Alterations in membrane-bound and cytoplasmic K-ras protein levels in mouse lung induced by treatment with lovastatin, cholestyramine, or niacin: Effects are highly mouse strain dependent

Biochemical Pharmacology

Volumn 64, Issue 1, 2002, Pages 41-48

  Calvert, Richard J ^a,b   Ramakrishna, Gayatri ^b   Tepper, Shirley ^c   Diwan, Bhalchandra A ^d   Anderson, Lucy M ^b   Kritchevsky, David ^c  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c WISTAR INSTITUTE   (United States)

^d SAIC FREDERICK INC   (United States)

Author keywords

Cholesterol; Cholestyramine; K ras; Lovastatin; Mouse lung; Niacin

Indexed keywords

CHOLESTEROL; COLESTYRAMINE; CYTOPLASM PROTEIN; K RAS PROTEIN; MEMBRANE PROTEIN; MEVINOLIN; NICOTINIC ACID; ONCOPROTEIN; PROTEIN ANTIBODY; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY SPECIFICITY; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; IMMUNOPRECIPITATION; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; ONCOGENE K RAS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN LOCALIZATION; STRAIN DIFFERENCE; TRIACYLGLYCEROL BLOOD LEVEL; WESTERN BLOTTING;

ANIMALS; ANTILIPEMIC AGENTS; BODY WEIGHT; CELL MEMBRANE; CHOLESTEROL; CHOLESTYRAMINE; CYTOPLASM; GENES, RAS; LOVASTATIN; LUNG; MICE; MICE, INBRED C57BL; NIACIN; TRIGLYCERIDES;

EID: 0036639438     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(02)01077-8     Document Type: Article

References (22)

1. Serum cholesterol and cancer risk: An epidemiologic perspective
2. Differential distribution and increased levels of ras proteins during lung development
3. K-ras p21 expression and activity in lung and lung tumors
4. Decrease in K-ras p21 and increase in Raf1 and activated Erk 1 and 2 in murine lung tumors initiated by N-nitrosodimethylamine and promoted by TCDD
5. Diet-induced reduction in serum lipoproteins stimulates cell proliferation in weanling rats
6. Effect of cholesterol and cholestyramine feeding and of fasting on sterol synthesis in liver, ileum, and lung of the guinea pig
7. Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity
8. Substrate binding is required for release of product from mammalian protein farnesyltransferase
9. Cholestyramine promotes 7,12-dimethylbenzanthracene induced mammary cancer in Wistar rats
10. A rat model for studying colon cancer: Effect of cholestyramine on induced tumors
11. Inhibition of lung tumor growth and mouse lung tumor formation by lovastatin
12. Chemoprevention by pravastatin, a 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor of N-methyl-N-nitrosourea-induced colon carcinogenesis in F344 rats
13. Influence of nicotinic acid on metabolism of cholesterol and triglycerides in man
14. AIN-93 purified diets for laboratory rodents: Final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet
15. Inhibition of ras p21 membrane localization and modulation of protein kinase C isoenzyme expression during regression of chemical carcinogen-induced murine skin tumors by lovastatin
16. Levels and membrane localization of the c-K-ras p21 protein in lungs of mice of different genetic strains and effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and Aroclor 1254
17. Relationship between the formation of promutagenic adducts and the activation of the K-ras protooncogene in lung tumors from A/J mice treated with nitrosamines
18. Effects of K-ras gene mutations in the development of lung lesions induced by 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone in A/J mice
19. Genetic and dietary interactions in the regulation of HMG-CoA reductase gene expression
20. Feedback regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in livers of mice treated with mevinolin, a competitive inhibitor of the reductase
21. The lovastatin-treated rodent: A new model of barrier disruption and epidermal hyperplasia
22. Promising new developments in cancer chemotherapy