayer, M., Abankwa, D., Hancock, J. F. & McCammon, J. A. (2007). Structure and dynamics of the full-length lipid-modified H-Ras protein in a 1, 2-dimyristoylglycero-3-phosphocholine bilayer. Journal of Medicinal Chemistry 50, 674-684.
-
(2007)
Journal of Medicinal Chemistry
, vol.50
, pp. 674-684
-
-
Gorfe, A.A.1
Hanzal-Bayer, M.2
Abankwa, D.3
Hancock, J.F.4
McCammon, J.A.5
-
22
-
-
84867030014
-
N-Ras forms dimers at POPC membranes
-
Guldenhaupt, J., Rudack, T., Bachler, P., Mann, D., Triola, G., Waldmann, H., Kotting, C. & Gerwert, K. (2012). N-Ras forms dimers at POPC membranes. Biophysical Journal 103, 1585-1593.
-
(2012)
Biophysical Journal
, vol.103
, pp. 1585-1593
-
-
Guldenhaupt, J.1
Rudack, T.2
Bachler, P.3
Mann, D.4
Triola, G.5
Waldmann, H.6
Kotting, C.7
Gerwert, K.8
-
23
-
-
0037542854
-
Ras proteins: different signals from different locations
-
Hancock, J. F. (2003). Ras proteins: different signals from different locations. Nature Reviews Molecular Cell Biology 4, 373-384.
-
(2003)
Nature Reviews Molecular Cell Biology
, vol.4
, pp. 373-384
-
-
Hancock, J.F.1
-
24
-
-
48449092211
-
Using plasma membrane nanoclusters to build better signaling circuits
-
Harding, A. S. & Hancock, J. F. (2008). Using plasma membrane nanoclusters to build better signaling circuits. Trends in Cell Biology 18, 364-371.
-
(2008)
Trends in Cell Biology
, vol.18
, pp. 364-371
-
-
Harding, A.S.1
Hancock, J.F.2
-
25
-
-
61449215145
-
Ras acylation, compartmentalization and signaling nanoclusters (Review)
-
Henis, Y. I., Hancock, J. F. & Prior, I. A. (2009). Ras acylation, compartmentalization and signaling nanoclusters (Review). Molecular Membrane Biology 26, 80-92.
-
(2009)
Molecular Membrane Biology
, vol.26
, pp. 80-92
-
-
Henis, Y.I.1
Hancock, J.F.2
Prior, I.A.3
-
26
-
-
0037996880
-
Lipid rafts in the maintenance of synapses, dendritic spines, and surface AMPA receptor stability
-
Hering, H., Lin, C. C. & Sheng, M. (2003). Lipid rafts in the maintenance of synapses, dendritic spines, and surface AMPA receptor stability. The Journal of Neuroscience 23, 3262-3271.
-
(2003)
The Journal of Neuroscience
, vol.23
, pp. 3262-3271
-
-
Hering, H.1
Lin, C.C.2
Sheng, M.3
-
27
-
-
0035924322
-
Crystal structure of an Eph receptor-ephrin complex
-
Himanen, J. P., Rajashankar, K. R., Lackmann, M., Cowan, C. A., Henkemeyer, M. & Nikolov, D. B. (2001). Crystal structure of an Eph receptor-ephrin complex. Nature 414, 933-938.
-
(2001)
Nature
, vol.414
, pp. 933-938
-
-
Himanen, J.P.1
Rajashankar, K.R.2
Lackmann, M.3
Cowan, C.A.4
Henkemeyer, M.5
Nikolov, D.B.6
-
28
-
-
35548948069
-
Cell-cell signaling via Eph receptors and ephrins
-
Himanen, J. P., Saha, N. & Nikolov, D. B. (2007). Cell-cell signaling via Eph receptors and ephrins. Current Opinion in Cell Biology 19, 534-542.
-
(2007)
Current Opinion in Cell Biology
, vol.19
, pp. 534-542
-
-
Himanen, J.P.1
Saha, N.2
Nikolov, D.B.3
-
29
-
-
77954627688
-
Architecture of Eph receptor clusters
-
Himanen, J. P., Yermekbayeva, L., Janes, P. W., Walker, J. R., Xu, K., Atapattu, L., Rajashankar, K. R., Mensinga, A., Lackmann, M., Nikolov, D. B. & Dhe-Paganon, S. (2010). Architecture of Eph receptor clusters. Proceedings of the National Academy of Sciences of the United States of America 107, 10860-10865.
-
(2010)
Proceedings of the National Academy of Sciences of the United States of America
, vol.107
, pp. 10860-10865
-
-
Himanen, J.P.1
Yermekbayeva, L.2
Janes, P.W.3
Walker, J.R.4
Xu, K.5
Atapattu, L.6
Rajashankar, K.R.7
Mensinga, A.8
Lackmann, M.9
Nikolov, D.B.10
Dhe-Paganon, S.11
-
30
-
-
0034635502
-
Formation of the Ras dimer is essential for Raf-1 activation
-
Inouye, K., Mizutani, S., Koide, H. & Kaziro, Y. (2000). Formation of the Ras dimer is essential for Raf-1 activation. The Journal of Biological Chemistry 275, 3737-3740.
-
(2000)
The Journal of Biological Chemistry
, vol.275
, pp. 3737-3740
-
-
Inouye, K.1
Mizutani, S.2
Koide, H.3
Kaziro, Y.4
-
31
-
-
84867572593
-
The role of G-domain orientation and nucleotide state on the Ras isoform-specific membrane interaction
-
Kapoor, S., Weise, K., Erlkamp, M., Triola, G., Waldmann, H. & Winter, R. (2012). The role of G-domain orientation and nucleotide state on the Ras isoform-specific membrane interaction. European Biophysics Journal 41, 801-813.
-
(2012)
European Biophysics Journal
, vol.41
, pp. 801-813
-
-
Kapoor, S.1
Weise, K.2
Erlkamp, M.3
Triola, G.4
Waldmann, H.5
Winter, R.6
-
32
-
-
78149473070
-
Allostery and population shift in drug discovery
-
Kar, G., Keskin, O., Gursoy, A. & Nussinov, R. (2010). Allostery and population shift in drug discovery. Current Opinion in Pharmacology 10, 715-722.
-
(2010)
Current Opinion in Pharmacology
, vol.10
, pp. 715-722
-
-
Kar, G.1
Keskin, O.2
Gursoy, A.3
Nussinov, R.4
-
34
-
-
84872221774
-
Structure-function of the G protein-coupled receptor superfamily
-
Katritch, V., Cherezov, V. & Stevens, R. C. (2013). Structure-function of the G protein-coupled receptor superfamily. Annual Review of Pharmacology and Toxicology 53, 531-556.
-
(2013)
Annual Review of Pharmacology and Toxicology
, vol.53
, pp. 531-556
-
-
Katritch, V.1
Cherezov, V.2
Stevens, R.C.3
-
35
-
-
77952903562
-
Signalling ballet in space and time
-
Kholodenko, B. N., Hancock, J. F. & Kolch, W. (2010). Signalling ballet in space and time. Nature Reviews Molecular Cell Biology 11, 414-426.
-
(2010)
Nature Reviews Molecular Cell Biology
, vol.11
, pp. 414-426
-
-
Kholodenko, B.N.1
Hancock, J.F.2
Kolch, W.3
-
36
-
-
84874274026
-
How membrane structures control T cell signaling
-
Klammt, C. & Lillemeier, B. F. (2012). How membrane structures control T cell signaling. Frontiers in Immunology 3, 291(9).
-
(2012)
Frontiers in Immunology
, vol.3
, Issue.9
, pp. 291
-
-
Klammt, C.1
Lillemeier, B.F.2
-
37
-
-
84867882834
-
Eph/ephrin signalling during development
-
Klein, R. (2012). Eph/ephrin signalling during development. Development 139, 4105-4109.
-
(2012)
Development
, vol.139
, pp. 4105-4109
-
-
Klein, R.1
-
38
-
-
84861731097
-
Vav1 oncogenic mutation inhibits T cell receptor-induced calcium mobilization through inhibition of phospholipase Cgamma1 activation
-
Knyazhitsky, M., Moas, E., Shaginov, E., Luria, A. & Braiman, A. (2012). Vav1 oncogenic mutation inhibits T cell receptor-induced calcium mobilization through inhibition of phospholipase Cgamma1 activation. Journal of Biological Chemistry 287, 19725-19735.
-
(2012)
Journal of Biological Chemistry
, vol.287
, pp. 19725-19735
-
-
Knyazhitsky, M.1
Moas, E.2
Shaginov, E.3
Luria, A.4
Braiman, A.5
-
39
-
-
17844364513
-
Paradigm shift of the plasma membrane concept from the two-dimensional continuum fluid to the partitioned fluid: high-speed single-molecule tracking of membrane molecules
-
Kusumi, A., Nakada, C., Ritchie, K., Murase, K., Suzuki, K., Murakoshi, H., Kasai, R. S., Kondo, J. & Fujiwara, T. (2005). Paradigm shift of the plasma membrane concept from the two-dimensional continuum fluid to the partitioned fluid: high-speed single-molecule tracking of membrane molecules. Annual Review of Biophysics and Biomolecular Structure 34, 351-378.
-
(2005)
Annual Review of Biophysics and Biomolecular Structure
, vol.34
, pp. 351-378
-
-
Kusumi, A.1
Nakada, C.2
Ritchie, K.3
Murase, K.4
Suzuki, K.5
Murakoshi, H.6
Kasai, R.S.7
Kondo, J.8
Fujiwara, T.9
-
40
-
-
83455259711
-
Cancer: a drug-resistant duo
-
Lavoie, H. & Therrien, M. (2011). Cancer: a drug-resistant duo. Nature 480, 329-330.
-
(2011)
Nature
, vol.480
, pp. 329-330
-
-
Lavoie, H.1
Therrien, M.2
-
41
-
-
84879422871
-
Inhibitors that stabilize a closed RAF kinase domain conformation induce dimerization
-
Lavoie, H., Thevakumaran, N., Gavory, G., Li, J. J., Padeganeh, A., Guiral, S., Duchaine, J., Mao, D. Y., Bouvier, M., Sicheri, F. & Therrien, M. (2013). Inhibitors that stabilize a closed RAF kinase domain conformation induce dimerization. Nature Chemical Biology 9, 428-436.
-
(2013)
Nature Chemical Biology
, vol.9
, pp. 428-436
-
-
Lavoie, H.1
Thevakumaran, N.2
Gavory, G.3
Li, J.J.4
Padeganeh, A.5
Guiral, S.6
Duchaine, J.7
Mao, D.Y.8
Bouvier, M.9
Sicheri, F.10
Therrien, M.11
-
42
-
-
33846962842
-
IQGAP1 stimulates actin assembly through the N-WASP-Arp2/3 pathway
-
Le Clainche, C., Schlaepfer, D., Ferrari, A., Klingauf, M., Grohmanova, K., Veligodskiy, A., Didry, D., Le, D., Egile, C., Carlier, M. F. & Kroschewski, R. (2007). IQGAP1 stimulates actin assembly through the N-WASP-Arp2/3 pathway. Journal of Biological Chemistry 282, 426-435.
-
(2007)
Journal of Biological Chemistry
, vol.282
, pp. 426-435
-
-
Le Clainche, C.1
Schlaepfer, D.2
Ferrari, A.3
Klingauf, M.4
Grohmanova, K.5
Veligodskiy, A.6
Didry, D.7
Le, D.8
Egile, C.9
Carlier, M.F.10
Kroschewski, R.11
-
43
-
-
84888326531
-
Deformation of a two-domain lipid bilayer due to asymmetric insertion of lipid-modified Ras peptides
-
Li, Z. & Gorfe, A. A. (2013). Deformation of a two-domain lipid bilayer due to asymmetric insertion of lipid-modified Ras peptides. Soft Matter 9, 11249-11256.
-
(2013)
Soft Matter
, vol.9
, pp. 11249-11256
-
-
Li, Z.1
Gorfe, A.A.2
-
44
-
-
84861961427
-
Structural basis for allosteric regulation of GPCRs by sodium ions
-
Liu, W., Chun, E., Thompson, A. A., Chubukov, P., Xu, F., Katritch, V., Han, G. W., Roth, C. B., Heitman, L. H., Ijzerman, A. P., Cherezov, V. & Stevens, R. C. (2012). Structural basis for allosteric regulation of GPCRs by sodium ions. Science 337, 232-236.
-
(2012)
Science
, vol.337
, pp. 232-236
-
-
Liu, W.1
Chun, E.2
Thompson, A.A.3
Chubukov, P.4
Xu, F.5
Katritch, V.6
Han, G.W.7
Roth, C.B.8
Heitman, L.H.9
Ijzerman, A.P.10
Cherezov, V.11
Stevens, R.C.12
-
45
-
-
79960189344
-
Dynamic allostery: linkers are not merely flexible
-
Ma, B., Tsai, C. J., Haliloglu, T. & Nussinov, R. (2011). Dynamic allostery: linkers are not merely flexible. Structure 19, 907-917.
-
(2011)
Structure
, vol.19
, pp. 907-917
-
-
Ma, B.1
Tsai, C.J.2
Haliloglu, T.3
Nussinov, R.4
-
46
-
-
79955574252
-
Interactions between kinase scaffold MP1/p14 and its endosomal anchoring protein p18
-
Magee, J. & Cygler, M. (2011). Interactions between kinase scaffold MP1/p14 and its endosomal anchoring protein p18. Biochemistry 50, 3696-3705.
-
(2011)
Biochemistry
, vol.50
, pp. 3696-3705
-
-
Magee, J.1
Cygler, M.2
-
47
-
-
84857476097
-
IQGAP1: a regulator of intracellular spacetime relativity
-
Malarkannan, S., Awasthi, A., Rajasekaran, K., Kumar, P., Schuldt, K. M., Bartoszek, A., Manoharan, N., Goldner, N. K., Umhoefer, C. M. & Thakar, M. S. (2012). IQGAP1: a regulator of intracellular spacetime relativity. Journal of Immunology 188, 2057-2063.
-
(2012)
Journal of Immunology
, vol.188
, pp. 2057-2063
-
-
Malarkannan, S.1
Awasthi, A.2
Rajasekaran, K.3
Kumar, P.4
Schuldt, K.M.5
Bartoszek, A.6
Manoharan, N.7
Goldner, N.K.8
Umhoefer, C.M.9
Thakar, M.S.10
-
48
-
-
77951620965
-
Spatial organization and signal transduction at intercellular junctions
-
Manz, B. N. & Groves, J. T. (2010). Spatial organization and signal transduction at intercellular junctions. Nature Reviews Molecular Cell Biology 11, 342-352.
-
(2010)
Nature Reviews Molecular Cell Biology
, vol.11
, pp. 342-352
-
-
Manz, B.N.1
Groves, J.T.2
-
49
-
-
84875538701
-
The actin and tetraspanin networks organize receptor nanoclusters to regulate B cell receptor-mediated signaling
-
Mattila, P. K., Feest, C., Depoil, D., Treanor, B., Montaner, B., Otipoby, K. L., Carter, R., Justement, L. B., Bruckbauer, A. & Batista, F. D. (2013). The actin and tetraspanin networks organize receptor nanoclusters to regulate B cell receptor-mediated signaling. Immunity 38, 461-474.
-
(2013)
Immunity
, vol.38
, pp. 461-474
-
-
Mattila, P.K.1
Feest, C.2
Depoil, D.3
Treanor, B.4
Montaner, B.5
Otipoby, K.L.6
Carter, R.7
Justement, L.B.8
Bruckbauer, A.9
Batista, F.D.10
-
50
-
-
84874849890
-
Membrane-dependent modulation of the mTOR activator Rheb: NMR observations of a GTPase tethered to a lipid-bilayer nanodisc
-
Mazhab-Jafari, M. T., Marshall, C. B., Stathopulos, P. B., Kobashigawa, Y., Stambolic, V., Kay, L. E., Inagaki, F. & Ikura, M. (2013). Membrane-dependent modulation of the mTOR activator Rheb: NMR observations of a GTPase tethered to a lipid-bilayer nanodisc. Journal of the American Chemical Society 135, 3367-3370.
-
(2013)
Journal of the American Chemical Society
, vol.135
, pp. 3367-3370
-
-
Mazhab-Jafari, M.T.1
Marshall, C.B.2
Stathopulos, P.B.3
Kobashigawa, Y.4
Stambolic, V.5
Kay, L.E.6
Inagaki, F.7
Ikura, M.8
-
51
-
-
33645310982
-
ITAM-mediated tonic signalling through pre-BCR and BCR complexes
-
Monroe, J. G. (2006). ITAM-mediated tonic signalling through pre-BCR and BCR complexes. Nature Reviews Immunology 6, 283-294.
-
(2006)
Nature Reviews Immunology
, vol.6
, pp. 283-294
-
-
Monroe, J.G.1
-
52
-
-
30744456032
-
Visualizing association of N-ras in lipid microdomains: influence of domain structure and interfacial adsorption
-
Nicolini, C., Baranski, J., Schlummer, S., Palomo, J., Lumbierres-Burgues, M., Kahms, M., Kuhlmann, J., Sanchez, S., Gratton, E., Waldmann, H. & Winter, R. (2006). Visualizing association of N-ras in lipid microdomains: influence of domain structure and interfacial adsorption. Journal of the American Chemical Society 128, 192-201.
-
(2006)
Journal of the American Chemical Society
, vol.128
, pp. 192-201
-
-
Nicolini, C.1
Baranski, J.2
Schlummer, S.3
Palomo, J.4
Lumbierres-Burgues, M.5
Kahms, M.6
Kuhlmann, J.7
Sanchez, S.8
Gratton, E.9
Waldmann, H.10
Winter, R.11
-
53
-
-
84884501302
-
Eph/ephrin recognition and the role of Eph/ephrin clusters in signaling initiation
-
Nikolov, D. B., Xu, K. & Himanen, J. P. (2013). Eph/ephrin recognition and the role of Eph/ephrin clusters in signaling initiation. Biochimica et Biophysica Acta 1834, 2160-2165.
-
(2013)
Biochimica et Biophysica Acta
, vol.1834
, pp. 2160-2165
-
-
Nikolov, D.B.1
Xu, K.2
Himanen, J.P.3
-
54
-
-
84881493915
-
The spatial structure of cell signaling systems
-
Nussinov, R. (2013). The spatial structure of cell signaling systems. Physical Biology 10, 045004.
-
(2013)
Physical Biology
, vol.10
, pp. 045004
-
-
Nussinov, R.1
-
55
-
-
84856078561
-
Protein dynamics and conformational selection in bidirectional signal transduction
-
Nussinov, R. & Ma, B. (2012). Protein dynamics and conformational selection in bidirectional signal transduction. BMC Biology 10, 2(5).
-
(2012)
BMC Biology
, vol.10
, Issue.5
, pp. 2
-
-
Nussinov, R.1
Ma, B.2
-
56
-
-
84876296757
-
A broad view of scaffolding suggests that scaffolding proteins can actively control regulation and signaling of multienzyme complexes through allostery
-
Nussinov, R., Ma, B. & Tsai, C. J. (2013a). A broad view of scaffolding suggests that scaffolding proteins can actively control regulation and signaling of multienzyme complexes through allostery. Biochimica et Biophysica Acta 1834, 820-829.
-
(2013)
Biochimica et Biophysica Acta
, vol.1834
, pp. 820-829
-
-
Nussinov, R.1
Ma, B.2
Tsai, C.J.3
-
57
-
-
84883480131
-
Allosteric conformational barcodes direct signaling in the cell
-
Nussinov, R., Ma, B., Tsai, C. J. & Csermely, P. (2013b). Allosteric conformational barcodes direct signaling in the cell. Structure 21, 1509-1521.
-
(2013)
Structure
, vol.21
, pp. 1509-1521
-
-
Nussinov, R.1
Ma, B.2
Tsai, C.J.3
Csermely, P.4
-
58
-
-
84876275408
-
The underappreciated role of allostery in the cellular network
-
Nussinov, R., Tsai, C. J. & Ma, B. (2013c). The underappreciated role of allostery in the cellular network. Annual Review of Biophysics 42, 169-189.
-
(2013)
Annual Review of Biophysics
, vol.42
, pp. 169-189
-
-
Nussinov, R.1
Tsai, C.J.2
Ma, B.3
-
59
-
-
84897052340
-
Free energy diagrams for protein function
-
Nussinov, R. & Tsai, C. J. (2014). Free energy diagrams for protein function. Chemistry & Biology 21, 311-318.
-
(2014)
Chemistry & Biology
, vol.21
, pp. 311-318
-
-
Nussinov, R.1
Tsai, C.J.2
-
60
-
-
84866597525
-
Allosteric post-translational modification codes
-
Nussinov, R., Tsai, C. J., Xin, F. & Radivojac, P. (2012). Allosteric post-translational modification codes. Trends in Biochemical Sciences 37, 447-455.
-
(2012)
Trends in Biochemical Sciences
, vol.37
, pp. 447-455
-
-
Nussinov, R.1
Tsai, C.J.2
Xin, F.3
Radivojac, P.4
-
61
-
-
84861805331
-
The role of cholesterol on the activity and stability of neurotensin receptor 1
-
Oates, J., Faust, B., Attrill, H., Harding, P., Orwick, M. & Watts, A. (2012). The role of cholesterol on the activity and stability of neurotensin receptor 1. Biochimica et Biophysica Acta 1818, 2228-2233.
-
(2012)
Biochimica et Biophysica Acta
, vol.1818
, pp. 2228-2233
-
-
Oates, J.1
Faust, B.2
Attrill, H.3
Harding, P.4
Orwick, M.5
Watts, A.6
-
62
-
-
62149129986
-
Compartmentalized signalling: Ras proteins and signalling nanoclusters
-
Omerovic, J. & Prior, I. A. (2009). Compartmentalized signalling: Ras proteins and signalling nanoclusters. The FEBS Journal 276, 1817-1825.
-
(2009)
The FEBS Journal
, vol.276
, pp. 1817-1825
-
-
Omerovic, J.1
Prior, I.A.2
-
63
-
-
84874284008
-
Spatial coupling of JNK activation to the B cell antigen receptor by tyrosine-phosphorylated ezrin
-
Parameswaran, N., Enyindah-Asonye, G., Bagheri, N., Shah, N. B. & Gupta, N. (2013). Spatial coupling of JNK activation to the B cell antigen receptor by tyrosine-phosphorylated ezrin. Journal of Immunology 190, 2017-2026.
-
(2013)
Journal of Immunology
, vol.190
, pp. 2017-2026
-
-
Parameswaran, N.1
Enyindah-Asonye, G.2
Bagheri, N.3
Shah, N.B.4
Gupta, N.5
-
64
-
-
46149107301
-
Electrostatic interactions positively regulate K-Ras nanocluster formation and function
-
Plowman, S. J., Ariotti, N., Goodall, A., Parton, R. G. & Hancock, J. F. (2008). Electrostatic interactions positively regulate K-Ras nanocluster formation and function. Molecular and Cellular Biology 28, 4377-4385.
-
(2008)
Molecular and Cellular Biology
, vol.28
, pp. 4377-4385
-
-
Plowman, S.J.1
Ariotti, N.2
Goodall, A.3
Parton, R.G.4
Hancock, J.F.5
-
65
-
-
27344456331
-
H-ras, K-ras, and inner plasma membrane raft proteins operate in nanoclusters with differential dependence on the actin cytoskeleton
-
Plowman, S. J., Muncke, C., Parton, R. G. & Hancock, J. F. (2005). H-ras, K-ras, and inner plasma membrane raft proteins operate in nanoclusters with differential dependence on the actin cytoskeleton. Proceedings of the National Academy of Sciences of the United States of America 102, 15500-15505.
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, pp. 15500-15505
-
-
Plowman, S.J.1
Muncke, C.2
Parton, R.G.3
Hancock, J.F.4
-
66
-
-
83455254767
-
RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)
-
Poulikakos, P. I., Persaud, Y., Janakiraman, M., Kong, X., Ng, C., Moriceau, G., Shi, H., Atefi, M., Titz, B., Gabay, M. T., Salton, M., Dahlman, K. B., Tadi, M., Wargo, J. A., Flaherty, K. T., Kelley, M. C., Misteli, T., Chapman, P. B., Sosman, J. A., Graeber, T. G., Ribas, A., Lo, R. S., Rosen, N. & Solit, D. B. (2011). RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E). Nature 480, 387-390.
-
(2011)
Nature
, vol.480
, pp. 387-390
-
-
Poulikakos, P.I.1
Persaud, Y.2
Janakiraman, M.3
Kong, X.4
Ng, C.5
Moriceau, G.6
Shi, H.7
Atefi, M.8
Titz, B.9
Gabay, M.T.10
Salton, M.11
Dahlman, K.B.12
Tadi, M.13
Wargo, J.A.14
Flaherty, K.T.15
Kelley, M.C.16
Misteli, T.17
Chapman, P.B.18
Sosman, J.A.19
Graeber, T.G.20
Ribas, A.21
Lo, R.S.22
Rosen, N.23
Solit, D.B.24
more..
-
67
-
-
0037455589
-
Direct visualization of Ras proteins in spatially distinct cell surface microdomains
-
Prior, I. A., Muncke, C., Parton, R. G. & Hancock, J. F. (2003). Direct visualization of Ras proteins in spatially distinct cell surface microdomains. The Journal of Cell Biology 160, 165-170.
-
(2003)
The Journal of Cell Biology
, vol.160
, pp. 165-170
-
-
Prior, I.A.1
Muncke, C.2
Parton, R.G.3
Hancock, J.F.4
-
68
-
-
0030926137
-
Ligand-specific oligomerization of T-cell receptor molecules
-
Reich, Z., Boniface, J. J., Lyons, D. S., Borochov, N., Wachtel, E. J. & Davis, M. M. (1997). Ligand-specific oligomerization of T-cell receptor molecules. Nature 387, 617-620.
-
(1997)
Nature
, vol.387
, pp. 617-620
-
-
Reich, Z.1
Boniface, J.J.2
Lyons, D.S.3
Borochov, N.4
Wachtel, E.J.5
Davis, M.M.6
-
69
-
-
84871201282
-
Conformational states of the kinase Lck regulate clustering in early T cell signaling
-
Rossy, J., Owen, D. M., Williamson, D. J., Yang, Z. & Gaus, K. (2013). Conformational states of the kinase Lck regulate clustering in early T cell signaling. Nature Immunology 14, 82-89.
-
(2013)
Nature Immunology
, vol.14
, pp. 82-89
-
-
Rossy, J.1
Owen, D.M.2
Williamson, D.J.3
Yang, Z.4
Gaus, K.5
-
70
-
-
84881480308
-
Structurally encoded intraclass differences in EphA clusters drive distinct cell responses
-
Seiradake, E., Schaupp, A., Del Toro Ruiz, D., Kaufmann, R., Mitakidis, N., Harlos, K., Aricescu, A. R., Klein, R. & Jones, E. Y. (2013). Structurally encoded intraclass differences in EphA clusters drive distinct cell responses. Nature Structural & Molecular Biology 20, 958-964.
-
(2013)
Nature Structural & Molecular Biology
, vol.20
, pp. 958-964
-
-
Seiradake, E.1
Schaupp, A.2
Del Toro Ruiz, D.3
Kaufmann, R.4
Mitakidis, N.5
Harlos, K.6
Aricescu, A.R.7
Klein, R.8
Jones, E.Y.9
-
71
-
-
84871551631
-
Cholesterol modulates the structure, binding modes, and energetics of caveolin-membrane interactions
-
Sengupta, D. (2012). Cholesterol modulates the structure, binding modes, and energetics of caveolin-membrane interactions. The Journal of Physical Chemistry B 116, 14556-14564.
-
(2012)
The Journal of Physical Chemistry B
, vol.116
, pp. 14556-14564
-
-
Sengupta, D.1
-
73
-
-
78650147139
-
Allostery at G protein-coupled receptor homo- and heteromers: uncharted pharmacological landscapes
-
Smith, N. J. & Milligan, G. (2010). Allostery at G protein-coupled receptor homo- and heteromers: uncharted pharmacological landscapes. Pharmacological Reviews 62, 701-725.
-
(2010)
Pharmacological Reviews
, vol.62
, pp. 701-725
-
-
Smith, N.J.1
Milligan, G.2
-
74
-
-
68149157248
-
The origin of allosteric functional modulation: multiple pre-existing pathways
-
del Sol, A., Tsai, C. J., Ma, B. & Nussinov, R. (2009). The origin of allosteric functional modulation: multiple pre-existing pathways. Structure 17, 1042-1050.
-
(2009)
Structure
, vol.17
, pp. 1042-1050
-
-
del Sol, A.1
Tsai, C.J.2
Ma, B.3
Nussinov, R.4
-
75
-
-
70350304558
-
PI3 kinase signals BCR-dependent mature B cell survival
-
Srinivasan, L., Sasaki, Y., Calado, D. P., Zhang, B., Paik, J. H., DePinho, R. A., Kutok, J. L., Kearney, J. F., Otipoby, K. L. & Rajewsky, K. (2009). PI3 kinase signals BCR-dependent mature B cell survival. Cell 139, 573-586.
-
(2009)
Cell
, vol.139
, pp. 573-586
-
-
Srinivasan, L.1
Sasaki, Y.2
Calado, D.P.3
Zhang, B.4
Paik, J.H.5
DePinho, R.A.6
Kutok, J.L.7
Kearney, J.F.8
Otipoby, K.L.9
Rajewsky, K.10
-
76
-
-
84863107745
-
A conserved role of IQGAP1 in regulating TOR complex 1
-
Tekletsadik, Y. K., Sonn, R. & Osman, M. A. (2012). A conserved role of IQGAP1 in regulating TOR complex 1. Journal of Cell Science 125, 2041-2052.
-
(2012)
Journal of Cell Science
, vol.125
, pp. 2041-2052
-
-
Tekletsadik, Y.K.1
Sonn, R.2
Osman, M.A.3
-
77
-
-
34547561587
-
Plasma membrane nanoswitches generate high-fidelity Ras signal transduction
-
Tian, T., Harding, A., Inder, K., Plowman, S., Parton, R. G. & Hancock, J. F. (2007). Plasma membrane nanoswitches generate high-fidelity Ras signal transduction. Nature Cell Biology 9, 905-914.
-
(2007)
Nature Cell Biology
, vol.9
, pp. 905-914
-
-
Tian, T.1
Harding, A.2
Inder, K.3
Plowman, S.4
Parton, R.G.5
Hancock, J.F.6
-
78
-
-
77953536657
-
Organisation and dynamics of antigen receptors: implications for lymphocyte signalling
-
Treanor, B. & Batista, F. D. (2010). Organisation and dynamics of antigen receptors: implications for lymphocyte signalling. Current Opinion in Immunology 22, 299-307.
-
(2010)
Current Opinion in Immunology
, vol.22
, pp. 299-307
-
-
Treanor, B.1
Batista, F.D.2
-
79
-
-
84881109637
-
The molecular basis of targeting protein kinases in cancer therapeutics
-
Tsai, C. J. & Nussinov, R. (2013). The molecular basis of targeting protein kinases in cancer therapeutics. Seminars in Cancer Biology 23, 235-242.
-
(2013)
Seminars in Cancer Biology
, vol.23
, pp. 235-242
-
-
Tsai, C.J.1
Nussinov, R.2
-
80
-
-
60649109828
-
Protein allostery, signal transmission and dynamics: a classification scheme of allosteric mechanisms
-
Tsai, C. J., del Sol, A. & Nussinov, R. (2009). Protein allostery, signal transmission and dynamics: a classification scheme of allosteric mechanisms. Molecular Biosystems 5, 207-216.
-
(2009)
Molecular Biosystems
, vol.5
, pp. 207-216
-
-
Tsai, C.J.1
del Sol, A.2
Nussinov, R.3
-
81
-
-
79951581366
-
Mechanistic principles of RAF kinase signaling
-
Udell, C. M., Rajakulendran, T., Sicheri, F. & Therrien, M. (2011). Mechanistic principles of RAF kinase signaling. Cellular and Molecular Life Sciences 68, 553-565.
-
(2011)
Cellular and Molecular Life Sciences
, vol.68
, pp. 553-565
-
-
Udell, C.M.1
Rajakulendran, T.2
Sicheri, F.3
Therrien, M.4
-
82
-
-
79851483766
-
Membrane-mediated induction and sorting of K-Ras microdomain signaling platforms
-
Weise, K., Kapoor, S., Denter, C., Nikolaus, J., Opitz, N., Koch, S., Triola, G., Herrmann, A., Waldmann, H. & Winter, R. (2011). Membrane-mediated induction and sorting of K-Ras microdomain signaling platforms. Journal of the American Chemical Society 133, 880-887.
-
(2011)
Journal of the American Chemical Society
, vol.133
, pp. 880-887
-
-
Weise, K.1
Kapoor, S.2
Denter, C.3
Nikolaus, J.4
Opitz, N.5
Koch, S.6
Triola, G.7
Herrmann, A.8
Waldmann, H.9
Winter, R.10
-
83
-
-
84863967918
-
Dissociation of the K-Ras4B/PDEdelta complex upon contact with lipid membranes: membrane delivery instead of extraction
-
Weise, K., Kapoor, S., Werkmuller, A., Mobitz, S., Zimmermann, G., Triola, G., Waldmann, H. & Winter, R. (2012). Dissociation of the K-Ras4B/PDEdelta complex upon contact with lipid membranes: membrane delivery instead of extraction. Journal of the American Chemical Society 134, 11503-11510.
-
(2012)
Journal of the American Chemical Society
, vol.134
, pp. 11503-11510
-
-
Weise, K.1
Kapoor, S.2
Werkmuller, A.3
Mobitz, S.4
Zimmermann, G.5
Triola, G.6
Waldmann, H.7
Winter, R.8
-
84
-
-
84856219974
-
IQGAP1 and its binding proteins control diverse biological functions
-
White, C. D., Erdemir, H. H. & Sacks, D. B. (2012). IQGAP1 and its binding proteins control diverse biological functions. Cellular Signalling 24, 826-834.
-
(2012)
Cellular Signalling
, vol.24
, pp. 826-834
-
-
White, C.D.1
Erdemir, H.H.2
Sacks, D.B.3
-
85
-
-
0032508517
-
Ras isoforms vary in their ability to activate Raf-1 and phosphoinositide 3-kinase
-
Yan, J., Roy, S., Apolloni, A., Lane, A. & Hancock, J. F. (1998). Ras isoforms vary in their ability to activate Raf-1 and phosphoinositide 3-kinase. The Journal of Biological Chemistry 273, 24052-24056.
-
(1998)
The Journal of Biological Chemistry
, vol.273
, pp. 24052-24056
-
-
Yan, J.1
Roy, S.2
Apolloni, A.3
Lane, A.4
Hancock, J.F.5
-
86
-
-
33745002702
-
An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor
-
Zhang, X., Gureasko, J., Shen, K., Cole, P. A. & Kuriyan, J. (2006). An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor. Cell 125, 1137-1149.
-
(2006)
Cell
, vol.125
, pp. 1137-1149
-
-
Zhang, X.1
Gureasko, J.2
Shen, K.3
Cole, P.A.4
Kuriyan, J.5
|