Effects of point substitutions on the structure of toxic Alzheimer's β-amyloid channels: Atomic force microscopy and molecular dynamics simulations

Biochemistry

Volumn 51, Issue 14, 2012, Pages 3031-3038

  Connelly, Laura ^a   Jang, Hyunbum ^b   Teran Arce, Fernando ^a   Ramachandran, Srinivasan ^a   Kagan, Bruce L ^c   Nussinov, Ruth ^b,d   Lal, Ratnesh ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SAIC FREDERICK INC   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d TEL AVIV UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

AFM; AFM IMAGE; ALZHEIMER'S; ALZHEIMER'S DISEASE; AMINO ACID SEQUENCE; ATOMIC FORCE MICROSCOPIES (AFM); BILAYER SYSTEMS; CHANNEL STRUCTURES; DRUG DEVELOPMENT; IONIC HOMEOSTASIS; MD SIMULATION; MEMORY LOSS; MISFOLDED PROTEINS; MOLECULAR DYNAMICS SIMULATIONS; MOLECULAR SIGNALS; NEURODEGENERATION; SENILE PLAQUES; SITE-SPECIFIC; STRUCTURE ACTIVITY RELATIONSHIPS; THERAPEUTIC TARGETS; VIA BLOCKAGE; WILD TYPES;

AMINO ACIDS; ATOMIC FORCE MICROSCOPY; FORECASTING; GLYCOPROTEINS; LIPID BILAYERS; MEDICAL PROBLEMS; MOLECULAR DYNAMICS; NEURODEGENERATIVE DISEASES; PEPTIDES; PORE STRUCTURE;

COMPUTER SIMULATION;

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-42]; PHENYLALANINE; PROLINE;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; AMNESIA; ARTICLE; ATOMIC FORCE MICROSCOPY; BETA SHEET; CONDUCTANCE; HOMEOSTASIS; LIPID BILAYER; MOLECULAR DYNAMICS; MOLECULAR MODEL; NERVE DEGENERATION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN STRUCTURE; SENILE PLAQUE; SIGNAL TRANSDUCTION; SIMULATION; WILD TYPE;

ALZHEIMER DISEASE; AMYLOID; AMYLOID BETA-PEPTIDES; LIPID BILAYERS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; PEPTIDE FRAGMENTS; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84859622200     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi300257e     Document Type: Article

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