Expression and functional relevance of UGT1A4 in a cohort of human drug-resistant epileptic brains

Epilepsia

Volumn 54, Issue 9, 2013, Pages 1562-1570

  Ghosh, Chaitali ^a   Hossain, Mohammed ^a   Puvenna, Vikram ^a   Martinez Gonzalez, Jorge ^a   Alexopolous, Andreas ^a   Janigro, Damir ^a,b   Marchi, Nicola ^a,b  

^a LERNER RESEARCH INSTITUTE   (United States)

^b CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE   (United States)

Author keywords

Antiepileptic drugs; Cerebrovasculature; Lamotrigine; Phase II metabolism; Seizures; UGT1A4

Indexed keywords

2 N GLUCURONIDE; CARBAMAZEPINE; DIAZEPAM; DNA; DRUG METABOLITE; ETIRACETAM; GABAPENTIN; GLUCURONOSYLTRANSFERASE 1A4; HARKOSERIDE; LAMOTRIGINE; PHENOBARBITAL; PHENYTOIN; PREGABALIN; PRIMIDONE; TOPIRAMATE; UNCLASSIFIED DRUG; VALPROIC ACID;

ADULT; ARTICLE; BLOOD BRAIN BARRIER; BLOOD SAMPLING; CELL STRESS; CELL SURVIVAL; CELL VIABILITY; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE MARKER; DRUG METABOLISM; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; MALE; MICROVASCULAR ENDOTHELIAL CELL; NERVE CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; TEMPORAL LOBE EPILEPSY; TEMPORAL LOBECTOMY; WESTERN BLOTTING;

ANTIEPILEPTIC DRUGS; CEREBROVASCULATURE; LAMOTRIGINE; PHASE II METABOLISM; SEIZURES; UGT1A4;

ADULT; ANTICONVULSANTS; BLOOD-BRAIN BARRIER; BRAIN; DRUG RESISTANCE, MULTIPLE; ENDOTHELIAL CELLS; EPILEPSY; FEMALE; GLUCURONOSYLTRANSFERASE; HUMANS; MALE; MIDDLE AGED; NEURONS; TRIAZINES;

EID: 84883739935     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/epi.12318     Document Type: Article

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